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Entry version 185 (07 Oct 2020)
Sequence version 3 (17 Oct 2006)
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Protein

E3 ubiquitin-protein ligase TRIM41

Gene

TRIM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri20 – 61RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8WV44

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00143

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q8WV44, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM41 (EC:2.3.2.27)
Alternative name(s):
RING finger-interacting protein with C kinase
Short name:
RINCK
RING-type E3 ubiquitin transferase TRIM41Curated
Tripartite motif-containing protein 41
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM41
Synonyms:RINCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000146063.18

Human Gene Nomenclature Database

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HGNCi
HGNC:19013, TRIM41

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610530, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8WV44

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20C → A: Abolishes E3 ligase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
90933

Open Targets

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OpenTargetsi
ENSG00000146063

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134918519

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q8WV44, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TRIM41

Domain mapping of disease mutations (DMDM)

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DMDMi
116242826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562621 – 630E3 ubiquitin-protein ligase TRIM41Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei84PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei447PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WV44

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8WV44

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8WV44

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8WV44

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WV44

PeptideAtlas

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PeptideAtlasi
Q8WV44

PRoteomics IDEntifications database

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PRIDEi
Q8WV44

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
74747 [Q8WV44-1]
74748 [Q8WV44-2]
74749 [Q8WV44-3]
74750 [Q8WV44-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8WV44

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8WV44

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in multiple tissues with the highest levels in heart and skeletal muscle.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by muramyl-dipeptide and lipopolysaccharide.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000146063, Expressed in medial globus pallidus and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WV44, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WV44, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000146063, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRKCA (PubMed:17893151).

Interacts with NOD2 (PubMed:27812135).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8WV44
With#Exp.IntAct
AEN [Q8WTP8]3EBI-725997,EBI-8637627
ANKRD23 [Q86SG2]3EBI-725997,EBI-5661893
AP1M1 [Q9BXS5]3EBI-725997,EBI-541426
AQP1 [P29972]3EBI-725997,EBI-745213
BIVM [Q86UB2]3EBI-725997,EBI-12191873
BYSL [Q13895]5EBI-725997,EBI-358049
C10orf4 [D3DR40]3EBI-725997,EBI-10176576
C8orf33 [Q9H7E9]3EBI-725997,EBI-715389
CARD10 [Q9BWT7]3EBI-725997,EBI-3866279
CCNL2 - isoform 5 [Q96S94-5]3EBI-725997,EBI-12024864
CEP44 [Q9C0F1]3EBI-725997,EBI-744115
CHD2 [O14647]4EBI-725997,EBI-1210503
CSNK2A1 [P68400]3EBI-725997,EBI-347804
CSNK2A2 [P19784]7EBI-725997,EBI-347451
DVL3 [Q92997]3EBI-725997,EBI-739789
EHHADH [Q08426]7EBI-725997,EBI-2339219
EZHIP [Q86X51]3EBI-725997,EBI-12827735
FAM124A [Q86V42]3EBI-725997,EBI-744506
FAM161A [Q3B820]3EBI-725997,EBI-719941
FAM9A [Q8IZU1]3EBI-725997,EBI-8468186
FLACC1 - isoform 2 [Q96Q35-2]3EBI-725997,EBI-11533409
GAS8 [O95995]3EBI-725997,EBI-1052570
GPATCH2L [Q9NWQ4]3EBI-725997,EBI-5666657
GPATCH2L - isoform 2 [Q9NWQ4-1]3EBI-725997,EBI-11959863
JRK - isoform 2 [O75564-2]3EBI-725997,EBI-17181882
KATNBL1 [Q9H079]5EBI-725997,EBI-715394
KIFC3 [Q9BVG8]3EBI-725997,EBI-2125614
KRTAP10-8 [P60410]3EBI-725997,EBI-10171774
KRTAP10-9 [P60411]5EBI-725997,EBI-10172052
MAGEH1 [Q9H213]3EBI-725997,EBI-473834
MCRS1 [Q96EZ8]3EBI-725997,EBI-348259
MEOX1 [P50221]3EBI-725997,EBI-2864512
MEOX2 [P50222]3EBI-725997,EBI-748397
MEOX2 [Q6FHY5]3EBI-725997,EBI-16439278
MFAP1 [P55081]3EBI-725997,EBI-1048159
MID2 - isoform 2 [Q9UJV3-2]3EBI-725997,EBI-10172526
MOBP - isoform 3 [Q13875-3]3EBI-725997,EBI-12013470
MORF4L1 [Q9UBU8]3EBI-725997,EBI-399246
MORF4L1 - isoform 2 [Q9UBU8-2]5EBI-725997,EBI-10288852
MORF4L2 [Q15014]3EBI-725997,EBI-399257
NCK2 [O43639]8EBI-725997,EBI-713635
PBX4 [Q9BYU1]3EBI-725997,EBI-10302990
PHC2 [Q8IXK0]3EBI-725997,EBI-713786
PHF11 [Q9UIL8]3EBI-725997,EBI-2861403
PLAGL2 [Q9UPG8]3EBI-725997,EBI-2876622
PRDM14 [Q9GZV8]3EBI-725997,EBI-3957793
PRPF31 [Q8WWY3]3EBI-725997,EBI-1567797
PTPN3 [P26045]3EBI-725997,EBI-1047946
PUS7L [Q9H0K6]3EBI-725997,EBI-5464419
RBAK [Q9NYW8]3EBI-725997,EBI-1210429
RNPS1 [D3DU92]3EBI-725997,EBI-10176640
SORBS3 [O60504]3EBI-725997,EBI-741237
STX11 [O75558]3EBI-725997,EBI-714135
SUV39H1 [O43463]3EBI-725997,EBI-349968
SYCE1 [Q8N0S2]3EBI-725997,EBI-6872807
SYTL4 [Q96C24]3EBI-725997,EBI-747142
TCEA2 [Q15560]3EBI-725997,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]5EBI-725997,EBI-11955057
TLE5 [Q08117]3EBI-725997,EBI-717810
TLE5 - isoform 2 [Q08117-2]5EBI-725997,EBI-11741437
TNNI1 [P19237]3EBI-725997,EBI-746692
TOP3B [O95985]4EBI-725997,EBI-373403
TRIM17 [Q9Y577]4EBI-725997,EBI-743894
itself5EBI-725997,EBI-725997
ZBTB24 [O43167]6EBI-725997,EBI-744471
ZBTB26 [Q9HCK0]5EBI-725997,EBI-3918996
ZBTB39 [O15060]3EBI-725997,EBI-9995672
ZBTB48 [P10074]4EBI-725997,EBI-744864
ZBTB8A [Q96BR9]4EBI-725997,EBI-742740
ZCCHC7 [Q8N3Z6]3EBI-725997,EBI-7265024
ZFP1 [Q6P2D0]3EBI-725997,EBI-2555749
ZFP2 [Q6ZN57]6EBI-725997,EBI-7236323
ZFP64 [Q9NTW7]7EBI-725997,EBI-711679
ZMAT5 [Q9UDW3]3EBI-725997,EBI-7850213
ZNF121 [P58317]3EBI-725997,EBI-1228269
ZNF134 [P52741]3EBI-725997,EBI-18054945
ZNF138 [P52744]3EBI-725997,EBI-10746567
ZNF138 - isoform 2 [P52744-2]3EBI-725997,EBI-10213071
ZNF165 [P49910]3EBI-725997,EBI-741694
ZNF2 [Q9BSG1]3EBI-725997,EBI-8489229
ZNF219 [Q9P2Y4]3EBI-725997,EBI-3937106
ZNF250 - isoform 3 [P15622-3]9EBI-725997,EBI-10177272
ZNF251 [Q9BRH9]3EBI-725997,EBI-7254491
ZNF26 [P17031]3EBI-725997,EBI-2841331
ZNF263 [O14978]5EBI-725997,EBI-744493
ZNF264 [O43296]4EBI-725997,EBI-4395808
ZNF264 [Q14C61]3EBI-725997,EBI-2826570
ZNF266 [Q14584]6EBI-725997,EBI-7115319
ZNF275 [Q9NSD4]6EBI-725997,EBI-17263125
ZNF286A [Q9HBT8]3EBI-725997,EBI-10754950
ZNF319 [Q9P2F9]3EBI-725997,EBI-11993110
ZNF329 [Q86UD4]4EBI-725997,EBI-7233259
ZNF343 [Q6P1L6]3EBI-725997,EBI-10252492
ZNF398 [Q8TD17]3EBI-725997,EBI-8643207
ZNF408 [Q9H9D4]4EBI-725997,EBI-347633
ZNF417 [Q8TAU3]8EBI-725997,EBI-740727
ZNF439 [Q8NDP4]3EBI-725997,EBI-747580
ZNF460 [Q14592]3EBI-725997,EBI-2555738
ZNF473 [Q8WTR7]5EBI-725997,EBI-751409
ZNF48 [Q96MX3]3EBI-725997,EBI-12006434
ZNF490 [Q9ULM2]7EBI-725997,EBI-1105370
ZNF497 [Q6ZNH5]3EBI-725997,EBI-10486136
ZNF526 [Q8TF50]3EBI-725997,EBI-11035148
ZNF552 [Q9H707]3EBI-725997,EBI-2555731
ZNF564 [Q8TBZ8]3EBI-725997,EBI-10273713
ZNF575 [Q86XF7]3EBI-725997,EBI-14069183
ZNF587 [Q96SQ5]6EBI-725997,EBI-6427977
ZNF629 [Q9UEG4]3EBI-725997,EBI-9977294
ZNF648 [Q5T619]3EBI-725997,EBI-11985915
ZNF653 [Q96CK0]3EBI-725997,EBI-12217757
ZNF655 [Q8N720]3EBI-725997,EBI-625509
ZNF670 [Q9BS34]6EBI-725997,EBI-745276
ZNF691 [Q5VV52]3EBI-725997,EBI-720883
ZNF696 [Q9H7X3]3EBI-725997,EBI-11090299
ZNF71 [Q9NQZ8]8EBI-725997,EBI-7138235
ZNF773 [Q6PK81]3EBI-725997,EBI-2686307
ZNF780A [O75290]3EBI-725997,EBI-13335739
ZNF784 [Q8NCA9]3EBI-725997,EBI-7138303
ZNF792 [Q3KQV3]3EBI-725997,EBI-10240849
ZNF835 [Q9Y2P0]6EBI-725997,EBI-5667516
ZNF837 [Q96EG3]3EBI-725997,EBI-11962574
ZSCAN16 [Q9H4T2]3EBI-725997,EBI-723596
ZSCAN21 [Q9Y5A6]3EBI-725997,EBI-10281938
ZSCAN26 [Q16670]3EBI-725997,EBI-3920053
Q9H6F03EBI-725997,EBI-10307481
NP [C5E522] from Influenza A virus (A/New York/1682/2009(H1N1)).3EBI-725997,EBI-12583355
NP [P03466] from Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).5EBI-725997,EBI-2547640
NP [Q1K9H2] from Influenza A virus (strain A/Wilson-Smith/1933 H1N1).3EBI-725997,EBI-6050688
NP [Q5EP28] from Influenza A virus (A/Viet Nam/1203/2004(H5N1)).3EBI-725997,EBI-12582202
Isoform 2 [Q8WV44-2]
With#Exp.IntAct
Prkcb - isoform Beta-II [P68403-2] from Rattus norvegicus.3EBI-726015,EBI-397092

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124780, 185 interactors

Protein interaction database and analysis system

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IntActi
Q8WV44, 180 interactors

Molecular INTeraction database

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MINTi
Q8WV44

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320869

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WV44, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WV44

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WV44

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini413 – 630B30.2/SPRYPROSITE-ProRule annotationAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili264 – 373Sequence analysisAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 163Glu-richAdd BLAST113

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 61RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154294

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013137_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WV44

KEGG Orthology (KO)

More...
KOi
K12017

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWSPDPC

Database of Orthologous Groups

More...
OrthoDBi
423686at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WV44

TreeFam database of animal gene trees

More...
TreeFami
TF342569

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021, BBOX, 1 hit
cd13741, SPRY_PRY_TRIM41, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR003877, SPRY_dom
IPR042828, TRIM41_SPRY_PRY
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13765, PRY, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01407, BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WV44-1) [UniParc]FASTAAdd to basket
Also known as: TRIM41a, TRIM41alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG
60 70 80 90 100
EDEEDRDELD REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE
110 120 130 140 150
EEEEGVFWTS GMSRSSWDNM DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE
160 170 180 190 200
EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC FTCPQCRKSF PRRSFRPNLQ
210 220 230 240 250
LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV DEEAICVVCR
260 270 280 290 300
ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT
310 320 330 340 350
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA
360 370 380 390 400
SRLAEQAAQL SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW
410 420 430 440 450
SPDPCQPHSH DFLTDAIVRK MSRMFCQAAR VDLTLDPDTA HPALMLSPDR
460 470 480 490 500
RGVRLAERRQ EVADHPKRFS ADCCVLGAQG FRSGRHYWEV EVGGRRGWAV
510 520 530 540 550
GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP QQPLLQREVW
560 570 580 590 600
CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH
610 620 630
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP
Length:630
Mass (Da):71,670
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E704CBEAB928BF5
GO
Isoform 2 (identifier: Q8WV44-2) [UniParc]FASTAAdd to basket
Also known as: TRIM41b, TRIM41beta, RINCK1

The sequence of this isoform differs from the canonical sequence as follows:
     490-518: VEVGGRRGWAVGAARESTHHKEKVGPGGS → EPKEPSWPPAQPSLTYYVCPTDRPEFSFT
     519-630: Missing.

Show »
Length:518
Mass (Da):59,302
Checksum:i88078577B9A3C98E
GO
Isoform 3 (identifier: Q8WV44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.

Show »
Length:210
Mass (Da):23,608
Checksum:i6354BEB70AFB1C7C
GO
Isoform 4 (identifier: Q8WV44-4) [UniParc]FASTAAdd to basket
Also known as: RINCK2

The sequence of this isoform differs from the canonical sequence as follows:
     381-381: D → V
     382-630: Missing.

Show »
Length:381
Mass (Da):43,491
Checksum:i2716AF100B4CA18B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9T3H0Y9T3_HUMAN
E3 ubiquitin-protein ligase TRIM41
TRIM41
362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REK2D6REK2_HUMAN
E3 ubiquitin-protein ligase TRIM41
TRIM41
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAD6H0YAD6_HUMAN
E3 ubiquitin-protein ligase TRIM41
TRIM41
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti276G → E in BAD07472 (PubMed:16022281).Curated1
Sequence conflicti276G → E in BAD07473 (PubMed:16022281).Curated1
Sequence conflicti276G → E in BAB70617 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02791478A → T. Corresponds to variant dbSNP:rs6601178Ensembl.1
Natural variantiVAR_027915438D → G. Corresponds to variant dbSNP:rs2241371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0125151 – 420Missing in isoform 3. 2 PublicationsAdd BLAST420
Alternative sequenceiVSP_012516381D → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_012517382 – 630Missing in isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_010395490 – 518VEVGG…GPGGS → EPKEPSWPPAQPSLTYYVCP TDRPEFSFT in isoform 2. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_010396519 – 630Missing in isoform 2. 3 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB100366 mRNA Translation: BAD07472.1
AB100367 mRNA Translation: BAD07473.1
AF258579 mRNA Translation: AAG23782.1
CR457349 mRNA Translation: CAG33630.1
AK027601 mRNA Translation: BAG51358.1
CH471165 Genomic DNA Translation: EAW53712.1
CH471165 Genomic DNA Translation: EAW53708.1
CH471165 Genomic DNA Translation: EAW53709.1
BC004956 mRNA Translation: AAH04956.1
BC009762 mRNA Translation: AAH09762.2
BC018765 mRNA Translation: AAH18765.2
BC071887 mRNA Translation: AAH71887.1
BC090953 mRNA Translation: AAH90953.1
AB063180 mRNA Translation: BAB70617.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4465.1 [Q8WV44-2]
CCDS4466.1 [Q8WV44-1]

NCBI Reference Sequences

More...
RefSeqi
NP_291027.3, NM_033549.4 [Q8WV44-1]
NP_963921.1, NM_201627.2 [Q8WV44-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315073; ENSP00000320869; ENSG00000146063 [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063 [Q8WV44-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90933

UCSC genome browser

More...
UCSCi
uc003mnd.3, human [Q8WV44-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100366 mRNA Translation: BAD07472.1
AB100367 mRNA Translation: BAD07473.1
AF258579 mRNA Translation: AAG23782.1
CR457349 mRNA Translation: CAG33630.1
AK027601 mRNA Translation: BAG51358.1
CH471165 Genomic DNA Translation: EAW53712.1
CH471165 Genomic DNA Translation: EAW53708.1
CH471165 Genomic DNA Translation: EAW53709.1
BC004956 mRNA Translation: AAH04956.1
BC009762 mRNA Translation: AAH09762.2
BC018765 mRNA Translation: AAH18765.2
BC071887 mRNA Translation: AAH71887.1
BC090953 mRNA Translation: AAH90953.1
AB063180 mRNA Translation: BAB70617.1
CCDSiCCDS4465.1 [Q8WV44-2]
CCDS4466.1 [Q8WV44-1]
RefSeqiNP_291027.3, NM_033549.4 [Q8WV44-1]
NP_963921.1, NM_201627.2 [Q8WV44-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EGMNMR-A214-263[»]
SMRiQ8WV44
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124780, 185 interactors
IntActiQ8WV44, 180 interactors
MINTiQ8WV44
STRINGi9606.ENSP00000320869

Protein family/group databases

MoonDBiQ8WV44, Predicted

PTM databases

iPTMnetiQ8WV44
PhosphoSitePlusiQ8WV44

Polymorphism and mutation databases

BioMutaiTRIM41
DMDMi116242826

Proteomic databases

EPDiQ8WV44
jPOSTiQ8WV44
MassIVEiQ8WV44
MaxQBiQ8WV44
PaxDbiQ8WV44
PeptideAtlasiQ8WV44
PRIDEiQ8WV44
ProteomicsDBi74747 [Q8WV44-1]
74748 [Q8WV44-2]
74749 [Q8WV44-3]
74750 [Q8WV44-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17930, 205 antibodies

The DNASU plasmid repository

More...
DNASUi
90933

Genome annotation databases

EnsembliENST00000315073; ENSP00000320869; ENSG00000146063 [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063 [Q8WV44-2]
GeneIDi90933
KEGGihsa:90933
UCSCiuc003mnd.3, human [Q8WV44-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90933
DisGeNETi90933
EuPathDBiHostDB:ENSG00000146063.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM41
HGNCiHGNC:19013, TRIM41
HPAiENSG00000146063, Tissue enhanced (brain)
MIMi610530, gene
neXtProtiNX_Q8WV44
OpenTargetsiENSG00000146063
PharmGKBiPA134918519

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000154294
HOGENOMiCLU_013137_0_3_1
InParanoidiQ8WV44
KOiK12017
OMAiIWSPDPC
OrthoDBi423686at2759
PhylomeDBiQ8WV44
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ8WV44
ReactomeiR-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
90933, 11 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIM41, human
EvolutionaryTraceiQ8WV44

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRIM41

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90933
PharosiQ8WV44, Tdark

Protein Ontology

More...
PROi
PR:Q8WV44
RNActiQ8WV44, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146063, Expressed in medial globus pallidus and 213 other tissues
ExpressionAtlasiQ8WV44, baseline and differential
GenevisibleiQ8WV44, HS

Family and domain databases

CDDicd00021, BBOX, 1 hit
cd13741, SPRY_PRY_TRIM41, 1 hit
Gene3Di2.60.120.920, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR003877, SPRY_dom
IPR042828, TRIM41_SPRY_PRY
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF13765, PRY, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit
PRINTSiPR01407, BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI41_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WV44
Secondary accession number(s): B3KNJ6
, D3DWR9, Q5BKT0, Q7L484, Q96Q10, Q9BSL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 17, 2006
Last modified: October 7, 2020
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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