UniProtKB - Q8WVF5 (KCTD4_HUMAN)
Protein
BTB/POZ domain-containing protein KCTD4
Gene
KCTD4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- protein homooligomerization Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q8WVF5 |
Names & Taxonomyi
Protein namesi | Recommended name: BTB/POZ domain-containing protein KCTD4 |
Gene namesi | Name:KCTD4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23227, KCTD4 |
neXtProti | NX_Q8WVF5 |
VEuPathDBi | HostDB:ENSG00000180332.6 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000180332 |
PharmGKBi | PA134880839 |
Miscellaneous databases
Pharosi | Q8WVF5, Tdark |
Genetic variation databases
BioMutai | KCTD4 |
DMDMi | 206729877 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191289 | 1 – 259 | BTB/POZ domain-containing protein KCTD4Add BLAST | 259 |
Proteomic databases
MassIVEi | Q8WVF5 |
MaxQBi | Q8WVF5 |
PaxDbi | Q8WVF5 |
PeptideAtlasi | Q8WVF5 |
PRIDEi | Q8WVF5 |
ProteomicsDBi | 74792 |
PTM databases
iPTMneti | Q8WVF5 |
PhosphoSitePlusi | Q8WVF5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180332, Expressed in pigmented layer of retina and 116 other tissues |
Genevisiblei | Q8WVF5, HS |
Organism-specific databases
HPAi | ENSG00000180332, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Hide detailsQ8WVF5
With | #Exp. | IntAct |
---|---|---|
DAXX [Q9UER7] | 3 | EBI-741463,EBI-77321 |
EFHC1 [Q5JVL4] | 6 | EBI-741463,EBI-743105 |
NTAQ1 [Q96HA8] | 3 | EBI-741463,EBI-741158 |
Protein-protein interaction databases
BioGRIDi | 132114, 11 interactors |
IntActi | Q8WVF5, 6 interactors |
STRINGi | 9606.ENSP00000368402 |
Miscellaneous databases
RNActi | Q8WVF5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 134 | BTBAdd BLAST | 102 |
Phylogenomic databases
eggNOGi | KOG2723, Eukaryota |
GeneTreei | ENSGT00940000159552 |
HOGENOMi | CLU_1081647_0_0_1 |
InParanoidi | Q8WVF5 |
OMAi | LKLETVM |
OrthoDBi | 1051383at2759 |
PhylomeDBi | Q8WVF5 |
TreeFami | TF315332 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WVF5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT
60 70 80 90 100
LTKYPDTFLE GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL
110 120 130 140 150
PEGFRENQLL AQEAEFFQLK GLAEEVKSRW EKEQLTPRET TFLEITDNHD
160 170 180 190 200
RSQGLRIFCN APDFISKIKS RIVLVSKSRL DGFPEEFSIS SNIIQFKYFI
210 220 230 240 250
KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT SLDCSKGSIV
HSDALHFIK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 195 | Q → R in AAH18063 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290675 mRNA Translation: BAF83364.1 AL138693 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08730.1 BC018063 mRNA Translation: AAH18063.1 |
CCDSi | CCDS9396.1 |
RefSeqi | NP_940686.2, NM_198404.2 |
Genome annotation databases
Ensembli | ENST00000379108; ENSP00000368402; ENSG00000180332 |
GeneIDi | 386618 |
KEGGi | hsa:386618 |
UCSCi | uc058wts.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290675 mRNA Translation: BAF83364.1 AL138693 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08730.1 BC018063 mRNA Translation: AAH18063.1 |
CCDSi | CCDS9396.1 |
RefSeqi | NP_940686.2, NM_198404.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132114, 11 interactors |
IntActi | Q8WVF5, 6 interactors |
STRINGi | 9606.ENSP00000368402 |
PTM databases
iPTMneti | Q8WVF5 |
PhosphoSitePlusi | Q8WVF5 |
Genetic variation databases
BioMutai | KCTD4 |
DMDMi | 206729877 |
Proteomic databases
MassIVEi | Q8WVF5 |
MaxQBi | Q8WVF5 |
PaxDbi | Q8WVF5 |
PeptideAtlasi | Q8WVF5 |
PRIDEi | Q8WVF5 |
ProteomicsDBi | 74792 |
Protocols and materials databases
Antibodypediai | 23595, 166 antibodies |
DNASUi | 386618 |
Genome annotation databases
Ensembli | ENST00000379108; ENSP00000368402; ENSG00000180332 |
GeneIDi | 386618 |
KEGGi | hsa:386618 |
UCSCi | uc058wts.1, human |
Organism-specific databases
CTDi | 386618 |
GeneCardsi | KCTD4 |
HGNCi | HGNC:23227, KCTD4 |
HPAi | ENSG00000180332, Tissue enriched (brain) |
neXtProti | NX_Q8WVF5 |
OpenTargetsi | ENSG00000180332 |
PharmGKBi | PA134880839 |
VEuPathDBi | HostDB:ENSG00000180332.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2723, Eukaryota |
GeneTreei | ENSGT00940000159552 |
HOGENOMi | CLU_1081647_0_0_1 |
InParanoidi | Q8WVF5 |
OMAi | LKLETVM |
OrthoDBi | 1051383at2759 |
PhylomeDBi | Q8WVF5 |
TreeFami | TF315332 |
Enzyme and pathway databases
PathwayCommonsi | Q8WVF5 |
Miscellaneous databases
BioGRID-ORCSi | 386618, 7 hits in 985 CRISPR screens |
GenomeRNAii | 386618 |
Pharosi | Q8WVF5, Tdark |
PROi | PR:Q8WVF5 |
RNActi | Q8WVF5, protein |
Gene expression databases
Bgeei | ENSG00000180332, Expressed in pigmented layer of retina and 116 other tissues |
Genevisiblei | Q8WVF5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCTD4_HUMAN | |
Accessioni | Q8WVF5Primary (citable) accession number: Q8WVF5 Secondary accession number(s): Q5W0P9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM