DCAKD

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	8 – 15	ATPSequence analysis		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
dephospho-CoA kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

coenzyme A biosynthetic process Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	ATP-binding, Nucleotide-binding

Ligand

ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dephospho-CoA kinase domain-containing protein
Gene namesⁱ	Name:DCAKD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172992.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26238 DCAKD
neXtProtⁱ	NX_Q8WVC6

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79877
Open Targets More...OpenTargetsⁱ	ENSG00000172992
PharmGKBⁱ	PA142672013

Polymorphism and mutation databases

BioMutaⁱ	DCAKD
DMDMⁱ	74730834

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000316849	1 – 231	Dephospho-CoA kinase domain-containing proteinAdd BLAST		231

Proteomic databases

EPDⁱ	Q8WVC6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WVC6
PaxDbⁱ	Q8WVC6
PeptideAtlas More...PeptideAtlasⁱ	Q8WVC6
PRIDEⁱ	Q8WVC6
ProteomicsDBⁱ	74776 74777 [Q8WVC6-2]

PTM databases

iPTMnetⁱ	Q8WVC6
PhosphoSitePlusⁱ	Q8WVC6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172992
CleanExⁱ	HS_DCAKD
ExpressionAtlasⁱ	Q8WVC6 baseline and differential
Genevisibleⁱ	Q8WVC6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060997

HPAⁱ

HPA060997

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122965, 29 interactors
IntActⁱ	Q8WVC6, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q8WVC6
STRINGⁱ	9606.ENSP00000341504

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WVC6
SMRⁱ	Q8WVC6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 207	DPCKAdd BLAST		205

Sequence similaritiesⁱ

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3220 Eukaryota COG0237 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075038
HOGENOMⁱ	HOG000020768
HOVERGENⁱ	HBG061063
InParanoidⁱ	Q8WVC6
OMAⁱ	LVTEIWV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IZH
PhylomeDBⁱ	Q8WVC6
TreeFamⁱ	TF314815

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02022 DPCK, 1 hit
HAMAPⁱ	MF_00376 Dephospho_CoA_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR001977 Depp_CoAkinase IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01121 CoaE, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00152 TIGR00152, 1 hit
PROSITEⁱ	View protein in PROSITE PS51219 DPCK, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8WVC6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV 
        60         70         80         90        100
EVFGTEVLLE NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF 
       110        120        130        140        150
KYFLRGYRYV ILDIPLLFET KKLLKYMKHT VVVYCDRDTQ LARLMRRNSL 
       160        170        180        190        200
NRKDAEARIN AQLPLTDKAR MARHVLDNSG EWSVTKRQVI LLHTELERSL 
       210        220        230 
EYLPLRFGVL TGLAAIASLL YLLTHYLLPY A

Length:231

Mass (Da):26,550

Last modified:March 1, 2002 - v1

Checksum:ⁱE3AE93E8E3962544

GO

Isoform 2 (identifier: Q8WVC6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
106-132: GYRYVILDIPLLFETKKLLKYMKHTVV → EPRTSPRGKKHVPSALKEADSLMRRDT
133-231: Missing.

« Hide

        10         20         30         40         50
MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV 
        60         70         80         90        100
EVFGTEVLLE NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF 
       110        120        130 
KYFLREPRTS PRGKKHVPSA LKEADSLMRR DT

Show »

Length:132

Mass (Da):14,927

Checksum:ⁱ33228A5A74EDA3AF

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	218	S → N in BAF83444 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_038406	84	N → I1 PublicationCorresponds to variant dbSNP:rs17850104Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_030810	106 – 132	GYRYV…KHTVV → EPRTSPRGKKHVPSALKEAD SLMRRDT in isoform 2. 1 PublicationAdd BLAST		27
Alternative sequenceⁱVSP_030811	133 – 231	Missing in isoform 2. 1 PublicationAdd BLAST		99

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK026608 mRNA Translation: BAB15508.1 AK290755 mRNA Translation: BAF83444.1 CH471178 Genomic DNA Translation: EAW51558.1 CH471178 Genomic DNA Translation: EAW51559.1 CH471178 Genomic DNA Translation: EAW51560.1 CH471178 Genomic DNA Translation: EAW51561.1 CH471178 Genomic DNA Translation: EAW51562.1 BC006472 mRNA Translation: AAH06472.1 BC006546 mRNA Translation: AAH06546.1 BC018132 mRNA Translation: AAH18132.1 BC033299 mRNA Translation: AAH33299.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11493.1 [Q8WVC6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001122103.1, NM_001128631.2 [Q8WVC6-1] NP_001275583.1, NM_001288654.2 [Q8WVC6-1] NP_001275584.1, NM_001288655.1 [Q8WVC6-1] NP_001308255.1, NM_001321326.1 [Q8WVC6-1] NP_079095.3, NM_024819.6 [Q8WVC6-1] XP_005257745.1, XM_005257688.2 [Q8WVC6-2] XP_011523564.1, XM_011525262.2 [Q8WVC6-1] XP_016880591.1, XM_017025102.1 [Q8WVC6-2] XP_016880592.1, XM_017025103.1 [Q8WVC6-2] XP_016880593.1, XM_017025104.1 [Q8WVC6-2]
UniGeneⁱ	Hs.463148

Genome annotation databases

Ensemblⁱ	ENST00000310604; ENSP00000308515; ENSG00000172992 [Q8WVC6-1] ENST00000342350; ENSP00000341504; ENSG00000172992 [Q8WVC6-1] ENST00000452796; ENSP00000413483; ENSG00000172992 [Q8WVC6-1] ENST00000588499; ENSP00000467913; ENSG00000172992 [Q8WVC6-1] ENST00000614054; ENSP00000478909; ENSG00000172992 [Q8WVC6-1]
GeneIDⁱ	79877
KEGGⁱ	hsa:79877
UCSC genome browser More...UCSCⁱ	uc002ihx.3 human [Q8WVC6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length
Q8WVC6	Dephospho-CoA kinase domain-containing protein (Fragment)		HUMAN		209
UPI0003C18E4A		PANHO		283
Dephospho-CoA kinase domain containing		SHEEP		232
dephospho-CoA kinase domain-containing protein		ERIEU		231
UPI00033319B1		JACJA		231
+76
Q8WVC6-2	Uncharacterized protein		PONAB		132
UPI0003ABB29D		MACFA		132

Protein	Similar proteins		Species	Score	Length
Q8WVC6	Dephospho-CoA kinase domain-containing protein (Fragment)		HUMAN		209
UPI0003C18E4A		PANHO		283
Dephospho-CoA kinase domain containing		SHEEP		232
Dephospho-CoA kinase domain containing		CANLF		231
UPI00046BDC83		EPTFU		231
+90
Q8WVC6-2	Dephospho-CoA kinase domain containing		MACFA		135
dephospho-CoA kinase domain-containing protein		DIPOR		135
UPI0003C4D7F5		MYOLU		135
Dephospho-CoA kinase domain-containing protein (Fragment)		COLST		134
UPI0007B8D9DA		Sinocyclocheilus anshuiensis		120
+7

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK026608 mRNA Translation: BAB15508.1 AK290755 mRNA Translation: BAF83444.1 CH471178 Genomic DNA Translation: EAW51558.1 CH471178 Genomic DNA Translation: EAW51559.1 CH471178 Genomic DNA Translation: EAW51560.1 CH471178 Genomic DNA Translation: EAW51561.1 CH471178 Genomic DNA Translation: EAW51562.1 BC006472 mRNA Translation: AAH06472.1 BC006546 mRNA Translation: AAH06546.1 BC018132 mRNA Translation: AAH18132.1 BC033299 mRNA Translation: AAH33299.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11493.1 [Q8WVC6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001122103.1, NM_001128631.2 [Q8WVC6-1] NP_001275583.1, NM_001288654.2 [Q8WVC6-1] NP_001275584.1, NM_001288655.1 [Q8WVC6-1] NP_001308255.1, NM_001321326.1 [Q8WVC6-1] NP_079095.3, NM_024819.6 [Q8WVC6-1] XP_005257745.1, XM_005257688.2 [Q8WVC6-2] XP_011523564.1, XM_011525262.2 [Q8WVC6-1] XP_016880591.1, XM_017025102.1 [Q8WVC6-2] XP_016880592.1, XM_017025103.1 [Q8WVC6-2] XP_016880593.1, XM_017025104.1 [Q8WVC6-2]
UniGeneⁱ	Hs.463148

3D structure databases

ProteinModelPortalⁱ	Q8WVC6
SMRⁱ	Q8WVC6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122965, 29 interactors
IntActⁱ	Q8WVC6, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q8WVC6
STRINGⁱ	9606.ENSP00000341504

PTM databases

iPTMnetⁱ	Q8WVC6
PhosphoSitePlusⁱ	Q8WVC6

Polymorphism and mutation databases

BioMutaⁱ	DCAKD
DMDMⁱ	74730834

Proteomic databases

EPDⁱ	Q8WVC6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WVC6
PaxDbⁱ	Q8WVC6
PeptideAtlas More...PeptideAtlasⁱ	Q8WVC6
PRIDEⁱ	Q8WVC6
ProteomicsDBⁱ	74776 74777 [Q8WVC6-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79877
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000310604; ENSP00000308515; ENSG00000172992 [Q8WVC6-1] ENST00000342350; ENSP00000341504; ENSG00000172992 [Q8WVC6-1] ENST00000452796; ENSP00000413483; ENSG00000172992 [Q8WVC6-1] ENST00000588499; ENSP00000467913; ENSG00000172992 [Q8WVC6-1] ENST00000614054; ENSP00000478909; ENSG00000172992 [Q8WVC6-1]
GeneIDⁱ	79877
KEGGⁱ	hsa:79877
UCSC genome browser More...UCSCⁱ	uc002ihx.3 human [Q8WVC6-1]

Organism-specific databases

CTDⁱ	79877
DisGeNET More...DisGeNETⁱ	79877
EuPathDBⁱ	HostDB:ENSG00000172992.11
GeneCardsⁱ	DCAKD
H-InvDBⁱ	HIX0020552
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26238 DCAKD
Human Protein Atlas More...HPAⁱ	HPA060997
neXtProtⁱ	NX_Q8WVC6
Open Targets More...OpenTargetsⁱ	ENSG00000172992
PharmGKBⁱ	PA142672013
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3220 Eukaryota COG0237 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075038
HOGENOMⁱ	HOG000020768
HOVERGENⁱ	HBG061063
InParanoidⁱ	Q8WVC6
OMAⁱ	LVTEIWV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IZH
PhylomeDBⁱ	Q8WVC6
TreeFamⁱ	TF314815

Miscellaneous databases

ChiTaRSⁱ	DCAKD human
GenomeRNAiⁱ	79877
Protein Ontology More...PROⁱ	PR:Q8WVC6

Gene expression databases

Bgeeⁱ	ENSG00000172992
CleanExⁱ	HS_DCAKD
ExpressionAtlasⁱ	Q8WVC6 baseline and differential
Genevisibleⁱ	Q8WVC6 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02022 DPCK, 1 hit
HAMAPⁱ	MF_00376 Dephospho_CoA_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR001977 Depp_CoAkinase IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01121 CoaE, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00152 TIGR00152, 1 hit
PROSITEⁱ	View protein in PROSITE PS51219 DPCK, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCAKD_HUMAN
Accessionⁱ	Q8WVC6Primary (citable) accession number: Q8WVC6 Secondary accession number(s): A8K3Z0 , D3DX60, D3DX62, Q9BR71, Q9H5W1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	March 1, 2002
	Last modified:	July 18, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8WVC6 (DCAKD_HUMAN)

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Dephospho-CoA kinase domain-containing protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ