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Protein

Dephospho-CoA kinase domain-containing protein

Gene

DCAKD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase domain-containing protein
Gene namesi
Name:DCAKD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000172992.11
HGNCiHGNC:26238 DCAKD
neXtProtiNX_Q8WVC6

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi79877
OpenTargetsiENSG00000172992
PharmGKBiPA142672013

Polymorphism and mutation databases

BioMutaiDCAKD
DMDMi74730834

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168491 – 231Dephospho-CoA kinase domain-containing proteinAdd BLAST231

Proteomic databases

EPDiQ8WVC6
MaxQBiQ8WVC6
PaxDbiQ8WVC6
PeptideAtlasiQ8WVC6
PRIDEiQ8WVC6
ProteomicsDBi74776
74777 [Q8WVC6-2]

PTM databases

iPTMnetiQ8WVC6
PhosphoSitePlusiQ8WVC6

Expressioni

Gene expression databases

BgeeiENSG00000172992
CleanExiHS_DCAKD
ExpressionAtlasiQ8WVC6 baseline and differential
GenevisibleiQ8WVC6 HS

Organism-specific databases

HPAiHPA060997

Interactioni

Protein-protein interaction databases

BioGridi122965, 29 interactors
IntActiQ8WVC6, 7 interactors
MINTiQ8WVC6
STRINGi9606.ENSP00000341504

Structurei

3D structure databases

ProteinModelPortaliQ8WVC6
SMRiQ8WVC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 207DPCKAdd BLAST205

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiKOG3220 Eukaryota
COG0237 LUCA
GeneTreeiENSGT00550000075038
HOGENOMiHOG000020768
HOVERGENiHBG061063
InParanoidiQ8WVC6
OMAiLVTEIWV
OrthoDBiEOG091G0IZH
PhylomeDBiQ8WVC6
TreeFamiTF314815

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVC6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV
60 70 80 90 100
EVFGTEVLLE NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF
110 120 130 140 150
KYFLRGYRYV ILDIPLLFET KKLLKYMKHT VVVYCDRDTQ LARLMRRNSL
160 170 180 190 200
NRKDAEARIN AQLPLTDKAR MARHVLDNSG EWSVTKRQVI LLHTELERSL
210 220 230
EYLPLRFGVL TGLAAIASLL YLLTHYLLPY A
Length:231
Mass (Da):26,550
Last modified:March 1, 2002 - v1
Checksum:iE3AE93E8E3962544
GO
Isoform 2 (identifier: Q8WVC6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-132: GYRYVILDIPLLFETKKLLKYMKHTVV → EPRTSPRGKKHVPSALKEADSLMRRDT
     133-231: Missing.

Show »
Length:132
Mass (Da):14,927
Checksum:i33228A5A74EDA3AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218S → N in BAF83444 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03840684N → I1 PublicationCorresponds to variant dbSNP:rs17850104Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030810106 – 132GYRYV…KHTVV → EPRTSPRGKKHVPSALKEAD SLMRRDT in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_030811133 – 231Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026608 mRNA Translation: BAB15508.1
AK290755 mRNA Translation: BAF83444.1
CH471178 Genomic DNA Translation: EAW51558.1
CH471178 Genomic DNA Translation: EAW51559.1
CH471178 Genomic DNA Translation: EAW51560.1
CH471178 Genomic DNA Translation: EAW51561.1
CH471178 Genomic DNA Translation: EAW51562.1
BC006472 mRNA Translation: AAH06472.1
BC006546 mRNA Translation: AAH06546.1
BC018132 mRNA Translation: AAH18132.1
BC033299 mRNA Translation: AAH33299.1
CCDSiCCDS11493.1 [Q8WVC6-1]
RefSeqiNP_001122103.1, NM_001128631.2 [Q8WVC6-1]
NP_001275583.1, NM_001288654.2 [Q8WVC6-1]
NP_001275584.1, NM_001288655.1 [Q8WVC6-1]
NP_001308255.1, NM_001321326.1 [Q8WVC6-1]
NP_079095.3, NM_024819.6 [Q8WVC6-1]
XP_005257745.1, XM_005257688.2 [Q8WVC6-2]
XP_011523564.1, XM_011525262.2 [Q8WVC6-1]
XP_016880591.1, XM_017025102.1 [Q8WVC6-2]
XP_016880592.1, XM_017025103.1 [Q8WVC6-2]
XP_016880593.1, XM_017025104.1 [Q8WVC6-2]
UniGeneiHs.463148

Genome annotation databases

EnsembliENST00000310604; ENSP00000308515; ENSG00000172992 [Q8WVC6-1]
ENST00000342350; ENSP00000341504; ENSG00000172992 [Q8WVC6-1]
ENST00000452796; ENSP00000413483; ENSG00000172992 [Q8WVC6-1]
ENST00000588499; ENSP00000467913; ENSG00000172992 [Q8WVC6-1]
ENST00000614054; ENSP00000478909; ENSG00000172992 [Q8WVC6-1]
GeneIDi79877
KEGGihsa:79877
UCSCiuc002ihx.3 human [Q8WVC6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDCAKD_HUMAN
AccessioniPrimary (citable) accession number: Q8WVC6
Secondary accession number(s): A8K3Z0
, D3DX60, D3DX62, Q9BR71, Q9H5W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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