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UniProtKB - Q8WVM7 (STAG1_HUMAN)

Entry version 174 (02 Dec 2020)
Sequence version 3 (14 Oct 2008)
Previous versions | rss
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Protein

Cohesin subunit SA-1

Gene

STAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WVM7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1221632, Meiotic synapsis
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2468052, Establishment of Sister Chromatid Cohesion
R-HSA-2470946, Cohesin Loading onto Chromatin
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cohesin subunit SA-1
Alternative name(s):
SCC3 homolog 1
Stromal antigen 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAG1
Synonyms:SA1, SCC31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000118007.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:11354, STAG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604358, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WVM7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 47 (MRD47)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD47 patients manifest developmental delay and mild to moderate intellectual disability, usually with delayed speech.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079487214Q → R in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553738694EnsemblClinVar.1
Natural variantiVAR_079488216R → G in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553738686EnsemblClinVar.1
Natural variantiVAR_079489220H → R in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1057519153EnsemblClinVar.1
Natural variantiVAR_079490333K → Q in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553728634EnsemblClinVar.1
Natural variantiVAR_079491351L → W in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553727865EnsemblClinVar.1
Natural variantiVAR_079492373R → Q in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1376334317EnsemblClinVar.1
Natural variantiVAR_079493478H → P in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553722309EnsemblClinVar.1
Natural variantiVAR_079494979K → R in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1471479119EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		10274

MalaCards human disease database

More...MalaCardsi		STAG1
MIMi617635, phenotype

Open Targets

More...OpenTargetsi		ENSG00000118007

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		502434, STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36176

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WVM7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STAG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001201821 – 1258Cohesin subunit SA-1Add BLAST1258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Modified residuei1062PhosphoserineCombined sources1
Modified residuei1065PhosphoserineBy similarity1
Modified residuei1093PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WVM7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WVM7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WVM7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WVM7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WVM7

PeptideAtlas

More...PeptideAtlasi		Q8WVM7

PRoteomics IDEntifications database

More...PRIDEi		Q8WVM7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66881
74804 [Q8WVM7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WVM7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WVM7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118007, Expressed in calcaneal tendon and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WVM7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WVM7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118007, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3 (PubMed:11076961).

Interacts directly with RAD21 in cohesin complex (By similarity).

Found in a cohesin complex with SMC1A, SMC3 and RAD21 (PubMed:22628566).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115564, 41 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8WVM7

Database of interacting proteins

More...DIPi		DIP-35421N

Protein interaction database and analysis system

More...IntActi		Q8WVM7, 34 interactors

Molecular INTeraction database

More...MINTi		Q8WVM7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000372689

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WVM7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WVM7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini296 – 381SCDPROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi684 – 687Poly-Asp4
Compositional biasi1065 – 1070Poly-Ser6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCC3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2011, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005067_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WVM7

Identification of Orthologs from Complete Genome Data

More...OMAi		EAMPEKY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WVM7

TreeFam database of animal gene trees

More...TreeFami		TF314604

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR039662, Cohesin_Scc3/SA
IPR020839, SCD
IPR013721, STAG

The PANTHER Classification System

More...PANTHERi		PTHR11199, PTHR11199, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08514, STAG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51425, SCD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WVM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MITSELPVLQ DSTNETTAHS DAGSELEETE VKGKRKRGRP GRPPSTNKKP 
        60         70         80         90        100
RKSPGEKSRI EAGIRGAGRG RANGHPQQNG EGEPVTLFEV VKLGKSAMQS 
       110        120        130        140        150
VVDDWIESYK QDRDIALLDL INFFIQCSGC RGTVRIEMFR NMQNAEIIRK 
       160        170        180        190        200
MTEEFDEDSG DYPLTMPGPQ WKKFRSNFCE FIGVLIRQCQ YSIIYDEYMM 
       210        220        230        240        250
DTVISLLTGL SDSQVRAFRH TSTLAAMKLM TALVNVALNL SIHQDNTQRQ 
       260        270        280        290        300
YEAERNKMIG KRANERLELL LQKRKELQEN QDEIENMMNS IFKGIFVHRY 
       310        320        330        340        350
RDAIAEIRAI CIEEIGVWMK MYSDAFLNDS YLKYVGWTLH DRQGEVRLKC 
       360        370        380        390        400
LKALQSLYTN RELFPKLELF TNRFKDRIVS MTLDKEYDVA VEAIRLVTLI 
       410        420        430        440        450
LHGSEEALSN EDCENVYHLV YSAHRPVAVA AGEFLHKKLF SRHDPQAEEA 
       460        470        480        490        500
LAKRRGRNSP NGNLIRMLVL FFLESELHEH AAYLVDSLWE SSQELLKDWE 
       510        520        530        540        550
CMTELLLEEP VQGEEAMSDR QESALIELMV CTIRQAAEAH PPVGRGTGKR 
       560        570        580        590        600
VLTAKERKTQ IDDRNKLTEH FIITLPMLLS KYSADAEKVA NLLQIPQYFD 
       610        620        630        640        650
LEIYSTGRME KHLDALLKQI KFVVEKHVES DVLEACSKTY SILCSEEYTI 
       660        670        680        690        700
QNRVDIARSQ LIDEFVDRFN HSVEDLLQEG EEADDDDIYN VLSTLKRLTS 
       710        720        730        740        750
FHNAHDLTKW DLFGNCYRLL KTGIEHGAMP EQIVVQALQC SHYSILWQLV 
       760        770        780        790        800
KITDGSPSKE DLLVLRKTVK SFLAVCQQCL SNVNTPVKEQ AFMLLCDLLM 
       810        820        830        840        850
IFSHQLMTGG REGLQPLVFN PDTGLQSELL SFVMDHVFID QDEENQSMEG 
       860        870        880        890        900
DEEDEANKIE ALHKRRNLLA AFSKLIIYDI VDMHAAADIF KHYMKYYNDY 
       910        920        930        940        950
GDIIKETLSK TRQIDKIQCA KTLILSLQQL FNELVQEQGP NLDRTSAHVS 
       960        970        980        990       1000
GIKELARRFA LTFGLDQIKT REAVATLHKD GIEFAFKYQN QKGQEYPPPN 
      1010       1020       1030       1040       1050
LAFLEVLSEF SSKLLRQDKK TVHSYLEKFL TEQMMERRED VWLPLISYRN 
      1060       1070       1080       1090       1100
SLVTGGEDDR MSVNSGSSSS KTSSVRNKKG RPPLHKKRVE DESLDNTWLN 
      1110       1120       1130       1140       1150
RTDTMIQTPG PLPAPQLTST VLRENSRPMG DQIQEPESEH GSEPDFLHNP 
      1160       1170       1180       1190       1200
QMQISWLGQP KLEDLNRKDR TGMNYMKVRT GVRHAVRGLM EEDAEPIFED 
      1210       1220       1230       1240       1250
VMMSSRSQLE DMNEEFEDTM VIDLPPSRNR RERAELRPDF FDSAAIIEDD 

SGFGMPMF
Length:1,258
Mass (Da):144,427
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAF911998EC52179
GO
Isoform 2 (identifier: Q8WVM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1150-1186: Missing.

Show »
Length:1,221
Mass (Da):140,090
Checksum:iF0FAFDD544430F8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q68DW7Q68DW7_HUMAN
Cohesin subunit SA-1
STAG1 DKFZp781D1416
998Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJQ0C9JJQ0_HUMAN
Cohesin subunit SA-1
STAG1
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCB3F8WCB3_HUMAN
Cohesin subunit SA-1
STAG1
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF82F8WF82_HUMAN
Cohesin subunit SA-1
STAG1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C595H7C595_HUMAN
Cohesin subunit SA-1
STAG1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti645S → N in CAA99731 (PubMed:9305759).Curated1
Sequence conflicti702H → Q in CAA99731 (PubMed:9305759).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08229185V → I Found in a patient with cohesinopathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1559904167EnsemblClinVar.1
Natural variantiVAR_079487214Q → R in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553738694EnsemblClinVar.1
Natural variantiVAR_079488216R → G in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553738686EnsemblClinVar.1
Natural variantiVAR_079489220H → R in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1057519153EnsemblClinVar.1
Natural variantiVAR_079490333K → Q in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553728634EnsemblClinVar.1
Natural variantiVAR_079491351L → W in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553727865EnsemblClinVar.1
Natural variantiVAR_079492373R → Q in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1376334317EnsemblClinVar.1
Natural variantiVAR_082292377R → C Found in a patient with cohesinopathy. 1 PublicationCorresponds to variant dbSNP:rs1559824939EnsemblClinVar.1
Natural variantiVAR_079493478H → P in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1553722309EnsemblClinVar.1
Natural variantiVAR_079494979K → R in MRD47. 1 PublicationCorresponds to variant dbSNP:rs1471479119EnsemblClinVar.1
Natural variantiVAR_0469681132Q → H. Corresponds to variant dbSNP:rs34149860Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0544961150 – 1186Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z75330 mRNA Translation: CAA99731.1
AC069514 Genomic DNA No translation available.
AC069524 Genomic DNA No translation available.
AC107425 Genomic DNA No translation available.
AC117382 Genomic DNA No translation available.
AC128712 Genomic DNA No translation available.
BC017735 mRNA Translation: AAH17735.1
BC064699 mRNA Translation: AAH64699.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3090.1 [Q8WVM7-1]

NCBI Reference Sequences

More...RefSeqi		NP_005853.2, NM_005862.2 [Q8WVM7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000236698; ENSP00000236698; ENSG00000118007 [Q8WVM7-2]
ENST00000383202; ENSP00000372689; ENSG00000118007 [Q8WVM7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10274

UCSC genome browser

More...UCSCi		uc003era.2, human [Q8WVM7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75330 mRNA Translation: CAA99731.1
AC069514 Genomic DNA No translation available.
AC069524 Genomic DNA No translation available.
AC107425 Genomic DNA No translation available.
AC117382 Genomic DNA No translation available.
AC128712 Genomic DNA No translation available.
BC017735 mRNA Translation: AAH17735.1
BC064699 mRNA Translation: AAH64699.1
CCDSiCCDS3090.1 [Q8WVM7-1]
RefSeqiNP_005853.2, NM_005862.2 [Q8WVM7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5QSMX-ray2.74A/B459-915[»]
5QSNX-ray2.66A/B459-915[»]
5QSOX-ray2.70A/B457-900[»]
5QSPX-ray2.89A/B457-900[»]
5QSQX-ray2.48A/B459-915[»]
5QSRX-ray3.28A/B459-915[»]
5QSSX-ray3.08A/B459-915[»]
5QSTX-ray2.58A/B/C/D86-420[»]
5QSUX-ray2.73A/B/C/D86-420[»]
5QSVX-ray2.76A/B/C/D86-420[»]
5QSWX-ray3.03A/B/C/D86-420[»]
5QSXX-ray2.34A/B/C/D86-420[»]
5QSYX-ray2.40A/B459-915[»]
5QSZX-ray3.08A/B459-915[»]
6QB5X-ray2.02A/B/C/D86-420[»]
6R7OX-ray2.31A/B459-915[»]
6RRCX-ray2.37A/C86-420[»]
6RRKX-ray3.17A/B459-915[»]
6WG3electron microscopy5.30D1-1258[»]
SMRiQ8WVM7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115564, 41 interactors
CORUMiQ8WVM7
DIPiDIP-35421N
IntActiQ8WVM7, 34 interactors
MINTiQ8WVM7
STRINGi9606.ENSP00000372689

PTM databases

iPTMnetiQ8WVM7
PhosphoSitePlusiQ8WVM7

Polymorphism and mutation databases

BioMutaiSTAG1
DMDMi209572720

Proteomic databases

EPDiQ8WVM7
jPOSTiQ8WVM7
MassIVEiQ8WVM7
MaxQBiQ8WVM7
PaxDbiQ8WVM7
PeptideAtlasiQ8WVM7
PRIDEiQ8WVM7
ProteomicsDBi66881
74804 [Q8WVM7-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17829, 253 antibodies

Genome annotation databases

EnsembliENST00000236698; ENSP00000236698; ENSG00000118007 [Q8WVM7-2]
ENST00000383202; ENSP00000372689; ENSG00000118007 [Q8WVM7-1]
GeneIDi10274
KEGGihsa:10274
UCSCiuc003era.2, human [Q8WVM7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10274
DisGeNETi10274
EuPathDBiHostDB:ENSG00000118007.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		STAG1
HGNCiHGNC:11354, STAG1
HPAiENSG00000118007, Low tissue specificity
MalaCardsiSTAG1
MIMi604358, gene
617635, phenotype
neXtProtiNX_Q8WVM7
OpenTargetsiENSG00000118007
Orphaneti502434, STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome
PharmGKBiPA36176

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2011, Eukaryota
GeneTreeiENSGT00950000182972
HOGENOMiCLU_005067_1_0_1
InParanoidiQ8WVM7
OMAiEAMPEKY
PhylomeDBiQ8WVM7
TreeFamiTF314604

Enzyme and pathway databases

PathwayCommonsiQ8WVM7
ReactomeiR-HSA-1221632, Meiotic synapsis
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2468052, Establishment of Sister Chromatid Cohesion
R-HSA-2470946, Cohesin Loading onto Chromatin
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-9018519, Estrogen-dependent gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10274, 41 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STAG1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STAG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10274
PharosiQ8WVM7, Tbio

Protein Ontology

More...PROi		PR:Q8WVM7
RNActiQ8WVM7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118007, Expressed in calcaneal tendon and 245 other tissues
ExpressionAtlasiQ8WVM7, baseline and differential
GenevisibleiQ8WVM7, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR039662, Cohesin_Scc3/SA
IPR020839, SCD
IPR013721, STAG
PANTHERiPTHR11199, PTHR11199, 1 hit
PfamiView protein in Pfam
PF08514, STAG, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51425, SCD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WVM7
Secondary accession number(s): O00539, Q6P275
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 14, 2008
Last modified: December 2, 2020
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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