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Protein

PEST proteolytic signal-containing nuclear protein

Gene

PCNP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell cycle regulation.

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
PEST proteolytic signal-containing nuclear protein
Short name:
PCNP
Short name:
PEST-containing nuclear protein
Gene namesi
Name:PCNP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000081154.11
HGNCiHGNC:30023 PCNP
MIMi615210 gene
neXtProtiNX_Q8WW12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081154
PharmGKBiPA143485572

Polymorphism and mutation databases

BioMutaiPCNP
DMDMi67460963

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000582532 – 178PEST proteolytic signal-containing nuclear proteinAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei53PhosphoserineCombined sources1
Modified residuei64N6-acetyllysineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei139PhosphothreonineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei150N6-acetyllysineCombined sources1
Modified residuei152N6-acetyllysineCombined sources1

Post-translational modificationi

Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.1 Publication
N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WW12
MaxQBiQ8WW12
PaxDbiQ8WW12
PeptideAtlasiQ8WW12
PRIDEiQ8WW12
ProteomicsDBi74842
74843 [Q8WW12-2]
74844 [Q8WW12-3]
TopDownProteomicsiQ8WW12-1 [Q8WW12-1]
Q8WW12-2 [Q8WW12-2]
Q8WW12-3 [Q8WW12-3]

PTM databases

iPTMnetiQ8WW12
PhosphoSitePlusiQ8WW12

Expressioni

Gene expression databases

BgeeiENSG00000081154 Expressed in 234 organ(s), highest expression level in caudate nucleus
CleanExiHS_PCNP
ExpressionAtlasiQ8WW12 baseline and differential
GenevisibleiQ8WW12 HS

Organism-specific databases

HPAiHPA035011

Interactioni

Subunit structurei

Interacts with UHRF2/NIRF.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-10972020,EBI-750109

Protein-protein interaction databases

BioGridi121360, 19 interactors
IntActiQ8WW12, 11 interactors
STRINGi9606.ENSP00000265260

Structurei

3D structure databases

ProteinModelPortaliQ8WW12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IWUJ Eukaryota
ENOG4111S9J LUCA
GeneTreeiENSGT00390000010218
HOGENOMiHOG000088639
HOVERGENiHBG059581
InParanoidiQ8WW12
OMAiPAKMSKF
OrthoDBiEOG091G14A2
PhylomeDBiQ8WW12
TreeFamiTF333058

Family and domain databases

InterProiView protein in InterPro
IPR029169 PCNP
PANTHERiPTHR16523 PTHR16523, 1 hit
PfamiView protein in Pfam
PF15473 PCNP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WW12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADGKAGDEK PEKSQRAGAA GGPEEEAEKP VKTKTVSSSN GGESSSRSAE
60 70 80 90 100
KRSAEEEAAD LPTKPTKISK FGFAIGSQTT KKASAISIKL GSSKPKETVP
110 120 130 140 150
TLAPKTLSVA AAFNEDEDSE PEEMPPEAKM RMKNIGRDTP TSAGPNSFNK
160 170
GKHGFSDNQK LWERNIKSHL GNVHDQDN
Length:178
Mass (Da):18,925
Last modified:June 7, 2005 - v2
Checksum:iB79D49B362892AE1
GO
Isoform 2 (identifier: Q8WW12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-130: SEPEEMPPEAKM → GYTNISWTKLLQ
     131-178: Missing.

Note: No experimental confirmation available.
Show »
Length:130
Mass (Da):13,544
Checksum:i60256023D3435196
GO
Isoform 3 (identifier: Q8WW12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Show »
Length:55
Mass (Da):6,233
Checksum:iC95818E33C1461F0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9V9G5E9V9_HUMAN
PEST proteolytic signal containing ...
PCNP hCG_2023069
40Annotation score:
A0A0B4J1Z9A0A0B4J1Z9_HUMAN
PEST proteolytic signal containing ...
PCNP hCG_2023069
57Annotation score:

Sequence cautioni

The sequence EAW79790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW79792 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126P → Q in AAH22001 (PubMed:15489334).Curated1
Sequence conflicti150K → E in BAD96698 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0138791 – 123Missing in isoform 3. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_013880119 – 130SEPEE…PEAKM → GYTNISWTKLLQ in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_013881131 – 178Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037675 mRNA Translation: BAB03501.1
AK314629 mRNA Translation: BAG37194.1
AK222978 mRNA Translation: BAD96698.1
CR627371 mRNA Translation: CAH10470.1
CH471052 Genomic DNA Translation: EAW79790.1 Different initiation.
CH471052 Genomic DNA Translation: EAW79792.1 Different initiation.
BC013916 mRNA Translation: AAH13916.1
BC022001 mRNA Translation: AAH22001.1
CCDSiCCDS2942.1 [Q8WW12-1]
RefSeqiNP_001307324.1, NM_001320395.1 [Q8WW12-2]
NP_001307326.1, NM_001320397.1
NP_001307327.1, NM_001320398.1
NP_001307328.1, NM_001320399.1
NP_001307329.1, NM_001320400.1
NP_001307330.1, NM_001320401.1
NP_065090.1, NM_020357.2 [Q8WW12-1]
UniGeneiHs.732633
Hs.744968

Genome annotation databases

EnsembliENST00000265260; ENSP00000265260; ENSG00000081154 [Q8WW12-1]
ENST00000469941; ENSP00000470810; ENSG00000081154 [Q8WW12-3]
GeneIDi57092
KEGGihsa:57092
UCSCiuc003dva.4 human [Q8WW12-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037675 mRNA Translation: BAB03501.1
AK314629 mRNA Translation: BAG37194.1
AK222978 mRNA Translation: BAD96698.1
CR627371 mRNA Translation: CAH10470.1
CH471052 Genomic DNA Translation: EAW79790.1 Different initiation.
CH471052 Genomic DNA Translation: EAW79792.1 Different initiation.
BC013916 mRNA Translation: AAH13916.1
BC022001 mRNA Translation: AAH22001.1
CCDSiCCDS2942.1 [Q8WW12-1]
RefSeqiNP_001307324.1, NM_001320395.1 [Q8WW12-2]
NP_001307326.1, NM_001320397.1
NP_001307327.1, NM_001320398.1
NP_001307328.1, NM_001320399.1
NP_001307329.1, NM_001320400.1
NP_001307330.1, NM_001320401.1
NP_065090.1, NM_020357.2 [Q8WW12-1]
UniGeneiHs.732633
Hs.744968

3D structure databases

ProteinModelPortaliQ8WW12
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121360, 19 interactors
IntActiQ8WW12, 11 interactors
STRINGi9606.ENSP00000265260

PTM databases

iPTMnetiQ8WW12
PhosphoSitePlusiQ8WW12

Polymorphism and mutation databases

BioMutaiPCNP
DMDMi67460963

Proteomic databases

EPDiQ8WW12
MaxQBiQ8WW12
PaxDbiQ8WW12
PeptideAtlasiQ8WW12
PRIDEiQ8WW12
ProteomicsDBi74842
74843 [Q8WW12-2]
74844 [Q8WW12-3]
TopDownProteomicsiQ8WW12-1 [Q8WW12-1]
Q8WW12-2 [Q8WW12-2]
Q8WW12-3 [Q8WW12-3]

Protocols and materials databases

DNASUi57092
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265260; ENSP00000265260; ENSG00000081154 [Q8WW12-1]
ENST00000469941; ENSP00000470810; ENSG00000081154 [Q8WW12-3]
GeneIDi57092
KEGGihsa:57092
UCSCiuc003dva.4 human [Q8WW12-1]

Organism-specific databases

CTDi57092
EuPathDBiHostDB:ENSG00000081154.11
GeneCardsiPCNP
HGNCiHGNC:30023 PCNP
HPAiHPA035011
MIMi615210 gene
neXtProtiNX_Q8WW12
OpenTargetsiENSG00000081154
PharmGKBiPA143485572
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWUJ Eukaryota
ENOG4111S9J LUCA
GeneTreeiENSGT00390000010218
HOGENOMiHOG000088639
HOVERGENiHBG059581
InParanoidiQ8WW12
OMAiPAKMSKF
OrthoDBiEOG091G14A2
PhylomeDBiQ8WW12
TreeFamiTF333058

Miscellaneous databases

ChiTaRSiPCNP human
GenomeRNAii57092
PROiPR:Q8WW12
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081154 Expressed in 234 organ(s), highest expression level in caudate nucleus
CleanExiHS_PCNP
ExpressionAtlasiQ8WW12 baseline and differential
GenevisibleiQ8WW12 HS

Family and domain databases

InterProiView protein in InterPro
IPR029169 PCNP
PANTHERiPTHR16523 PTHR16523, 1 hit
PfamiView protein in Pfam
PF15473 PCNP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCNP_HUMAN
AccessioniPrimary (citable) accession number: Q8WW12
Secondary accession number(s): B2RBE7
, D3DN52, Q53GF3, Q6AI44, Q96CU3, Q9NS81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 12, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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