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Protein

Butyrophilin subfamily 2 member A2

Gene

BTN2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8851680 Butyrophilin (BTN) family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 2 member A2
Gene namesi
Name:BTN2A2
Synonyms:BT2.2, BTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124508.16
HGNCiHGNC:1137 BTN2A2
MIMi613591 gene
neXtProtiNX_Q8WVV5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 265ExtracellularSequence analysisAdd BLAST233
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 523CytoplasmicSequence analysisAdd BLAST237

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10385
OpenTargetsiENSG00000124508
PharmGKBiPA25457

Polymorphism and mutation databases

BioMutaiBTN2A2
DMDMi83288459

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001453033 – 523Butyrophilin subfamily 2 member A2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi55 ↔ 129PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8WVV5
MaxQBiQ8WVV5
PaxDbiQ8WVV5
PeptideAtlasiQ8WVV5
PRIDEiQ8WVV5
ProteomicsDBi74823
74824 [Q8WVV5-2]
74825 [Q8WVV5-3]
74826 [Q8WVV5-4]

PTM databases

iPTMnetiQ8WVV5
PhosphoSitePlusiQ8WVV5

Expressioni

Tissue specificityi

Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000124508
CleanExiHS_BTN2A2
ExpressionAtlasiQ8WVV5 baseline and differential
GenevisibleiQ8WVV5 HS

Organism-specific databases

HPAiHPA051504

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115658, 35 interactors
IntActiQ8WVV5, 8 interactors
MINTiQ8WVV5
STRINGi9606.ENSP00000349143

Structurei

3D structure databases

ProteinModelPortaliQ8WVV5
SMRiQ8WVV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 145Ig-like V-typeAdd BLAST112
Domaini153 – 234Ig-like C2-typeAdd BLAST82
Domaini309 – 502B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili286 – 321Sequence analysisAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJI4 Eukaryota
ENOG410YA6W LUCA
GeneTreeiENSGT00760000118933
HOGENOMiHOG000230860
HOVERGENiHBG050747
InParanoidiQ8WVV5
KOiK06712
OMAiFICPAFT
OrthoDBiEOG091G07OP
PhylomeDBiQ8WVV5
TreeFamiTF331083

Family and domain databases

CDDicd15819 SPRY_PRY_BTN1_2, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR037958 SPRY/PRY_BTN1/2
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAAALHFS LPASLLLLLL LLLLSLCALV SAQFTVVGPA NPILAMVGEN
60 70 80 90 100
TTLRCHLSPE KNAEDMEVRW FRSQFSPAVF VYKGGRERTE EQMEEYRGRI
110 120 130 140 150
TFVSKDINRG SVALVIHNVT AQENGIYRCY FQEGRSYDEA ILRLVVAGLG
160 170 180 190 200
SKPLIEIKAQ EDGSIWLECI SGGWYPEPLT VWRDPYGEVV PALKEVSIAD
210 220 230 240 250
ADGLFMVTTA VIIRDKYVRN VSCSVNNTLL GQEKETVIFI PESFMPSASP
260 270 280 290 300
WMVALAVILT ASPWMVSMTV ILAVFIIFMA VSICCIKKLQ REKKILSGEK
310 320 330 340 350
KVEQEEKEIA QQLQEELRWR RTFLHAADVV LDPDTAHPEL FLSEDRRSVR
360 370 380 390 400
RGPYRQRVPD NPERFDSQPC VLGWESFASG KHYWEVEVEN VMVWTVGVCR
410 420 430 440 450
HSVERKGEVL LIPQNGFWTL EMFGNQYRAL SSPERILPLK ESLCRVGVFL
460 470 480 490 500
DYEAGDVSFY NMRDRSHIYT CPRSAFTVPV RPFFRLGSDD SPIFICPALT
510 520
GASGVMVPEE GLKLHRVGTH QSL
Length:523
Mass (Da):59,070
Last modified:February 1, 2005 - v2
Checksum:i122099CE635F279D
GO
Isoform 2 (identifier: Q8WVV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-336: ADVVLDPDTA → DVNLTGLRNT
     337-523: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):37,714
Checksum:i5AEE282BA52506FF
GO
Isoform 3 (identifier: Q8WVV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-241: Missing.
     327-350: ADVVLDPDTAHPELFLSEDRRSVR → GYELPGIRGPSWKRPLHGEPPSAF
     351-523: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,927
Checksum:i283491E103090795
GO
Isoform 4 (identifier: Q8WVV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-147: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):45,827
Checksum:i7BFB2302A387BF64
GO
Isoform 5 (identifier: Q8WVV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-241: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,493
Checksum:i1242D946AE321E50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243S → P in BAG57008 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049829479P → S. Corresponds to variant dbSNP:rs16891646Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04486132 – 241Missing in isoform 5. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_04356132 – 147Missing in isoform 4. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_043562148 – 241Missing in isoform 3. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_043563327 – 350ADVVL…RRSVR → GYELPGIRGPSWKRPLHGEP PSAF in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_012712327 – 336ADVVLDPDTA → DVNLTGLRNT in isoform 2. 1 Publication10
Alternative sequenceiVSP_012713337 – 523Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_043564351 – 523Missing in isoform 3. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90550 mRNA Translation: AAB53428.1
AK289883 mRNA Translation: BAF82572.1
AK293526 mRNA Translation: BAG57008.1
AK298570 mRNA Translation: BAG60763.1
AL021917 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55565.1
BC014021 mRNA Translation: AAH14021.1
BC017497 mRNA Translation: AAH17497.1
CCDSiCCDS4606.1 [Q8WVV5-1]
CCDS4607.1 [Q8WVV5-4]
CCDS56401.1 [Q8WVV5-2]
CCDS56402.1 [Q8WVV5-3]
CCDS56403.1 [Q8WVV5-5]
RefSeqiNP_001184166.1, NM_001197237.1 [Q8WVV5-1]
NP_001184167.1, NM_001197238.1 [Q8WVV5-2]
NP_001184168.1, NM_001197239.1 [Q8WVV5-5]
NP_001184169.1, NM_001197240.1 [Q8WVV5-3]
NP_008926.2, NM_006995.4 [Q8WVV5-1]
NP_853509.1, NM_181531.2 [Q8WVV5-4]
XP_005248854.1, XM_005248797.3 [Q8WVV5-1]
XP_005248855.1, XM_005248798.4 [Q8WVV5-4]
XP_006715016.1, XM_006714953.3 [Q8WVV5-1]
XP_011512530.1, XM_011514228.2 [Q8WVV5-1]
XP_011512533.1, XM_011514231.2 [Q8WVV5-5]
XP_016865656.1, XM_017010167.1 [Q8WVV5-4]
UniGeneiHs.373938

Genome annotation databases

EnsembliENST00000352867; ENSP00000337117; ENSG00000124508 [Q8WVV5-4]
ENST00000356709; ENSP00000349143; ENSG00000124508 [Q8WVV5-1]
ENST00000416795; ENSP00000399308; ENSG00000124508 [Q8WVV5-1]
ENST00000432533; ENSP00000394241; ENSG00000124508 [Q8WVV5-3]
ENST00000469230; ENSP00000417472; ENSG00000124508 [Q8WVV5-2]
ENST00000482536; ENSP00000419451; ENSG00000124508 [Q8WVV5-5]
GeneIDi10385
KEGGihsa:10385
UCSCiuc003nhq.4 human [Q8WVV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBT2A2_HUMAN
AccessioniPrimary (citable) accession number: Q8WVV5
Secondary accession number(s): A6NM84
, B4DE97, B4DQ01, E9PH07, O00480
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: June 20, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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