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Protein

Pleckstrin homology-like domain family A member 1

Gene

PHLDA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.2 Publications

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-8854521 Interaction between PHLDA1 and AURKA

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family A member 1
Alternative name(s):
Apoptosis-associated nuclear protein
Proline- and glutamine-rich protein
Short name:
PQ-rich protein
Short name:
PQR protein
Proline- and histidine-rich protein
T-cell death-associated gene 51 protein
Gene namesi
Name:PHLDA1
Synonyms:PHRIP, TDAG51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139289.13
HGNCiHGNC:8933 PHLDA1
MIMi605335 gene
neXtProtiNX_Q8WV24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22822
OpenTargetsiENSG00000139289
PharmGKBiPA33274

Polymorphism and mutation databases

BioMutaiPHLDA1
DMDMi229463035

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538971 – 401Pleckstrin homology-like domain family A member 1Add BLAST401

Proteomic databases

EPDiQ8WV24
MaxQBiQ8WV24
PaxDbiQ8WV24
PeptideAtlasiQ8WV24
PRIDEiQ8WV24
ProteomicsDBi74739

PTM databases

iPTMnetiQ8WV24
PhosphoSitePlusiQ8WV24

Expressioni

Tissue specificityi

Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).2 Publications

Inductioni

Induced by homocysteine and other endoplasmic reticulum stress-inducing reagents. Induced by phorbol ester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells.1 Publication

Gene expression databases

BgeeiENSG00000139289
CleanExiHS_PHLDA1
ExpressionAtlasiQ8WV24 baseline and differential
GenevisibleiQ8WV24 HS

Organism-specific databases

HPAiCAB016160
HPA019000
HPA063520

Interactioni

Subunit structurei

Interacts with RPL14, EIF3S7 and PABPC4.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116498, 13 interactors
IntActiQ8WV24, 9 interactors
STRINGi9606.ENSP00000266671

Structurei

3D structure databases

ProteinModelPortaliQ8WV24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 283PHAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni311 – 34615 X 2 AA repeats of P-QAdd BLAST36
Regioni352 – 38914 X 2 AA repeats of P-HAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 204Poly-GlnAdd BLAST18

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXHQ Eukaryota
ENOG4111IXF LUCA
GeneTreeiENSGT00440000039564
HOVERGENiHBG108249
InParanoidiQ8WV24
OMAiQPHGHRL
OrthoDBiEOG091G0FTL
PhylomeDBiQ8WV24
TreeFamiTF332320

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
SMARTiView protein in SMART
SM00233 PH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WV24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAPAAERL LELGFPPRCG RQEPPFPLGV TRGWGRWPIQ KRREGARPVP
60 70 80 90 100
FSERSQEDGR GPAARSSGTL WRIRTRLSLC RDPEPPPPLC LLRVSLLCAL
110 120 130 140 150
RAGGRGSRWG EDGARLLLLP PARAAGNGEA EPSGGPSYAG RMLESSGCKA
160 170 180 190 200
LKEGVLEKRS DGLLQLWKKK CCILTEEGLL LIPPKQLQHQ QQQQQQQQQQ
210 220 230 240 250
QQQQPGQGPA EPSQPSGPAV ASLEPPVKLK ELHFSNMKTV DCVERKGKYM
260 270 280 290 300
YFTVVMAEGK EIDFRCPQDQ GWNAEITLQM VQYKNRQAIL AVKSTRQKQQ
310 320 330 340 350
HLVQQQPPSQ PQPQPQLQPQ PQPQPQPQPQ PQSQPQPQPQ PKPQPQQLHP
360 370 380 390 400
YPHPHPHPHS HPHSHPHPHP HPHPHQIPHP HPQPHSQPHG HRLLRSTSNS

A
Length:401
Mass (Da):45,016
Last modified:May 5, 2009 - v4
Checksum:i1E01E7F75116A517
GO

Sequence cautioni

The sequence AAH18929 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI10821 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI26426 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204Missing in AAF64165 (PubMed:10894922).Curated1
Sequence conflicti204Missing in CAA90576 (Ref. 2) Curated1
Sequence conflicti204Missing (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239986 Genomic DNA Translation: AAF64165.1
Z50194 mRNA Translation: CAA90576.1
BC018929 mRNA Translation: AAH18929.3 Different initiation.
BC110820 mRNA Translation: AAI10821.1 Different initiation.
BC126425 mRNA Translation: AAI26426.2 Different initiation.
AF220656 mRNA Translation: AAF36387.1
CCDSiCCDS31861.1
PIRiS58222
RefSeqiNP_031376.3, NM_007350.3
UniGeneiHs.602085

Genome annotation databases

EnsembliENST00000266671; ENSP00000266671; ENSG00000139289
ENST00000619060; ENSP00000480767; ENSG00000139289
GeneIDi22822
KEGGihsa:22822
UCSCiuc001sxu.3 human

Similar proteinsi

Entry informationi

Entry nameiPHLA1_HUMAN
AccessioniPrimary (citable) accession number: Q8WV24
Secondary accession number(s): A1A4G9
, Q15184, Q2TAN2, Q9NZ17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 122 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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