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Protein

Uncharacterized protein C4orf3

Gene

C4orf3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.50.6.1 the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C4orf3
Alternative name(s):
Hepatitis C virus F protein-transactivated protein 1
Short name:
HCV F-transactivated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C4orf3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000164096.12

Human Gene Nomenclature Database

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HGNCi
HGNC:19225 C4orf3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WVX3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei45 – 65HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000164096

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164717306

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C4orf3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003257841 – 66Uncharacterized protein C4orf3Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WVX3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8WVX3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8WVX3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WVX3

PeptideAtlas

More...
PeptideAtlasi
Q8WVX3

PRoteomics IDEntifications database

More...
PRIDEi
Q8WVX3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74831
74832 [Q8WVX3-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8WVX3-1 [Q8WVX3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WVX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WVX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164096 Expressed in 216 organ(s), highest expression level in endothelial cell

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WVX3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026907

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
134952, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WVX3, 55 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382026

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WVX3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WVX3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410JCJ6 Eukaryota
ENOG41117U8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064570

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WVX3

Identification of Orthologs from Complete Genome Data

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OMAi
EGNNRCQ

Database of Orthologous Groups

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OrthoDBi
1307860at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WVX3

TreeFam database of animal gene trees

More...
TreeFami
TF343305

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038780 C4orf3

The PANTHER Classification System

More...
PANTHERi
PTHR37367 PTHR37367, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WVX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVDAPGVDG RDGLRERRGF SEGGRQNFDV RPQSGANGLP KHSYWLDLWL
60
FILFDVVVFL FVYFLP
Length:66
Mass (Da):7,604
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6973371B80AE75CC
GO
Isoform 2 (identifier: Q8WVX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSLINSPIN...GLLRSCRSEM

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):22,558
Checksum:i78988F83DB793925
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03991117R → Q1 PublicationCorresponds to variant dbSNP:rs17851522Ensembl.1
Natural variantiVAR_03991232P → H. Corresponds to variant dbSNP:rs11544530Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0324051M → MTSLINSPINRRPLQNVEGN NRCQRKAKNYGNKYFIHCLD LEKITLSPRRKHDIEGGDKL NVKFSQLRSRRQRKAEPGAC ALGRVGSECIPEPGARRTAQ AAGLRSVSGAANTKVRELKH FRFLGLLRSCRSEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY605045 mRNA Translation: AAT35812.1
AC092656 Genomic DNA No translation available.
BC017399 mRNA Translation: AAH17399.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43266.1 [Q8WVX3-1]
CCDS54798.1 [Q8WVX3-2]

NCBI Reference Sequences

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RefSeqi
NP_001001701.2, NM_001001701.3 [Q8WVX3-1]
NP_001163801.1, NM_001170330.1 [Q8WVX3-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.173705

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399075; ENSP00000382026; ENSG00000164096 [Q8WVX3-2]
ENST00000504110; ENSP00000485697; ENSG00000164096 [Q8WVX3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
401152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:401152

UCSC genome browser

More...
UCSCi
uc003icv.5 human [Q8WVX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605045 mRNA Translation: AAT35812.1
AC092656 Genomic DNA No translation available.
BC017399 mRNA Translation: AAH17399.1
CCDSiCCDS43266.1 [Q8WVX3-1]
CCDS54798.1 [Q8WVX3-2]
RefSeqiNP_001001701.2, NM_001001701.3 [Q8WVX3-1]
NP_001163801.1, NM_001170330.1 [Q8WVX3-2]
UniGeneiHs.173705

3D structure databases

ProteinModelPortaliQ8WVX3
SMRiQ8WVX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134952, 10 interactors
IntActiQ8WVX3, 55 interactors
STRINGi9606.ENSP00000382026

Protein family/group databases

TCDBi1.A.50.6.1 the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family

PTM databases

iPTMnetiQ8WVX3
PhosphoSitePlusiQ8WVX3

Polymorphism and mutation databases

BioMutaiC4orf3

Proteomic databases

EPDiQ8WVX3
jPOSTiQ8WVX3
MaxQBiQ8WVX3
PaxDbiQ8WVX3
PeptideAtlasiQ8WVX3
PRIDEiQ8WVX3
ProteomicsDBi74831
74832 [Q8WVX3-2]
TopDownProteomicsiQ8WVX3-1 [Q8WVX3-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
401152
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399075; ENSP00000382026; ENSG00000164096 [Q8WVX3-2]
ENST00000504110; ENSP00000485697; ENSG00000164096 [Q8WVX3-1]
GeneIDi401152
KEGGihsa:401152
UCSCiuc003icv.5 human [Q8WVX3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
401152
EuPathDBiHostDB:ENSG00000164096.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C4orf3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004468
HGNCiHGNC:19225 C4orf3
HPAiHPA026907
neXtProtiNX_Q8WVX3
OpenTargetsiENSG00000164096
PharmGKBiPA164717306

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JCJ6 Eukaryota
ENOG41117U8 LUCA
GeneTreeiENSGT00530000064570
InParanoidiQ8WVX3
OMAiEGNNRCQ
OrthoDBi1307860at2759
PhylomeDBiQ8WVX3
TreeFamiTF343305

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C4orf3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
401152

Protein Ontology

More...
PROi
PR:Q8WVX3

Gene expression databases

BgeeiENSG00000164096 Expressed in 216 organ(s), highest expression level in endothelial cell
GenevisibleiQ8WVX3 HS

Family and domain databases

InterProiView protein in InterPro
IPR038780 C4orf3
PANTHERiPTHR37367 PTHR37367, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD003_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WVX3
Secondary accession number(s): Q6J203
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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