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Protein

Nucleoside diphosphate-linked moiety X motif 8

Gene

NUDT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Magnesium or manganeseBy similarity1
Metal bindingi89Magnesium or manganeseBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 8 (EC:3.6.1.-)
Short name:
Nudix motif 8
Gene namesi
Name:NUDT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000167799.9
HGNCiHGNC:8055 NUDT8
neXtProtiNX_Q8WV74

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167799
PharmGKBiPA31841

Polymorphism and mutation databases

BioMutaiNUDT8
DMDMi68565920

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000199481 – 236Nucleoside diphosphate-linked moiety X motif 8Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70N6-succinyllysineBy similarity1

Proteomic databases

EPDiQ8WV74
MaxQBiQ8WV74
PaxDbiQ8WV74
PeptideAtlasiQ8WV74
PRIDEiQ8WV74
ProteomicsDBi74757
74758 [Q8WV74-2]

PTM databases

iPTMnetiQ8WV74
PhosphoSitePlusiQ8WV74

Expressioni

Gene expression databases

BgeeiENSG00000167799
CleanExiHS_NUDT8

Organism-specific databases

HPAiHPA041252
HPA041466

Interactioni

Protein-protein interaction databases

BioGridi129040, 10 interactors
IntActiQ8WV74, 1 interactor
STRINGi9606.ENSP00000301490

Structurei

3D structure databases

ProteinModelPortaliQ8WV74
SMRiQ8WV74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 172Nudix hydrolasePROSITE-ProRule annotationAdd BLAST148

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi70 – 91Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG3069 Eukaryota
COG0494 LUCA
GeneTreeiENSGT00530000063767
HOGENOMiHOG000250455
HOVERGENiHBG082068
InParanoidiQ8WV74
KOiK18665
OMAiRIQVWGE
OrthoDBiEOG091G0QFW
PhylomeDBiQ8WV74
TreeFamiTF106350

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WV74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPDCLSAEG ELRCRRLLAG ATARLRARPA SAAVLVPLCS VRGVPALLYT
60 70 80 90 100
LRSSRLTGRH KGDVSFPGGK CDPADQDVVH TALRETREEL GLAVPEEHVW
110 120 130 140 150
GLLRPVYDPQ KATVVPVLAG VGPLDPQSLR PNSEEVDEVF ALPLAHLLQT
160 170 180 190 200
QNQGYTHFCR GGHFRYTLPV FLHGPHRVWG LTAVITEFAL QLLAPGTYQP
210 220 230
RLAGLTCSGA EGLARPKQPL ASPCQASSTP GLNKGL
Length:236
Mass (Da):25,370
Last modified:July 5, 2005 - v2
Checksum:i7DDD2A56010B4D9F
GO
Isoform 2 (identifier: Q8WV74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-140: DEVF → SWGI
     141-236: Missing.

Note: No experimental confirmation available.
Show »
Length:140
Mass (Da):15,052
Checksum:iCE854912E843E501
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014282137 – 140DEVF → SWGI in isoform 2. 1 Publication4
Alternative sequenceiVSP_014283141 – 236Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123561 mRNA Translation: BAC85646.1
BC018644 mRNA Translation: AAH18644.1
CCDSiCCDS58151.1 [Q8WV74-1]
CCDS8174.1 [Q8WV74-2]
RefSeqiNP_001230679.1, NM_001243750.1 [Q8WV74-1]
NP_862826.1, NM_181843.2 [Q8WV74-2]
UniGeneiHs.433329

Genome annotation databases

EnsembliENST00000301490; ENSP00000301490; ENSG00000167799 [Q8WV74-2]
ENST00000376693; ENSP00000365883; ENSG00000167799 [Q8WV74-1]
GeneIDi254552
KEGGihsa:254552
UCSCiuc001omn.4 human [Q8WV74-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNUDT8_HUMAN
AccessioniPrimary (citable) accession number: Q8WV74
Secondary accession number(s): Q6ZW59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 20, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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