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Protein

Probable palmitoyltransferase ZDHHC19

Gene

ZDHHC19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC19 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 19
Short name:
DHHC-19
Gene namesi
Name:ZDHHC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163958.13
HGNCiHGNC:20713 ZDHHC19
neXtProtiNX_Q8WVZ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163958
PharmGKBiPA134871748

Polymorphism and mutation databases

BioMutaiZDHHC19
DMDMi218511970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129041 – 309Probable palmitoyltransferase ZDHHC19Add BLAST309

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8WVZ1
PeptideAtlasiQ8WVZ1
PRIDEiQ8WVZ1
ProteomicsDBi74836

PTM databases

PhosphoSitePlusiQ8WVZ1

Expressioni

Gene expression databases

BgeeiENSG00000163958 Expressed in 92 organ(s), highest expression level in testis
CleanExiHS_ZDHHC19
ExpressionAtlasiQ8WVZ1 baseline and differential
GenevisibleiQ8WVZ1 HS

Interactioni

Protein-protein interaction databases

BioGridi126283, 3 interactors
STRINGi9606.ENSP00000296326

Structurei

3D structure databases

ProteinModelPortaliQ8WVZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 162DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000065755
HOVERGENiHBG067319
InParanoidiQ8WVZ1
KOiK18932
OMAiFRLQWCP
OrthoDBiEOG091G0GD9
PhylomeDBiQ8WVZ1
TreeFamiTF319798

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q8WVZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLLTDATPL VKEPHPLPLV PRPWFLPSLF AAFNVVLLVF FSGLFFAFPC
60 70 80 90 100
RWLAQNGEWA FPVITGSLFV LTFFSLVSLN FSDPGILHQG SAEQGPLTVH
110 120 130 140 150
VVWVNHGAFR LQWCPKCCFH RPPRTYHCPW CNICVEDFDH HCKWVNNCIG
160 170 180 190 200
HRNFRFFMLL VLSLCLYSGA MLVTCLIFLV RTTHLPFSTD KAIAIVVAVS
210 220 230 240 250
AAGLLVPLSL LLLIQALSVS SADRTYKGKC RHLQGYNPFD QGCASNWYLT
260 270 280 290 300
ICAPLGPKYM AEAVQLQRVV GPDWTSMPNL HPPMSPSALN PPAPTSGSLQ

SREGTPGAW
Length:309
Mass (Da):34,352
Last modified:December 16, 2008 - v2
Checksum:i645B007F74692FA1
GO
Isoform 2 (identifier: Q8WVZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-309: Missing.

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):25,718
Checksum:i143D96E744463D42
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1W2A0A0B4J1W2_HUMAN
Palmitoyltransferase
ZDHHC19 hCG_2039710
282Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05297966G → A. Corresponds to variant dbSNP:rs13315830Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056001230 – 309Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122907 mRNA Translation: BAG53793.1
AC069257 Genomic DNA No translation available.
CH471191 Genomic DNA Translation: EAW53668.1
CCDSiCCDS43190.1 [Q8WVZ1-1]
RefSeqiNP_001034706.1, NM_001039617.1 [Q8WVZ1-1]
UniGeneiHs.111591

Genome annotation databases

EnsembliENST00000296326; ENSP00000296326; ENSG00000163958 [Q8WVZ1-1]
ENST00000438232; ENSP00000393710; ENSG00000163958 [Q8WVZ1-2]
GeneIDi131540
KEGGihsa:131540
UCSCiuc003fwc.4 human [Q8WVZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122907 mRNA Translation: BAG53793.1
AC069257 Genomic DNA No translation available.
CH471191 Genomic DNA Translation: EAW53668.1
CCDSiCCDS43190.1 [Q8WVZ1-1]
RefSeqiNP_001034706.1, NM_001039617.1 [Q8WVZ1-1]
UniGeneiHs.111591

3D structure databases

ProteinModelPortaliQ8WVZ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126283, 3 interactors
STRINGi9606.ENSP00000296326

PTM databases

PhosphoSitePlusiQ8WVZ1

Polymorphism and mutation databases

BioMutaiZDHHC19
DMDMi218511970

Proteomic databases

PaxDbiQ8WVZ1
PeptideAtlasiQ8WVZ1
PRIDEiQ8WVZ1
ProteomicsDBi74836

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296326; ENSP00000296326; ENSG00000163958 [Q8WVZ1-1]
ENST00000438232; ENSP00000393710; ENSG00000163958 [Q8WVZ1-2]
GeneIDi131540
KEGGihsa:131540
UCSCiuc003fwc.4 human [Q8WVZ1-1]

Organism-specific databases

CTDi131540
EuPathDBiHostDB:ENSG00000163958.13
GeneCardsiZDHHC19
HGNCiHGNC:20713 ZDHHC19
neXtProtiNX_Q8WVZ1
OpenTargetsiENSG00000163958
PharmGKBiPA134871748
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000065755
HOVERGENiHBG067319
InParanoidiQ8WVZ1
KOiK18932
OMAiFRLQWCP
OrthoDBiEOG091G0GD9
PhylomeDBiQ8WVZ1
TreeFamiTF319798

Miscellaneous databases

GenomeRNAii131540
PROiPR:Q8WVZ1

Gene expression databases

BgeeiENSG00000163958 Expressed in 92 organ(s), highest expression level in testis
CleanExiHS_ZDHHC19
ExpressionAtlasiQ8WVZ1 baseline and differential
GenevisibleiQ8WVZ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZDH19_HUMAN
AccessioniPrimary (citable) accession number: Q8WVZ1
Secondary accession number(s): A8MSY6, B3KVI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 16, 2008
Last modified: September 12, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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