Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NudC domain-containing protein 2

Gene

NUDCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.1 Publication

GO - Molecular functioni

  • unfolded protein binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ8WVJ2

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 2
Gene namesi
Name:NUDCD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170584.10
HGNCiHGNC:30535 NUDCD2
neXtProtiNX_Q8WVJ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170584
PharmGKBiPA134991349

Polymorphism and mutation databases

BioMutaiNUDCD2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000579822 – 157NudC domain-containing protein 2Add BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei145PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8WVJ2
MaxQBiQ8WVJ2
PaxDbiQ8WVJ2
PeptideAtlasiQ8WVJ2
PRIDEiQ8WVJ2
ProteomicsDBi74798
TopDownProteomicsiQ8WVJ2

PTM databases

GlyConnecti1583
iPTMnetiQ8WVJ2
PhosphoSitePlusiQ8WVJ2

Expressioni

Gene expression databases

BgeeiENSG00000170584 Expressed in 199 organ(s), highest expression level in oocyte
CleanExiHS_NUDCD2
ExpressionAtlasiQ8WVJ2 baseline and differential
GenevisibleiQ8WVJ2 HS

Organism-specific databases

HPAiHPA037384
HPA037385

Interactioni

Subunit structurei

Interacts with LIS1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126402, 53 interactors
DIPiDIP-59509N
IntActiQ8WVJ2, 36 interactors
MINTiQ8WVJ2
STRINGi9606.ENSP00000304854

Structurei

3D structure databases

ProteinModelPortaliQ8WVJ2
SMRiQ8WVJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 104CSPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

eggNOGiKOG2265 Eukaryota
ENOG410XQVU LUCA
GeneTreeiENSGT00390000001644
HOGENOMiHOG000282991
HOVERGENiHBG056555
InParanoidiQ8WVJ2
OMAiNREAGNC
OrthoDBiEOG091G0OQY
PhylomeDBiQ8WVJ2
TreeFamiTF332391

Family and domain databases

CDDicd06494 p23_NUDCD2_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR037898 NudC_fam
IPR037902 p23_NUDCD2
PANTHERiPTHR12356 PTHR12356, 1 hit
PfamiView protein in Pfam
PF04969 CS, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8WVJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR
60 70 80 90 100
HVALSVGGRE ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW
110 120 130 140 150
TSLLESEYAA DPWVQDQMQR KLTLERFQKE NPGFDFSGAE ISGNYTKGGP

DFSNLEK
Length:157
Mass (Da):17,676
Last modified:March 1, 2002 - v1
Checksum:i8A425EA4F6F321FD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFP0E5RFP0_HUMAN
NudC domain-containing protein 2
NUDCD2
132Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ215684 mRNA Translation: ACJ05660.1
AK311957 mRNA Translation: BAG34897.1
BX538290 mRNA Translation: CAD98085.1
CH471062 Genomic DNA Translation: EAW61527.1
BC017934 mRNA Translation: AAH17934.1
CCDSiCCDS4361.1
RefSeqiNP_660309.1, NM_145266.5
UniGeneiHs.140443
Hs.563261

Genome annotation databases

EnsembliENST00000302764; ENSP00000304854; ENSG00000170584
GeneIDi134492
KEGGihsa:134492
UCSCiuc003lze.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ215684 mRNA Translation: ACJ05660.1
AK311957 mRNA Translation: BAG34897.1
BX538290 mRNA Translation: CAD98085.1
CH471062 Genomic DNA Translation: EAW61527.1
BC017934 mRNA Translation: AAH17934.1
CCDSiCCDS4361.1
RefSeqiNP_660309.1, NM_145266.5
UniGeneiHs.140443
Hs.563261

3D structure databases

ProteinModelPortaliQ8WVJ2
SMRiQ8WVJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126402, 53 interactors
DIPiDIP-59509N
IntActiQ8WVJ2, 36 interactors
MINTiQ8WVJ2
STRINGi9606.ENSP00000304854

PTM databases

GlyConnecti1583
iPTMnetiQ8WVJ2
PhosphoSitePlusiQ8WVJ2

Polymorphism and mutation databases

BioMutaiNUDCD2

Proteomic databases

EPDiQ8WVJ2
MaxQBiQ8WVJ2
PaxDbiQ8WVJ2
PeptideAtlasiQ8WVJ2
PRIDEiQ8WVJ2
ProteomicsDBi74798
TopDownProteomicsiQ8WVJ2

Protocols and materials databases

DNASUi134492
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302764; ENSP00000304854; ENSG00000170584
GeneIDi134492
KEGGihsa:134492
UCSCiuc003lze.4 human

Organism-specific databases

CTDi134492
EuPathDBiHostDB:ENSG00000170584.10
GeneCardsiNUDCD2
HGNCiHGNC:30535 NUDCD2
HPAiHPA037384
HPA037385
neXtProtiNX_Q8WVJ2
OpenTargetsiENSG00000170584
PharmGKBiPA134991349
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2265 Eukaryota
ENOG410XQVU LUCA
GeneTreeiENSGT00390000001644
HOGENOMiHOG000282991
HOVERGENiHBG056555
InParanoidiQ8WVJ2
OMAiNREAGNC
OrthoDBiEOG091G0OQY
PhylomeDBiQ8WVJ2
TreeFamiTF332391

Enzyme and pathway databases

SIGNORiQ8WVJ2

Miscellaneous databases

ChiTaRSiNUDCD2 human
GeneWikiiNUDCD2
GenomeRNAii134492
PROiPR:Q8WVJ2

Gene expression databases

BgeeiENSG00000170584 Expressed in 199 organ(s), highest expression level in oocyte
CleanExiHS_NUDCD2
ExpressionAtlasiQ8WVJ2 baseline and differential
GenevisibleiQ8WVJ2 HS

Family and domain databases

CDDicd06494 p23_NUDCD2_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR037898 NudC_fam
IPR037902 p23_NUDCD2
PANTHERiPTHR12356 PTHR12356, 1 hit
PfamiView protein in Pfam
PF04969 CS, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUDC2_HUMAN
AccessioniPrimary (citable) accession number: Q8WVJ2
Secondary accession number(s): B2R4V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: October 10, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again