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Protein

Putative C->U-editing enzyme APOBEC-4

Gene

APOBEC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative C to U editing enzyme whose physiological substrate is not yet known.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93Zinc; catalyticBy similarity1
Active sitei95Proton donorBy similarity1
Metal bindingi127Zinc; catalyticBy similarity1
Metal bindingi134Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72200 mRNA Editing: C to U Conversion
R-HSA-75094 Formation of the Editosome

Names & Taxonomyi

Protein namesi
Recommended name:
Putative C->U-editing enzyme APOBEC-4 (EC:3.5.4.-)
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Gene namesi
Name:APOBEC4
Synonyms:C1orf169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173627.7
HGNCiHGNC:32152 APOBEC4
MIMi609908 gene
neXtProtiNX_Q8WW27

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173627
PharmGKBiPA142672597

Polymorphism and mutation databases

BioMutaiAPOBEC4
DMDMi74751569

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393551 – 367Putative C->U-editing enzyme APOBEC-4Add BLAST367

Proteomic databases

PaxDbiQ8WW27
PeptideAtlasiQ8WW27
PRIDEiQ8WW27
ProteomicsDBi74852

PTM databases

iPTMnetiQ8WW27
PhosphoSitePlusiQ8WW27

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000173627 Expressed in 39 organ(s), highest expression level in testis
CleanExiHS_APOBEC4
GenevisibleiQ8WW27 HS

Organism-specific databases

HPAiHPA015636
HPA015637

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310622

Structurei

3D structure databases

ProteinModelPortaliQ8WW27
SMRiQ8WW27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 177CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi299 – 314Leu-richAdd BLAST16

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410II65 Eukaryota
ENOG4111QES LUCA
GeneTreeiENSGT00390000014243
HOGENOMiHOG000033767
HOVERGENiHBG080811
KOiK18773
OMAiVKPYYWL
OrthoDBiEOG091G0T9Y
PhylomeDBiQ8WW27
TreeFamiTF338173

Family and domain databases

InterProiView protein in InterPro
IPR038953 APOBEC4
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
PANTHERiPTHR35672 PTHR35672, 1 hit
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
PROSITEiView protein in PROSITE
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WW27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ
60 70 80 90 100
IFGFPYGTTF PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE
110 120 130 140 150
MNGYLDSAIY NNDSIRHIIL YSNNSPCNEA NHCCISKMYN FLITYPGITL
160 170 180 190 200
SIYFSQLYHT EMDFPASAWN REALRSLASL WPRVVLSPIS GGIWHSVLHS
210 220 230 240 250
FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT DVLLQTKRNP
260 270 280 290 300
NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD
310 320 330 340 350
LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ
360
FASSKEADEK KKKKGKK
Length:367
Mass (Da):41,581
Last modified:March 1, 2002 - v1
Checksum:iB5ACD9AB875482C6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02663975S → F. Corresponds to variant dbSNP:rs16861394Ensembl.1
Natural variantiVAR_026640271F → S1 PublicationCorresponds to variant dbSNP:rs1174658Ensembl.1
Natural variantiVAR_026641275P → S. Corresponds to variant dbSNP:rs10911391Ensembl.1
Natural variantiVAR_048724300D → G. Corresponds to variant dbSNP:rs16861381Ensembl.1
Natural variantiVAR_026642331K → E1 PublicationCorresponds to variant dbSNP:rs1174657Ensembl.1
Natural variantiVAR_026643345V → M. Corresponds to variant dbSNP:rs10911390Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098557 mRNA Translation: BAC05332.1
AL137800 Genomic DNA No translation available.
BC021711 mRNA Translation: AAH21711.1
CCDSiCCDS1358.1
RefSeqiNP_982279.1, NM_203454.2
UniGeneiHs.97335

Genome annotation databases

EnsembliENST00000308641; ENSP00000310622; ENSG00000173627
GeneIDi403314
KEGGihsa:403314
UCSCiuc001gqn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098557 mRNA Translation: BAC05332.1
AL137800 Genomic DNA No translation available.
BC021711 mRNA Translation: AAH21711.1
CCDSiCCDS1358.1
RefSeqiNP_982279.1, NM_203454.2
UniGeneiHs.97335

3D structure databases

ProteinModelPortaliQ8WW27
SMRiQ8WW27
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310622

PTM databases

iPTMnetiQ8WW27
PhosphoSitePlusiQ8WW27

Polymorphism and mutation databases

BioMutaiAPOBEC4
DMDMi74751569

Proteomic databases

PaxDbiQ8WW27
PeptideAtlasiQ8WW27
PRIDEiQ8WW27
ProteomicsDBi74852

Protocols and materials databases

DNASUi403314
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308641; ENSP00000310622; ENSG00000173627
GeneIDi403314
KEGGihsa:403314
UCSCiuc001gqn.4 human

Organism-specific databases

CTDi403314
EuPathDBiHostDB:ENSG00000173627.7
GeneCardsiAPOBEC4
HGNCiHGNC:32152 APOBEC4
HPAiHPA015636
HPA015637
MIMi609908 gene
neXtProtiNX_Q8WW27
OpenTargetsiENSG00000173627
PharmGKBiPA142672597
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II65 Eukaryota
ENOG4111QES LUCA
GeneTreeiENSGT00390000014243
HOGENOMiHOG000033767
HOVERGENiHBG080811
KOiK18773
OMAiVKPYYWL
OrthoDBiEOG091G0T9Y
PhylomeDBiQ8WW27
TreeFamiTF338173

Enzyme and pathway databases

ReactomeiR-HSA-72200 mRNA Editing: C to U Conversion
R-HSA-75094 Formation of the Editosome

Miscellaneous databases

GeneWikiiAPOBEC4
GenomeRNAii403314
PROiPR:Q8WW27
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173627 Expressed in 39 organ(s), highest expression level in testis
CleanExiHS_APOBEC4
GenevisibleiQ8WW27 HS

Family and domain databases

InterProiView protein in InterPro
IPR038953 APOBEC4
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
PANTHERiPTHR35672 PTHR35672, 1 hit
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
PROSITEiView protein in PROSITE
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABEC4_HUMAN
AccessioniPrimary (citable) accession number: Q8WW27
Secondary accession number(s): Q8N7F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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