UniProtKB - Q8WVC6 (DCAKD_HUMAN)
Protein
Dephospho-CoA kinase domain-containing protein
Gene
DCAKD
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 8 – 15 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- dephospho-CoA kinase activity Source: GO_Central
GO - Biological processi
- coenzyme A biosynthetic process Source: GO_Central
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WVC6 |
Names & Taxonomyi
Protein namesi | Recommended name: Dephospho-CoA kinase domain-containing protein |
Gene namesi | Name:DCAKD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172992.11 |
HGNCi | HGNC:26238, DCAKD |
neXtProti | NX_Q8WVC6 |
Subcellular locationi
Other locations
- membrane Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000172992 |
PharmGKBi | PA142672013 |
Miscellaneous databases
Pharosi | Q8WVC6, Tdark |
Polymorphism and mutation databases
BioMutai | DCAKD |
DMDMi | 74730834 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316849 | 1 – 231 | Dephospho-CoA kinase domain-containing proteinAdd BLAST | 231 |
Proteomic databases
EPDi | Q8WVC6 |
jPOSTi | Q8WVC6 |
MassIVEi | Q8WVC6 |
MaxQBi | Q8WVC6 |
PaxDbi | Q8WVC6 |
PeptideAtlasi | Q8WVC6 |
PRIDEi | Q8WVC6 |
ProteomicsDBi | 74776 [Q8WVC6-1] 74777 [Q8WVC6-2] |
PTM databases
iPTMneti | Q8WVC6 |
PhosphoSitePlusi | Q8WVC6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172992, Expressed in subventricular zone (inner) (primate) and 190 other tissues |
ExpressionAtlasi | Q8WVC6, baseline and differential |
Genevisiblei | Q8WVC6, HS |
Organism-specific databases
HPAi | ENSG00000172992, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122965, 35 interactors |
IntActi | Q8WVC6, 17 interactors |
MINTi | Q8WVC6 |
STRINGi | 9606.ENSP00000308515 |
Miscellaneous databases
RNActi | Q8WVC6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 207 | DPCKAdd BLAST | 205 |
Sequence similaritiesi
Belongs to the CoaE family.Curated
Phylogenomic databases
eggNOGi | KOG3220, Eukaryota |
GeneTreei | ENSGT00550000075038 |
InParanoidi | Q8WVC6 |
OMAi | QMDIEQK |
OrthoDBi | 1263008at2759 |
PhylomeDBi | Q8WVC6 |
TreeFami | TF314815 |
Family and domain databases
HAMAPi | MF_00376, Dephospho_CoA_kinase, 1 hit |
InterProi | View protein in InterPro IPR001977, Depp_CoAkinase IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01121, CoaE, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00152, TIGR00152, 1 hit |
PROSITEi | View protein in PROSITE PS51219, DPCK, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WVC6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV
60 70 80 90 100
EVFGTEVLLE NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF
110 120 130 140 150
KYFLRGYRYV ILDIPLLFET KKLLKYMKHT VVVYCDRDTQ LARLMRRNSL
160 170 180 190 200
NRKDAEARIN AQLPLTDKAR MARHVLDNSG EWSVTKRQVI LLHTELERSL
210 220 230
EYLPLRFGVL TGLAAIASLL YLLTHYLLPY A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7ESP4 | K7ESP4_HUMAN | Dephospho-CoA kinase domain-contain... | DCAKD | 209 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 218 | S → N in BAF83444 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038406 | 84 | N → I1 PublicationCorresponds to variant dbSNP:rs17850104Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030810 | 106 – 132 | GYRYV…KHTVV → EPRTSPRGKKHVPSALKEAD SLMRRDT in isoform 2. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_030811 | 133 – 231 | Missing in isoform 2. 1 PublicationAdd BLAST | 99 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026608 mRNA Translation: BAB15508.1 AK290755 mRNA Translation: BAF83444.1 CH471178 Genomic DNA Translation: EAW51558.1 CH471178 Genomic DNA Translation: EAW51559.1 CH471178 Genomic DNA Translation: EAW51560.1 CH471178 Genomic DNA Translation: EAW51561.1 CH471178 Genomic DNA Translation: EAW51562.1 BC006472 mRNA Translation: AAH06472.1 BC006546 mRNA Translation: AAH06546.1 BC018132 mRNA Translation: AAH18132.1 BC033299 mRNA Translation: AAH33299.1 |
CCDSi | CCDS11493.1 [Q8WVC6-1] |
RefSeqi | NP_001122103.1, NM_001128631.2 [Q8WVC6-1] NP_001275583.1, NM_001288654.2 [Q8WVC6-1] NP_001275584.1, NM_001288655.1 [Q8WVC6-1] NP_001308255.1, NM_001321326.1 [Q8WVC6-1] NP_079095.3, NM_024819.6 [Q8WVC6-1] XP_005257745.1, XM_005257688.2 [Q8WVC6-2] XP_011523564.1, XM_011525262.2 [Q8WVC6-1] XP_016880591.1, XM_017025102.1 XP_016880592.1, XM_017025103.1 [Q8WVC6-2] XP_016880593.1, XM_017025104.1 [Q8WVC6-2] |
Genome annotation databases
Ensembli | ENST00000310604; ENSP00000308515; ENSG00000172992 [Q8WVC6-1] ENST00000342350; ENSP00000341504; ENSG00000172992 [Q8WVC6-1] ENST00000452796; ENSP00000413483; ENSG00000172992 [Q8WVC6-1] ENST00000588499; ENSP00000467913; ENSG00000172992 [Q8WVC6-1] ENST00000614054; ENSP00000478909; ENSG00000172992 [Q8WVC6-1] ENST00000651974; ENSP00000498268; ENSG00000172992 [Q8WVC6-1] |
GeneIDi | 79877 |
KEGGi | hsa:79877 |
UCSCi | uc002ihx.3, human [Q8WVC6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026608 mRNA Translation: BAB15508.1 AK290755 mRNA Translation: BAF83444.1 CH471178 Genomic DNA Translation: EAW51558.1 CH471178 Genomic DNA Translation: EAW51559.1 CH471178 Genomic DNA Translation: EAW51560.1 CH471178 Genomic DNA Translation: EAW51561.1 CH471178 Genomic DNA Translation: EAW51562.1 BC006472 mRNA Translation: AAH06472.1 BC006546 mRNA Translation: AAH06546.1 BC018132 mRNA Translation: AAH18132.1 BC033299 mRNA Translation: AAH33299.1 |
CCDSi | CCDS11493.1 [Q8WVC6-1] |
RefSeqi | NP_001122103.1, NM_001128631.2 [Q8WVC6-1] NP_001275583.1, NM_001288654.2 [Q8WVC6-1] NP_001275584.1, NM_001288655.1 [Q8WVC6-1] NP_001308255.1, NM_001321326.1 [Q8WVC6-1] NP_079095.3, NM_024819.6 [Q8WVC6-1] XP_005257745.1, XM_005257688.2 [Q8WVC6-2] XP_011523564.1, XM_011525262.2 [Q8WVC6-1] XP_016880591.1, XM_017025102.1 XP_016880592.1, XM_017025103.1 [Q8WVC6-2] XP_016880593.1, XM_017025104.1 [Q8WVC6-2] |
3D structure databases
SMRi | Q8WVC6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122965, 35 interactors |
IntActi | Q8WVC6, 17 interactors |
MINTi | Q8WVC6 |
STRINGi | 9606.ENSP00000308515 |
PTM databases
iPTMneti | Q8WVC6 |
PhosphoSitePlusi | Q8WVC6 |
Polymorphism and mutation databases
BioMutai | DCAKD |
DMDMi | 74730834 |
Proteomic databases
EPDi | Q8WVC6 |
jPOSTi | Q8WVC6 |
MassIVEi | Q8WVC6 |
MaxQBi | Q8WVC6 |
PaxDbi | Q8WVC6 |
PeptideAtlasi | Q8WVC6 |
PRIDEi | Q8WVC6 |
ProteomicsDBi | 74776 [Q8WVC6-1] 74777 [Q8WVC6-2] |
Protocols and materials databases
Antibodypediai | 29945, 170 antibodies |
DNASUi | 79877 |
Genome annotation databases
Ensembli | ENST00000310604; ENSP00000308515; ENSG00000172992 [Q8WVC6-1] ENST00000342350; ENSP00000341504; ENSG00000172992 [Q8WVC6-1] ENST00000452796; ENSP00000413483; ENSG00000172992 [Q8WVC6-1] ENST00000588499; ENSP00000467913; ENSG00000172992 [Q8WVC6-1] ENST00000614054; ENSP00000478909; ENSG00000172992 [Q8WVC6-1] ENST00000651974; ENSP00000498268; ENSG00000172992 [Q8WVC6-1] |
GeneIDi | 79877 |
KEGGi | hsa:79877 |
UCSCi | uc002ihx.3, human [Q8WVC6-1] |
Organism-specific databases
CTDi | 79877 |
EuPathDBi | HostDB:ENSG00000172992.11 |
GeneCardsi | DCAKD |
HGNCi | HGNC:26238, DCAKD |
HPAi | ENSG00000172992, Low tissue specificity |
neXtProti | NX_Q8WVC6 |
OpenTargetsi | ENSG00000172992 |
PharmGKBi | PA142672013 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3220, Eukaryota |
GeneTreei | ENSGT00550000075038 |
InParanoidi | Q8WVC6 |
OMAi | QMDIEQK |
OrthoDBi | 1263008at2759 |
PhylomeDBi | Q8WVC6 |
TreeFami | TF314815 |
Enzyme and pathway databases
PathwayCommonsi | Q8WVC6 |
Miscellaneous databases
BioGRID-ORCSi | 79877, 5 hits in 844 CRISPR screens |
ChiTaRSi | DCAKD, human |
GenomeRNAii | 79877 |
Pharosi | Q8WVC6, Tdark |
PROi | PR:Q8WVC6 |
RNActi | Q8WVC6, protein |
Gene expression databases
Bgeei | ENSG00000172992, Expressed in subventricular zone (inner) (primate) and 190 other tissues |
ExpressionAtlasi | Q8WVC6, baseline and differential |
Genevisiblei | Q8WVC6, HS |
Family and domain databases
HAMAPi | MF_00376, Dephospho_CoA_kinase, 1 hit |
InterProi | View protein in InterPro IPR001977, Depp_CoAkinase IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01121, CoaE, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00152, TIGR00152, 1 hit |
PROSITEi | View protein in PROSITE PS51219, DPCK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCAKD_HUMAN | |
Accessioni | Q8WVC6Primary (citable) accession number: Q8WVC6 Secondary accession number(s): A8K3Z0 Q9H5W1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations