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Entry version 149 (18 Sep 2019)
Sequence version 3 (17 Oct 2006)
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Protein

DDB1- and CUL4-associated factor 4

Gene

DCAF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8WV16

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 4
Alternative name(s):
WD repeat-containing protein 21A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCAF4
Synonyms:WDR21, WDR21A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20229 DCAF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616372 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WV16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26094

Open Targets

More...
OpenTargetsi
ENSG00000119599

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165478762

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WV16

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCAF4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242844

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513681 – 495DDB1- and CUL4-associated factor 4Add BLAST495

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WV16

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WV16

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WV16

PeptideAtlas

More...
PeptideAtlasi
Q8WV16

PRoteomics IDEntifications database

More...
PRIDEi
Q8WV16

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33399
70640
74734 [Q8WV16-1]
74735 [Q8WV16-2]
74736 [Q8WV16-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WV16

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WV16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119599 Expressed in 168 organ(s), highest expression level in skin of abdomen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WV16 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WV16 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047276

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DDB1 and CUL4A.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q165312EBI-2559135,EBI-350322

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117545, 31 interactors

Database of interacting proteins

More...
DIPi
DIP-48761N

Protein interaction database and analysis system

More...
IntActi
Q8WV16, 29 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351147

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1495
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WV16

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WV16

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati368 – 407WD 1Add BLAST40
Repeati410 – 451WD 2Add BLAST42

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2695 Eukaryota
ENOG410XQIU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WV16

KEGG Orthology (KO)

More...
KOi
K11799

Identification of Orthologs from Complete Genome Data

More...
OMAi
YNGCRSG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WV16

TreeFam database of animal gene trees

More...
TreeFami
TF332050

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WV16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKSRWQSRR RHGRRSHQQN PWFRLRDSED RSDSRAAQPA HDSGHGDDES
60 70 80 90 100
PSTSSGTAGT SSVPELPGFY FDPEKKRYFR LLPGHNNCNP LTKESIRQKE
110 120 130 140 150
MESKRLRLLQ EEDRRKKIAR MGFNASSMLR KSQLGFLNVT NYCHLAHELR
160 170 180 190 200
LSCMERKKVQ IRSMDPSALA SDRFNLILAD TNSDRLFTVN DVKVGGSKYG
210 220 230 240 250
IINLQSLKTP TLKVFMHENL YFTNRKVNSV CWASLNHLDS HILLCLMGLA
260 270 280 290 300
ETPGCATLLP ASLFVNSHPG IDRPGMLCSF RIPGAWSCAW SLNIQANNCF
310 320 330 340 350
STGLSRRVLL TNVVTGHRQS FGTNSDVLAQ QFALMAPLLF NGCRSGEIFA
360 370 380 390 400
IDLRCGNQGK GWKATRLFHD SAVTSVRILQ DEQYLMASDM AGKIKLWDLR
410 420 430 440 450
TTKCVRQYEG HVNEYAYLPL HVHEEEGILV AVGQDCYTRI WSLHDARLLR
460 470 480 490
TIPSPYPASK ADIPSVAFSS RLGGSRGAPG LLMAVGQDLY CYSYS
Length:495
Mass (Da):55,694
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF104B7F1FC6B5C33
GO
Isoform 2 (identifier: Q8WV16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     432-433: VG → GT
     434-495: Missing.

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):48,933
Checksum:i109E83E34CC003B2
GO
Isoform 3 (identifier: Q8WV16-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-178: Missing.
     269-269: P → PA

Note: No experimental confirmation available.
Show »
Length:435
Mass (Da):48,798
Checksum:iB1C5BAC49BDD9B60
GO
Isoform 4 (identifier: Q8WV16-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:395
Mass (Da):44,161
Checksum:i6BC9F63E4A6D85D3
GO
Isoform 5 (identifier: Q8WV16-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-269: P → PA
     329-335: Missing.

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):54,975
Checksum:i362DF3B15C3D7656
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86SY2Q86SY2_HUMAN
DDB1- and CUL4-associated factor 4
DCAF4
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3D6G3V3D6_HUMAN
DDB1- and CUL4-associated factor 4
DCAF4 WDR21A, hCG_21523
333Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCB5D6RCB5_HUMAN
DDB1- and CUL4-associated factor 4
DCAF4
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4S → G in CAB45748 (PubMed:17974005).Curated1
Sequence conflicti35R → Q in BAB55337 (PubMed:14702039).Curated1
Sequence conflicti45H → Y in BAB55337 (PubMed:14702039).Curated1
Sequence conflicti65E → G in BAB55337 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

An intronic G-to-A transition (rs2535913) has been associated with leukocyte telomere length. The minor A allele is associated with shorter telomeres and lower expression in lymphoblastoid cells and in sun-exposed skin (PubMed:25624462).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02790822W → C. Corresponds to variant dbSNP:rs2302588Ensembl.1
Natural variantiVAR_027909193K → T2 PublicationsCorresponds to variant dbSNP:rs17856582Ensembl.1
Natural variantiVAR_027910266N → S. Corresponds to variant dbSNP:rs7155812Ensembl.1
Natural variantiVAR_027911334L → F2 PublicationsCorresponds to variant dbSNP:rs17856583Ensembl.1
Natural variantiVAR_027912345S → C. Corresponds to variant dbSNP:rs3815460Ensembl.1
Natural variantiVAR_027913439R → I1 PublicationCorresponds to variant dbSNP:rs17856584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454271 – 100Missing in isoform 4. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_047171118 – 178Missing in isoform 3. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_047172269P → PA in isoform 3 and isoform 5. 1 Publication1
Alternative sequenceiVSP_047173329 – 335Missing in isoform 5. 1 Publication7
Alternative sequenceiVSP_020986432 – 433VG → GT in isoform 2. 1 Publication2
Alternative sequenceiVSP_020987434 – 495Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX247962 mRNA Translation: CAD62301.1
AK027745 mRNA Translation: BAB55337.1
AK300786 mRNA Translation: BAG62448.1
AC007160 Genomic DNA No translation available.
AL442663 Genomic DNA No translation available.
BC018979 mRNA Translation: AAH18979.1
BC035901 mRNA Translation: AAH35901.1
AL080157 mRNA Translation: CAB45748.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41968.2 [Q8WV16-3]
CCDS55926.1 [Q8WV16-5]
CCDS9809.1 [Q8WV16-1]
CCDS9810.1 [Q8WV16-4]

Protein sequence database of the Protein Information Resource

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PIRi
T12541

NCBI Reference Sequences

More...
RefSeqi
NP_001156980.1, NM_001163508.1 [Q8WV16-5]
NP_001156981.1, NM_001163509.1
NP_056419.2, NM_015604.3 [Q8WV16-1]
NP_851937.1, NM_181340.2 [Q8WV16-4]
NP_851938.2, NM_181341.2 [Q8WV16-3]
XP_016876696.1, XM_017021207.1 [Q8WV16-1]
XP_016876697.1, XM_017021208.1 [Q8WV16-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358377; ENSP00000351147; ENSG00000119599 [Q8WV16-1]
ENST00000394234; ENSP00000377781; ENSG00000119599 [Q8WV16-4]
ENST00000509153; ENSP00000426178; ENSG00000119599 [Q8WV16-3]
ENST00000555042; ENSP00000452131; ENSG00000119599 [Q8WV16-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26094

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26094

UCSC genome browser

More...
UCSCi
uc001xng.4 human [Q8WV16-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX247962 mRNA Translation: CAD62301.1
AK027745 mRNA Translation: BAB55337.1
AK300786 mRNA Translation: BAG62448.1
AC007160 Genomic DNA No translation available.
AL442663 Genomic DNA No translation available.
BC018979 mRNA Translation: AAH18979.1
BC035901 mRNA Translation: AAH35901.1
AL080157 mRNA Translation: CAB45748.1
CCDSiCCDS41968.2 [Q8WV16-3]
CCDS55926.1 [Q8WV16-5]
CCDS9809.1 [Q8WV16-1]
CCDS9810.1 [Q8WV16-4]
PIRiT12541
RefSeqiNP_001156980.1, NM_001163508.1 [Q8WV16-5]
NP_001156981.1, NM_001163509.1
NP_056419.2, NM_015604.3 [Q8WV16-1]
NP_851937.1, NM_181340.2 [Q8WV16-4]
NP_851938.2, NM_181341.2 [Q8WV16-3]
XP_016876696.1, XM_017021207.1 [Q8WV16-1]
XP_016876697.1, XM_017021208.1 [Q8WV16-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I8CX-ray2.80B124-136[»]
SMRiQ8WV16
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117545, 31 interactors
DIPiDIP-48761N
IntActiQ8WV16, 29 interactors
STRINGi9606.ENSP00000351147

PTM databases

iPTMnetiQ8WV16
PhosphoSitePlusiQ8WV16

Polymorphism and mutation databases

BioMutaiDCAF4
DMDMi116242844

Proteomic databases

MassIVEiQ8WV16
MaxQBiQ8WV16
PaxDbiQ8WV16
PeptideAtlasiQ8WV16
PRIDEiQ8WV16
ProteomicsDBi33399
70640
74734 [Q8WV16-1]
74735 [Q8WV16-2]
74736 [Q8WV16-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
26094

Genome annotation databases

EnsembliENST00000358377; ENSP00000351147; ENSG00000119599 [Q8WV16-1]
ENST00000394234; ENSP00000377781; ENSG00000119599 [Q8WV16-4]
ENST00000509153; ENSP00000426178; ENSG00000119599 [Q8WV16-3]
ENST00000555042; ENSP00000452131; ENSG00000119599 [Q8WV16-5]
GeneIDi26094
KEGGihsa:26094
UCSCiuc001xng.4 human [Q8WV16-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26094
DisGeNETi26094

GeneCards: human genes, protein and diseases

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GeneCardsi
DCAF4
HGNCiHGNC:20229 DCAF4
HPAiHPA047276
MIMi616372 gene
neXtProtiNX_Q8WV16
OpenTargetsiENSG00000119599
PharmGKBiPA165478762

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2695 Eukaryota
ENOG410XQIU LUCA
GeneTreeiENSGT00390000009546
HOGENOMiHOG000065756
InParanoidiQ8WV16
KOiK11799
OMAiYNGCRSG
PhylomeDBiQ8WV16
TreeFamiTF332050

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-8951664 Neddylation
SignaLinkiQ8WV16

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DCAF4 human
EvolutionaryTraceiQ8WV16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26094
PharosiQ8WV16

Protein Ontology

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PROi
PR:Q8WV16

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119599 Expressed in 168 organ(s), highest expression level in skin of abdomen
ExpressionAtlasiQ8WV16 baseline and differential
GenevisibleiQ8WV16 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCAF4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WV16
Secondary accession number(s): B4DUT6
, G3V522, Q86U31, Q8IV10, Q96K22, Q9Y4P5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 17, 2006
Last modified: September 18, 2019
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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