TEKT4

Functionⁱ

May be a structural component of the sperm flagellum. Contributes to normal sperm motility.By similarity

GO - Biological processⁱ

cilium assembly Source: GO_Central
cilium movement involved in cell motility Source: GO_Central
flagellated sperm motility Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation

Biological process

Cilium biogenesis/degradation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tektin-4
Gene namesⁱ	Name:TEKT4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163060.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31012 TEKT4
neXtProtⁱ	NX_Q8WW24

Keywords - Cellular componentⁱ

Cell projection, Cilium, Flagellum

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	150483
Open Targets More...OpenTargetsⁱ	ENSG00000163060
PharmGKBⁱ	PA142670819

Polymorphism and mutation databases

BioMutaⁱ	TEKT4
DMDMⁱ	74730916

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000261161	1 – 435	Tektin-4Add BLAST		435

Proteomic databases

PaxDbⁱ	Q8WW24
PeptideAtlas More...PeptideAtlasⁱ	Q8WW24
PRIDEⁱ	Q8WW24
ProteomicsDBⁱ	74851

PTM databases

iPTMnetⁱ	Q8WW24
PhosphoSitePlusⁱ	Q8WW24

Expressionⁱ

Tissue specificityⁱ

Strongly expressed in spermatozoa. Also detected at low levels in pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163060 Expressed in 80 organ(s), highest expression level in testis
CleanExⁱ	HS_TEKT4

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048600 HPA053929

HPAⁱ

HPA048600
HPA053929

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ALAS1	P13196	5	EBI-750487,EBI-3905054
ATG5	A9UGY9	3	EBI-750487,EBI-10175276
GSE1	Q14687	3	EBI-750487,EBI-372619
HNRNPH1	P31943	4	EBI-750487,EBI-351590
HNRNPM	P52272	3	EBI-750487,EBI-486809
IKZF3	Q9UKT9	6	EBI-750487,EBI-747204
KRTAP26-1	Q6PEX3	3	EBI-750487,EBI-3957672
MAGEA4	P43358	3	EBI-750487,EBI-743122
MAGEA4	Q1RN33	3	EBI-750487,EBI-10194128
PPP1R32	Q7Z5V6-2	4	EBI-750487,EBI-12000762
PRDM14	Q9GZV8	5	EBI-750487,EBI-3957793
RARA	P10276	3	EBI-750487,EBI-413374
RARA	P10276-2	3	EBI-750487,EBI-10197061
RECK	Q6P9E2	5	EBI-750487,EBI-10253121
SLC25A6	P12236	3	EBI-750487,EBI-356254
SMAD3	P84022	3	EBI-750487,EBI-347161
TADA2A	O75478	3	EBI-750487,EBI-742268
TRIP6	Q15654	3	EBI-750487,EBI-742327

Protein-protein interaction databases

BioGridⁱ	127301, 28 interactors
IntActⁱ	Q8WW24, 102 interactors
Molecular INTeraction database More...MINTⁱ	Q8WW24
STRINGⁱ	9606.ENSP00000295201

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WW24
SMRⁱ	Q8WW24
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	102 – 180	Sequence analysisAdd BLAST	79
Coiled coilⁱ	310 – 336	Sequence analysisAdd BLAST	27
Coiled coilⁱ	363 – 411	Sequence analysisAdd BLAST	49

Sequence similaritiesⁱ

Belongs to the tektin family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2685 Eukaryota ENOG410XSCN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016344
HOGENOMⁱ	HOG000246943
HOVERGENⁱ	HBG056503
InParanoidⁱ	Q8WW24
KEGG Orthology (KO) More...KOⁱ	K18631
OMAⁱ	GFRTAKY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AJL
PhylomeDBⁱ	Q8WW24
TreeFamⁱ	TF320754

Family and domain databases

InterProⁱ	View protein in InterPro IPR000435 Tektin
PANTHERⁱ	PTHR19960 PTHR19960, 1 hit
PRINTSⁱ	PR00511 TEKTIN

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WW24-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQTVPPCEL PCKEYDVARN TGAYTSSGLA TASFRTSKYL LEEWFQNCYA 
        60         70         80         90        100
RYHQAFADRD QSERQRHESQ QLATETQALA QRTQQDSTRT VGERLQDTHS 
       110        120        130        140        150
WKSELQREME ALAAETNLLL AQKQRLERAL DATEVPFSIT TDNLQCRERR 
       160        170        180        190        200
EHPNLVRDHV ETELLKEAEL IRNIQELLKR TIMQAVSQIR LNREHKETCE 
       210        220        230        240        250
MDWSDKMEAY NIDETCGRHH SQSTEVQAHP YSTTFQESAS TPETRAKFTQ 
       260        270        280        290        300
DNLCRAQRER LASANLRVLV DCILRDTSED LRLQCDAVNL AFGRRCEELE 
       310        320        330        340        350
DARYKLHHHL HKTLREITDQ EHNVAALKQA IKDKEAPLHV AQTRLYLRSH 
       360        370        380        390        400
RPNMELCRDA AQFRLLSEVE ELNMSLTALR EKLLEAEQSL RNLEDIHMSL 
       410        420        430 
EKDIAAMTNS LFIDRQKCMA HRTRYPTILQ LAGYQ

Length:435

Mass (Da):50,649

Last modified:March 1, 2002 - v1

Checksum:ⁱ90C16D8B0F782CED

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029085	83	T → M. Corresponds to variant dbSNP:rs4854235Ensembl.	1
Natural variantⁱVAR_062151	100	S → G. Corresponds to variant dbSNP:rs11164112Ensembl.	1
Natural variantⁱVAR_029086	102	K → N. Corresponds to variant dbSNP:rs17802433Ensembl.	1
Natural variantⁱVAR_035941	272	C → S in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_029087	409	N → K. Corresponds to variant dbSNP:rs17120062Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC097374 Genomic DNA Translation: AAX88873.1 BC021716 mRNA Translation: AAH21716.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2005.1
NCBI Reference Sequences More...RefSeqⁱ	NP_653306.1, NM_144705.3
UniGeneⁱ	Hs.631517

Genome annotation databases

Ensemblⁱ	ENST00000295201; ENSP00000295201; ENSG00000163060
GeneIDⁱ	150483
KEGGⁱ	hsa:150483
UCSC genome browser More...UCSCⁱ	uc002stw.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WW24	TEKT4 isoform 2		PONAB		447	UniRef90_Q8WW24
Uncharacterized protein		CHLSB		447
Uncharacterized protein		SAIBB		447
Uncharacterized protein		COLAP		436
Uncharacterized protein		CERAT		435
+31

Protein	Similar proteins		Species	Score	Length	Source
Q8WW24	Tektin-4		MOUSE		447	UniRef50_Q8WW24
Tektin-4		RAT		447
Uncharacterized protein		SAIBB		447
Uncharacterized protein		CHLSB		447
TEKT4 isoform 2		PONAB		447
+70

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC097374 Genomic DNA Translation: AAX88873.1 BC021716 mRNA Translation: AAH21716.1
CCDSⁱ	CCDS2005.1
RefSeqⁱ	NP_653306.1, NM_144705.3
UniGeneⁱ	Hs.631517

3D structure databases

ProteinModelPortalⁱ	Q8WW24
SMRⁱ	Q8WW24
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127301, 28 interactors
IntActⁱ	Q8WW24, 102 interactors
MINTⁱ	Q8WW24
STRINGⁱ	9606.ENSP00000295201

PTM databases

iPTMnetⁱ	Q8WW24
PhosphoSitePlusⁱ	Q8WW24

Polymorphism and mutation databases

BioMutaⁱ	TEKT4
DMDMⁱ	74730916

Proteomic databases

PaxDbⁱ	Q8WW24
PeptideAtlasⁱ	Q8WW24
PRIDEⁱ	Q8WW24
ProteomicsDBⁱ	74851

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	150483
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295201; ENSP00000295201; ENSG00000163060
GeneIDⁱ	150483
KEGGⁱ	hsa:150483
UCSCⁱ	uc002stw.3 human

Organism-specific databases

CTDⁱ	150483
DisGeNETⁱ	150483
EuPathDBⁱ	HostDB:ENSG00000163060.7
GeneCardsⁱ	TEKT4
H-InvDBⁱ	HIX0176446
HGNCⁱ	HGNC:31012 TEKT4
HPAⁱ	HPA048600 HPA053929
neXtProtⁱ	NX_Q8WW24
OpenTargetsⁱ	ENSG00000163060
PharmGKBⁱ	PA142670819
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2685 Eukaryota ENOG410XSCN LUCA
GeneTreeⁱ	ENSGT00390000016344
HOGENOMⁱ	HOG000246943
HOVERGENⁱ	HBG056503
InParanoidⁱ	Q8WW24
KOⁱ	K18631
OMAⁱ	GFRTAKY
OrthoDBⁱ	EOG091G0AJL
PhylomeDBⁱ	Q8WW24
TreeFamⁱ	TF320754

Miscellaneous databases

GenomeRNAiⁱ	150483
Protein Ontology More...PROⁱ	PR:Q8WW24

Gene expression databases

Bgeeⁱ	ENSG00000163060 Expressed in 80 organ(s), highest expression level in testis
CleanExⁱ	HS_TEKT4

Family and domain databases

InterProⁱ	View protein in InterPro IPR000435 Tektin
PANTHERⁱ	PTHR19960 PTHR19960, 1 hit
PRINTSⁱ	PR00511 TEKTIN
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TEKT4_HUMAN
Accessionⁱ	Q8WW24Primary (citable) accession number: Q8WW24
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	March 1, 2002
	Last modified:	October 10, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WW24 (TEKT4_HUMAN)

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Tektin-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ