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Entry version 149 (18 Sep 2019)
Sequence version 2 (01 Feb 2005)
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Protein

Butyrophilin subfamily 2 member A2

Gene

BTN2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8851680 Butyrophilin (BTN) family interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Butyrophilin subfamily 2 member A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BTN2A2
Synonyms:BT2.2, BTF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1137 BTN2A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613591 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WVV5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 265ExtracellularSequence analysisAdd BLAST233
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 523CytoplasmicSequence analysisAdd BLAST237

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10385

Open Targets

More...
OpenTargetsi
ENSG00000124508

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25457

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BTN2A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
83288459

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001453033 – 523Butyrophilin subfamily 2 member A2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 129PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WVV5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WVV5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WVV5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WVV5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WVV5

PeptideAtlas

More...
PeptideAtlasi
Q8WVV5

PRoteomics IDEntifications database

More...
PRIDEi
Q8WVV5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
20433
74823 [Q8WVV5-1]
74824 [Q8WVV5-2]
74825 [Q8WVV5-3]
74826 [Q8WVV5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WVV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WVV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124508 Expressed in 204 organ(s), highest expression level in epithelium of bronchus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WVV5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WVV5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051504

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115658, 35 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WVV5, 54 interactors

Molecular INTeraction database

More...
MINTi
Q8WVV5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349143

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WVV5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 145Ig-like V-typeAdd BLAST112
Domaini153 – 234Ig-like C2-typeAdd BLAST82
Domaini309 – 502B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili286 – 321Sequence analysisAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJI4 Eukaryota
ENOG410YA6W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158017

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230860

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WVV5

KEGG Orthology (KO)

More...
KOi
K06712

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPYGEIM

Database of Orthologous Groups

More...
OrthoDBi
522383at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WVV5

TreeFam database of animal gene trees

More...
TreeFami
TF331083

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15819 SPRY_PRY_BTN1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR037958 SPRY/PRY_BTN1/2
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WVV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAAALHFS LPASLLLLLL LLLLSLCALV SAQFTVVGPA NPILAMVGEN
60 70 80 90 100
TTLRCHLSPE KNAEDMEVRW FRSQFSPAVF VYKGGRERTE EQMEEYRGRI
110 120 130 140 150
TFVSKDINRG SVALVIHNVT AQENGIYRCY FQEGRSYDEA ILRLVVAGLG
160 170 180 190 200
SKPLIEIKAQ EDGSIWLECI SGGWYPEPLT VWRDPYGEVV PALKEVSIAD
210 220 230 240 250
ADGLFMVTTA VIIRDKYVRN VSCSVNNTLL GQEKETVIFI PESFMPSASP
260 270 280 290 300
WMVALAVILT ASPWMVSMTV ILAVFIIFMA VSICCIKKLQ REKKILSGEK
310 320 330 340 350
KVEQEEKEIA QQLQEELRWR RTFLHAADVV LDPDTAHPEL FLSEDRRSVR
360 370 380 390 400
RGPYRQRVPD NPERFDSQPC VLGWESFASG KHYWEVEVEN VMVWTVGVCR
410 420 430 440 450
HSVERKGEVL LIPQNGFWTL EMFGNQYRAL SSPERILPLK ESLCRVGVFL
460 470 480 490 500
DYEAGDVSFY NMRDRSHIYT CPRSAFTVPV RPFFRLGSDD SPIFICPALT
510 520
GASGVMVPEE GLKLHRVGTH QSL
Length:523
Mass (Da):59,070
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i122099CE635F279D
GO
Isoform 2 (identifier: Q8WVV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-336: ADVVLDPDTA → DVNLTGLRNT
     337-523: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):37,714
Checksum:i5AEE282BA52506FF
GO
Isoform 3 (identifier: Q8WVV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-241: Missing.
     327-350: ADVVLDPDTAHPELFLSEDRRSVR → GYELPGIRGPSWKRPLHGEPPSAF
     351-523: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,927
Checksum:i283491E103090795
GO
Isoform 4 (identifier: Q8WVV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-147: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):45,827
Checksum:i7BFB2302A387BF64
GO
Isoform 5 (identifier: Q8WVV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-241: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,493
Checksum:i1242D946AE321E50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8J5C9J8J5_HUMAN
Butyrophilin subfamily 2 member A2
BTN2A2
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZY2C9IZY2_HUMAN
Butyrophilin subfamily 2 member A2
BTN2A2
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IY66C9IY66_HUMAN
Butyrophilin subfamily 2 member A2
BTN2A2
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8R3C9J8R3_HUMAN
Butyrophilin subfamily 2 member A2
BTN2A2
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAJ6C9JAJ6_HUMAN
Butyrophilin subfamily 2 member A2
BTN2A2
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWH2C9JWH2_HUMAN
Butyrophilin subfamily 2 member A2
BTN2A2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4E8H7C4E8_HUMAN
Butyrophilin subfamily 2 member A2
BTN2A2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC65F8WC65_HUMAN
Butyrophilin subfamily 2 member A2
BTN2A2
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti243S → P in BAG57008 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049829479P → S. Corresponds to variant dbSNP:rs16891646Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04486132 – 241Missing in isoform 5. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_04356132 – 147Missing in isoform 4. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_043562148 – 241Missing in isoform 3. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_043563327 – 350ADVVL…RRSVR → GYELPGIRGPSWKRPLHGEP PSAF in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_012712327 – 336ADVVLDPDTA → DVNLTGLRNT in isoform 2. 1 Publication10
Alternative sequenceiVSP_012713337 – 523Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_043564351 – 523Missing in isoform 3. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U90550 mRNA Translation: AAB53428.1
AK289883 mRNA Translation: BAF82572.1
AK293526 mRNA Translation: BAG57008.1
AK298570 mRNA Translation: BAG60763.1
AL021917 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55565.1
BC014021 mRNA Translation: AAH14021.1
BC017497 mRNA Translation: AAH17497.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4606.1 [Q8WVV5-1]
CCDS4607.1 [Q8WVV5-4]
CCDS56401.1 [Q8WVV5-2]
CCDS56402.1 [Q8WVV5-3]
CCDS56403.1 [Q8WVV5-5]

NCBI Reference Sequences

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RefSeqi
NP_001184166.1, NM_001197237.1 [Q8WVV5-1]
NP_001184167.1, NM_001197238.1 [Q8WVV5-2]
NP_001184168.1, NM_001197239.1 [Q8WVV5-5]
NP_001184169.1, NM_001197240.1 [Q8WVV5-3]
NP_008926.2, NM_006995.4 [Q8WVV5-1]
NP_853509.1, NM_181531.2 [Q8WVV5-4]
XP_005248854.1, XM_005248797.3 [Q8WVV5-1]
XP_005248855.1, XM_005248798.4 [Q8WVV5-4]
XP_006715016.1, XM_006714953.3 [Q8WVV5-1]
XP_011512530.1, XM_011514228.2 [Q8WVV5-1]
XP_011512533.1, XM_011514231.2 [Q8WVV5-5]
XP_016865656.1, XM_017010167.1 [Q8WVV5-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000352867; ENSP00000337117; ENSG00000124508 [Q8WVV5-4]
ENST00000356709; ENSP00000349143; ENSG00000124508 [Q8WVV5-1]
ENST00000416795; ENSP00000399308; ENSG00000124508 [Q8WVV5-1]
ENST00000432533; ENSP00000394241; ENSG00000124508 [Q8WVV5-3]
ENST00000469230; ENSP00000417472; ENSG00000124508 [Q8WVV5-2]
ENST00000482536; ENSP00000419451; ENSG00000124508 [Q8WVV5-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10385

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10385

UCSC genome browser

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UCSCi
uc003nhq.4 human [Q8WVV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90550 mRNA Translation: AAB53428.1
AK289883 mRNA Translation: BAF82572.1
AK293526 mRNA Translation: BAG57008.1
AK298570 mRNA Translation: BAG60763.1
AL021917 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55565.1
BC014021 mRNA Translation: AAH14021.1
BC017497 mRNA Translation: AAH17497.1
CCDSiCCDS4606.1 [Q8WVV5-1]
CCDS4607.1 [Q8WVV5-4]
CCDS56401.1 [Q8WVV5-2]
CCDS56402.1 [Q8WVV5-3]
CCDS56403.1 [Q8WVV5-5]
RefSeqiNP_001184166.1, NM_001197237.1 [Q8WVV5-1]
NP_001184167.1, NM_001197238.1 [Q8WVV5-2]
NP_001184168.1, NM_001197239.1 [Q8WVV5-5]
NP_001184169.1, NM_001197240.1 [Q8WVV5-3]
NP_008926.2, NM_006995.4 [Q8WVV5-1]
NP_853509.1, NM_181531.2 [Q8WVV5-4]
XP_005248854.1, XM_005248797.3 [Q8WVV5-1]
XP_005248855.1, XM_005248798.4 [Q8WVV5-4]
XP_006715016.1, XM_006714953.3 [Q8WVV5-1]
XP_011512530.1, XM_011514228.2 [Q8WVV5-1]
XP_011512533.1, XM_011514231.2 [Q8WVV5-5]
XP_016865656.1, XM_017010167.1 [Q8WVV5-4]

3D structure databases

SMRiQ8WVV5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115658, 35 interactors
IntActiQ8WVV5, 54 interactors
MINTiQ8WVV5
STRINGi9606.ENSP00000349143

PTM databases

iPTMnetiQ8WVV5
PhosphoSitePlusiQ8WVV5

Polymorphism and mutation databases

BioMutaiBTN2A2
DMDMi83288459

Proteomic databases

EPDiQ8WVV5
jPOSTiQ8WVV5
MassIVEiQ8WVV5
MaxQBiQ8WVV5
PaxDbiQ8WVV5
PeptideAtlasiQ8WVV5
PRIDEiQ8WVV5
ProteomicsDBi20433
74823 [Q8WVV5-1]
74824 [Q8WVV5-2]
74825 [Q8WVV5-3]
74826 [Q8WVV5-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q8WVV5
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352867; ENSP00000337117; ENSG00000124508 [Q8WVV5-4]
ENST00000356709; ENSP00000349143; ENSG00000124508 [Q8WVV5-1]
ENST00000416795; ENSP00000399308; ENSG00000124508 [Q8WVV5-1]
ENST00000432533; ENSP00000394241; ENSG00000124508 [Q8WVV5-3]
ENST00000469230; ENSP00000417472; ENSG00000124508 [Q8WVV5-2]
ENST00000482536; ENSP00000419451; ENSG00000124508 [Q8WVV5-5]
GeneIDi10385
KEGGihsa:10385
UCSCiuc003nhq.4 human [Q8WVV5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10385
DisGeNETi10385

GeneCards: human genes, protein and diseases

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GeneCardsi
BTN2A2
HGNCiHGNC:1137 BTN2A2
HPAiHPA051504
MIMi613591 gene
neXtProtiNX_Q8WVV5
OpenTargetsiENSG00000124508
PharmGKBiPA25457

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJI4 Eukaryota
ENOG410YA6W LUCA
GeneTreeiENSGT00940000158017
HOGENOMiHOG000230860
InParanoidiQ8WVV5
KOiK06712
OMAiDPYGEIM
OrthoDBi522383at2759
PhylomeDBiQ8WVV5
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-HSA-8851680 Butyrophilin (BTN) family interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BTN2A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Butyrophilin,_subfamily_2,_member_A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10385

Pharos

More...
Pharosi
Q8WVV5

Protein Ontology

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PROi
PR:Q8WVV5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124508 Expressed in 204 organ(s), highest expression level in epithelium of bronchus
ExpressionAtlasiQ8WVV5 baseline and differential
GenevisibleiQ8WVV5 HS

Family and domain databases

CDDicd15819 SPRY_PRY_BTN1_2, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR037958 SPRY/PRY_BTN1/2
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBT2A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WVV5
Secondary accession number(s): A6NM84
, B4DE97, B4DQ01, E9PH07, O00480
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: September 18, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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