NSMCE1

Functionⁱ

RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:29225034, PubMed:20864041). NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888). MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors (PubMed:29225034).3 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	191 – 232	RING-type; atypicalPROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
protein dimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27427983
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20864041

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

double-strand break repair via homologous recombination Source: GO_Central
intracellular signal transduction Source: InterPro
positive regulation of response to DNA damage stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18086888
postreplication repair Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	DNA damage, DNA recombination, DNA repair, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Reactomeⁱ

R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Non-structural maintenance of chromosomes element 1 homolog (EC:2.3.2.272 Publications) Short name: Non-SMC element 1 homolog
Gene namesⁱ	Name:NSMCE1Imported ORF Names:HSPC333, HSPC337
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169189.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29897 NSMCE1
MIMⁱ	617263 gene
neXtProtⁱ	NX_Q8WV22

Keywords - Cellular componentⁱ

Chromosome, Nucleus, Telomere

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000169189
PharmGKBⁱ	PA134943761

Polymorphism and mutation databases

BioMutaⁱ	NSMCE1
DMDMⁱ	209572785

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000270944	1 – 266	Non-structural maintenance of chromosomes element 1 homologAdd BLAST		266

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	251	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Ubiquitinated.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8WV22
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WV22
PaxDbⁱ	Q8WV22
PeptideAtlas More...PeptideAtlasⁱ	Q8WV22
PRIDEⁱ	Q8WV22
ProteomicsDBⁱ	74738

PTM databases

iPTMnetⁱ	Q8WV22
PhosphoSitePlusⁱ	Q8WV22

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000169189 Expressed in 202 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_NSMCE1
ExpressionAtlasⁱ	Q8WV22 baseline and differential
Genevisibleⁱ	Q8WV22 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041567 HPA043091

HPAⁱ

HPA041567
HPA043091

Interactionⁱ

Subunit structureⁱ

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5-SMC6 heterodimer (PubMed:18086888, PubMed:20864041). Interacts with NSMCE3 (PubMed:27427983). Interacts with MAGEF1 (PubMed:29225034).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NSMCE3	Q96MG7	15	EBI-2557372,EBI-2557356
SMC6	Q96SB8	9	EBI-2557372,EBI-605415

GO - Molecular functionⁱ

protein dimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27427983

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	128255, 19 interactors
IntActⁱ	Q8WV22, 12 interactors
STRINGⁱ	9606.ENSP00000355077

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	13 – 24	Combined sources	12
Beta strandⁱ	25 – 29	Combined sources	5
Helixⁱ	30 – 43	Combined sources	14
Helixⁱ	53 – 64	Combined sources	12
Helixⁱ	65 – 67	Combined sources	3
Beta strandⁱ	69 – 75	Combined sources	7
Turnⁱ	77 – 79	Combined sources	3
Beta strandⁱ	82 – 91	Combined sources	10
Helixⁱ	95 – 98	Combined sources	4
Helixⁱ	103 – 118	Combined sources	16
Beta strandⁱ	119 – 122	Combined sources	4
Helixⁱ	126 – 130	Combined sources	5
Helixⁱ	131 – 133	Combined sources	3
Beta strandⁱ	137 – 139	Combined sources	3
Helixⁱ	143 – 155	Combined sources	13
Beta strandⁱ	158 – 162	Combined sources	5
Beta strandⁱ	165 – 168	Combined sources	4
Helixⁱ	170 – 183	Combined sources	14
Turnⁱ	185 – 187	Combined sources	3
Beta strandⁱ	189 – 191	Combined sources	3
Turnⁱ	192 – 194	Combined sources	3
Beta strandⁱ	197 – 200	Combined sources	4
Beta strandⁱ	205 – 207	Combined sources	3
Helixⁱ	213 – 219	Combined sources	7
Turnⁱ	220 – 222	Combined sources	3
Turnⁱ	229 – 231	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8WV22
SMRⁱ	Q8WV22
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8WV22

EvolutionaryTraceⁱ

Q8WV22

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 102	Interaction with NSMCE31 PublicationAdd BLAST		102

Sequence similaritiesⁱ

Belongs to the NSE1 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	191 – 232	RING-type; atypicalPROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4718 Eukaryota ENOG4111RNS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009084
HOGENOMⁱ	HOG000006778
HOVERGENⁱ	HBG082058
InParanoidⁱ	Q8WV22
KEGG Orthology (KO) More...KOⁱ	K22817
OMAⁱ	NKWLIEK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JE5
PhylomeDBⁱ	Q8WV22
TreeFamⁱ	TF314721

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd16493 RING-CH-C4HC3_NSE1, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011513 Nse1 IPR002219 PE/DAG-bd IPR036388 WH-like_DNA-bd_sf IPR001841 Znf_RING IPR014857 Znf_RING-like IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR20973 PTHR20973, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07574 SMC_Nse1, 1 hit PF08746 zf-RING-like, 1 hit
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

Q8WV22-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQGSTRRMGV MTDVHRRFLQ LLMTHGVLEE WDVKRLQTHC YKVHDRNATV 
        60         70         80         90        100
DKLEDFINNI NSVLESLYIE IKRGVTEDDG RPIYALVNLA TTSISKMATD 
       110        120        130        140        150
FAENELDLFR KALELIIDSE TGFASSTNIL NLVDQLKGKK MRKKEAEQVL 
       160        170        180        190        200
QKFVQNKWLI EKEGEFTLHG RAILEMEQYI RETYPDAVKI CNICHSLLIQ 
       210        220        230        240        250
GQSCETCGIR MHLPCVAKYF QSNAEPRCPH CNDYWPHEIP KVFDPEKERE 
       260 
SGVLKSNKKS LRSRQH

Length:266

Mass (Da):30,855

Last modified:October 14, 2008 - v5

Checksum:ⁱ58A3C2AF70FC8F39

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L1I3	I3L1I3_HUMAN	Non-structural maintenance of chrom... Non-structural maintenance of chromosomes element 1 homolog	NSMCE1	193	Annotation score:
H3BV05	H3BV05_HUMAN	Non-structural maintenance of chrom... Non-structural maintenance of chromosomes element 1 homolog	NSMCE1	78	Annotation score:
H3BSL0	H3BSL0_HUMAN	Non-structural maintenance of chrom... Non-structural maintenance of chromosomes element 1 homolog	NSMCE1	138	Annotation score:
H3BR73	H3BR73_HUMAN	Non-structural maintenance of chrom... Non-structural maintenance of chromosomes element 1 homolog	NSMCE1	144	Annotation score:
H3BN81	H3BN81_HUMAN	Non-structural maintenance of chrom... Non-structural maintenance of chromosomes element 1 homolog	NSMCE1	73	Annotation score:
H3BR31	H3BR31_HUMAN	Non-structural maintenance of chrom... Non-structural maintenance of chromosomes element 1 homolog	NSMCE1	70	Annotation score:

Sequence cautionⁱ

The sequence AAF29011 differs from that shown. Reason: Frameshift at several positions.Curated

The sequence AAF29015 differs from that shown. Reason: Frameshift at position 147.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029822	38	T → R. Corresponds to variant dbSNP:rs7195194Ensembl.		1
Natural variantⁱVAR_029823	47	N → S1 PublicationCorresponds to variant dbSNP:rs17856580Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF161451 mRNA Translation: AAF29011.1 Sequence problems. AF161455 mRNA Translation: AAF29015.1 Sequence problems. AC106739 Genomic DNA No translation available. CH471145 Genomic DNA Translation: EAW55756.1 CH471145 Genomic DNA Translation: EAW55757.1 BC018938 mRNA Translation: AAH18938.4
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10628.2
NCBI Reference Sequences More...RefSeqⁱ	NP_659547.2, NM_145080.3 XP_006721086.1, XM_006721023.3
UniGeneⁱ	Hs.284295

Genome annotation databases

Ensemblⁱ	ENST00000361439; ENSP00000355077; ENSG00000169189
GeneIDⁱ	197370
KEGGⁱ	hsa:197370
UCSC genome browser More...UCSCⁱ	uc002doi.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WV22	Non-structural maintenance of chromosomes element 1 homolog (Fragment)		HUMAN		73	UniRef100_Q8WV22
Non-structural maintenance of chromosomes element 1 homolog (Fragment)		HUMAN		138
Non-structural maintenance of chromosomes element 1 homolog (Fragment)		HUMAN		144
UPI0001E5ECC3		HUMAN		238
UPI00001A8399		HUMAN		170

Protein	Similar proteins		Species	Score	Length	Source
Q8WV22	Non-structural maintenance of chromosomes element 1 homolog		BOVIN		266	UniRef90_Q8WV22
Non-structural maintenance of chromosomes element 1 homolog		PONAB		266
Non-structural maintenance of chromosomes element 1 homolog (Fragment)		HUMAN		73
Uncharacterized protein		PIG		324
non-structural maintenance of chromosomes element 1 homolog isoform X2		DELLE		303
+58

Protein	Similar proteins		Species	Score	Length	Source
Q8WV22	Non-structural maintenance of chromosomes element 1 homolog		BOVIN		266	UniRef50_Q8WV22
Non-structural maintenance of chromosomes element 1 homolog		PONAB		266
Non-structural maintenance of chromosomes element 1 homolog (Fragment)		HUMAN		73
Uncharacterized protein		PIG		324
non-structural maintenance of chromosomes element 1 homolog isoform X2		DELLE		303
+66

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF161451 mRNA Translation: AAF29011.1 Sequence problems. AF161455 mRNA Translation: AAF29015.1 Sequence problems. AC106739 Genomic DNA No translation available. CH471145 Genomic DNA Translation: EAW55756.1 CH471145 Genomic DNA Translation: EAW55757.1 BC018938 mRNA Translation: AAH18938.4
CCDSⁱ	CCDS10628.2
RefSeqⁱ	NP_659547.2, NM_145080.3 XP_006721086.1, XM_006721023.3
UniGeneⁱ	Hs.284295

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CT0	NMR	-	A	181-241	[»]
	5HVQ	X-ray	2.92	C	9-246	[»]
	5WY5	X-ray	2.92	A	9-246	[»]
ProteinModelPortalⁱ	Q8WV22
SMRⁱ	Q8WV22
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128255, 19 interactors
IntActⁱ	Q8WV22, 12 interactors
STRINGⁱ	9606.ENSP00000355077

PTM databases

iPTMnetⁱ	Q8WV22
PhosphoSitePlusⁱ	Q8WV22

Polymorphism and mutation databases

BioMutaⁱ	NSMCE1
DMDMⁱ	209572785

Proteomic databases

EPDⁱ	Q8WV22
MaxQBⁱ	Q8WV22
PaxDbⁱ	Q8WV22
PeptideAtlasⁱ	Q8WV22
PRIDEⁱ	Q8WV22
ProteomicsDBⁱ	74738

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	197370
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361439; ENSP00000355077; ENSG00000169189
GeneIDⁱ	197370
KEGGⁱ	hsa:197370
UCSCⁱ	uc002doi.2 human

Organism-specific databases

CTDⁱ	197370
EuPathDBⁱ	HostDB:ENSG00000169189.16
GeneCardsⁱ	NSMCE1
H-InvDBⁱ	HIX0012912
HGNCⁱ	HGNC:29897 NSMCE1
HPAⁱ	HPA041567 HPA043091
MIMⁱ	617263 gene
neXtProtⁱ	NX_Q8WV22
OpenTargetsⁱ	ENSG00000169189
PharmGKBⁱ	PA134943761
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4718 Eukaryota ENOG4111RNS LUCA
GeneTreeⁱ	ENSGT00390000009084
HOGENOMⁱ	HOG000006778
HOVERGENⁱ	HBG082058
InParanoidⁱ	Q8WV22
KOⁱ	K22817
OMAⁱ	NKWLIEK
OrthoDBⁱ	EOG091G0JE5
PhylomeDBⁱ	Q8WV22
TreeFamⁱ	TF314721

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Reactomeⁱ

R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

ChiTaRSⁱ	NSMCE1 human
EvolutionaryTraceⁱ	Q8WV22
GenomeRNAiⁱ	197370
Protein Ontology More...PROⁱ	PR:Q8WV22
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169189 Expressed in 202 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_NSMCE1
ExpressionAtlasⁱ	Q8WV22 baseline and differential
Genevisibleⁱ	Q8WV22 HS

Family and domain databases

CDDⁱ	cd16493 RING-CH-C4HC3_NSE1, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011513 Nse1 IPR002219 PE/DAG-bd IPR036388 WH-like_DNA-bd_sf IPR001841 Znf_RING IPR014857 Znf_RING-like IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR20973 PTHR20973, 1 hit
Pfamⁱ	View protein in Pfam PF07574 SMC_Nse1, 1 hit PF08746 zf-RING-like, 1 hit
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NSE1_HUMAN
Accessionⁱ	Q8WV22Primary (citable) accession number: Q8WV22 Secondary accession number(s): D3DWF6, Q9P045, Q9P049
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	October 14, 2008
	Last modified:	October 10, 2018
	This is version 148 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8WV22 (NSE1_HUMAN)

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Non-structural maintenance of chromosomes element 1 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ