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Protein

Chromosome transmission fidelity protein 18 homolog

Gene

CHTF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi374 – 381ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 18 homolog
Short name:
hCTF18
Alternative name(s):
CHL12
Gene namesi
Name:CHTF18
Synonyms:C16orf41, CTF18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000127586.16
HGNCiHGNC:18435 CHTF18
MIMi613201 gene
neXtProtiNX_Q8WVB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi63922
OpenTargetsiENSG00000127586
PharmGKBiPA134908713

Polymorphism and mutation databases

BioMutaiCHTF18
DMDMi74751544

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003400811 – 975Chromosome transmission fidelity protein 18 homologAdd BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphothreonineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVB6
MaxQBiQ8WVB6
PaxDbiQ8WVB6
PeptideAtlasiQ8WVB6
PRIDEiQ8WVB6
ProteomicsDBi74770
74771 [Q8WVB6-2]
74772 [Q8WVB6-3]

PTM databases

iPTMnetiQ8WVB6
PhosphoSitePlusiQ8WVB6

Expressioni

Gene expression databases

BgeeiENSG00000127586 Expressed in 137 organ(s), highest expression level in cerebellum
CleanExiHS_CHTF18
ExpressionAtlasiQ8WVB6 baseline and differential
GenevisibleiQ8WVB6 HS

Organism-specific databases

HPAiHPA040976
HPA056209

Interactioni

Subunit structurei

Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5 (PubMed:12766176, PubMed:12930902). During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1 (PubMed:12766176, PubMed:12930902). The CTF18-RFC complex associates with PCNA and with DNA polymerase POLH (PubMed:12766176, PubMed:17545166). The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex (PubMed:12766176). CTF18 interacts with SMC1A and RAD21 (PubMed:12930902). Interacts with DDX11 (PubMed:18499658).4 Publications

Protein-protein interaction databases

BioGridi121991, 31 interactors
CORUMiQ8WVB6
IntActiQ8WVB6, 6 interactors
STRINGi9606.ENSP00000262315

Structurei

3D structure databases

ProteinModelPortaliQ8WVB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1969 Eukaryota
ENOG410XP8M LUCA
GeneTreeiENSGT00550000075029
HOVERGENiHBG062099
InParanoidiQ8WVB6
KOiK11269
PhylomeDBiQ8WVB6
TreeFamiTF314392

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WVB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDYEQELCG VEDDFHNQFA AELEVLAELE GASTPSPSGV PLFTAGRPPR
60 70 80 90 100
TFEEALARGD AASSPAPAAS VGSSQGGARK RQVDADLQPA GSLPHAPRIK
110 120 130 140 150
RPRLQVVKRL NFRSEEMEEP PPPDSSPTDI TPPPSPEDLA ELWGHGVSEA
160 170 180 190 200
AADVGLTRAS PAARNPVLRR PPILEDYVHV TSTEGVRAYL VLRADPMAPG
210 220 230 240 250
VQGSLLHVPW RGGGQLDLLG VSLASLKKQV DGERRERLLQ EAQKLSDTLH
260 270 280 290 300
SLRSGEEEAA QPLGAPEEEP TDGQDASSHC LWVDEFAPRH YTELLSDDFT
310 320 330 340 350
NRCLLKWLKL WDLVVFGHER PSRKPRPSVE PARVSKEATA PGKWKSHEQV
360 370 380 390 400
LEEMLEAGLD PSQRPKQKVA LLCGPPGLGK TTLAHVIARH AGYSVVEMNA
410 420 430 440 450
SDDRSPEVFR TRIEAATQME SVLGAGGKPN CLVIDEIDGA PVAAINVLLS
460 470 480 490 500
ILNRKGPQEV GPQGPAVPSG GGRRRRAEGG LLMRPIICIC NDQFAPSLRQ
510 520 530 540 550
LKQQAFLLHF PPTLPSRLVQ RLQEVSLRQG MRADPGVLAA LCEKTDNDIR
560 570 580 590 600
ACINTLQFLY SRGQRELSVR DVQATRVGLK DQRRGLFSVW QEVFQLPRAQ
610 620 630 640 650
RRRVGQDPAL PADTLLLGDG DAGSLTSASQ RFYRVLHAAA SAGEHEKVVQ
660 670 680 690 700
GLFDNFLRLR LRDSSLGAVC VALDWLAFDD LLAGAAHHSQ SFQLLRYPPF
710 720 730 740 750
LPVAFHVLFA SSHTPRITFP SSQQEAQNRM SQMRNLIQTL VSGIAPATRS
760 770 780 790 800
RATPQALLLD ALCLLLDILA PKLRPVSTQL YSTREKQQLA SLVGTMLAYS
810 820 830 840 850
LTYRQERTPD GQYIYRLEPN VEELCRFPEL PARKPLTYQT KQLIAREIEV
860 870 880 890 900
EKMRRAEASA RVENSPQVDG SPPGLEGLLG GIGEKGVHRP APRNHEQRLE
910 920 930 940 950
HIMRRAAREE QPEKDFFGRV VVRSTAVPSA GDTAPEQDSV ERRMGTAVGR
960 970
SEVWFRFNEG VSNAVRRSLY IRDLL
Length:975
Mass (Da):107,383
Last modified:March 1, 2002 - v1
Checksum:i1C71B8D71DA916CB
GO
Isoform 2 (identifier: Q8WVB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: H → HGRLAALPQGLRSGREAEEASGSLHVSPP

Show »
Length:1,003
Mass (Da):110,208
Checksum:i667E07BD080C1DA8
GO
Isoform 3 (identifier: Q8WVB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-418: Missing.

Note: No experimental confirmation available.
Show »
Length:557
Mass (Da):61,869
Checksum:i8544B6372474219B
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SF58A0A0D9SF58_HUMAN
Chromosome transmission fidelity pr...
CHTF18
1,184Annotation score:
E7EXA6E7EXA6_HUMAN
Chromosome transmission fidelity pr...
CHTF18
975Annotation score:
F8WCC1F8WCC1_HUMAN
Chromosome transmission fidelity pr...
CHTF18
456Annotation score:
H0Y7D3H0Y7D3_HUMAN
Chromosome transmission fidelity pr...
CHTF18
264Annotation score:
H3BT35H3BT35_HUMAN
Chromosome transmission fidelity pr...
CHTF18
103Annotation score:
H3BN43H3BN43_HUMAN
Chromosome transmission fidelity pr...
CHTF18
81Annotation score:

Sequence cautioni

The sequence AAH06437 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15766 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04399063S → F. Corresponds to variant dbSNP:rs2277902Ensembl.1
Natural variantiVAR_04399182Q → P1 PublicationCorresponds to variant dbSNP:rs2277901Ensembl.1
Natural variantiVAR_043992244K → R1 PublicationCorresponds to variant dbSNP:rs3765263Ensembl.1
Natural variantiVAR_043993466A → S. Corresponds to variant dbSNP:rs34595992Ensembl.1
Natural variantiVAR_043994928P → L1 PublicationCorresponds to variant dbSNP:rs2294451Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0341791 – 418Missing in isoform 3. 1 PublicationAdd BLAST418
Alternative sequenceiVSP_03418095H → HGRLAALPQGLRSGREAEEA SGSLHVSPP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024476 mRNA Translation: BAB15766.1 Different initiation.
AL031033 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85706.1
CH471112 Genomic DNA Translation: EAW85707.1
CH471112 Genomic DNA Translation: EAW85711.1
BC006278 mRNA Translation: AAH06278.2
BC006437 mRNA Translation: AAH06437.1 Different initiation.
BC018184 mRNA Translation: AAH18184.1
CCDSiCCDS45371.1 [Q8WVB6-1]
RefSeqiNP_071375.1, NM_022092.2 [Q8WVB6-1]
XP_005255528.1, XM_005255471.3 [Q8WVB6-2]
XP_011520875.1, XM_011522573.1 [Q8WVB6-3]
UniGeneiHs.153850

Genome annotation databases

EnsembliENST00000262315; ENSP00000262315; ENSG00000127586 [Q8WVB6-1]
ENST00000455171; ENSP00000406252; ENSG00000127586 [Q8WVB6-2]
GeneIDi63922
KEGGihsa:63922
UCSCiuc002cke.4 human [Q8WVB6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024476 mRNA Translation: BAB15766.1 Different initiation.
AL031033 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85706.1
CH471112 Genomic DNA Translation: EAW85707.1
CH471112 Genomic DNA Translation: EAW85711.1
BC006278 mRNA Translation: AAH06278.2
BC006437 mRNA Translation: AAH06437.1 Different initiation.
BC018184 mRNA Translation: AAH18184.1
CCDSiCCDS45371.1 [Q8WVB6-1]
RefSeqiNP_071375.1, NM_022092.2 [Q8WVB6-1]
XP_005255528.1, XM_005255471.3 [Q8WVB6-2]
XP_011520875.1, XM_011522573.1 [Q8WVB6-3]
UniGeneiHs.153850

3D structure databases

ProteinModelPortaliQ8WVB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121991, 31 interactors
CORUMiQ8WVB6
IntActiQ8WVB6, 6 interactors
STRINGi9606.ENSP00000262315

PTM databases

iPTMnetiQ8WVB6
PhosphoSitePlusiQ8WVB6

Polymorphism and mutation databases

BioMutaiCHTF18
DMDMi74751544

Proteomic databases

EPDiQ8WVB6
MaxQBiQ8WVB6
PaxDbiQ8WVB6
PeptideAtlasiQ8WVB6
PRIDEiQ8WVB6
ProteomicsDBi74770
74771 [Q8WVB6-2]
74772 [Q8WVB6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262315; ENSP00000262315; ENSG00000127586 [Q8WVB6-1]
ENST00000455171; ENSP00000406252; ENSG00000127586 [Q8WVB6-2]
GeneIDi63922
KEGGihsa:63922
UCSCiuc002cke.4 human [Q8WVB6-1]

Organism-specific databases

CTDi63922
DisGeNETi63922
EuPathDBiHostDB:ENSG00000127586.16
GeneCardsiCHTF18
HGNCiHGNC:18435 CHTF18
HPAiHPA040976
HPA056209
MIMi613201 gene
neXtProtiNX_Q8WVB6
OpenTargetsiENSG00000127586
PharmGKBiPA134908713
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1969 Eukaryota
ENOG410XP8M LUCA
GeneTreeiENSGT00550000075029
HOVERGENiHBG062099
InParanoidiQ8WVB6
KOiK11269
PhylomeDBiQ8WVB6
TreeFamiTF314392

Miscellaneous databases

ChiTaRSiCHTF18 human
GeneWikiiCHTF18
GenomeRNAii63922
PROiPR:Q8WVB6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127586 Expressed in 137 organ(s), highest expression level in cerebellum
CleanExiHS_CHTF18
ExpressionAtlasiQ8WVB6 baseline and differential
GenevisibleiQ8WVB6 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTF18_HUMAN
AccessioniPrimary (citable) accession number: Q8WVB6
Secondary accession number(s): B7ZBA2
, D3DU68, Q7Z6Y4, Q7Z6Y6, Q9BR83, Q9BRG5, Q9H7K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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