UniProtKB - Q8WVQ1 (CANT1_HUMAN)
Protein
Soluble calcium-activated nucleotidase 1
Gene
CANT1
Organism
Homo sapiens (Human)
Status
Functioni
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336).5 Publications
Miscellaneous
Not inhibited by azide.
Catalytic activityi
- a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H+ + phosphate3 PublicationsEC:3.6.1.63 Publications
Cofactori
Ca2+4 Publications
pH dependencei
Optimum pH is 6.8.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 160 | Important for dimer formation1 Publication | 1 | |
Metal bindingi | 168 | Calcium; via carbonyl oxygenCombined sources2 Publications | 1 | |
Metal bindingi | 169 | CalciumCombined sources2 Publications | 1 | |
Sitei | 200 | Important for dimer formation1 Publication | 1 | |
Sitei | 202 | Important for dimer formation1 Publication | 1 | |
Metal bindingi | 215 | Calcium; via carbonyl oxygenCombined sources2 Publications | 1 | |
Sitei | 256 | Important for dimer formation1 Publication | 1 | |
Metal bindingi | 284 | Calcium; via carbonyl oxygenCombined sources2 Publications | 1 | |
Metal bindingi | 345 | Calcium; via carbonyl oxygenCombined sources2 Publications | 1 | |
Metal bindingi | 396 | Calcium; via carbonyl oxygenCombined sources2 Publications | 1 |
GO - Molecular functioni
- adenosine-diphosphatase activity Source: UniProtKB
- calcium ion binding Source: UniProtKB
- guanosine-diphosphatase activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- uridine-diphosphatase activity Source: GO_Central
GO - Biological processi
- neutrophil degranulation Source: Reactome
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- proteoglycan biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WVQ1 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Soluble calcium-activated nucleotidase 1 (EC:3.6.1.64 Publications)Short name: SCAN-1 Alternative name(s): Apyrase homolog Putative MAPK-activating protein PM09 Putative NF-kappa-B-activating protein 107 |
Gene namesi | Name:CANT1 Synonyms:SHAPY |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19721, CANT1 |
MIMi | 613165, gene |
neXtProti | NX_Q8WVQ1 |
VEuPathDBi | HostDB:ENSG00000171302.16 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Golgi apparatus
- Golgi stack membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Note: Processed form: Secreted.
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Golgi apparatus
- Golgi cisterna membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- ficolin-1-rich granule lumen Source: Reactome
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
- specific granule lumen Source: Reactome
- tertiary granule lumen Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 44 | CytoplasmicSequence analysisAdd BLAST | 44 | |
Transmembranei | 45 – 62 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 18 | |
Topological domaini | 63 – 401 | LumenalSequence analysisAdd BLAST | 339 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Desbuquois dysplasia 1 (DBQD1)6 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence or absence of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068655 | 112 | D → E in DBQD1. 1 PublicationCorresponds to variant dbSNP:rs749246739Ensembl. | 1 | |
Natural variantiVAR_068656 | 125 | W → C in DBQD1; severely affects activity. 1 PublicationCorresponds to variant dbSNP:rs587776898EnsemblClinVar. | 1 | |
Natural variantiVAR_068657 | 165 | M → T in DBQD1; severely affects activity. 1 Publication | 1 | |
Natural variantiVAR_068658 | 224 | L → P in DBQD1; affects protein stability and secretion. 1 PublicationCorresponds to variant dbSNP:rs150181226EnsemblClinVar. | 1 | |
Natural variantiVAR_068659 | 226 | V → M in DBQD1 and EDM7; severely affects activity. 3 PublicationsCorresponds to variant dbSNP:rs377546036EnsemblClinVar. | 1 | |
Natural variantiVAR_062980 | 299 | P → L in DBQD1. 1 PublicationCorresponds to variant dbSNP:rs267606700EnsemblClinVar. | 1 | |
Natural variantiVAR_062981 | 300 | R → C in DBQD1; severely affects activity. 2 PublicationsCorresponds to variant dbSNP:rs267606701EnsemblClinVar. | 1 | |
Natural variantiVAR_062982 | 300 | R → H in DBQD1. 2 PublicationsCorresponds to variant dbSNP:rs267606699EnsemblClinVar. | 1 | |
Natural variantiVAR_068660 | 303 | S → R in DBQD1. 1 Publication | 1 | |
Natural variantiVAR_068662 | 360 | A → D in DBQD1; affects protein secretion. 1 PublicationCorresponds to variant dbSNP:rs387907081EnsemblClinVar. | 1 | |
Natural variantiVAR_068663 | 374 | I → N in DBQD1. 1 Publication | 1 |
Epiphyseal dysplasia, multiple, 7 (EDM7)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of multiple epiphyseal dysplasia, a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. EDM7 inheritance is autosomal recessive.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080400 | 171 | I → F in EDM7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1014317450EnsemblClinVar. | 1 | |
Natural variantiVAR_068659 | 226 | V → M in DBQD1 and EDM7; severely affects activity. 3 PublicationsCorresponds to variant dbSNP:rs377546036EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 60 | C → S: Loss of dimer formation. 1 Publication | 1 | |
Mutagenesisi | 112 | D → A: Reduces activity by 99%. 1 Publication | 1 | |
Mutagenesisi | 114 | D → A: Reduces activity by 99%. 2 Publications | 1 | |
Mutagenesisi | 139 | S → C: Reduces GDPase and ADPase activities 1.7-fold. Severe loss of dimer formation; when associated with S-287. 1 Publication | 1 | |
Mutagenesisi | 152 | G → E: Slightly reduced activity. 1 Publication | 1 | |
Mutagenesisi | 160 | E → Y: Increases GDPase activity 2-fold and ADPase activity 5-fold. Forms dimer even at suboptimal Ca(2+) concentrations. 2 Publications | 1 | |
Mutagenesisi | 163 | R → A: Reduces activity by 98%. 1 Publication | 1 | |
Mutagenesisi | 166 | E → Q: Reduces activity by 95%. 1 Publication | 1 | |
Mutagenesisi | 168 | S → A: Reduces activity by over 99.9%. 1 Publication | 1 | |
Mutagenesisi | 169 | D → N: Reduces activity by 96%. 1 Publication | 1 | |
Mutagenesisi | 181 | D → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 182 | D → N: Reduces activity by over 99.9%. 1 Publication | 1 | |
Mutagenesisi | 200 | I → C: Reduces GDPase activity 2-fold and ADPase activity 2.5-fold. No effect on dimer formation; when associated with S-287. 1 Publication | 1 | |
Mutagenesisi | 202 | S → C: Reduces GDPase activity 1.7-fold and ADPase activity 1.5-fold. No effect on dimer formation; when associated with S-287. 1 Publication | 1 | |
Mutagenesisi | 205 | D → A: Slightly reduced activity. 1 Publication | 1 | |
Mutagenesisi | 215 | E → Q: Reduces activity by 99%. 1 Publication | 1 | |
Mutagenesisi | 246 | E → M: Increases activity 5-fold. 1 Publication | 1 | |
Mutagenesisi | 256 | S → C: No effect on GDPase and ADPase activities. No effect on dimer formation; when associated with S-287. 1 Publication | 1 | |
Mutagenesisi | 287 | C → S: Reduces GDPase and ADPase activities 1.3-fold. 1 Publication | 1 | |
Mutagenesisi | 301 | R → A: Reduces activity by 99%. 2 Publications | 1 | |
Mutagenesisi | 308 | S → C: Reduces GDPase activity 1.3-fold and ADPase activity 2-fold. Severe loss of dimer formation; when associated with S-287. 1 Publication | 1 | |
Mutagenesisi | 317 | A → C: Reduces GDPase activity 1.7-fold and ADPase activity 1.5-fold. Severe loss of dimer formation; when associated with S-287. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, DwarfismOrganism-specific databases
DisGeNETi | 124583 |
MalaCardsi | CANT1 |
MIMi | 251450, phenotype 617719, phenotype |
OpenTargetsi | ENSG00000171302 |
Orphaneti | 1425, Desbuquois syndrome |
PharmGKBi | PA134984439 |
Miscellaneous databases
Pharosi | Q8WVQ1, Tbio |
Chemistry databases
DrugBanki | DB03486, Phosphomethylphosphonic acid guanosyl ester |
Genetic variation databases
BioMutai | CANT1 |
DMDMi | 66774052 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209925 | 1 – 401 | Soluble calcium-activated nucleotidase 1Add BLAST | 401 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 60 | Interchain1 Publication | ||
Glycosylationi | 88 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q8WVQ1 |
jPOSTi | Q8WVQ1 |
MassIVEi | Q8WVQ1 |
MaxQBi | Q8WVQ1 |
PaxDbi | Q8WVQ1 |
PeptideAtlasi | Q8WVQ1 |
PRIDEi | Q8WVQ1 |
ProteomicsDBi | 74813 [Q8WVQ1-1] 74814 [Q8WVQ1-2] |
PTM databases
GlyConnecti | 1760, 4 N-Linked glycans (1 site) |
GlyGeni | Q8WVQ1, 2 sites |
iPTMneti | Q8WVQ1 |
PhosphoSitePlusi | Q8WVQ1 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000171302, Expressed in colonic mucosa and 228 other tissues |
ExpressionAtlasi | Q8WVQ1, baseline and differential |
Genevisiblei | Q8WVQ1, HS |
Organism-specific databases
HPAi | ENSG00000171302, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ8WVQ1
With | #Exp. | IntAct |
---|---|---|
CLRN1 [P58418] | 3 | EBI-16770554,EBI-17274839 |
FAM209A [Q5JX71] | 3 | EBI-16770554,EBI-18304435 |
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 125875, 39 interactors |
IntActi | Q8WVQ1, 15 interactors |
STRINGi | 9606.ENSP00000307674 |
Miscellaneous databases
RNActi | Q8WVQ1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8WVQ1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WVQ1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the apyrase family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4494, Eukaryota |
GeneTreei | ENSGT00390000012872 |
HOGENOMi | CLU_047493_0_0_1 |
InParanoidi | Q8WVQ1 |
OMAi | RTGLIYE |
OrthoDBi | 1579117at2759 |
PhylomeDBi | Q8WVQ1 |
TreeFami | TF315248 |
Family and domain databases
Gene3Di | 2.120.10.100, 1 hit |
InterProi | View protein in InterPro IPR009283, Apyrase IPR036258, Apyrase_sf |
PANTHERi | PTHR13023, PTHR13023, 1 hit |
SUPFAMi | SSF101887, SSF101887, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WVQ1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVQLSEHPE WNESMHSLRI SVGGLPVLAS MTKAADPRFR PRWKVILTFF
60 70 80 90 100
VGAAILWLLC SHRPAPGRPP THNAHNWRLG QAPANWYNDT YPLSPPQRTP
110 120 130 140 150
AGIRYRIAVI ADLDTESRAQ EENTWFSYLK KGYLTLSDSG DKVAVEWDKD
160 170 180 190 200
HGVLESHLAE KGRGMELSDL IVFNGKLYSV DDRTGVVYQI EGSKAVPWVI
210 220 230 240 250
LSDGDGTVEK GFKAEWLAVK DERLYVGGLG KEWTTTTGDV VNENPEWVKV
260 270 280 290 300
VGYKGSVDHE NWVSNYNALR AAAGIQPPGY LIHESACWSD TLQRWFFLPR
310 320 330 340 350
RASQERYSEK DDERKGANLL LSASPDFGDI AVSHVGAVVP THGFSSFKFI
360 370 380 390 400
PNTDDQIIVA LKSEEDSGRV ASYIMAFTLD GRFLLPETKI GSVKYEGIEF
I
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EN15 | K7EN15_HUMAN | Soluble calcium-activated nucleotid... | CANT1 | 264 | Annotation score: | ||
K7EKT2 | K7EKT2_HUMAN | Soluble calcium-activated nucleotid... | CANT1 | 76 | Annotation score: | ||
K7EMT2 | K7EMT2_HUMAN | Soluble calcium-activated nucleotid... | CANT1 | 65 | Annotation score: | ||
K7EQT4 | K7EQT4_HUMAN | Soluble calcium-activated nucleotid... | CANT1 | 61 | Annotation score: | ||
K7EKW6 | K7EKW6_HUMAN | Soluble calcium-activated nucleotid... | CANT1 | 118 | Annotation score: | ||
K7EIP9 | K7EIP9_HUMAN | Soluble calcium-activated nucleotid... | CANT1 | 38 | Annotation score: | ||
K7EQD4 | K7EQD4_HUMAN | Soluble calcium-activated nucleotid... | CANT1 | 15 | Annotation score: |
Sequence cautioni
The sequence AAM94564 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068655 | 112 | D → E in DBQD1. 1 PublicationCorresponds to variant dbSNP:rs749246739Ensembl. | 1 | |
Natural variantiVAR_068656 | 125 | W → C in DBQD1; severely affects activity. 1 PublicationCorresponds to variant dbSNP:rs587776898EnsemblClinVar. | 1 | |
Natural variantiVAR_068657 | 165 | M → T in DBQD1; severely affects activity. 1 Publication | 1 | |
Natural variantiVAR_080400 | 171 | I → F in EDM7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1014317450EnsemblClinVar. | 1 | |
Natural variantiVAR_068658 | 224 | L → P in DBQD1; affects protein stability and secretion. 1 PublicationCorresponds to variant dbSNP:rs150181226EnsemblClinVar. | 1 | |
Natural variantiVAR_068659 | 226 | V → M in DBQD1 and EDM7; severely affects activity. 3 PublicationsCorresponds to variant dbSNP:rs377546036EnsemblClinVar. | 1 | |
Natural variantiVAR_062980 | 299 | P → L in DBQD1. 1 PublicationCorresponds to variant dbSNP:rs267606700EnsemblClinVar. | 1 | |
Natural variantiVAR_062981 | 300 | R → C in DBQD1; severely affects activity. 2 PublicationsCorresponds to variant dbSNP:rs267606701EnsemblClinVar. | 1 | |
Natural variantiVAR_062982 | 300 | R → H in DBQD1. 2 PublicationsCorresponds to variant dbSNP:rs267606699EnsemblClinVar. | 1 | |
Natural variantiVAR_068660 | 303 | S → R in DBQD1. 1 Publication | 1 | |
Natural variantiVAR_068661 | 323 | A → T Does not affect activity. 1 PublicationCorresponds to variant dbSNP:rs9903215EnsemblClinVar. | 1 | |
Natural variantiVAR_068662 | 360 | A → D in DBQD1; affects protein secretion. 1 PublicationCorresponds to variant dbSNP:rs387907081EnsemblClinVar. | 1 | |
Natural variantiVAR_068663 | 374 | I → N in DBQD1. 1 Publication | 1 | |
Natural variantiVAR_068664 | 391 | G → E Does not affect activity. 1 PublicationCorresponds to variant dbSNP:rs34082669EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054260 | 41 – 91 | Missing in isoform 3. 1 PublicationAdd BLAST | 51 | |
Alternative sequenceiVSP_013760 | 220 – 245 | KDERL…VNENP → REIVRKRWRLVKQVSHVGVL GQWIQR in isoform 2. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_013761 | 246 – 401 | Missing in isoform 2. 1 PublicationAdd BLAST | 156 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF328554 mRNA Translation: AAM94564.1 Different initiation. AB097006 mRNA Translation: BAC77359.1 AB097033 mRNA Translation: BAC77386.1 AK074687 mRNA Translation: BAC11139.1 AK295930 mRNA Translation: BAG58716.1 BC005104 mRNA Translation: AAH05104.1 BC017655 mRNA Translation: AAH17655.1 BC065038 mRNA Translation: AAH65038.1 AJ312208 mRNA Translation: CAC85468.1 |
CCDSi | CCDS11760.1 [Q8WVQ1-1] |
RefSeqi | NP_001153244.1, NM_001159772.1 [Q8WVQ1-1] NP_001153245.1, NM_001159773.1 [Q8WVQ1-1] NP_620148.1, NM_138793.3 [Q8WVQ1-1] XP_005257078.1, XM_005257021.1 [Q8WVQ1-1] XP_005257079.1, XM_005257022.1 [Q8WVQ1-1] XP_006721746.1, XM_006721683.1 [Q8WVQ1-1] XP_011522593.1, XM_011524291.1 [Q8WVQ1-1] XP_011522595.1, XM_011524293.1 [Q8WVQ1-1] XP_011522596.1, XM_011524294.1 [Q8WVQ1-1] XP_011522597.1, XM_011524295.2 [Q8WVQ1-1] |
Genome annotation databases
Ensembli | ENST00000302345; ENSP00000307674; ENSG00000171302 [Q8WVQ1-1] ENST00000392446; ENSP00000376241; ENSG00000171302 [Q8WVQ1-1] ENST00000591773; ENSP00000467437; ENSG00000171302 [Q8WVQ1-1] ENST00000620915; ENSP00000477798; ENSG00000171302 [Q8WVQ1-1] |
GeneIDi | 124583 |
KEGGi | hsa:124583 |
UCSCi | uc002jwj.4, human [Q8WVQ1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF328554 mRNA Translation: AAM94564.1 Different initiation. AB097006 mRNA Translation: BAC77359.1 AB097033 mRNA Translation: BAC77386.1 AK074687 mRNA Translation: BAC11139.1 AK295930 mRNA Translation: BAG58716.1 BC005104 mRNA Translation: AAH05104.1 BC017655 mRNA Translation: AAH17655.1 BC065038 mRNA Translation: AAH65038.1 AJ312208 mRNA Translation: CAC85468.1 |
CCDSi | CCDS11760.1 [Q8WVQ1-1] |
RefSeqi | NP_001153244.1, NM_001159772.1 [Q8WVQ1-1] NP_001153245.1, NM_001159773.1 [Q8WVQ1-1] NP_620148.1, NM_138793.3 [Q8WVQ1-1] XP_005257078.1, XM_005257021.1 [Q8WVQ1-1] XP_005257079.1, XM_005257022.1 [Q8WVQ1-1] XP_006721746.1, XM_006721683.1 [Q8WVQ1-1] XP_011522593.1, XM_011524291.1 [Q8WVQ1-1] XP_011522595.1, XM_011524293.1 [Q8WVQ1-1] XP_011522596.1, XM_011524294.1 [Q8WVQ1-1] XP_011522597.1, XM_011524295.2 [Q8WVQ1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S18 | X-ray | 1.70 | A/B | 71-401 | [»] | |
1S1D | X-ray | 1.60 | A/B | 71-401 | [»] | |
2H2N | X-ray | 2.30 | A/B | 69-401 | [»] | |
2H2U | X-ray | 2.40 | A/B | 69-401 | [»] | |
SMRi | Q8WVQ1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125875, 39 interactors |
IntActi | Q8WVQ1, 15 interactors |
STRINGi | 9606.ENSP00000307674 |
Chemistry databases
DrugBanki | DB03486, Phosphomethylphosphonic acid guanosyl ester |
PTM databases
GlyConnecti | 1760, 4 N-Linked glycans (1 site) |
GlyGeni | Q8WVQ1, 2 sites |
iPTMneti | Q8WVQ1 |
PhosphoSitePlusi | Q8WVQ1 |
Genetic variation databases
BioMutai | CANT1 |
DMDMi | 66774052 |
Proteomic databases
EPDi | Q8WVQ1 |
jPOSTi | Q8WVQ1 |
MassIVEi | Q8WVQ1 |
MaxQBi | Q8WVQ1 |
PaxDbi | Q8WVQ1 |
PeptideAtlasi | Q8WVQ1 |
PRIDEi | Q8WVQ1 |
ProteomicsDBi | 74813 [Q8WVQ1-1] 74814 [Q8WVQ1-2] |
Protocols and materials databases
Antibodypediai | 19748, 319 antibodies |
Genome annotation databases
Ensembli | ENST00000302345; ENSP00000307674; ENSG00000171302 [Q8WVQ1-1] ENST00000392446; ENSP00000376241; ENSG00000171302 [Q8WVQ1-1] ENST00000591773; ENSP00000467437; ENSG00000171302 [Q8WVQ1-1] ENST00000620915; ENSP00000477798; ENSG00000171302 [Q8WVQ1-1] |
GeneIDi | 124583 |
KEGGi | hsa:124583 |
UCSCi | uc002jwj.4, human [Q8WVQ1-1] |
Organism-specific databases
CTDi | 124583 |
DisGeNETi | 124583 |
GeneCardsi | CANT1 |
HGNCi | HGNC:19721, CANT1 |
HPAi | ENSG00000171302, Low tissue specificity |
MalaCardsi | CANT1 |
MIMi | 251450, phenotype 613165, gene 617719, phenotype |
neXtProti | NX_Q8WVQ1 |
OpenTargetsi | ENSG00000171302 |
Orphaneti | 1425, Desbuquois syndrome |
PharmGKBi | PA134984439 |
VEuPathDBi | HostDB:ENSG00000171302.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4494, Eukaryota |
GeneTreei | ENSGT00390000012872 |
HOGENOMi | CLU_047493_0_0_1 |
InParanoidi | Q8WVQ1 |
OMAi | RTGLIYE |
OrthoDBi | 1579117at2759 |
PhylomeDBi | Q8WVQ1 |
TreeFami | TF315248 |
Enzyme and pathway databases
PathwayCommonsi | Q8WVQ1 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 124583, 9 hits in 871 CRISPR screens |
ChiTaRSi | CANT1, human |
EvolutionaryTracei | Q8WVQ1 |
GeneWikii | CANT1 |
GenomeRNAii | 124583 |
Pharosi | Q8WVQ1, Tbio |
PROi | PR:Q8WVQ1 |
RNActi | Q8WVQ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171302, Expressed in colonic mucosa and 228 other tissues |
ExpressionAtlasi | Q8WVQ1, baseline and differential |
Genevisiblei | Q8WVQ1, HS |
Family and domain databases
Gene3Di | 2.120.10.100, 1 hit |
InterProi | View protein in InterPro IPR009283, Apyrase IPR036258, Apyrase_sf |
PANTHERi | PTHR13023, PTHR13023, 1 hit |
SUPFAMi | SSF101887, SSF101887, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CANT1_HUMAN | |
Accessioni | Q8WVQ1Primary (citable) accession number: Q8WVQ1 Secondary accession number(s): B4DJ54 Q9BSD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families