UniProtKB - Q8WV19 (SFT2A_HUMAN)
Protein
Vesicle transport protein SFT2A
Gene
SFT2D1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.By similarity
GO - Biological processi
- protein transport Source: UniProtKB-KW
- vesicle-mediated transport Source: InterPro
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8WV19 |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle transport protein SFT2AAlternative name(s): SFT2 domain-containing protein 1 pRGR1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198818.9 |
HGNCi | HGNC:21102, SFT2D1 |
neXtProti | NX_Q8WV19 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 37 – 57 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 58 – 62 | LumenalSequence analysis | 5 | |
Transmembranei | 63 – 83 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 84 – 97 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 98 – 118 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 122 | LumenalSequence analysis | 4 | |
Transmembranei | 123 – 143 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 159 | CytoplasmicSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198818 |
PharmGKBi | PA134962126 |
Miscellaneous databases
Pharosi | Q8WV19, Tdark |
Polymorphism and mutation databases
BioMutai | SFT2D1 |
DMDMi | 74751535 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000238607 | 1 – 159 | Vesicle transport protein SFT2AAdd BLAST | 159 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8WV19 |
jPOSTi | Q8WV19 |
MassIVEi | Q8WV19 |
MaxQBi | Q8WV19 |
PaxDbi | Q8WV19 |
PeptideAtlasi | Q8WV19 |
PRIDEi | Q8WV19 |
ProteomicsDBi | 74737 |
PTM databases
iPTMneti | Q8WV19 |
PhosphoSitePlusi | Q8WV19 |
SwissPalmi | Q8WV19 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198818, Expressed in pancreas and 220 other tissues |
Genevisiblei | Q8WV19, HS |
Organism-specific databases
HPAi | ENSG00000198818, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8WV19
Protein-protein interaction databases
BioGRIDi | 125243, 41 interactors |
IntActi | Q8WV19, 31 interactors |
STRINGi | 9606.ENSP00000354590 |
Miscellaneous databases
RNActi | Q8WV19, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SFT2 family.Sequence analysis
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2887, Eukaryota |
GeneTreei | ENSGT00390000018525 |
HOGENOMi | CLU_099529_2_2_1 |
InParanoidi | Q8WV19 |
OMAi | VFWWHKK |
OrthoDBi | 1476123at2759 |
PhylomeDBi | Q8WV19 |
TreeFami | TF315157 |
Family and domain databases
InterProi | View protein in InterPro IPR007305, Vesicle_transpt_Got1/SFT2 IPR011691, Vesicle_transpt_SFT2 |
PANTHERi | PTHR23137, PTHR23137, 1 hit |
Pfami | View protein in Pfam PF04178, Got1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WV19-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKLRRVLSG QDDEEQGLTA QVLDASSLSF NTRLKWFAIC FVCGVFFSIL
60 70 80 90 100
GTGLLWLPGG IKLFAVFYTL GNLAALASTC FLMGPVKQLK KMFEATRLLA
110 120 130 140 150
TIVMLLCFIF TLCAALWWHK KGLAVLFCIL QFLSMTWYSL SYIPYARDAV
IKCCSSLLS
Sequence cautioni
The sequence AAF18564 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | F → C in AAF18564 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034492 | 109 | I → V. Corresponds to variant dbSNP:rs11551053Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041429 mRNA Translation: AAF18564.1 Different initiation. AL022069 Genomic DNA No translation available. AL121956 Genomic DNA No translation available. BC018969 mRNA Translation: AAH18969.1 |
CCDSi | CCDS5292.1 |
RefSeqi | NP_660152.1, NM_145169.2 |
Genome annotation databases
Ensembli | ENST00000361731; ENSP00000354590; ENSG00000198818 |
GeneIDi | 113402 |
KEGGi | hsa:113402 |
UCSCi | uc003qux.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041429 mRNA Translation: AAF18564.1 Different initiation. AL022069 Genomic DNA No translation available. AL121956 Genomic DNA No translation available. BC018969 mRNA Translation: AAH18969.1 |
CCDSi | CCDS5292.1 |
RefSeqi | NP_660152.1, NM_145169.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125243, 41 interactors |
IntActi | Q8WV19, 31 interactors |
STRINGi | 9606.ENSP00000354590 |
PTM databases
iPTMneti | Q8WV19 |
PhosphoSitePlusi | Q8WV19 |
SwissPalmi | Q8WV19 |
Polymorphism and mutation databases
BioMutai | SFT2D1 |
DMDMi | 74751535 |
Proteomic databases
EPDi | Q8WV19 |
jPOSTi | Q8WV19 |
MassIVEi | Q8WV19 |
MaxQBi | Q8WV19 |
PaxDbi | Q8WV19 |
PeptideAtlasi | Q8WV19 |
PRIDEi | Q8WV19 |
ProteomicsDBi | 74737 |
Protocols and materials databases
Antibodypediai | 20056, 13 antibodies |
Genome annotation databases
Ensembli | ENST00000361731; ENSP00000354590; ENSG00000198818 |
GeneIDi | 113402 |
KEGGi | hsa:113402 |
UCSCi | uc003qux.4, human |
Organism-specific databases
CTDi | 113402 |
EuPathDBi | HostDB:ENSG00000198818.9 |
GeneCardsi | SFT2D1 |
HGNCi | HGNC:21102, SFT2D1 |
HPAi | ENSG00000198818, Low tissue specificity |
neXtProti | NX_Q8WV19 |
OpenTargetsi | ENSG00000198818 |
PharmGKBi | PA134962126 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2887, Eukaryota |
GeneTreei | ENSGT00390000018525 |
HOGENOMi | CLU_099529_2_2_1 |
InParanoidi | Q8WV19 |
OMAi | VFWWHKK |
OrthoDBi | 1476123at2759 |
PhylomeDBi | Q8WV19 |
TreeFami | TF315157 |
Enzyme and pathway databases
PathwayCommonsi | Q8WV19 |
Miscellaneous databases
BioGRID-ORCSi | 113402, 6 hits in 846 CRISPR screens |
ChiTaRSi | SFT2D1, human |
GenomeRNAii | 113402 |
Pharosi | Q8WV19, Tdark |
PROi | PR:Q8WV19 |
RNActi | Q8WV19, protein |
Gene expression databases
Bgeei | ENSG00000198818, Expressed in pancreas and 220 other tissues |
Genevisiblei | Q8WV19, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007305, Vesicle_transpt_Got1/SFT2 IPR011691, Vesicle_transpt_SFT2 |
PANTHERi | PTHR23137, PTHR23137, 1 hit |
Pfami | View protein in Pfam PF04178, Got1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SFT2A_HUMAN | |
Accessioni | Q8WV19Primary (citable) accession number: Q8WV19 Secondary accession number(s): Q5TI64, Q9UIC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations