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Protein

Sorting nexin-33

Gene

SNX33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.6 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphatidylinositol binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-33
Alternative name(s):
SH3 and PX domain-containing protein 3
Gene namesi
Name:SNX33
Synonyms:SH3PX3, SH3PXD3C, SNX30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000173548.8
HGNCiHGNC:28468 SNX33
neXtProtiNX_Q8WV41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173548
PharmGKBiPA162404345

Polymorphism and mutation databases

BioMutaiSNX33
DMDMi74751538

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119481 – 574Sorting nexin-33Add BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WV41
MaxQBiQ8WV41
PaxDbiQ8WV41
PeptideAtlasiQ8WV41
PRIDEiQ8WV41
ProteomicsDBi74746

PTM databases

iPTMnetiQ8WV41
PhosphoSitePlusiQ8WV41

Expressioni

Tissue specificityi

Detected in heart and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000173548 Expressed in 194 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SNX30
HS_SNX33
ExpressionAtlasiQ8WV41 baseline and differential
GenevisibleiQ8WV41 HS

Organism-specific databases

HPAiHPA040988

Interactioni

Subunit structurei

Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL.6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129214, 17 interactors
IntActiQ8WV41, 17 interactors
MINTiQ8WV41
STRINGi9606.ENSP00000311427

Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WV41
SMRiQ8WV41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61SH3PROSITE-ProRule annotationAdd BLAST61
Domaini230 – 340PXPROSITE-ProRule annotationAdd BLAST111
Domaini371 – 574BARAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi112 – 122Poly-AspAdd BLAST11

Domaini

The PX and BAR domains mediate association with membranes and are required for membrane tubulation.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2528 Eukaryota
ENOG410XPHZ LUCA
GeneTreeiENSGT00510000046469
HOGENOMiHOG000261633
HOVERGENiHBG009996
InParanoidiQ8WV41
KOiK17923
OMAiGSMVGRN
OrthoDBiEOG091G07IM
PhylomeDBiQ8WV41
TreeFamiTF314082

Family and domain databases

CDDicd07669 BAR_SNX33, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028642 SNX33
IPR037427 SNX33_BAR
IPR014536 Snx9_fam
IPR039358 Sorting_nexin-like
IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERiPTHR10555 PTHR10555, 1 hit
PTHR10555:SF121 PTHR10555:SF121, 1 hit
PfamiView protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit
PIRSFiPIRSF027744 Snx9, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8WV41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKGRALYD FHSENKEEIS IQQDEDLVIF SETSLDGWLQ GQNSRGETGL
60 70 80 90 100
FPASYVEIVR SGISTNHADY SSSPAGSPGA QVSLYNSPSV ASPARSGGGS
110 120 130 140 150
GFLSNQGSFE EDDDDDWDDW DDGCTVVEEP RAGGLGTNGH PPLNLSYPGA
160 170 180 190 200
YPSQHMAFRP KPPLERQDSL ASAKRGSVVG RNLNRFSCFV RSGVEAFILG
210 220 230 240 250
DVPMMAKIAE TYSIEMGPRG PQWKANPHPF ACSVEDPTKQ TKFKGIKSYI
260 270 280 290 300
SYKLTPTHAA SPVYRRYKHF DWLYNRLLHK FTVISVPHLP EKQATGRFEE
310 320 330 340 350
DFIEKRKRRL ILWMDHMTSH PVLSQYEGFQ HFLSCLDDKQ WKMGKRRAEK
360 370 380 390 400
DEMVGASFLL TFQIPTEHQD LQDVEDRVDT FKAFSKKMDD SVLQLSTVAS
410 420 430 440 450
ELVRKHVGGF RKEFQKLGSA FQAISHSFQM DPPFCSEALN SAISHTGRTY
460 470 480 490 500
EAIGEMFAEQ PKNDLFQMLD TLSLYQGLLS NFPDIIHLQK GAFAKVKESQ
510 520 530 540 550
RMSDEGRMVQ DEADGIRRRC RVVGFALQAE MNHFHQRREL DFKHMMQNYL
560 570
RQQILFYQRV GQQLEKTLRM YDNL
Length:574
Mass (Da):65,265
Last modified:March 1, 2002 - v1
Checksum:i7CE51C0F35DDBC3C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPR3H3BPR3_HUMAN
Sorting nexin-33
SNX33
283Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF219141 mRNA Translation: ABN09670.1
EF653821 mRNA Translation: ABV26009.1
AL833039 mRNA Translation: CAH56299.1
CH471136 Genomic DNA Translation: EAW99243.1
BC018775 mRNA Translation: AAH18775.1
CCDSiCCDS10283.1
RefSeqiNP_001305075.1, NM_001318146.1
NP_695003.1, NM_153271.1
UniGeneiHs.8705

Genome annotation databases

EnsembliENST00000308527; ENSP00000311427; ENSG00000173548
GeneIDi257364
KEGGihsa:257364
UCSCiuc002bau.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF219141 mRNA Translation: ABN09670.1
EF653821 mRNA Translation: ABV26009.1
AL833039 mRNA Translation: CAH56299.1
CH471136 Genomic DNA Translation: EAW99243.1
BC018775 mRNA Translation: AAH18775.1
CCDSiCCDS10283.1
RefSeqiNP_001305075.1, NM_001318146.1
NP_695003.1, NM_153271.1
UniGeneiHs.8705

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AKVX-ray2.65A/B212-574[»]
ProteinModelPortaliQ8WV41
SMRiQ8WV41
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129214, 17 interactors
IntActiQ8WV41, 17 interactors
MINTiQ8WV41
STRINGi9606.ENSP00000311427

PTM databases

iPTMnetiQ8WV41
PhosphoSitePlusiQ8WV41

Polymorphism and mutation databases

BioMutaiSNX33
DMDMi74751538

Proteomic databases

EPDiQ8WV41
MaxQBiQ8WV41
PaxDbiQ8WV41
PeptideAtlasiQ8WV41
PRIDEiQ8WV41
ProteomicsDBi74746

Protocols and materials databases

DNASUi257364
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308527; ENSP00000311427; ENSG00000173548
GeneIDi257364
KEGGihsa:257364
UCSCiuc002bau.4 human

Organism-specific databases

CTDi257364
EuPathDBiHostDB:ENSG00000173548.8
GeneCardsiSNX33
H-InvDBiHIX0012446
HGNCiHGNC:28468 SNX33
HPAiHPA040988
neXtProtiNX_Q8WV41
OpenTargetsiENSG00000173548
PharmGKBiPA162404345
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2528 Eukaryota
ENOG410XPHZ LUCA
GeneTreeiENSGT00510000046469
HOGENOMiHOG000261633
HOVERGENiHBG009996
InParanoidiQ8WV41
KOiK17923
OMAiGSMVGRN
OrthoDBiEOG091G07IM
PhylomeDBiQ8WV41
TreeFamiTF314082

Miscellaneous databases

ChiTaRSiSNX33 human
GenomeRNAii257364
PROiPR:Q8WV41

Gene expression databases

BgeeiENSG00000173548 Expressed in 194 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SNX30
HS_SNX33
ExpressionAtlasiQ8WV41 baseline and differential
GenevisibleiQ8WV41 HS

Family and domain databases

CDDicd07669 BAR_SNX33, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028642 SNX33
IPR037427 SNX33_BAR
IPR014536 Snx9_fam
IPR039358 Sorting_nexin-like
IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERiPTHR10555 PTHR10555, 1 hit
PTHR10555:SF121 PTHR10555:SF121, 1 hit
PfamiView protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit
PIRSFiPIRSF027744 Snx9, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX33_HUMAN
AccessioniPrimary (citable) accession number: Q8WV41
Secondary accession number(s): B1NM17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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