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Entry version 123 (07 Apr 2021)
Sequence version 3 (28 Mar 2018)
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Protein

Uncharacterized protein C10orf82

Gene

C10orf82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8WW14

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C10orf82
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28500, C10orf82

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WW14

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000165863.16

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
143379

Open Targets

More...
OpenTargetsi
ENSG00000165863

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134919914

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WW14, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C10orf82

Domain mapping of disease mutations (DMDM)

More...
DMDMi
221222443

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898071 – 234Uncharacterized protein C10orf82Add BLAST234

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WW14

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WW14

PeptideAtlas

More...
PeptideAtlasi
Q8WW14

PRoteomics IDEntifications database

More...
PRIDEi
Q8WW14

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74845 [Q8WW14-1]
74846 [Q8WW14-2]
74847 [Q8WW14-3]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165863, Expressed in testis and 128 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WW14, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165863, Group enriched (blood, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
126799, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WW14, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358212

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WW14, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WW14

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SAX8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017460

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_143590_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WW14

Identification of Orthologs from Complete Genome Data

More...
OMAi
HPLSLEC

Database of Orthologous Groups

More...
OrthoDBi
1205710at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WW14

TreeFam database of animal gene trees

More...
TreeFami
TF337656

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043246, C10orf82-like

The PANTHER Classification System

More...
PANTHERi
PTHR47301, PTHR47301, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WW14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPSKTFMRN LPITPGYSGF VPFLSCQGMS KEDDMNHCVK TFQEKTQRYK
60 70 80 90 100
EQLRELCCAV ATAPKLKPVN SEETVLQALH QYNLQYHPLI LECKYVKKPL
110 120 130 140 150
QEPPIPGWAG YLPRAKVTEF GCGTRYTVMA KNCYKDFLEI TERAKKAHLK
160 170 180 190 200
PYEEIYGVSS TKTSAPSPKV LQHEELLPKY PDFSIPDGSC PALGRPLRED
210 220 230
PKTPLTCGCA QRPSIPCSGK MYLEPLSSAK YAEG
Length:234
Mass (Da):26,343
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB10AB6D67800822A
GO
Isoform 2 (identifier: Q8WW14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-234: Missing.

Show »
Length:154
Mass (Da):17,797
Checksum:i38C00B1F8780EED1
GO
Isoform 3 (identifier: Q8WW14-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-110: ECKYVKKPLQEPPIPGWAG → GSSALKPFPLTPGHPCRFS
     111-234: Missing.

Show »
Length:110
Mass (Da):12,473
Checksum:iE0C48F433EE875BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050854124T → M. Corresponds to variant dbSNP:rs11551267Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03611792 – 110ECKYV…PGWAG → GSSALKPFPLTPGHPCRFS in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_036118111 – 234Missing in isoform 3. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_036119155 – 234Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097587 mRNA Translation: BAG53491.1
AC016825 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49444.1
CH471066 Genomic DNA Translation: EAW49445.1
BC021737 mRNA Translation: AAH21737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7596.1 [Q8WW14-2]
CCDS81510.1 [Q8WW14-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001317071.1, NM_001330142.1 [Q8WW14-1]
NP_653262.1, NM_144661.2 [Q8WW14-2]
XP_016871242.1, XM_017015753.1
XP_016871244.1, XM_017015755.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369210; ENSP00000358212; ENSG00000165863 [Q8WW14-2]
ENST00000588184; ENSP00000465712; ENSG00000165863 [Q8WW14-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
143379

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:143379

UCSC genome browser

More...
UCSCi
uc001lcr.3, human [Q8WW14-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097587 mRNA Translation: BAG53491.1
AC016825 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49444.1
CH471066 Genomic DNA Translation: EAW49445.1
BC021737 mRNA Translation: AAH21737.1
CCDSiCCDS7596.1 [Q8WW14-2]
CCDS81510.1 [Q8WW14-1]
RefSeqiNP_001317071.1, NM_001330142.1 [Q8WW14-1]
NP_653262.1, NM_144661.2 [Q8WW14-2]
XP_016871242.1, XM_017015753.1
XP_016871244.1, XM_017015755.1

3D structure databases

SMRiQ8WW14
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126799, 13 interactors
IntActiQ8WW14, 8 interactors
STRINGi9606.ENSP00000358212

Genetic variation databases

BioMutaiC10orf82
DMDMi221222443

Proteomic databases

MassIVEiQ8WW14
PaxDbiQ8WW14
PeptideAtlasiQ8WW14
PRIDEiQ8WW14
ProteomicsDBi74845 [Q8WW14-1]
74846 [Q8WW14-2]
74847 [Q8WW14-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53097, 59 antibodies

The DNASU plasmid repository

More...
DNASUi
143379

Genome annotation databases

EnsembliENST00000369210; ENSP00000358212; ENSG00000165863 [Q8WW14-2]
ENST00000588184; ENSP00000465712; ENSG00000165863 [Q8WW14-1]
GeneIDi143379
KEGGihsa:143379
UCSCiuc001lcr.3, human [Q8WW14-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
143379
DisGeNETi143379

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C10orf82
HGNCiHGNC:28500, C10orf82
HPAiENSG00000165863, Group enriched (blood, testis)
neXtProtiNX_Q8WW14
OpenTargetsiENSG00000165863
PharmGKBiPA134919914
VEuPathDBiHostDB:ENSG00000165863.16

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SAX8, Eukaryota
GeneTreeiENSGT00390000017460
HOGENOMiCLU_143590_0_0_1
InParanoidiQ8WW14
OMAiHPLSLEC
OrthoDBi1205710at2759
PhylomeDBiQ8WW14
TreeFamiTF337656

Enzyme and pathway databases

PathwayCommonsiQ8WW14

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
143379, 7 hits in 966 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
143379
PharosiQ8WW14, Tdark

Protein Ontology

More...
PROi
PR:Q8WW14
RNActiQ8WW14, protein

Gene expression databases

BgeeiENSG00000165863, Expressed in testis and 128 other tissues
GenevisibleiQ8WW14, HS

Family and domain databases

InterProiView protein in InterPro
IPR043246, C10orf82-like
PANTHERiPTHR47301, PTHR47301, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCJ082_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WW14
Secondary accession number(s): B3KUM9, D3DRC3, K7EKP3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 28, 2018
Last modified: April 7, 2021
This is version 123 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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