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Protein

Secreted and transmembrane protein 1

Gene

SECTM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in thymocyte signaling.1 Publication

GO - Molecular functioni

  • cytokine activity Source: ProtInc

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted and transmembrane protein 1
Alternative name(s):
Protein K-12
Gene namesi
Name:SECTM1
Synonyms:K12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141574.7
HGNCiHGNC:10707 SECTM1
MIMi602602 gene
neXtProtiNX_Q8WVN6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 145ExtracellularSequence analysisAdd BLAST117
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 248CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6398
OpenTargetsiENSG00000141574
PharmGKBiPA35630

Polymorphism and mutation databases

BioMutaiSECTM1
DMDMi25009245

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002228629 – 248Secreted and transmembrane protein 1Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 55Sequence analysis
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8WVN6
MaxQBiQ8WVN6
PaxDbiQ8WVN6
PeptideAtlasiQ8WVN6
PRIDEiQ8WVN6
ProteomicsDBi74806

PTM databases

iPTMnetiQ8WVN6
PhosphoSitePlusiQ8WVN6

Expressioni

Tissue specificityi

Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts.2 Publications

Inductioni

By IFNG/IFN-gamma (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000141574 Expressed in 181 organ(s), highest expression level in blood
CleanExiHS_SECTM1
ExpressionAtlasiQ8WVN6 baseline and differential
GenevisibleiQ8WVN6 HS

Organism-specific databases

HPAiHPA051214

Interactioni

Subunit structurei

Interacts with CD7.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112298, 1 interactor
IntActiQ8WVN6, 3 interactors
STRINGi9606.ENSP00000269389

Structurei

3D structure databases

ProteinModelPortaliQ8WVN6
SMRiQ8WVN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SECTM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JFYD Eukaryota
ENOG411174Z LUCA
GeneTreeiENSGT00530000064499
HOGENOMiHOG000231222
HOVERGENiHBG061092
InParanoidiQ8WVN6
OrthoDBiEOG091G0QEP
PhylomeDBiQ8WVN6
TreeFamiTF336992

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR033231 SECTM1
PANTHERiPTHR15123 PTHR15123, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q8WVN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN
60 70 80 90 100
TVMSCNISNA FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA
110 120 130 140 150
QLVIKGARDS HAGLYMWHLV GHQRNNRQVT LEVSGAEPQS APDTGFWPVP
160 170 180 190 200
AVVTAVFILL VALVMFAWYR CRCSQQRREK KFFLLEPQMK VAALRAGAQQ
210 220 230 240
GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP LFPYAADP
Length:248
Mass (Da):27,039
Last modified:November 8, 2002 - v2
Checksum:i21E3066B67920487
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTR4J3KTR4_HUMAN
Secreted and transmembrane protein ...
SECTM1
178Annotation score:
J3QKK2J3QKK2_HUMAN
Secreted and transmembrane protein ...
SECTM1
170Annotation score:
J3QQU6J3QQU6_HUMAN
Secreted and transmembrane protein ...
SECTM1
149Annotation score:
J3KSN0J3KSN0_HUMAN
Secreted and transmembrane protein ...
SECTM1
146Annotation score:
J3KS40J3KS40_HUMAN
Secreted and transmembrane protein ...
SECTM1
85Annotation score:
J3QRU5J3QRU5_HUMAN
Secreted and transmembrane protein ...
SECTM1
44Annotation score:
J3QR99J3QR99_HUMAN
Secreted and transmembrane protein ...
SECTM1
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191V → F in AAH17716 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77643 mRNA Translation: AAC52044.1
AK312980 mRNA Translation: BAG35817.1
CH471099 Genomic DNA Translation: EAW89766.1
BC017716 mRNA Translation: AAH17716.1
CCDSiCCDS11808.1
RefSeqiNP_002995.1, NM_003004.2
XP_005256449.1, XM_005256392.3
XP_011521890.1, XM_011523588.2
UniGeneiHs.558009

Genome annotation databases

EnsembliENST00000269389; ENSP00000269389; ENSG00000141574
GeneIDi6398
KEGGihsa:6398
UCSCiuc002keo.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77643 mRNA Translation: AAC52044.1
AK312980 mRNA Translation: BAG35817.1
CH471099 Genomic DNA Translation: EAW89766.1
BC017716 mRNA Translation: AAH17716.1
CCDSiCCDS11808.1
RefSeqiNP_002995.1, NM_003004.2
XP_005256449.1, XM_005256392.3
XP_011521890.1, XM_011523588.2
UniGeneiHs.558009

3D structure databases

ProteinModelPortaliQ8WVN6
SMRiQ8WVN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112298, 1 interactor
IntActiQ8WVN6, 3 interactors
STRINGi9606.ENSP00000269389

PTM databases

iPTMnetiQ8WVN6
PhosphoSitePlusiQ8WVN6

Polymorphism and mutation databases

BioMutaiSECTM1
DMDMi25009245

Proteomic databases

EPDiQ8WVN6
MaxQBiQ8WVN6
PaxDbiQ8WVN6
PeptideAtlasiQ8WVN6
PRIDEiQ8WVN6
ProteomicsDBi74806

Protocols and materials databases

DNASUi6398
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269389; ENSP00000269389; ENSG00000141574
GeneIDi6398
KEGGihsa:6398
UCSCiuc002keo.4 human

Organism-specific databases

CTDi6398
DisGeNETi6398
EuPathDBiHostDB:ENSG00000141574.7
GeneCardsiSECTM1
HGNCiHGNC:10707 SECTM1
HPAiHPA051214
MIMi602602 gene
neXtProtiNX_Q8WVN6
OpenTargetsiENSG00000141574
PharmGKBiPA35630
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFYD Eukaryota
ENOG411174Z LUCA
GeneTreeiENSGT00530000064499
HOGENOMiHOG000231222
HOVERGENiHBG061092
InParanoidiQ8WVN6
OrthoDBiEOG091G0QEP
PhylomeDBiQ8WVN6
TreeFamiTF336992

Miscellaneous databases

ChiTaRSiSECTM1 human
GeneWikiiSECTM1
GenomeRNAii6398
PROiPR:Q8WVN6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141574 Expressed in 181 organ(s), highest expression level in blood
CleanExiHS_SECTM1
ExpressionAtlasiQ8WVN6 baseline and differential
GenevisibleiQ8WVN6 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR033231 SECTM1
PANTHERiPTHR15123 PTHR15123, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCTM1_HUMAN
AccessioniPrimary (citable) accession number: Q8WVN6
Secondary accession number(s): B2R7H0, O00466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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