UniProtKB - Q8WW24 (TEKT4_HUMAN)
Protein
Tektin-4
Gene
TEKT4
Organism
Homo sapiens (Human)
Status
Functioni
May be a structural component of the sperm flagellum. Contributes to normal sperm motility.By similarity
GO - Biological processi
- cilium assembly Source: GO_Central
- cilium movement involved in cell motility Source: GO_Central
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q8WW24 |
Names & Taxonomyi
Protein namesi | Recommended name: Tektin-4 |
Gene namesi | Name:TEKT4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31012, TEKT4 |
neXtProti | NX_Q8WW24 |
VEuPathDBi | HostDB:ENSG00000163060.7 |
Subcellular locationi
Other locations
- flagellum By similarity
Note: Found in the abaxial (convex) surface of outer dense fibers in sperm flagella.By similarity
Cytoskeleton
- microtubule cytoskeleton Source: GO_Central
Nucleus
- nucleus Source: UniProtKB
Other locations
- sperm flagellum Source: GO_Central
Keywords - Cellular componenti
Cell projection, Cilium, FlagellumPathology & Biotechi
Organism-specific databases
DisGeNETi | 150483 |
OpenTargetsi | ENSG00000163060 |
PharmGKBi | PA142670819 |
Miscellaneous databases
Pharosi | Q8WW24, Tbio |
Genetic variation databases
BioMutai | TEKT4 |
DMDMi | 74730916 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261161 | 1 – 435 | Tektin-4Add BLAST | 435 |
Proteomic databases
MassIVEi | Q8WW24 |
PaxDbi | Q8WW24 |
PeptideAtlasi | Q8WW24 |
PRIDEi | Q8WW24 |
ProteomicsDBi | 74851 |
PTM databases
iPTMneti | Q8WW24 |
PhosphoSitePlusi | Q8WW24 |
Expressioni
Tissue specificityi
Strongly expressed in spermatozoa. Also detected at low levels in pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000163060, Expressed in testis and 91 other tissues |
ExpressionAtlasi | Q8WW24, baseline and differential |
Organism-specific databases
HPAi | ENSG00000163060, Tissue enhanced (fallopian tube, testis) |
Interactioni
Binary interactionsi
Q8WW24
Protein-protein interaction databases
BioGRIDi | 127301, 117 interactors |
IntActi | Q8WW24, 116 interactors |
MINTi | Q8WW24 |
STRINGi | 9606.ENSP00000295201 |
Miscellaneous databases
RNActi | Q8WW24, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 102 – 180 | Sequence analysisAdd BLAST | 79 | |
Coiled coili | 310 – 336 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 363 – 411 | Sequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Belongs to the tektin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2685, Eukaryota |
GeneTreei | ENSGT00950000182894 |
HOGENOMi | CLU_033588_2_1_1 |
InParanoidi | Q8WW24 |
OMAi | WAKFTQD |
OrthoDBi | 581072at2759 |
PhylomeDBi | Q8WW24 |
TreeFami | TF320754 |
Family and domain databases
InterProi | View protein in InterPro IPR000435, Tektin |
PANTHERi | PTHR19960, PTHR19960, 1 hit |
PRINTSi | PR00511, TEKTIN |
i Sequence
Sequence statusi: Complete.
Q8WW24-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQTVPPCEL PCKEYDVARN TGAYTSSGLA TASFRTSKYL LEEWFQNCYA
60 70 80 90 100
RYHQAFADRD QSERQRHESQ QLATETQALA QRTQQDSTRT VGERLQDTHS
110 120 130 140 150
WKSELQREME ALAAETNLLL AQKQRLERAL DATEVPFSIT TDNLQCRERR
160 170 180 190 200
EHPNLVRDHV ETELLKEAEL IRNIQELLKR TIMQAVSQIR LNREHKETCE
210 220 230 240 250
MDWSDKMEAY NIDETCGRHH SQSTEVQAHP YSTTFQESAS TPETRAKFTQ
260 270 280 290 300
DNLCRAQRER LASANLRVLV DCILRDTSED LRLQCDAVNL AFGRRCEELE
310 320 330 340 350
DARYKLHHHL HKTLREITDQ EHNVAALKQA IKDKEAPLHV AQTRLYLRSH
360 370 380 390 400
RPNMELCRDA AQFRLLSEVE ELNMSLTALR EKLLEAEQSL RNLEDIHMSL
410 420 430
EKDIAAMTNS LFIDRQKCMA HRTRYPTILQ LAGYQ
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029085 | 83 | T → M. Corresponds to variant dbSNP:rs4854235Ensembl. | 1 | |
Natural variantiVAR_062151 | 100 | S → G. Corresponds to variant dbSNP:rs11164112Ensembl. | 1 | |
Natural variantiVAR_029086 | 102 | K → N. Corresponds to variant dbSNP:rs17802433Ensembl. | 1 | |
Natural variantiVAR_035941 | 272 | C → S in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_029087 | 409 | N → K. Corresponds to variant dbSNP:rs17120062Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097374 Genomic DNA Translation: AAX88873.1 BC021716 mRNA Translation: AAH21716.1 |
CCDSi | CCDS2005.1 |
RefSeqi | NP_653306.1, NM_144705.3 |
Genome annotation databases
Ensembli | ENST00000295201; ENSP00000295201; ENSG00000163060 |
GeneIDi | 150483 |
KEGGi | hsa:150483 |
UCSCi | uc002stw.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097374 Genomic DNA Translation: AAX88873.1 BC021716 mRNA Translation: AAH21716.1 |
CCDSi | CCDS2005.1 |
RefSeqi | NP_653306.1, NM_144705.3 |
3D structure databases
SMRi | Q8WW24 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127301, 117 interactors |
IntActi | Q8WW24, 116 interactors |
MINTi | Q8WW24 |
STRINGi | 9606.ENSP00000295201 |
PTM databases
iPTMneti | Q8WW24 |
PhosphoSitePlusi | Q8WW24 |
Genetic variation databases
BioMutai | TEKT4 |
DMDMi | 74730916 |
Proteomic databases
MassIVEi | Q8WW24 |
PaxDbi | Q8WW24 |
PeptideAtlasi | Q8WW24 |
PRIDEi | Q8WW24 |
ProteomicsDBi | 74851 |
Protocols and materials databases
Antibodypediai | 32286, 168 antibodies |
DNASUi | 150483 |
Genome annotation databases
Ensembli | ENST00000295201; ENSP00000295201; ENSG00000163060 |
GeneIDi | 150483 |
KEGGi | hsa:150483 |
UCSCi | uc002stw.3, human |
Organism-specific databases
CTDi | 150483 |
DisGeNETi | 150483 |
GeneCardsi | TEKT4 |
HGNCi | HGNC:31012, TEKT4 |
HPAi | ENSG00000163060, Tissue enhanced (fallopian tube, testis) |
neXtProti | NX_Q8WW24 |
OpenTargetsi | ENSG00000163060 |
PharmGKBi | PA142670819 |
VEuPathDBi | HostDB:ENSG00000163060.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2685, Eukaryota |
GeneTreei | ENSGT00950000182894 |
HOGENOMi | CLU_033588_2_1_1 |
InParanoidi | Q8WW24 |
OMAi | WAKFTQD |
OrthoDBi | 581072at2759 |
PhylomeDBi | Q8WW24 |
TreeFami | TF320754 |
Enzyme and pathway databases
PathwayCommonsi | Q8WW24 |
Miscellaneous databases
BioGRID-ORCSi | 150483, 31 hits in 987 CRISPR screens |
GenomeRNAii | 150483 |
Pharosi | Q8WW24, Tbio |
PROi | PR:Q8WW24 |
RNActi | Q8WW24, protein |
Gene expression databases
Bgeei | ENSG00000163060, Expressed in testis and 91 other tissues |
ExpressionAtlasi | Q8WW24, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000435, Tektin |
PANTHERi | PTHR19960, PTHR19960, 1 hit |
PRINTSi | PR00511, TEKTIN |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEKT4_HUMAN | |
Accessioni | Q8WW24Primary (citable) accession number: Q8WW24 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families