UniProtKB - Q8WW27 (ABEC4_HUMAN)
Protein
Putative C->U-editing enzyme APOBEC-4
Gene
APOBEC4
Organism
Homo sapiens (Human)
Status
Functioni
Putative C to U editing enzyme whose physiological substrate is not yet known.By similarity
Cofactori
Zn2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 93 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 95 | Proton donorBy similarity | 1 | |
Metal bindingi | 127 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 134 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- mRNA processing Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | mRNA processing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8WW27 |
Reactomei | R-HSA-72200, mRNA Editing: C to U Conversion R-HSA-75094, Formation of the Editosome |
Names & Taxonomyi
Protein namesi | Recommended name: Putative C->U-editing enzyme APOBEC-4 (EC:3.5.4.-)Alternative name(s): Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4 |
Gene namesi | Name:APOBEC4 Synonyms:C1orf169 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000173627.7 |
HGNCi | HGNC:32152, APOBEC4 |
MIMi | 609908, gene |
neXtProti | NX_Q8WW27 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000173627 |
PharmGKBi | PA142672597 |
Miscellaneous databases
Pharosi | Q8WW27, Tdark |
Polymorphism and mutation databases
BioMutai | APOBEC4 |
DMDMi | 74751569 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239355 | 1 – 367 | Putative C->U-editing enzyme APOBEC-4Add BLAST | 367 |
Proteomic databases
PaxDbi | Q8WW27 |
PeptideAtlasi | Q8WW27 |
PRIDEi | Q8WW27 |
ProteomicsDBi | 74852 |
PTM databases
iPTMneti | Q8WW27 |
PhosphoSitePlusi | Q8WW27 |
Expressioni
Tissue specificityi
Predominantly expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000173627, Expressed in testis and 50 other tissues |
Genevisiblei | Q8WW27, HS |
Organism-specific databases
HPAi | ENSG00000173627, Tissue enhanced (fallopian tube, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 135625, 1 interactor |
STRINGi | 9606.ENSP00000310622 |
Miscellaneous databases
RNActi | Q8WW27, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 177 | CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST | 117 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 299 – 314 | Leu-richAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the cytidine and deoxycytidylate deaminase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQXT, Eukaryota |
GeneTreei | ENSGT00390000014243 |
HOGENOMi | CLU_832944_0_0_1 |
OMAi | SQLYHTE |
OrthoDBi | 1149880at2759 |
PhylomeDBi | Q8WW27 |
TreeFami | TF338173 |
Family and domain databases
InterProi | View protein in InterPro IPR038953, APOBEC4 IPR013158, APOBEC_N IPR002125, CMP_dCMP_dom |
PANTHERi | PTHR35672, PTHR35672, 1 hit |
Pfami | View protein in Pfam PF08210, APOBEC_N, 1 hit |
PROSITEi | View protein in PROSITE PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WW27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ
60 70 80 90 100
IFGFPYGTTF PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE
110 120 130 140 150
MNGYLDSAIY NNDSIRHIIL YSNNSPCNEA NHCCISKMYN FLITYPGITL
160 170 180 190 200
SIYFSQLYHT EMDFPASAWN REALRSLASL WPRVVLSPIS GGIWHSVLHS
210 220 230 240 250
FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT DVLLQTKRNP
260 270 280 290 300
NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD
310 320 330 340 350
LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ
360
FASSKEADEK KKKKGKK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026639 | 75 | S → F. Corresponds to variant dbSNP:rs16861394Ensembl. | 1 | |
Natural variantiVAR_026640 | 271 | F → S1 PublicationCorresponds to variant dbSNP:rs1174658Ensembl. | 1 | |
Natural variantiVAR_026641 | 275 | P → S. Corresponds to variant dbSNP:rs10911391Ensembl. | 1 | |
Natural variantiVAR_048724 | 300 | D → G. Corresponds to variant dbSNP:rs16861381EnsemblClinVar. | 1 | |
Natural variantiVAR_026642 | 331 | K → E1 PublicationCorresponds to variant dbSNP:rs1174657Ensembl. | 1 | |
Natural variantiVAR_026643 | 345 | V → M. Corresponds to variant dbSNP:rs10911390Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098557 mRNA Translation: BAC05332.1 AL137800 Genomic DNA No translation available. BC021711 mRNA Translation: AAH21711.1 |
CCDSi | CCDS1358.1 |
RefSeqi | NP_982279.1, NM_203454.2 |
Genome annotation databases
Ensembli | ENST00000308641; ENSP00000310622; ENSG00000173627 |
GeneIDi | 403314 |
KEGGi | hsa:403314 |
UCSCi | uc001gqn.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098557 mRNA Translation: BAC05332.1 AL137800 Genomic DNA No translation available. BC021711 mRNA Translation: AAH21711.1 |
CCDSi | CCDS1358.1 |
RefSeqi | NP_982279.1, NM_203454.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 135625, 1 interactor |
STRINGi | 9606.ENSP00000310622 |
PTM databases
iPTMneti | Q8WW27 |
PhosphoSitePlusi | Q8WW27 |
Polymorphism and mutation databases
BioMutai | APOBEC4 |
DMDMi | 74751569 |
Proteomic databases
PaxDbi | Q8WW27 |
PeptideAtlasi | Q8WW27 |
PRIDEi | Q8WW27 |
ProteomicsDBi | 74852 |
Protocols and materials databases
Antibodypediai | 2817, 241 antibodies |
DNASUi | 403314 |
Genome annotation databases
Ensembli | ENST00000308641; ENSP00000310622; ENSG00000173627 |
GeneIDi | 403314 |
KEGGi | hsa:403314 |
UCSCi | uc001gqn.4, human |
Organism-specific databases
CTDi | 403314 |
EuPathDBi | HostDB:ENSG00000173627.7 |
GeneCardsi | APOBEC4 |
HGNCi | HGNC:32152, APOBEC4 |
HPAi | ENSG00000173627, Tissue enhanced (fallopian tube, testis) |
MIMi | 609908, gene |
neXtProti | NX_Q8WW27 |
OpenTargetsi | ENSG00000173627 |
PharmGKBi | PA142672597 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQXT, Eukaryota |
GeneTreei | ENSGT00390000014243 |
HOGENOMi | CLU_832944_0_0_1 |
OMAi | SQLYHTE |
OrthoDBi | 1149880at2759 |
PhylomeDBi | Q8WW27 |
TreeFami | TF338173 |
Enzyme and pathway databases
PathwayCommonsi | Q8WW27 |
Reactomei | R-HSA-72200, mRNA Editing: C to U Conversion R-HSA-75094, Formation of the Editosome |
Miscellaneous databases
BioGRID-ORCSi | 403314, 23 hits in 843 CRISPR screens |
ChiTaRSi | APOBEC4, human |
GeneWikii | APOBEC4 |
GenomeRNAii | 403314 |
Pharosi | Q8WW27, Tdark |
PROi | PR:Q8WW27 |
RNActi | Q8WW27, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173627, Expressed in testis and 50 other tissues |
Genevisiblei | Q8WW27, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038953, APOBEC4 IPR013158, APOBEC_N IPR002125, CMP_dCMP_dom |
PANTHERi | PTHR35672, PTHR35672, 1 hit |
Pfami | View protein in Pfam PF08210, APOBEC_N, 1 hit |
PROSITEi | View protein in PROSITE PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABEC4_HUMAN | |
Accessioni | Q8WW27Primary (citable) accession number: Q8WW27 Secondary accession number(s): Q8N7F6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations