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UniProtKB - Q8WVX9 (FACR1_HUMAN)

Entry version 155 (02 Jun 2021)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
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Protein

Fatty acyl-CoA reductase 1

Gene

FAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123).

It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123).

In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS16231-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.2.1.84, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WVX9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9640463, Wax biosynthesis

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000208

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fatty acyl-CoA reductase 11 Publication (EC:1.2.1.842 Publications)
Alternative name(s):
Male sterility domain-containing protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAR1Imported
Synonyms:MLSTD2Imported
ORF Names:UNQ2423/PRO4981Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26222, FAR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616107, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WVX9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197601.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 465Cytoplasmic1 PublicationAdd BLAST465
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei466 – 483HelicalSequence analysisAdd BLAST18
Topological domaini484 – 515Peroxisomal1 PublicationAdd BLAST32

Keywords - Cellular componenti

Membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Peroxisomal fatty acyl-CoA reductase 1 disorder (PFCRD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive metabolic disorder clinically characterized by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072692165 – 169EVVYP → D in PFCRD; results in a complete loss of enzyme activity. 1 Publication5
Natural variantiVAR_072693365D → G in PFCRD; results in a complete loss of enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs724159963EnsemblClinVar.1

Keywords - Diseasei

Cataract, Disease variant, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		84188

MalaCards human disease database

More...MalaCardsi		FAR1
MIMi616154, phenotype

Open Targets

More...OpenTargetsi		ENSG00000197601

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		438178, Fatty acyl-CoA reductase 1 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162388007

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WVX9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74730902

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002613941 – 515Fatty acyl-CoA reductase 1Add BLAST515

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WVX9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WVX9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WVX9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WVX9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WVX9

PeptideAtlas

More...PeptideAtlasi		Q8WVX9

PRoteomics IDEntifications database

More...PRIDEi		Q8WVX9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74834

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WVX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WVX9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8WVX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by ether lipids/plasmalogen that induce its degradation (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197601, Expressed in corpus callosum and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WVX9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WVX9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197601, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEX19; PEX19 mediates the targeting of FAR1 to peroxisomes.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123936, 60 interactors

Protein interaction database and analysis system

More...IntActi		Q8WVX9, 40 interactors

Molecular INTeraction database

More...MINTi		Q8WVX9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346874

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WVX9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni451 – 507Necessary and sufficient for PEX19-mediated localization into peroxisome membrane1 PublicationAdd BLAST57

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fatty acyl-CoA reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1221, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006367

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024661_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WVX9

Identification of Orthologs from Complete Genome Data

More...OMAi		QPYTFYG

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WVX9

TreeFam database of animal gene trees

More...TreeFami		TF313011

Family and domain databases

Conserved Domains Database

More...CDDi		cd09071, FAR_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026055, FAR
IPR033640, FAR_C
IPR013120, Far_NAD-bd
IPR036291, NAD(P)-bd_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11011, PTHR11011, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07993, NAD_binding_4, 1 hit
PF03015, Sterile, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8WVX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSIPEYYEG KNVLLTGATG FLGKVLLEKL LRSCPKVNSV YVLVRQKAGQ 
        60         70         80         90        100
TPQERVEEVL SGKLFDRLRD ENPDFREKII AINSELTQPK LALSEEDKEV 
       110        120        130        140        150
IIDSTNIIFH CAATVRFNEN LRDAVQLNVI ATRQLILLAQ QMKNLEVFMH 
       160        170        180        190        200
VSTAYAYCNR KHIDEVVYPP PVDPKKLIDS LEWMDDGLVN DITPKLIGDR 
       210        220        230        240        250
PNTYIYTKAL AEYVVQQEGA KLNVAIVRPS IVGASWKEPF PGWIDNFNGP 
       260        270        280        290        300
SGLFIAAGKG ILRTIRASNN ALADLVPVDV VVNMSLAAAW YSGVNRPRNI 
       310        320        330        340        350
MVYNCTTGST NPFHWGEVEY HVISTFKRNP LEQAFRRPNV NLTSNHLLYH 
       360        370        380        390        400
YWIAVSHKAP AFLYDIYLRM TGRSPRMMKT ITRLHKAMVF LEYFTSNSWV 
       410        420        430        440        450
WNTENVNMLM NQLNPEDKKT FNIDVRQLHW AEYIENYCLG TKKYVLNEEM 
       460        470        480        490        500
SGLPAARKHL NKLRNIRYGF NTILVILIWR IFIARSQMAR NIWYFVVSLC 
       510 
YKFLSYFRAS STMRY
Length:515
Mass (Da):59,357
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF5CF7CDD161BCD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNW8E9PNW8_HUMAN
Fatty acyl-CoA reductase
FAR1
335Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPB8E9PPB8_HUMAN
Fatty acyl-CoA reductase 1
FAR1
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti275 – 276LV → PG in CAI56762 (PubMed:17974005).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05380096E → K. Corresponds to variant dbSNP:rs12793516EnsemblClinVar.1
Natural variantiVAR_072692165 – 169EVVYP → D in PFCRD; results in a complete loss of enzyme activity. 1 Publication5
Natural variantiVAR_072693365D → G in PFCRD; results in a complete loss of enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs724159963EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY600449 mRNA Translation: AAT42129.1
AY423606 mRNA Translation: AAR84086.1
AY358784 mRNA Translation: AAQ89144.1
CR936619 mRNA Translation: CAI56762.1
CH471064 Genomic DNA Translation: EAW68492.1
CH471064 Genomic DNA Translation: EAW68493.1
BC017377 mRNA Translation: AAH17377.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7813.1

NCBI Reference Sequences

More...RefSeqi		NP_115604.1, NM_032228.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354817; ENSP00000346874; ENSG00000197601

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84188

UCSC genome browser

More...UCSCi		uc001mld.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600449 mRNA Translation: AAT42129.1
AY423606 mRNA Translation: AAR84086.1
AY358784 mRNA Translation: AAQ89144.1
CR936619 mRNA Translation: CAI56762.1
CH471064 Genomic DNA Translation: EAW68492.1
CH471064 Genomic DNA Translation: EAW68493.1
BC017377 mRNA Translation: AAH17377.1
CCDSiCCDS7813.1
RefSeqiNP_115604.1, NM_032228.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123936, 60 interactors
IntActiQ8WVX9, 40 interactors
MINTiQ8WVX9
STRINGi9606.ENSP00000346874

Chemistry databases

SwissLipidsiSLP:000000208

PTM databases

iPTMnetiQ8WVX9
PhosphoSitePlusiQ8WVX9
SwissPalmiQ8WVX9

Genetic variation databases

BioMutaiFAR1
DMDMi74730902

Proteomic databases

EPDiQ8WVX9
jPOSTiQ8WVX9
MassIVEiQ8WVX9
MaxQBiQ8WVX9
PaxDbiQ8WVX9
PeptideAtlasiQ8WVX9
PRIDEiQ8WVX9
ProteomicsDBi74834

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2735, 39 antibodies

The DNASU plasmid repository

More...DNASUi		84188

Genome annotation databases

EnsembliENST00000354817; ENSP00000346874; ENSG00000197601
GeneIDi84188
KEGGihsa:84188
UCSCiuc001mld.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84188
DisGeNETi84188

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAR1
HGNCiHGNC:26222, FAR1
HPAiENSG00000197601, Low tissue specificity
MalaCardsiFAR1
MIMi616107, gene
616154, phenotype
neXtProtiNX_Q8WVX9
OpenTargetsiENSG00000197601
Orphaneti438178, Fatty acyl-CoA reductase 1 deficiency
PharmGKBiPA162388007
VEuPathDBiHostDB:ENSG00000197601.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1221, Eukaryota
GeneTreeiENSGT00390000006367
HOGENOMiCLU_024661_0_0_1
InParanoidiQ8WVX9
OMAiQPYTFYG
PhylomeDBiQ8WVX9
TreeFamiTF313011

Enzyme and pathway databases

BioCyciMetaCyc:HS16231-MONOMER
BRENDAi1.2.1.84, 2681
PathwayCommonsiQ8WVX9
ReactomeiR-HSA-9640463, Wax biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84188, 18 hits in 1005 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAR1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MLSTD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84188
PharosiQ8WVX9, Tbio

Protein Ontology

More...PROi		PR:Q8WVX9
RNActiQ8WVX9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197601, Expressed in corpus callosum and 217 other tissues
ExpressionAtlasiQ8WVX9, baseline and differential
GenevisibleiQ8WVX9, HS

Family and domain databases

CDDicd09071, FAR_C, 1 hit
InterProiView protein in InterPro
IPR026055, FAR
IPR033640, FAR_C
IPR013120, Far_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
PANTHERiPTHR11011, PTHR11011, 1 hit
PfamiView protein in Pfam
PF07993, NAD_binding_4, 1 hit
PF03015, Sterile, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFACR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WVX9
Secondary accession number(s): D3DQW8, Q5CZA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2002
Last modified: June 2, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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