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Protein

Tumor necrosis factor alpha-induced protein 8-like protein 1

Gene

TNFAIP8L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of mTOR activity.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1483255 PI Metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 1
Short name:
TIPE1By similarity
Short name:
TNF alpha-induced protein 8-like protein 1
Short name:
TNFAIP8-like protein 1
Alternative name(s):
Oxidative stress-regulated gene-beta1 Publication
Short name:
Oxy-beta1 Publication
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000185361.8
HGNCiHGNC:28279 TNFAIP8L1
MIMi615869 gene
neXtProtiNX_Q8WVP5

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi126282
OpenTargetsiENSG00000185361
PharmGKBiPA142670722

Polymorphism and mutation databases

BioMutaiTNFAIP8L1
DMDMi146325794

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857241 – 186Tumor necrosis factor alpha-induced protein 8-like protein 1Add BLAST186

Proteomic databases

EPDiQ8WVP5
PaxDbiQ8WVP5
PeptideAtlasiQ8WVP5
PRIDEiQ8WVP5
ProteomicsDBi74809

PTM databases

PhosphoSitePlusiQ8WVP5

Expressioni

Tissue specificityi

High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.1 Publication

Inductioni

Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.1 Publication

Gene expression databases

BgeeiENSG00000185361
CleanExiHS_TNFAIP8L1
GenevisibleiQ8WVP5 HS

Interactioni

Subunit structurei

Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125973, 5 interactors
IntActiQ8WVP5, 12 interactors
STRINGi9606.ENSP00000331827

Structurei

3D structure databases

ProteinModelPortaliQ8WVP5
SMRiQ8WVP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Phylogenomic databases

eggNOGiENOG410IEG9 Eukaryota
ENOG4111KN4 LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiQ8WVP5
OMAiFRKKVHT
OrthoDBiEOG091G0QQ9
PhylomeDBiQ8WVP5
TreeFamiTF323415

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WVP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT
60 70 80 90 100
RSRKEAQKML KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT
110 120 130 140 150
AVSFHQVDFT FDRRVLAAGL LECRDLLHQA VGPHLTAKSH GRINHVFGHL
160 170 180
ADCDFLAALY GPAEPYRSHL RRICEGLGRM LDEGSL
Length:186
Mass (Da):20,827
Last modified:May 1, 2007 - v2
Checksum:i352B0E7A2FB6D216
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032048118A → V1 PublicationCorresponds to variant dbSNP:rs17851549Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005339 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69204.1
CH471139 Genomic DNA Translation: EAW69205.1
BC017672 mRNA Translation: AAH17672.1
CCDSiCCDS12132.1
RefSeqiNP_001161414.1, NM_001167942.1
NP_689575.2, NM_152362.2
XP_005259544.1, XM_005259487.3
XP_011525982.1, XM_011527680.2
UniGeneiHs.465643

Genome annotation databases

EnsembliENST00000327473; ENSP00000331827; ENSG00000185361
ENST00000536716; ENSP00000444215; ENSG00000185361
GeneIDi126282
KEGGihsa:126282
UCSCiuc002max.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTP8L1_HUMAN
AccessioniPrimary (citable) accession number: Q8WVP5
Secondary accession number(s): D6W627
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 18, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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