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Entry version 164 (16 Oct 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Sec1 family domain-containing protein 1

Gene

SCFD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sec1 family domain-containing protein 1
Alternative name(s):
SLY1 homolog
Short name:
Sly1p
Syntaxin-binding protein 1-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCFD1
Synonyms:C14orf163, KIAA0917, STXBP1L2
ORF Names:FKSG23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20726 SCFD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618207 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WVM8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23256

Open Targets

More...
OpenTargetsi
ENSG00000092108

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134946073

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WVM8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCFD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316882

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002062872 – 642Sec1 family domain-containing protein 1Add BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei37PhosphoserineBy similarity1
Modified residuei303PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WVM8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WVM8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WVM8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WVM8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WVM8

PeptideAtlas

More...
PeptideAtlasi
Q8WVM8

PRoteomics IDEntifications database

More...
PRIDEi
Q8WVM8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6636
6669
74805 [Q8WVM8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WVM8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WVM8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8WVM8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000092108 Expressed in 230 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WVM8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WVM8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003579

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STX17.

Interacts with STX5A.

Interacts with the COG complex via COG4 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H9E310EBI-722569,EBI-368382

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116860, 68 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WVM8, 42 interactors

Molecular INTeraction database

More...
MINTi
Q8WVM8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000390783

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WVM8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 13Poly-AlaAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1301 Eukaryota
COG5158 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074845

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WVM8

KEGG Orthology (KO)

More...
KOi
K19998

Identification of Orthologs from Complete Genome Data

More...
OMAi
DRQLDNF

Database of Orthologous Groups

More...
OrthoDBi
917326at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WVM8

TreeFam database of animal gene trees

More...
TreeFami
TF105740

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1910, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11679 PTHR11679, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00995 Sec1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005715 VPS45_Sec1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56815 SSF56815, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WVM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAAATAA AAASIRERQT VALKRMLNFN VPHIKNSTGE PVWKVLIYDR
60 70 80 90 100
FGQDIISPLL SVKELRDMGI TLHLLLHSDR DPIPDVPAVY FVMPTEENID
110 120 130 140 150
RMCQDLRNQL YESYYLNFIS AISRSKLEDI ANAALAASAV TQVAKVFDQY
160 170 180 190 200
LNFITLEDDM FVLCNQNKEL VSYRAINRPD ITDTEMETVM DTIVDSLFCF
210 220 230 240 250
FVTLGAVPII RCSRGTAAEM VAVKLDKKLR ENLRDARNSL FTGDTLGAGQ
260 270 280 290 300
FSFQRPLLVL VDRNIDLATP LHHTWTYQAL VHDVLDFHLN RVNLEESSGV
310 320 330 340 350
ENSPAGARPK RKNKKSYDLT PVDKFWQKHK GSPFPEVAES VQQELESYRA
360 370 380 390 400
QEDEVKRLKS IMGLEGEDEG AISMLSDNTA KLTSAVSSLP ELLEKKRLID
410 420 430 440 450
LHTNVATAVL EHIKARKLDV YFEYEEKIMS KTTLDKSLLD IISDPDAGTP
460 470 480 490 500
EDKMRLFLIY YISTQQAPSE ADLEQYKKAL TDAGCNLNPL QYIKQWKAFT
510 520 530 540 550
KMASAPASYG STTTKPMGLL SRVMNTGSQF VMEGVKNLVL KQQNLPVTRI
560 570 580 590 600
LDNLMEMKSN PETDDYRYFD PKMLRGNDSS VPRNKNPFQE AIVFVVGGGN
610 620 630 640
YIEYQNLVDY IKGKQGKHIL YGCSELFNAT QFIKQLSQLG QK
Length:642
Mass (Da):72,380
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0340FB9F05CD24CE
GO
Isoform 2 (identifier: Q8WVM8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:550
Mass (Da):62,260
Checksum:iB920BFF92CE3533B
GO
Isoform 3 (identifier: Q8WVM8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:575
Mass (Da):65,061
Checksum:iD661C294F7170C05
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5F3G3V5F3_HUMAN
Sec1 family domain-containing prote...
SCFD1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2M8G3V2M8_HUMAN
Sec1 family domain-containing prote...
SCFD1
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5E2G3V5E2_HUMAN
Sec1 family domain-containing prote...
SCFD1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJY1H0YJY1_HUMAN
Sec1 family domain-containing prote...
SCFD1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V363G3V363_HUMAN
Sec1 family domain-containing prote...
SCFD1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4I1G3V4I1_HUMAN
Sec1 family domain-containing prote...
SCFD1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V551G3V551_HUMAN
Sec1 family domain-containing prote...
SCFD1
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJS6H0YJS6_HUMAN
Sec1 family domain-containing prote...
SCFD1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNG4J3KNG4_HUMAN
Sec1 family domain-containing prote...
SCFD1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIZ7H0YIZ7_HUMAN
Sec1 family domain-containing prote...
SCFD1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD40381 differs from that shown. Reason: Frameshift.Curated
The sequence AAD48586 differs from that shown. Reason: Frameshift.Curated
The sequence AAP97146 differs from that shown. Reason: Frameshift.Curated
The sequence BAA74940 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42V → I in AAG50273 (Ref. 3) Curated1
Sequence conflicti136 – 137AA → EL in AAD40381 (Ref. 2) Curated2
Sequence conflicti201 – 206FVTLGA → YGTRGD in AAD48586 (Ref. 2) Curated6
Sequence conflicti201 – 202FV → YG in AAD40381 (Ref. 2) Curated2
Sequence conflicti201 – 202FV → YG in AAP97146 (Ref. 4) Curated2
Sequence conflicti206A → D in AAP97146 (Ref. 4) Curated1
Sequence conflicti453K → N in AAD48586 (Ref. 2) Curated1
Sequence conflicti484 – 485GC → EM in AAD40381 (Ref. 2) Curated2
Sequence conflicti485Missing in AAD48586 (Ref. 2) Curated1
Sequence conflicti562 – 563ET → KL in AAD40381 (Ref. 2) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01961663K → R2 PublicationsCorresponds to variant dbSNP:rs229150Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470701 – 92Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0470711 – 67Missing in isoform 3. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB020724 mRNA Translation: BAA74940.2 Different initiation.
AF092139 mRNA Translation: AAD40381.1 Frameshift.
AF110646 mRNA Translation: AAD48586.1 Frameshift.
AF319958 mRNA Translation: AAG50273.1
AF086916 mRNA Translation: AAP97146.1 Frameshift.
AK290410 mRNA Translation: BAF83099.1
AK298622 mRNA Translation: BAH12830.1
AK297873 mRNA Translation: BAH12683.1
AK316212 mRNA Translation: BAH14583.1
AL121852 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65968.1
BC017734 mRNA Translation: AAH17734.1
AF067205 mRNA Translation: AAC17907.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45092.1 [Q8WVM8-3]
CCDS58308.1 [Q8WVM8-2]
CCDS9639.1 [Q8WVM8-1]

NCBI Reference Sequences

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RefSeqi
NP_001244305.1, NM_001257376.1 [Q8WVM8-2]
NP_001269961.1, NM_001283032.1
NP_057190.2, NM_016106.3 [Q8WVM8-1]
NP_878255.1, NM_182835.2 [Q8WVM8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000396629; ENSP00000379870; ENSG00000092108 [Q8WVM8-2]
ENST00000458591; ENSP00000390783; ENSG00000092108 [Q8WVM8-1]
ENST00000544052; ENSP00000443010; ENSG00000092108 [Q8WVM8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23256

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23256

UCSC genome browser

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UCSCi
uc001wqm.3 human [Q8WVM8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020724 mRNA Translation: BAA74940.2 Different initiation.
AF092139 mRNA Translation: AAD40381.1 Frameshift.
AF110646 mRNA Translation: AAD48586.1 Frameshift.
AF319958 mRNA Translation: AAG50273.1
AF086916 mRNA Translation: AAP97146.1 Frameshift.
AK290410 mRNA Translation: BAF83099.1
AK298622 mRNA Translation: BAH12830.1
AK297873 mRNA Translation: BAH12683.1
AK316212 mRNA Translation: BAH14583.1
AL121852 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65968.1
BC017734 mRNA Translation: AAH17734.1
AF067205 mRNA Translation: AAC17907.1
CCDSiCCDS45092.1 [Q8WVM8-3]
CCDS58308.1 [Q8WVM8-2]
CCDS9639.1 [Q8WVM8-1]
RefSeqiNP_001244305.1, NM_001257376.1 [Q8WVM8-2]
NP_001269961.1, NM_001283032.1
NP_057190.2, NM_016106.3 [Q8WVM8-1]
NP_878255.1, NM_182835.2 [Q8WVM8-3]

3D structure databases

SMRiQ8WVM8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116860, 68 interactors
IntActiQ8WVM8, 42 interactors
MINTiQ8WVM8
STRINGi9606.ENSP00000390783

PTM databases

iPTMnetiQ8WVM8
PhosphoSitePlusiQ8WVM8
SwissPalmiQ8WVM8

Polymorphism and mutation databases

BioMutaiSCFD1
DMDMi51316882

Proteomic databases

EPDiQ8WVM8
jPOSTiQ8WVM8
MassIVEiQ8WVM8
MaxQBiQ8WVM8
PaxDbiQ8WVM8
PeptideAtlasiQ8WVM8
PRIDEiQ8WVM8
ProteomicsDBi6636
6669
74805 [Q8WVM8-1]

Genome annotation databases

EnsembliENST00000396629; ENSP00000379870; ENSG00000092108 [Q8WVM8-2]
ENST00000458591; ENSP00000390783; ENSG00000092108 [Q8WVM8-1]
ENST00000544052; ENSP00000443010; ENSG00000092108 [Q8WVM8-3]
GeneIDi23256
KEGGihsa:23256
UCSCiuc001wqm.3 human [Q8WVM8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23256
DisGeNETi23256

GeneCards: human genes, protein and diseases

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GeneCardsi
SCFD1
HGNCiHGNC:20726 SCFD1
HPAiHPA003579
MIMi618207 gene
neXtProtiNX_Q8WVM8
OpenTargetsiENSG00000092108
PharmGKBiPA134946073

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1301 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00550000074845
InParanoidiQ8WVM8
KOiK19998
OMAiDRQLDNF
OrthoDBi917326at2759
PhylomeDBiQ8WVM8
TreeFamiTF105740

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SCFD1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SCFD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23256
PharosiQ8WVM8

Protein Ontology

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PROi
PR:Q8WVM8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000092108 Expressed in 230 organ(s), highest expression level in intestine
ExpressionAtlasiQ8WVM8 baseline and differential
GenevisibleiQ8WVM8 HS

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCFD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WVM8
Secondary accession number(s): A8K2Z5
, B7Z4U7, B7Z594, O60754, O94990, Q7Z529, Q9BZI3, Q9UNL3, Q9Y6A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 164 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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