Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small integral membrane protein 4

Gene

SMIM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 4
Gene namesi
Name:SMIM4
Synonyms:C3orf78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168273.7
HGNCiHGNC:37257 SMIM4
neXtProtiNX_Q8WVI0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168273
PharmGKBiPA165696922

Polymorphism and mutation databases

BioMutaiSMIM4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492431 – 70Small integral membrane protein 4Add BLAST70

Proteomic databases

EPDiQ8WVI0
MaxQBiQ8WVI0
PaxDbiQ8WVI0
PeptideAtlasiQ8WVI0
PRIDEiQ8WVI0
ProteomicsDBi74795
TopDownProteomicsiQ8WVI0

PTM databases

iPTMnetiQ8WVI0
PhosphoSitePlusiQ8WVI0

Expressioni

Gene expression databases

BgeeiENSG00000168273
ExpressionAtlasiQ8WVI0 baseline and differential
GenevisibleiQ8WVI0 HS

Organism-specific databases

HPAiHPA047771

Interactioni

Protein-protein interaction databases

IntActiQ8WVI0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8WVI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMIM4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2FX Eukaryota
ENOG4112BRX LUCA
GeneTreeiENSGT00390000013390
HOVERGENiHBG108640
InParanoidiQ8WVI0
OMAiFKRRQAK
OrthoDBiEOG091G0HEY
PhylomeDBiQ8WVI0
TreeFamiTF324402

Family and domain databases

InterProiView protein in InterPro
IPR028183 UPF0640
PANTHERiPTHR35250 PTHR35250, 1 hit
PfamiView protein in Pfam
PF15114 UPF0640, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WVI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTRAQVRRI LQRVPGKQRF GIYRFLPFFF VLGGTMEWIM IKVRVGQETF
60 70
YDVYRRKASE RQYQRRLEDE
Length:70
Mass (Da):8,696
Last modified:September 2, 2008 - v2
Checksum:iA7169DB86C6E111A
GO

Sequence cautioni

The sequence AAH17996 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112215 Genomic DNA No translation available.
BC017996 mRNA Translation: AAH17996.1 Different initiation.
CCDSiCCDS46844.1
RefSeqiNP_001118239.1, NM_001124767.1
UniGeneiHs.660577

Genome annotation databases

EnsembliENST00000477703; ENSP00000417806; ENSG00000168273
GeneIDi440957
KEGGihsa:440957
UCSCiuc003dep.3 human

Similar proteinsi

Entry informationi

Entry nameiSMIM4_HUMAN
AccessioniPrimary (citable) accession number: Q8WVI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 20, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health