APOBEC4

Functionⁱ

Putative C to U editing enzyme whose physiological substrate is not yet known.By similarity

Cofactorⁱ

Zn²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	93	Zinc; catalyticBy similarity	1
Active siteⁱ	95	Proton donorBy similarity	1
Metal bindingⁱ	127	Zinc; catalyticBy similarity	1
Metal bindingⁱ	134	Zinc; catalyticBy similarity	1

GO - Molecular functionⁱ

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA processing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	mRNA processing
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72200 mRNA Editing: C to U Conversion R-HSA-75094 Formation of the Editosome

Reactomeⁱ

R-HSA-72200 mRNA Editing: C to U Conversion
R-HSA-75094 Formation of the Editosome

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative C->U-editing enzyme APOBEC-4 (EC:3.5.4.-) Alternative name(s): Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Gene namesⁱ	Name:APOBEC4 Synonyms:C1orf169
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173627.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32152 APOBEC4
MIMⁱ	609908 gene
neXtProtⁱ	NX_Q8WW27

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000173627
PharmGKBⁱ	PA142672597

Polymorphism and mutation databases

BioMutaⁱ	APOBEC4
DMDMⁱ	74751569

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000239355	1 – 367	Putative C->U-editing enzyme APOBEC-4Add BLAST		367

Proteomic databases

PaxDbⁱ	Q8WW27
PeptideAtlas More...PeptideAtlasⁱ	Q8WW27
PRIDEⁱ	Q8WW27
ProteomicsDBⁱ	74852

PTM databases

iPTMnetⁱ	Q8WW27
PhosphoSitePlusⁱ	Q8WW27

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000173627 Expressed in 39 organ(s), highest expression level in testis
CleanExⁱ	HS_APOBEC4
Genevisibleⁱ	Q8WW27 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015636 HPA015637

HPAⁱ

HPA015636
HPA015637

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000310622

STRINGⁱ

9606.ENSP00000310622

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WW27
SMRⁱ	Q8WW27
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	61 – 177	CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST		117

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	299 – 314	Leu-richAdd BLAST		16

Sequence similaritiesⁱ

Belongs to the cytidine and deoxycytidylate deaminase family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410II65 Eukaryota ENOG4111QES LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014243
HOGENOMⁱ	HOG000033767
HOVERGENⁱ	HBG080811
KEGG Orthology (KO) More...KOⁱ	K18773
OMAⁱ	VKPYYWL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T9Y
PhylomeDBⁱ	Q8WW27
TreeFamⁱ	TF338173

Family and domain databases

InterProⁱ	View protein in InterPro IPR038953 APOBEC4 IPR013158 APOBEC_N IPR002125 CMP_dCMP_dom
PANTHERⁱ	PTHR35672 PTHR35672, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08210 APOBEC_N, 1 hit
PROSITEⁱ	View protein in PROSITE PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WW27-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ 
        60         70         80         90        100
IFGFPYGTTF PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE 
       110        120        130        140        150
MNGYLDSAIY NNDSIRHIIL YSNNSPCNEA NHCCISKMYN FLITYPGITL 
       160        170        180        190        200
SIYFSQLYHT EMDFPASAWN REALRSLASL WPRVVLSPIS GGIWHSVLHS 
       210        220        230        240        250
FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT DVLLQTKRNP 
       260        270        280        290        300
NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD 
       310        320        330        340        350
LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ 
       360 
FASSKEADEK KKKKGKK

Length:367

Mass (Da):41,581

Last modified:March 1, 2002 - v1

Checksum:ⁱB5ACD9AB875482C6

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_026639	75	S → F. Corresponds to variant dbSNP:rs16861394Ensembl.	1
Natural variantⁱVAR_026640	271	F → S1 PublicationCorresponds to variant dbSNP:rs1174658Ensembl.	1
Natural variantⁱVAR_026641	275	P → S. Corresponds to variant dbSNP:rs10911391Ensembl.	1
Natural variantⁱVAR_048724	300	D → G. Corresponds to variant dbSNP:rs16861381Ensembl.	1
Natural variantⁱVAR_026642	331	K → E1 PublicationCorresponds to variant dbSNP:rs1174657Ensembl.	1
Natural variantⁱVAR_026643	345	V → M. Corresponds to variant dbSNP:rs10911390Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098557 mRNA Translation: BAC05332.1 AL137800 Genomic DNA No translation available. BC021711 mRNA Translation: AAH21711.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1358.1
NCBI Reference Sequences More...RefSeqⁱ	NP_982279.1, NM_203454.2
UniGeneⁱ	Hs.97335

Genome annotation databases

Ensemblⁱ	ENST00000308641; ENSP00000310622; ENSG00000173627
GeneIDⁱ	403314
KEGGⁱ	hsa:403314
UCSC genome browser More...UCSCⁱ	uc001gqn.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8WW27	Putative C->U-editing enzyme APOBEC-4		MACFA		363	UniRef90_Q8WW27
APOBEC4 isoform 1		PONAB		368
Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4		GORGO		368
Uncharacterized protein		PANTR		367
Apolipoprotein B mRNA editing enzyme catalytic polypeptide 4		MACMU		363
+16

Protein	Similar proteins		Species	Score	Length	Source
Q8WW27	Putative C->U-editing enzyme APOBEC-4		MACFA		363	UniRef50_Q8WW27
Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4		GORGO		368
APOBEC4 isoform 1		PONAB		368
Uncharacterized protein		PANTR		367
Apolipoprotein B mRNA editing enzyme catalytic polypeptide 4		CHLAE		363
+130

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098557 mRNA Translation: BAC05332.1 AL137800 Genomic DNA No translation available. BC021711 mRNA Translation: AAH21711.1
CCDSⁱ	CCDS1358.1
RefSeqⁱ	NP_982279.1, NM_203454.2
UniGeneⁱ	Hs.97335

3D structure databases

ProteinModelPortalⁱ	Q8WW27
SMRⁱ	Q8WW27
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000310622

STRINGⁱ

9606.ENSP00000310622

PTM databases

iPTMnetⁱ	Q8WW27
PhosphoSitePlusⁱ	Q8WW27

Polymorphism and mutation databases

BioMutaⁱ	APOBEC4
DMDMⁱ	74751569

Proteomic databases

PaxDbⁱ	Q8WW27
PeptideAtlasⁱ	Q8WW27
PRIDEⁱ	Q8WW27
ProteomicsDBⁱ	74852

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	403314
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308641; ENSP00000310622; ENSG00000173627
GeneIDⁱ	403314
KEGGⁱ	hsa:403314
UCSCⁱ	uc001gqn.4 human

Organism-specific databases

CTDⁱ	403314
EuPathDBⁱ	HostDB:ENSG00000173627.7
GeneCardsⁱ	APOBEC4
HGNCⁱ	HGNC:32152 APOBEC4
HPAⁱ	HPA015636 HPA015637
MIMⁱ	609908 gene
neXtProtⁱ	NX_Q8WW27
OpenTargetsⁱ	ENSG00000173627
PharmGKBⁱ	PA142672597
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II65 Eukaryota ENOG4111QES LUCA
GeneTreeⁱ	ENSGT00390000014243
HOGENOMⁱ	HOG000033767
HOVERGENⁱ	HBG080811
KOⁱ	K18773
OMAⁱ	VKPYYWL
OrthoDBⁱ	EOG091G0T9Y
PhylomeDBⁱ	Q8WW27
TreeFamⁱ	TF338173

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72200 mRNA Editing: C to U Conversion R-HSA-75094 Formation of the Editosome

Reactomeⁱ

R-HSA-72200 mRNA Editing: C to U Conversion
R-HSA-75094 Formation of the Editosome

Miscellaneous databases

GeneWikiⁱ	APOBEC4
GenomeRNAiⁱ	403314
Protein Ontology More...PROⁱ	PR:Q8WW27
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173627 Expressed in 39 organ(s), highest expression level in testis
CleanExⁱ	HS_APOBEC4
Genevisibleⁱ	Q8WW27 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR038953 APOBEC4 IPR013158 APOBEC_N IPR002125 CMP_dCMP_dom
PANTHERⁱ	PTHR35672 PTHR35672, 1 hit
Pfamⁱ	View protein in Pfam PF08210 APOBEC_N, 1 hit
PROSITEⁱ	View protein in PROSITE PS51747 CYT_DCMP_DEAMINASES_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ABEC4_HUMAN
Accessionⁱ	Q8WW27Primary (citable) accession number: Q8WW27 Secondary accession number(s): Q8N7F6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
	Last sequence update:	March 1, 2002
	Last modified:	November 7, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8WW27 (ABEC4_HUMAN)

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Putative C->U-editing enzyme APOBEC-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ