SKA2

Functionⁱ

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).3 Publications

GO - Molecular functionⁱ

microtubule binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19289083

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17093495
chromosome segregation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19289083
mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19289083
regulation of microtubule polymerization or depolymerization
Source: UniProtKB
Inferred from direct assayⁱ
- 19289083

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Mitosis

Biological process

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-68877 Mitotic Prometaphase

Reactomeⁱ

R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spindle and kinetochore-associated protein 2 Alternative name(s): Protein FAM33A
Gene namesⁱ	Name:SKA2 Synonyms:FAM33A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182628.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28006 SKA2
MIMⁱ	616674 gene
neXtProtⁱ	NX_Q8WVK7

Keywords - Cellular componentⁱ

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	348235
Open Targets More...OpenTargetsⁱ	ENSG00000182628
PharmGKBⁱ	PA165432792

Polymorphism and mutation databases

BioMutaⁱ	SKA2

BioMutaⁱ

SKA2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000266035	1 – 121	Spindle and kinetochore-associated protein 2Add BLAST		121

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	101	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8WVK7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WVK7
PaxDbⁱ	Q8WVK7
PeptideAtlas More...PeptideAtlasⁱ	Q8WVK7
PRIDEⁱ	Q8WVK7
ProteomicsDBⁱ	74801

PTM databases

iPTMnetⁱ	Q8WVK7
PhosphoSitePlusⁱ	Q8WVK7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000182628 Expressed in 207 organ(s), highest expression level in forebrain
CleanExⁱ	HS_FAM33A
ExpressionAtlasⁱ	Q8WVK7 baseline and differential
Genevisibleⁱ	Q8WVK7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059235

HPAⁱ

HPA059235

Interactionⁱ

Subunit structureⁱ

Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much lower affinity than SKA1. May interact with NR3C1; the relevance of such interaction remains unclear in vivo.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SKA1	Q96BD8	11	EBI-1773994,EBI-741854

With

Entry

#Exp.

IntAct

Notes

SKA1

Q96BD8

11

EBI-1773994,EBI-741854

GO - Molecular functionⁱ

microtubule binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19289083

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	131515, 14 interactors
IntActⁱ	Q8WVK7, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q8WVK7
STRINGⁱ	9606.ENSP00000333433

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	2 – 32	Combined sources	31
Helixⁱ	44 – 96	Combined sources	53
Helixⁱ	104 – 112	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8WVK7
SMRⁱ	Q8WVK7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SKA2 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IZYA Eukaryota ENOG4111NBU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009588
HOGENOMⁱ	HOG000154333
HOVERGENⁱ	HBG093956
InParanoidⁱ	Q8WVK7
OMAⁱ	KNRICAT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10JL
PhylomeDBⁱ	Q8WVK7
TreeFamⁱ	TF332958

Family and domain databases

InterProⁱ	View protein in InterPro IPR026762 Ska2
PANTHERⁱ	PTHR32017 PTHR32017, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16740 SKA2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8WVK7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAEVDKLEL MFQKAESDLD YIQYRLEYEI KTNHPDSASE KNPVTLLKEL 
        60         70         80         90        100
SVIKSRYQTL YARFKPVAVE QKESKSRICA TVKKTMNMIQ KLQKQTDLEL 
       110        120 
SPLTKEEKTA AEQFKFHMPD L

Length:121

Mass (Da):14,188

Last modified:March 1, 2002 - v1

Checksum:ⁱD079F77E5BD4D7B0

GO

Isoform 2 (identifier: Q8WVK7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-75: MEAEVDKLEL...PVAVEQKESK → MASEVGHNLE...ILIQQVSCHH
76-121: Missing.

« Hide

        10         20         30         40         50
MASEVGHNLE SPETPGGGGW TRVEFPPPAP KGAATVWCLN RLGSRKLSLI 
        60         70 
WITFNTGWNM KSRLIILIQQ VSCHH

Note: No experimental confirmation available.

Show »

Length:75

Mass (Da):8,282

Checksum:ⁱBE3925745EDDA06B

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3QS74	J3QS74_HUMAN	Family with sequence similarity 33,... Family with sequence similarity 33, member A, isoform CRA_d (Spindle and kinetochore-associated protein 2)	SKA2 FAM33A, hCG_2000185	61	Annotation score:
J3KSP0	J3KSP0_HUMAN	Spindle and kinetochore-associated ... Spindle and kinetochore-associated protein 2	SKA2	109	Annotation score:
J3KRZ0	J3KRZ0_HUMAN	Spindle and kinetochore-associated ... Spindle and kinetochore-associated protein 2	SKA2	62	Annotation score:
J3QL03	J3QL03_HUMAN	Spindle and kinetochore-associated ... Spindle and kinetochore-associated protein 2	SKA2	66	Annotation score:
J3KTC5	J3KTC5_HUMAN	Spindle and kinetochore-associated ... Spindle and kinetochore-associated protein 2	SKA2	92	Annotation score:
J3QKN8	J3QKN8_HUMAN	Family with sequence similarity 33,... Family with sequence similarity 33, member A, isoform CRA_c (Spindle and kinetochore-associated protein 2)	SKA2 FAM33A, hCG_2000185	78	Annotation score:
J3KRW9	J3KRW9_HUMAN	Spindle and kinetochore-associated ... Spindle and kinetochore-associated protein 2	SKA2	46	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047348	1 – 75	MEAEV…QKESK → MASEVGHNLESPETPGGGGW TRVEFPPPAPKGAATVWCLN RLGSRKLSLIWITFNTGWNM KSRLIILIQQVSCHH in isoform 2. 1 PublicationAdd BLAST		75
Alternative sequenceⁱVSP_047349	76 – 121	Missing in isoform 2. 1 PublicationAdd BLAST		46

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056473 mRNA Translation: BAG51725.1 AC099850 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94420.1 BC017873 mRNA Translation: AAH17873.1 BC106003 mRNA Translation: AAI06004.1 BI835364 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45747.1 [Q8WVK7-1] CCDS45748.1 [Q8WVK7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001094065.1, NM_001100595.1 [Q8WVK7-2] NP_872426.1, NM_182620.3 [Q8WVK7-1]
UniGeneⁱ	Hs.463607

Genome annotation databases

Ensemblⁱ	ENST00000330137; ENSP00000333433; ENSG00000182628 [Q8WVK7-1] ENST00000437036; ENSP00000411231; ENSG00000182628 [Q8WVK7-2]
GeneIDⁱ	348235
KEGGⁱ	hsa:348235
UCSC genome browser More...UCSCⁱ	uc002ixd.3 human [Q8WVK7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WVK7	Spindle and kinetochore-associated protein 2 (Fragment)		HUMAN		66	UniRef100_Q8WVK7
UPI0002604904		HUMAN		123

Protein	Similar proteins		Species	Score	Length	Source
Q8WVK7	Spindle and kinetochore-associated protein 2		MACFA		121	UniRef90_Q8WVK7
Spindle and kinetochore-associated protein 2 (Fragment)		HUMAN		66
SKA2 isoform 1		PANTR		121
Spindle and kinetochore-associated protein 2 isoform 1		MACMU		121
SKA2 isoform 1		PONAB		121
+19
Q8WVK7-2	Family with sequence similarity 33, member A, isoform CRA_c		HUMAN		78	UniRef90_Q8WVK7-2
SKA2 isoform 8		PONAB		78
SKA2 isoform 8		PANTR		78
Uncharacterized protein		PANPA		71
Uncharacterized protein		PAPAN		75
+7

Protein	Similar proteins		Species	Score	Length	Source
Q8WVK7	Spindle and kinetochore-associated protein 2		MACFA		121	UniRef50_Q8WVK7
Spindle and kinetochore-associated protein 2		BOVIN		121
Spindle and kinetochore-associated protein 2 (Fragment)		HUMAN		66
Uncharacterized protein		NOMLE		121
Uncharacterized protein		CERAT		121
+66
Q8WVK7-2	SKA2 isoform 8		PANTR		78	UniRef50_Q8WVK7-2
Uncharacterized protein		PANPA		71
Family with sequence similarity 33, member A, isoform CRA_c		HUMAN		78
SKA2 isoform 8		PONAB		78
Uncharacterized protein		NOMLE		75
+25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056473 mRNA Translation: BAG51725.1 AC099850 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94420.1 BC017873 mRNA Translation: AAH17873.1 BC106003 mRNA Translation: AAI06004.1 BI835364 mRNA No translation available.
CCDSⁱ	CCDS45747.1 [Q8WVK7-1] CCDS45748.1 [Q8WVK7-2]
RefSeqⁱ	NP_001094065.1, NM_001100595.1 [Q8WVK7-2] NP_872426.1, NM_182620.3 [Q8WVK7-1]
UniGeneⁱ	Hs.463607

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4AJ5	X-ray	3.32	K/L/M/N/O/P/Q/R/S/T	1-121	[»]
ProteinModelPortalⁱ	Q8WVK7
SMRⁱ	Q8WVK7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131515, 14 interactors
IntActⁱ	Q8WVK7, 12 interactors
MINTⁱ	Q8WVK7
STRINGⁱ	9606.ENSP00000333433

PTM databases

iPTMnetⁱ	Q8WVK7
PhosphoSitePlusⁱ	Q8WVK7

Polymorphism and mutation databases

BioMutaⁱ	SKA2

BioMutaⁱ

SKA2

Proteomic databases

EPDⁱ	Q8WVK7
MaxQBⁱ	Q8WVK7
PaxDbⁱ	Q8WVK7
PeptideAtlasⁱ	Q8WVK7
PRIDEⁱ	Q8WVK7
ProteomicsDBⁱ	74801

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	348235
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000330137; ENSP00000333433; ENSG00000182628 [Q8WVK7-1] ENST00000437036; ENSP00000411231; ENSG00000182628 [Q8WVK7-2]
GeneIDⁱ	348235
KEGGⁱ	hsa:348235
UCSCⁱ	uc002ixd.3 human [Q8WVK7-1]

Organism-specific databases

CTDⁱ	348235
DisGeNETⁱ	348235
EuPathDBⁱ	HostDB:ENSG00000182628.12
GeneCardsⁱ	SKA2
HGNCⁱ	HGNC:28006 SKA2
HPAⁱ	HPA059235
MIMⁱ	616674 gene
neXtProtⁱ	NX_Q8WVK7
OpenTargetsⁱ	ENSG00000182628
PharmGKBⁱ	PA165432792
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZYA Eukaryota ENOG4111NBU LUCA
GeneTreeⁱ	ENSGT00390000009588
HOGENOMⁱ	HOG000154333
HOVERGENⁱ	HBG093956
InParanoidⁱ	Q8WVK7
OMAⁱ	KNRICAT
OrthoDBⁱ	EOG091G10JL
PhylomeDBⁱ	Q8WVK7
TreeFamⁱ	TF332958

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-68877 Mitotic Prometaphase

Reactomeⁱ

R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSⁱ	SKA2 human
GenomeRNAiⁱ	348235
Protein Ontology More...PROⁱ	PR:Q8WVK7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182628 Expressed in 207 organ(s), highest expression level in forebrain
CleanExⁱ	HS_FAM33A
ExpressionAtlasⁱ	Q8WVK7 baseline and differential
Genevisibleⁱ	Q8WVK7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026762 Ska2
PANTHERⁱ	PTHR32017 PTHR32017, 1 hit
Pfamⁱ	View protein in Pfam PF16740 SKA2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SKA2_HUMAN
Accessionⁱ	Q8WVK7Primary (citable) accession number: Q8WVK7 Secondary accession number(s): A6NIL3, B3KPL3, E9PCB8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	March 1, 2002
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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Supporting data

UniProtKB - Q8WVK7 (SKA2_HUMAN)

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Spindle and kinetochore-associated protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ