UniProtKB - Q8WV41 (SNX33_HUMAN)
Sorting nexin-33
SNX33
Functioni
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.
6 PublicationsGO - Molecular functioni
- identical protein binding Source: IntAct
- phosphatidylinositol binding Source: InterPro
GO - Biological processi
- cleavage furrow formation Source: UniProtKB
- endocytosis Source: UniProtKB
- endosomal transport Source: UniProtKB
- endosome organization Source: UniProtKB
- intracellular protein transport Source: InterPro
- macropinocytosis Source: UniProtKB
- mitotic cytokinesis Source: UniProtKB
- negative regulation of endocytosis Source: UniProtKB
- negative regulation of protein localization to cell surface Source: UniProtKB
- plasma membrane tubulation Source: UniProtKB
- positive regulation of membrane protein ectodomain proteolysis Source: UniProtKB
- positive regulation of protein localization to cell surface Source: UniProtKB
- protein import Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8WV41 |
SignaLinki | Q8WV41 |
Names & Taxonomyi
Protein namesi | Recommended name: Sorting nexin-33Alternative name(s): SH3 and PX domain-containing protein 3 |
Gene namesi | Name:SNX33 Synonyms:SH3PX3, SH3PXD3C, SNX30 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28468, SNX33 |
MIMi | 619107, gene |
neXtProti | NX_Q8WV41 |
VEuPathDBi | HostDB:ENSG00000173548 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Other locations
- cytoplasmic vesicle Source: UniProtKB
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- extrinsic component of membrane Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000173548 |
PharmGKBi | PA162404345 |
Miscellaneous databases
Pharosi | Q8WV41, Tbio |
Genetic variation databases
BioMutai | SNX33 |
DMDMi | 74751538 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311948 | 1 – 574 | Sorting nexin-33Add BLAST | 574 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 77 | PhosphoserineCombined sources | 1 | |
Modified residuei | 92 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8WV41 |
jPOSTi | Q8WV41 |
MassIVEi | Q8WV41 |
MaxQBi | Q8WV41 |
PaxDbi | Q8WV41 |
PeptideAtlasi | Q8WV41 |
PRIDEi | Q8WV41 |
ProteomicsDBi | 74746 |
PTM databases
iPTMneti | Q8WV41 |
PhosphoSitePlusi | Q8WV41 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000173548, Expressed in lower esophagus mucosa and 208 other tissues |
ExpressionAtlasi | Q8WV41, baseline and differential |
Genevisiblei | Q8WV41, HS |
Organism-specific databases
HPAi | ENSG00000173548, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (via BAR domain).
Interacts with ADAM15.
Interacts with FASLG.
Interacts (via SH3 domain) with DNM1 and DNM2.
Interacts with WASL.
Interacts with FCHSD1 (via the F-BAR domain) (By similarity).
By similarity6 PublicationsBinary interactionsi
Q8WV41
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 129214, 54 interactors |
IntActi | Q8WV41, 41 interactors |
MINTi | Q8WV41 |
STRINGi | 9606.ENSP00000311427 |
Miscellaneous databases
RNActi | Q8WV41, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8WV41 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 61 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 230 – 340 | PXPROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 371 – 574 | BARAdd BLAST | 204 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 119 | DisorderedSequence analysisAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 68 – 107 | Polar residuesSequence analysisAdd BLAST | 40 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG2528, Eukaryota |
GeneTreei | ENSGT00940000160162 |
HOGENOMi | CLU_021494_3_0_1 |
InParanoidi | Q8WV41 |
OMAi | KHMMQSY |
OrthoDBi | 811995at2759 |
PhylomeDBi | Q8WV41 |
TreeFami | TF314082 |
Family and domain databases
CDDi | cd07669, BAR_SNX33, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR001683, PX_dom IPR036871, PX_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR028642, SNX33 IPR037427, SNX33_BAR IPR014536, Snx9_fam IPR019497, Sorting_nexin_WASP-bd-dom |
PANTHERi | PTHR45827:SF3, PTHR45827:SF3, 1 hit |
Pfami | View protein in Pfam PF10456, BAR_3_WASP_bdg, 1 hit PF00787, PX, 1 hit PF14604, SH3_9, 1 hit |
PIRSFi | PIRSF027744, Snx9, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MALKGRALYD FHSENKEEIS IQQDEDLVIF SETSLDGWLQ GQNSRGETGL
60 70 80 90 100
FPASYVEIVR SGISTNHADY SSSPAGSPGA QVSLYNSPSV ASPARSGGGS
110 120 130 140 150
GFLSNQGSFE EDDDDDWDDW DDGCTVVEEP RAGGLGTNGH PPLNLSYPGA
160 170 180 190 200
YPSQHMAFRP KPPLERQDSL ASAKRGSVVG RNLNRFSCFV RSGVEAFILG
210 220 230 240 250
DVPMMAKIAE TYSIEMGPRG PQWKANPHPF ACSVEDPTKQ TKFKGIKSYI
260 270 280 290 300
SYKLTPTHAA SPVYRRYKHF DWLYNRLLHK FTVISVPHLP EKQATGRFEE
310 320 330 340 350
DFIEKRKRRL ILWMDHMTSH PVLSQYEGFQ HFLSCLDDKQ WKMGKRRAEK
360 370 380 390 400
DEMVGASFLL TFQIPTEHQD LQDVEDRVDT FKAFSKKMDD SVLQLSTVAS
410 420 430 440 450
ELVRKHVGGF RKEFQKLGSA FQAISHSFQM DPPFCSEALN SAISHTGRTY
460 470 480 490 500
EAIGEMFAEQ PKNDLFQMLD TLSLYQGLLS NFPDIIHLQK GAFAKVKESQ
510 520 530 540 550
RMSDEGRMVQ DEADGIRRRC RVVGFALQAE MNHFHQRREL DFKHMMQNYL
560 570
RQQILFYQRV GQQLEKTLRM YDNL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BPR3 | H3BPR3_HUMAN | Sorting nexin-33 | SNX33 | 283 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF219141 mRNA Translation: ABN09670.1 EF653821 mRNA Translation: ABV26009.1 AL833039 mRNA Translation: CAH56299.1 CH471136 Genomic DNA Translation: EAW99243.1 BC018775 mRNA Translation: AAH18775.1 |
CCDSi | CCDS10283.1 |
RefSeqi | NP_001305075.1, NM_001318146.1 NP_695003.1, NM_153271.1 |
Genome annotation databases
Ensembli | ENST00000308527; ENSP00000311427; ENSG00000173548 |
GeneIDi | 257364 |
KEGGi | hsa:257364 |
MANE-Selecti | ENST00000308527.6; ENSP00000311427.6; NM_153271.2; NP_695003.1 |
UCSCi | uc002bau.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF219141 mRNA Translation: ABN09670.1 EF653821 mRNA Translation: ABV26009.1 AL833039 mRNA Translation: CAH56299.1 CH471136 Genomic DNA Translation: EAW99243.1 BC018775 mRNA Translation: AAH18775.1 |
CCDSi | CCDS10283.1 |
RefSeqi | NP_001305075.1, NM_001318146.1 NP_695003.1, NM_153271.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4AKV | X-ray | 2.65 | A/B | 212-574 | [»] | |
SMRi | Q8WV41 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 129214, 54 interactors |
IntActi | Q8WV41, 41 interactors |
MINTi | Q8WV41 |
STRINGi | 9606.ENSP00000311427 |
PTM databases
iPTMneti | Q8WV41 |
PhosphoSitePlusi | Q8WV41 |
Genetic variation databases
BioMutai | SNX33 |
DMDMi | 74751538 |
Proteomic databases
EPDi | Q8WV41 |
jPOSTi | Q8WV41 |
MassIVEi | Q8WV41 |
MaxQBi | Q8WV41 |
PaxDbi | Q8WV41 |
PeptideAtlasi | Q8WV41 |
PRIDEi | Q8WV41 |
ProteomicsDBi | 74746 |
Protocols and materials databases
Antibodypediai | 27355, 132 antibodies from 22 providers |
DNASUi | 257364 |
Genome annotation databases
Ensembli | ENST00000308527; ENSP00000311427; ENSG00000173548 |
GeneIDi | 257364 |
KEGGi | hsa:257364 |
MANE-Selecti | ENST00000308527.6; ENSP00000311427.6; NM_153271.2; NP_695003.1 |
UCSCi | uc002bau.4, human |
Organism-specific databases
CTDi | 257364 |
GeneCardsi | SNX33 |
HGNCi | HGNC:28468, SNX33 |
HPAi | ENSG00000173548, Low tissue specificity |
MIMi | 619107, gene |
neXtProti | NX_Q8WV41 |
OpenTargetsi | ENSG00000173548 |
PharmGKBi | PA162404345 |
VEuPathDBi | HostDB:ENSG00000173548 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2528, Eukaryota |
GeneTreei | ENSGT00940000160162 |
HOGENOMi | CLU_021494_3_0_1 |
InParanoidi | Q8WV41 |
OMAi | KHMMQSY |
OrthoDBi | 811995at2759 |
PhylomeDBi | Q8WV41 |
TreeFami | TF314082 |
Enzyme and pathway databases
PathwayCommonsi | Q8WV41 |
SignaLinki | Q8WV41 |
Miscellaneous databases
BioGRID-ORCSi | 257364, 15 hits in 1045 CRISPR screens |
ChiTaRSi | SNX33, human |
GenomeRNAii | 257364 |
Pharosi | Q8WV41, Tbio |
PROi | PR:Q8WV41 |
RNActi | Q8WV41, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173548, Expressed in lower esophagus mucosa and 208 other tissues |
ExpressionAtlasi | Q8WV41, baseline and differential |
Genevisiblei | Q8WV41, HS |
Family and domain databases
CDDi | cd07669, BAR_SNX33, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR001683, PX_dom IPR036871, PX_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR028642, SNX33 IPR037427, SNX33_BAR IPR014536, Snx9_fam IPR019497, Sorting_nexin_WASP-bd-dom |
PANTHERi | PTHR45827:SF3, PTHR45827:SF3, 1 hit |
Pfami | View protein in Pfam PF10456, BAR_3_WASP_bdg, 1 hit PF00787, PX, 1 hit PF14604, SH3_9, 1 hit |
PIRSFi | PIRSF027744, Snx9, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SNX33_HUMAN | |
Accessioni | Q8WV41Primary (citable) accession number: Q8WV41 Secondary accession number(s): B1NM17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families