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Entry version 128 (03 Jul 2019)
Sequence version 3 (03 May 2011)
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Protein

Protein POF1B

Gene

POF1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein POF1B
Alternative name(s):
Premature ovarian failure protein 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POF1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13711 POF1B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300603 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WVV4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Premature ovarian failure 2B (POF2B)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028757329R → Q in POF2B; disrupts binding to nonmuscle actin filaments; abolishes tight junction localization; altered ciliogenesis and cystogenesis. 3 PublicationsCorresponds to variant dbSNP:rs75398746EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Premature ovarian failure

Organism-specific databases

DisGeNET

More...
DisGeNETi
79983

MalaCards human disease database

More...
MalaCardsi
POF1B
MIMi300604 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000124429

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
619 NON RARE IN EUROPE: Primary ovarian failure

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134937695

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POF1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
332278224

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002539111 – 589Protein POF1BAdd BLAST589

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WVV4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WVV4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WVV4

PeptideAtlas

More...
PeptideAtlasi
Q8WVV4

PRoteomics IDEntifications database

More...
PRIDEi
Q8WVV4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74820
74821 [Q8WVV4-1]
74822 [Q8WVV4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WVV4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WVV4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124429 Expressed in 134 organ(s), highest expression level in skin of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WVV4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002033
HPA050027

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nonmuscle actin.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123048, 57 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WVV4, 20 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262753

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WVV4

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WVV4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili334 – 443Sequence analysisAdd BLAST110

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IER4 Eukaryota
ENOG410YDPU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000141

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WVV4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LENDKMR

Database of Orthologous Groups

More...
OrthoDBi
724143at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331412

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026186 POF1B

The PANTHER Classification System

More...
PANTHERi
PTHR22546 PTHR22546, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q8WVV4-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSYWSETS SSSCGTQQLP EVLQCQPQHY HCYHQSSQAQ QPPEKNVVYE
60 70 80 90 100
RVRTYSGPMN KVVQALDPFN SREVLSPLKT TSSYQNLVWS DHSQELHSPT
110 120 130 140 150
LKISTCAPST LHITQNTEQE LHSPTVKLTT YPQTTIRKYV VQNPEQEPLS
160 170 180 190 200
QFLRGSHFFP GNNVIYEKTI RKVEKLNTDQ GCHPQAQCHH HIIQQPQVIH
210 220 230 240 250
SAHWQQPDSS QQIQAITGNN PISTHIGNEL CHSGSSQICE QVIIQDDGPE
260 270 280 290 300
KLDPRYFGEL LADLSRKNTD LYHCLLEHLQ RIGGSKQDFE STDESEDIES
310 320 330 340 350
LIPKGLSEFT KQQIRYILQM RGMSDKSLRL VLSTFSNIRE ELGHLQNDMT
360 370 380 390 400
SLENDKMRLE KDLSFKDTQL KEYEELLASV RANNHQQQQG LQDSSSKCQA
410 420 430 440 450
LEENNLSLRH TLSDMEYRLK ELEYCKRNLE QENQNLRMQV SETCTGPMLQ
460 470 480 490 500
AKMDEIGNHY TEMVKNLRME KDREICRLRS QLNQYHKDVS KREGSCSDFQ
510 520 530 540 550
FKLHELTSLL EEKDSLIKRQ SEELSKLRQE IYSSHNQPST GGRTTITTKK
560 570 580
YRTQYPILGL LYDDYEYIPP GSETQTIVIE KTEDKYTCP
Length:589
Mass (Da):68,065
Last modified:May 3, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6698CBE405364159
GO
Isoform 1 (identifier: Q8WVV4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     589-589: P → VSSLGHF

Show »
Length:595
Mass (Da):68,696
Checksum:iD2152F2FF86E8338
GO
Isoform 3 (identifier: Q8WVV4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-306: GSKQDFESTDESEDIESLIPKGL → RKQSLSSTYTIRHGIQTKRTGIL
     307-589: Missing.

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):34,841
Checksum:iF94BE58D7A070CA8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15061 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15485 differs from that shown. Reason: Frameshift at position 464.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti180Q → E in AAM93270 (PubMed:15459172).Curated1
Sequence conflicti503L → F in BAB15485 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028753207P → S. Corresponds to variant dbSNP:rs363766EnsemblClinVar.1
Natural variantiVAR_028754239C → S1 PublicationCorresponds to variant dbSNP:rs147563033EnsemblClinVar.1
Natural variantiVAR_028755296E → A. Corresponds to variant dbSNP:rs363751Ensembl.1
Natural variantiVAR_028756323M → V. Corresponds to variant dbSNP:rs363775Ensembl.1
Natural variantiVAR_028757329R → Q in POF2B; disrupts binding to nonmuscle actin filaments; abolishes tight junction localization; altered ciliogenesis and cystogenesis. 3 PublicationsCorresponds to variant dbSNP:rs75398746EnsemblClinVar.1
Natural variantiVAR_028758349M → L4 PublicationsCorresponds to variant dbSNP:rs363774EnsemblClinVar.1
Natural variantiVAR_028759434Q → K1 PublicationCorresponds to variant dbSNP:rs139385491EnsemblClinVar.1
Natural variantiVAR_028760444C → Y1 PublicationCorresponds to variant dbSNP:rs768162591Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021149284 – 306GSKQD…IPKGL → RKQSLSSTYTIRHGIQTKRT GIL in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_021150307 – 589Missing in isoform 3. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_021151589P → VSSLGHF in isoform 1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF309774 mRNA Translation: AAM93270.1
AK025039 mRNA Translation: BAB15055.1
AK025080 mRNA Translation: BAB15061.1 Different initiation.
AK026445 mRNA Translation: BAB15485.1 Sequence problems.
AK290360 mRNA Translation: BAF83049.1
AK314295 mRNA Translation: BAG36950.1
AL117325 Genomic DNA No translation available.
Z82216 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98561.1
BC017500 mRNA Translation: AAH17500.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14452.1 [Q8WVV4-2]
CCDS78497.1 [Q8WVV4-1]

NCBI Reference Sequences

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RefSeqi
NP_001294869.1, NM_001307940.1 [Q8WVV4-1]
NP_079197.3, NM_024921.3 [Q8WVV4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262753; ENSP00000262753; ENSG00000124429 [Q8WVV4-2]
ENST00000373145; ENSP00000362238; ENSG00000124429 [Q8WVV4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79983

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79983

UCSC genome browser

More...
UCSCi
uc004eer.3 human [Q8WVV4-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309774 mRNA Translation: AAM93270.1
AK025039 mRNA Translation: BAB15055.1
AK025080 mRNA Translation: BAB15061.1 Different initiation.
AK026445 mRNA Translation: BAB15485.1 Sequence problems.
AK290360 mRNA Translation: BAF83049.1
AK314295 mRNA Translation: BAG36950.1
AL117325 Genomic DNA No translation available.
Z82216 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98561.1
BC017500 mRNA Translation: AAH17500.1
CCDSiCCDS14452.1 [Q8WVV4-2]
CCDS78497.1 [Q8WVV4-1]
RefSeqiNP_001294869.1, NM_001307940.1 [Q8WVV4-1]
NP_079197.3, NM_024921.3 [Q8WVV4-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BH9X-ray1.70C53-62[»]
SMRiQ8WVV4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123048, 57 interactors
IntActiQ8WVV4, 20 interactors
STRINGi9606.ENSP00000262753

PTM databases

iPTMnetiQ8WVV4
PhosphoSitePlusiQ8WVV4

Polymorphism and mutation databases

BioMutaiPOF1B
DMDMi332278224

Proteomic databases

EPDiQ8WVV4
jPOSTiQ8WVV4
PaxDbiQ8WVV4
PeptideAtlasiQ8WVV4
PRIDEiQ8WVV4
ProteomicsDBi74820
74821 [Q8WVV4-1]
74822 [Q8WVV4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79983
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262753; ENSP00000262753; ENSG00000124429 [Q8WVV4-2]
ENST00000373145; ENSP00000362238; ENSG00000124429 [Q8WVV4-1]
GeneIDi79983
KEGGihsa:79983
UCSCiuc004eer.3 human [Q8WVV4-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79983
DisGeNETi79983

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POF1B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0021709
HIX0176741
HGNCiHGNC:13711 POF1B
HPAiHPA002033
HPA050027
MalaCardsiPOF1B
MIMi300603 gene
300604 phenotype
neXtProtiNX_Q8WVV4
OpenTargetsiENSG00000124429
Orphaneti619 NON RARE IN EUROPE: Primary ovarian failure
PharmGKBiPA134937695

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IER4 Eukaryota
ENOG410YDPU LUCA
GeneTreeiENSGT00390000000141
InParanoidiQ8WVV4
OMAiLENDKMR
OrthoDBi724143at2759
TreeFamiTF331412

Miscellaneous databases

EvolutionaryTraceiQ8WVV4

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
POF1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79983

Protein Ontology

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PROi
PR:Q8WVV4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124429 Expressed in 134 organ(s), highest expression level in skin of leg
GenevisibleiQ8WVV4 HS

Family and domain databases

InterProiView protein in InterPro
IPR026186 POF1B
PANTHERiPTHR22546 PTHR22546, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOF1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WVV4
Secondary accession number(s): A8K2U5
, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 3, 2011
Last modified: July 3, 2019
This is version 128 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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