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Protein

E3 ubiquitin-protein ligase TRIM41

Gene

TRIM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri20 – 61RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transferase activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to lipopolysaccharide Source: UniProtKB
  • cellular response to muramyl dipeptide Source: UniProtKB
  • protein ubiquitination Source: UniProtKB-UniPathway

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q8WV44 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM41 (EC:2.3.2.27)
Alternative name(s):
RING finger-interacting protein with C kinase
Short name:
RINCK
RING-type E3 ubiquitin transferase TRIM41Curated
Tripartite motif-containing protein 41
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM41
Synonyms:RINCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000146063.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19013 TRIM41

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610530 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WV44

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20C → A: Abolishes E3 ligase activity. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000146063

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134918519

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM41

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562621 – 630E3 ubiquitin-protein ligase TRIM41Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei84PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei447PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WV44

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WV44

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WV44

PeptideAtlas

More...
PeptideAtlasi
Q8WV44

PRoteomics IDEntifications database

More...
PRIDEi
Q8WV44

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74747
74748 [Q8WV44-2]
74749 [Q8WV44-3]
74750 [Q8WV44-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WV44

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WV44

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in multiple tissues with the highest levels in heart and skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by muramyl-dipeptide and lipopolysaccharide.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146063 Expressed in 200 organ(s), highest expression level in medial globus pallidus

CleanEx database of gene expression profiles

More...
CleanExi
HS_TRIM41

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WV44 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WV44 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024204

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRKCA (PubMed:17893151). Interacts with NOD2 (PubMed:27812135).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-725997,EBI-725997
Q9H6F03EBI-725997,EBI-10307481
AENQ8WTP83EBI-725997,EBI-8637627
AESQ081173EBI-725997,EBI-717810
C10orf4D3DR403EBI-725997,EBI-10176576
CEP44Q9C0F13EBI-725997,EBI-744115
CHD2O146474EBI-725997,EBI-1210503
CSNK2A1P684004EBI-725997,EBI-347804
CSNK2A2P197845EBI-725997,EBI-347451
EHHADHQ084265EBI-725997,EBI-2339219
FAM124AQ86V423EBI-725997,EBI-744506
GPATCH2LQ9NWQ43EBI-725997,EBI-5666657
KIFC3Q9BVG83EBI-725997,EBI-2125614
KRTAP10-9P604115EBI-725997,EBI-10172052
MAGEH1Q9H2133EBI-725997,EBI-473834
MEOX2P502223EBI-725997,EBI-748397
MORF4L1Q9UBU83EBI-725997,EBI-399246
NCK2O436395EBI-725997,EBI-713635
NPC5E5223EBI-725997,EBI-12583355From Influenza A virus (A/New York/1682/2009(H1N1)).
NPP034665EBI-725997,EBI-2547640From Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).
NPQ1K9H23EBI-725997,EBI-6050688From Influenza A virus (strain A/Wilson-Smith/1933 H1N1).
NPQ5EP283EBI-725997,EBI-12582202From Influenza A virus (A/Viet Nam/1203/2004(H5N1)).
PHC2Q8IXK03EBI-725997,EBI-713786
PrkcbP68403-23EBI-726015,EBI-397092From a different organism.
PRPF31Q8WWY33EBI-725997,EBI-1567797
PUS7LQ9H0K63EBI-725997,EBI-5464419
RNPS1D3DU923EBI-725997,EBI-10176640
SORBS3O605043EBI-725997,EBI-741237
TOP3BO959853EBI-725997,EBI-373403
TRIM17Q9Y5775EBI-725997,EBI-743894
ZBTB24O431675EBI-725997,EBI-744471
ZBTB48P100743EBI-725997,EBI-744864
ZBTB8AQ96BR93EBI-725997,EBI-742740
ZFP2Q6ZN575EBI-725997,EBI-7236323
ZFP64Q9NPA53EBI-725997,EBI-711679
ZFP64Q9NTW73EBI-725997,EBI-745730
ZNF138P52744-23EBI-725997,EBI-10213071
ZNF250P15622-37EBI-725997,EBI-10177272
ZNF26P170313EBI-725997,EBI-2841331
ZNF263O149783EBI-725997,EBI-744493
ZNF264Q14C613EBI-725997,EBI-2826570
ZNF266Q145846EBI-725997,EBI-7115319
ZNF275Q9NSD44EBI-725997,EBI-17263125
ZNF329Q86UD43EBI-725997,EBI-7233259
ZNF408Q9H9D44EBI-725997,EBI-347633
ZNF417Q8TAU35EBI-725997,EBI-740727
ZNF473Q8WTR73EBI-725997,EBI-751409
ZNF490Q9ULM25EBI-725997,EBI-1105370
ZNF564Q8TBZ83EBI-725997,EBI-10273713
ZNF587Q96SQ55EBI-725997,EBI-6427977
ZNF670Q9BS345EBI-725997,EBI-745276
ZNF71Q9NQZ84EBI-725997,EBI-7138235
ZSCAN21Q9Y5A63EBI-725997,EBI-10281938
ZSCAN26Q166703EBI-725997,EBI-3920053

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124780, 105 interactors

Protein interaction database and analysis system

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IntActi
Q8WV44, 150 interactors

Molecular INTeraction database

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MINTi
Q8WV44

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320869

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8WV44

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WV44

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WV44

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini413 – 630B30.2/SPRYPROSITE-ProRule annotationAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili264 – 373Sequence analysisAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 163Glu-richAdd BLAST113

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 61RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2177 Eukaryota
ENOG4111G04 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154294

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001357

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WV44

KEGG Orthology (KO)

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KOi
K12017

Identification of Orthologs from Complete Genome Data

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OMAi
WTSGMGG

Database of Orthologous Groups

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OrthoDBi
EOG091G04RX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WV44

TreeFam database of animal gene trees

More...
TreeFami
TF342569

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WV44-1) [UniParc]FASTAAdd to basket
Also known as: TRIM41a, TRIM41alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG
60 70 80 90 100
EDEEDRDELD REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE
110 120 130 140 150
EEEEGVFWTS GMSRSSWDNM DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE
160 170 180 190 200
EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC FTCPQCRKSF PRRSFRPNLQ
210 220 230 240 250
LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV DEEAICVVCR
260 270 280 290 300
ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT
310 320 330 340 350
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA
360 370 380 390 400
SRLAEQAAQL SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW
410 420 430 440 450
SPDPCQPHSH DFLTDAIVRK MSRMFCQAAR VDLTLDPDTA HPALMLSPDR
460 470 480 490 500
RGVRLAERRQ EVADHPKRFS ADCCVLGAQG FRSGRHYWEV EVGGRRGWAV
510 520 530 540 550
GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP QQPLLQREVW
560 570 580 590 600
CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH
610 620 630
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP
Length:630
Mass (Da):71,670
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E704CBEAB928BF5
GO
Isoform 2 (identifier: Q8WV44-2) [UniParc]FASTAAdd to basket
Also known as: TRIM41b, TRIM41beta, RINCK1

The sequence of this isoform differs from the canonical sequence as follows:
     490-518: VEVGGRRGWAVGAARESTHHKEKVGPGGS → EPKEPSWPPAQPSLTYYVCPTDRPEFSFT
     519-630: Missing.

Show »
Length:518
Mass (Da):59,302
Checksum:i88078577B9A3C98E
GO
Isoform 3 (identifier: Q8WV44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.

Show »
Length:210
Mass (Da):23,608
Checksum:i6354BEB70AFB1C7C
GO
Isoform 4 (identifier: Q8WV44-4) [UniParc]FASTAAdd to basket
Also known as: RINCK2

The sequence of this isoform differs from the canonical sequence as follows:
     381-381: D → V
     382-630: Missing.

Show »
Length:381
Mass (Da):43,491
Checksum:i2716AF100B4CA18B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9T3H0Y9T3_HUMAN
E3 ubiquitin-protein ligase TRIM41
TRIM41
362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REK2D6REK2_HUMAN
E3 ubiquitin-protein ligase TRIM41
TRIM41
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAD6H0YAD6_HUMAN
E3 ubiquitin-protein ligase TRIM41
TRIM41
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti276G → E in BAD07472 (PubMed:16022281).Curated1
Sequence conflicti276G → E in BAD07473 (PubMed:16022281).Curated1
Sequence conflicti276G → E in BAB70617 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02791478A → T. Corresponds to variant dbSNP:rs6601178Ensembl.1
Natural variantiVAR_027915438D → G. Corresponds to variant dbSNP:rs2241371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0125151 – 420Missing in isoform 3. 2 PublicationsAdd BLAST420
Alternative sequenceiVSP_012516381D → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_012517382 – 630Missing in isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_010395490 – 518VEVGG…GPGGS → EPKEPSWPPAQPSLTYYVCP TDRPEFSFT in isoform 2. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_010396519 – 630Missing in isoform 2. 3 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB100366 mRNA Translation: BAD07472.1
AB100367 mRNA Translation: BAD07473.1
AF258579 mRNA Translation: AAG23782.1
CR457349 mRNA Translation: CAG33630.1
AK027601 mRNA Translation: BAG51358.1
CH471165 Genomic DNA Translation: EAW53712.1
CH471165 Genomic DNA Translation: EAW53708.1
CH471165 Genomic DNA Translation: EAW53709.1
BC004956 mRNA Translation: AAH04956.1
BC009762 mRNA Translation: AAH09762.2
BC018765 mRNA Translation: AAH18765.2
BC071887 mRNA Translation: AAH71887.1
BC090953 mRNA Translation: AAH90953.1
AB063180 mRNA Translation: BAB70617.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4465.1 [Q8WV44-2]
CCDS4466.1 [Q8WV44-1]

NCBI Reference Sequences

More...
RefSeqi
NP_291027.3, NM_033549.4 [Q8WV44-1]
NP_963921.1, NM_201627.2 [Q8WV44-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.441488
Hs.700303

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315073; ENSP00000320869; ENSG00000146063 [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063 [Q8WV44-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90933

UCSC genome browser

More...
UCSCi
uc003mnd.3 human [Q8WV44-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100366 mRNA Translation: BAD07472.1
AB100367 mRNA Translation: BAD07473.1
AF258579 mRNA Translation: AAG23782.1
CR457349 mRNA Translation: CAG33630.1
AK027601 mRNA Translation: BAG51358.1
CH471165 Genomic DNA Translation: EAW53712.1
CH471165 Genomic DNA Translation: EAW53708.1
CH471165 Genomic DNA Translation: EAW53709.1
BC004956 mRNA Translation: AAH04956.1
BC009762 mRNA Translation: AAH09762.2
BC018765 mRNA Translation: AAH18765.2
BC071887 mRNA Translation: AAH71887.1
BC090953 mRNA Translation: AAH90953.1
AB063180 mRNA Translation: BAB70617.1
CCDSiCCDS4465.1 [Q8WV44-2]
CCDS4466.1 [Q8WV44-1]
RefSeqiNP_291027.3, NM_033549.4 [Q8WV44-1]
NP_963921.1, NM_201627.2 [Q8WV44-2]
UniGeneiHs.441488
Hs.700303

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EGMNMR-A214-263[»]
ProteinModelPortaliQ8WV44
SMRiQ8WV44
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124780, 105 interactors
IntActiQ8WV44, 150 interactors
MINTiQ8WV44
STRINGi9606.ENSP00000320869

Protein family/group databases

MoonDBiQ8WV44 Predicted

PTM databases

iPTMnetiQ8WV44
PhosphoSitePlusiQ8WV44

Polymorphism and mutation databases

BioMutaiTRIM41
DMDMi116242826

Proteomic databases

EPDiQ8WV44
MaxQBiQ8WV44
PaxDbiQ8WV44
PeptideAtlasiQ8WV44
PRIDEiQ8WV44
ProteomicsDBi74747
74748 [Q8WV44-2]
74749 [Q8WV44-3]
74750 [Q8WV44-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
90933
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315073; ENSP00000320869; ENSG00000146063 [Q8WV44-1]
ENST00000351937; ENSP00000336749; ENSG00000146063 [Q8WV44-2]
GeneIDi90933
KEGGihsa:90933
UCSCiuc003mnd.3 human [Q8WV44-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90933
EuPathDBiHostDB:ENSG00000146063.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM41

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0121034
HGNCiHGNC:19013 TRIM41
HPAiHPA024204
MIMi610530 gene
neXtProtiNX_Q8WV44
OpenTargetsiENSG00000146063
PharmGKBiPA134918519

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00940000154294
HOVERGENiHBG001357
InParanoidiQ8WV44
KOiK12017
OMAiWTSGMGG
OrthoDBiEOG091G04RX
PhylomeDBiQ8WV44
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIM41 human
EvolutionaryTraceiQ8WV44

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRIM41

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90933

Protein Ontology

More...
PROi
PR:Q8WV44

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146063 Expressed in 200 organ(s), highest expression level in medial globus pallidus
CleanExiHS_TRIM41
ExpressionAtlasiQ8WV44 baseline and differential
GenevisibleiQ8WV44 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI41_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WV44
Secondary accession number(s): B3KNJ6
, D3DWR9, Q5BKT0, Q7L484, Q96Q10, Q9BSL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 17, 2006
Last modified: December 5, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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