UniProtKB - Q8WV41 (SNX33_HUMAN)

BLAST

>sp|Q8WV41|SNX33_HUMAN Sorting nexin-33 OS=Homo sapiens OX=9606 GN=SNX33 PE=1 SV=1
MALKGRALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIVR
SGISTNHADYSSSPAGSPGAQVSLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDW
DDGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVG
RNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQ
TKFKGIKSYISYKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEE
DFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLL
TFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSA
FQAISHSFQMDPPFCSEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLS
NFPDIIHLQKGAFAKVKESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMNHFHQRREL
DFKHMMQNYLRQQILFYQRVGQQLEKTLRMYDNL

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History
Entry version 147 (12 Sep 2018)
Sequence version 1 (01 Mar 2002)
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Protein

Sorting nexin-33

Gene

SNX33

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.6 Publications

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19487689
- 23085988
phosphatidylinositol binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cleavage furrow formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22718350
endocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22718350
endosomal transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22718350
endosome organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21048941
intracellular protein transport Source: InterPro
macropinocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21048941
mitotic cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22718350
negative regulation of endocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 18353773
- 18419754
negative regulation of protein localization to cell surface
Source: UniProtKB
Inferred from direct assayⁱ
- 18419754
plasma membrane tubulation
Source: UniProtKB
Inferred from direct assayⁱ
- 20964629
positive regulation of membrane protein ectodomain proteolysis
Source: UniProtKB
Inferred from direct assayⁱ
- 18353773
- 18419754
positive regulation of protein localization to cell surface
Source: UniProtKB
Inferred from direct assayⁱ
- 18353773
protein import
Source: UniProtKB
Inferred from direct assayⁱ
- 18353773
- 18419754

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

Biological process

Cell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sorting nexin-33 Alternative name(s): SH3 and PX domain-containing protein 3
Gene namesⁱ	Name:SNX33 Synonyms:SH3PX3, SH3PXD3C, SNX30
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173548.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28468 SNX33
neXtProtⁱ	NX_Q8WV41

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000173548
PharmGKBⁱ	PA162404345

Polymorphism and mutation databases

BioMutaⁱ	SNX33
DMDMⁱ	74751538

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000311948	1 – 574	Sorting nexin-33Add BLAST		574

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	77	PhosphoserineCombined sources		1
Modified residueⁱ	92	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8WV41
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WV41
PaxDbⁱ	Q8WV41
PeptideAtlas More...PeptideAtlasⁱ	Q8WV41
PRIDEⁱ	Q8WV41
ProteomicsDBⁱ	74746

PTM databases

iPTMnetⁱ	Q8WV41
PhosphoSitePlusⁱ	Q8WV41

Expressionⁱ

Tissue specificityⁱ

Detected in heart and pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000173548 Expressed in 194 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SNX30 HS_SNX33
ExpressionAtlasⁱ	Q8WV41 baseline and differential
Genevisibleⁱ	Q8WV41 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040988

HPAⁱ

HPA040988

Interactionⁱ

Subunit structureⁱ

Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		2	EBI-2481535,EBI-2481535
ADAM15	Q13444	2	EBI-2481535,EBI-77818
DNM1	Q05193	2	EBI-2481535,EBI-713135
FASLG	P48023	2	EBI-2481535,EBI-495538
NAF1	Q96HR8	3	EBI-2481535,EBI-2515597
SNX9	Q9Y5X1	2	EBI-2481535,EBI-77848
WAS	P42768	3	EBI-2481535,EBI-346375

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19487689
- 23085988

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	129214, 17 interactors
IntActⁱ	Q8WV41, 17 interactors
Molecular INTeraction database More...MINTⁱ	Q8WV41
STRINGⁱ	9606.ENSP00000311427

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	213 – 215	Combined sources	3
Beta strandⁱ	220 – 223	Combined sources	4
Beta strandⁱ	232 – 235	Combined sources	4
Beta strandⁱ	252 – 256	Combined sources	5
Beta strandⁱ	259 – 261	Combined sources	3
Beta strandⁱ	263 – 265	Combined sources	3
Helixⁱ	267 – 280	Combined sources	14
Beta strandⁱ	282 – 284	Combined sources	3
Turnⁱ	302 – 304	Combined sources	3
Helixⁱ	305 – 318	Combined sources	14
Helixⁱ	323 – 325	Combined sources	3
Helixⁱ	327 – 333	Combined sources	7
Helixⁱ	339 – 349	Combined sources	11
Helixⁱ	355 – 360	Combined sources	6
Helixⁱ	371 – 407	Combined sources	37
Helixⁱ	409 – 427	Combined sources	19
Helixⁱ	432 – 434	Combined sources	3
Helixⁱ	437 – 459	Combined sources	23
Helixⁱ	460 – 462	Combined sources	3
Helixⁱ	465 – 504	Combined sources	40
Helixⁱ	510 – 568	Combined sources	59
Helixⁱ	569 – 571	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8WV41
SMRⁱ	Q8WV41
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 61	SH3PROSITE-ProRule annotationAdd BLAST	61
Domainⁱ	230 – 340	PXPROSITE-ProRule annotationAdd BLAST	111
Domainⁱ	371 – 574	BARAdd BLAST	204

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	112 – 122	Poly-AspAdd BLAST		11

Domainⁱ

The PX and BAR domains mediate association with membranes and are required for membrane tubulation.1 Publication

Sequence similaritiesⁱ

Belongs to the sorting nexin family.Curated

Keywords - Domainⁱ

SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG2528 Eukaryota ENOG410XPHZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046469
HOGENOMⁱ	HOG000261633
HOVERGENⁱ	HBG009996
InParanoidⁱ	Q8WV41
KEGG Orthology (KO) More...KOⁱ	K17923
OMAⁱ	GSMVGRN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07IM
PhylomeDBⁱ	Q8WV41
TreeFamⁱ	TF314082

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07669 BAR_SNX33, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 3.30.1520.10, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR001683 Phox IPR036871 PX_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR028642 SNX33 IPR037427 SNX33_BAR IPR014536 Snx9_fam IPR039358 Sorting_nexin-like IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERⁱ	PTHR10555 PTHR10555, 1 hit PTHR10555:SF121 PTHR10555:SF121, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10456 BAR_3_WASP_bdg, 1 hit PF00787 PX, 1 hit PF14604 SH3_9, 1 hit
PIRSFⁱ	PIRSF027744 Snx9, 1 hit
SMARTⁱ	View protein in SMART SM00312 PX, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF64268 SSF64268, 1 hit
PROSITEⁱ	View protein in PROSITE PS50195 PX, 1 hit PS50002 SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8WV41-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALKGRALYD FHSENKEEIS IQQDEDLVIF SETSLDGWLQ GQNSRGETGL 
        60         70         80         90        100
FPASYVEIVR SGISTNHADY SSSPAGSPGA QVSLYNSPSV ASPARSGGGS 
       110        120        130        140        150
GFLSNQGSFE EDDDDDWDDW DDGCTVVEEP RAGGLGTNGH PPLNLSYPGA 
       160        170        180        190        200
YPSQHMAFRP KPPLERQDSL ASAKRGSVVG RNLNRFSCFV RSGVEAFILG 
       210        220        230        240        250
DVPMMAKIAE TYSIEMGPRG PQWKANPHPF ACSVEDPTKQ TKFKGIKSYI 
       260        270        280        290        300
SYKLTPTHAA SPVYRRYKHF DWLYNRLLHK FTVISVPHLP EKQATGRFEE 
       310        320        330        340        350
DFIEKRKRRL ILWMDHMTSH PVLSQYEGFQ HFLSCLDDKQ WKMGKRRAEK 
       360        370        380        390        400
DEMVGASFLL TFQIPTEHQD LQDVEDRVDT FKAFSKKMDD SVLQLSTVAS 
       410        420        430        440        450
ELVRKHVGGF RKEFQKLGSA FQAISHSFQM DPPFCSEALN SAISHTGRTY 
       460        470        480        490        500
EAIGEMFAEQ PKNDLFQMLD TLSLYQGLLS NFPDIIHLQK GAFAKVKESQ 
       510        520        530        540        550
RMSDEGRMVQ DEADGIRRRC RVVGFALQAE MNHFHQRREL DFKHMMQNYL 
       560        570 
RQQILFYQRV GQQLEKTLRM YDNL

Length:574

Mass (Da):65,265

Last modified:March 1, 2002 - v1

Checksum:ⁱ7CE51C0F35DDBC3C

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BPR3	H3BPR3_HUMAN		Sorting nexin-33 Sorting nexin-33	SNX33	283	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF219141 mRNA Translation: ABN09670.1 EF653821 mRNA Translation: ABV26009.1 AL833039 mRNA Translation: CAH56299.1 CH471136 Genomic DNA Translation: EAW99243.1 BC018775 mRNA Translation: AAH18775.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10283.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305075.1, NM_001318146.1 NP_695003.1, NM_153271.1
UniGeneⁱ	Hs.8705

Genome annotation databases

Ensemblⁱ	ENST00000308527; ENSP00000311427; ENSG00000173548
GeneIDⁱ	257364
KEGGⁱ	hsa:257364
UCSC genome browser More...UCSCⁱ	uc002bau.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WV41	Sorting nexin-33		MOUSE		574	UniRef90_Q8WV41
Sorting nexin		CANLF		595
Sorting nexin		CERAT		588
Sorting nexin		RHIRO		575
Sorting nexin		PHYCD		575
+112

Protein	Similar proteins		Species	Score	Length	Source
Q8WV41	Sorting nexin-33		MOUSE		574	UniRef50_Q8WV41
Sorting nexin		CANLF		595
Sorting nexin		CERAT		588
Sorting nexin		RHIRO		575
Sorting nexin		PHYCD		575
+134

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF219141 mRNA Translation: ABN09670.1 EF653821 mRNA Translation: ABV26009.1 AL833039 mRNA Translation: CAH56299.1 CH471136 Genomic DNA Translation: EAW99243.1 BC018775 mRNA Translation: AAH18775.1
CCDSⁱ	CCDS10283.1
RefSeqⁱ	NP_001305075.1, NM_001318146.1 NP_695003.1, NM_153271.1
UniGeneⁱ	Hs.8705

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4AKV	X-ray	2.65	A/B	212-574	[»]
ProteinModelPortalⁱ	Q8WV41
SMRⁱ	Q8WV41
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129214, 17 interactors
IntActⁱ	Q8WV41, 17 interactors
MINTⁱ	Q8WV41
STRINGⁱ	9606.ENSP00000311427

PTM databases

iPTMnetⁱ	Q8WV41
PhosphoSitePlusⁱ	Q8WV41

Polymorphism and mutation databases

BioMutaⁱ	SNX33
DMDMⁱ	74751538

Proteomic databases

EPDⁱ	Q8WV41
MaxQBⁱ	Q8WV41
PaxDbⁱ	Q8WV41
PeptideAtlasⁱ	Q8WV41
PRIDEⁱ	Q8WV41
ProteomicsDBⁱ	74746

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	257364
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308527; ENSP00000311427; ENSG00000173548
GeneIDⁱ	257364
KEGGⁱ	hsa:257364
UCSCⁱ	uc002bau.4 human

Organism-specific databases

CTDⁱ	257364
EuPathDBⁱ	HostDB:ENSG00000173548.8
GeneCardsⁱ	SNX33
H-InvDBⁱ	HIX0012446
HGNCⁱ	HGNC:28468 SNX33
HPAⁱ	HPA040988
neXtProtⁱ	NX_Q8WV41
OpenTargetsⁱ	ENSG00000173548
PharmGKBⁱ	PA162404345
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2528 Eukaryota ENOG410XPHZ LUCA
GeneTreeⁱ	ENSGT00510000046469
HOGENOMⁱ	HOG000261633
HOVERGENⁱ	HBG009996
InParanoidⁱ	Q8WV41
KOⁱ	K17923
OMAⁱ	GSMVGRN
OrthoDBⁱ	EOG091G07IM
PhylomeDBⁱ	Q8WV41
TreeFamⁱ	TF314082

Miscellaneous databases

ChiTaRSⁱ	SNX33 human
GenomeRNAiⁱ	257364
Protein Ontology More...PROⁱ	PR:Q8WV41

Gene expression databases

Bgeeⁱ	ENSG00000173548 Expressed in 194 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SNX30 HS_SNX33
ExpressionAtlasⁱ	Q8WV41 baseline and differential
Genevisibleⁱ	Q8WV41 HS

Family and domain databases

CDDⁱ	cd07669 BAR_SNX33, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 3.30.1520.10, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR001683 Phox IPR036871 PX_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR028642 SNX33 IPR037427 SNX33_BAR IPR014536 Snx9_fam IPR039358 Sorting_nexin-like IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERⁱ	PTHR10555 PTHR10555, 1 hit PTHR10555:SF121 PTHR10555:SF121, 1 hit
Pfamⁱ	View protein in Pfam PF10456 BAR_3_WASP_bdg, 1 hit PF00787 PX, 1 hit PF14604 SH3_9, 1 hit
PIRSFⁱ	PIRSF027744 Snx9, 1 hit
SMARTⁱ	View protein in SMART SM00312 PX, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF64268 SSF64268, 1 hit
PROSITEⁱ	View protein in PROSITE PS50195 PX, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNX33_HUMAN
Accessionⁱ	Q8WV41Primary (citable) accession number: Q8WV41 Secondary accession number(s): B1NM17
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
	Last sequence update:	March 1, 2002
	Last modified:	September 12, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - Q8WV41 (SNX33_HUMAN)

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Sorting nexin-33

SNX33

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ