UniProtKB - Q8WV15 (T255B_HUMAN)
Protein
Transmembrane protein 255B
Gene
TMEM255B
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q8WV15 |
Protein family/group databases
TCDBi | 9.B.200.1.2, the 4 tms tmem255 or pfam fam70 (tmem255) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 255BAlternative name(s): Protein FAM70B |
Gene namesi | Name:TMEM255B Synonyms:FAM70B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28297, TMEM255B |
neXtProti | NX_Q8WV15 |
VEuPathDBi | HostDB:ENSG00000184497.12 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 26 – 46 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 85 – 105 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 348013 |
OpenTargetsi | ENSG00000184497 |
PharmGKBi | PA142671886 |
Miscellaneous databases
Pharosi | Q8WV15, Tdark |
Genetic variation databases
BioMutai | TMEM255B |
DMDMi | 74751534 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000266042 | 1 – 326 | Transmembrane protein 255BAdd BLAST | 326 |
Proteomic databases
MassIVEi | Q8WV15 |
MaxQBi | Q8WV15 |
PaxDbi | Q8WV15 |
PeptideAtlasi | Q8WV15 |
PRIDEi | Q8WV15 |
ProteomicsDBi | 74733 |
PTM databases
iPTMneti | Q8WV15 |
PhosphoSitePlusi | Q8WV15 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184497, Expressed in left lobe of thyroid gland and 162 other tissues |
ExpressionAtlasi | Q8WV15, baseline and differential |
Genevisiblei | Q8WV15, HS |
Organism-specific databases
HPAi | ENSG00000184497, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8WV15
Protein-protein interaction databases
BioGRIDi | 131501, 12 interactors |
IntActi | Q8WV15, 8 interactors |
STRINGi | 9606.ENSP00000364502 |
Miscellaneous databases
RNActi | Q8WV15, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 257 – 326 | Pro-richAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the TMEM255 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWXU, Eukaryota |
GeneTreei | ENSGT00940000160889 |
HOGENOMi | CLU_068698_1_0_1 |
InParanoidi | Q8WV15 |
OMAi | EVTCHTL |
OrthoDBi | 1106120at2759 |
PhylomeDBi | Q8WV15 |
TreeFami | TF331034 |
Family and domain databases
InterProi | View protein in InterPro IPR028014, TMEM255 |
PANTHERi | PTHR33721, PTHR33721, 1 hit |
Pfami | View protein in Pfam PF14967, FAM70, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8WV15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPPVPGPLG LLDPAEGLSR RKKTSLWFVG SLLLVSVLIV TVGLAATTRT
60 70 80 90 100
ENVTVGGYYP GIILGFGSFL GIIGINLVEN RRQMLVAAIV FISFGVVAAF
110 120 130 140 150
CCAIVDGVFA AQHIEPRPLT TGRCQFYSSG VGYLYDVYQT EVTCHSLDGK
160 170 180 190 200
CQLKVRSNTC YCCDLYACGS AEPSPAYYEF IGVSGCQDVL HLYRLLWASA
210 220 230 240 250
VLNVLGLFLG IITAAVLGAF KDMVPLSQLA YGPAVPPQTL YNPAQQILAY
260 270 280 290 300
AGFRLTPEPV PTCSSYPLPL QPCSRFPVAP SSALASSEDL QPPSPSSSGS
310 320
GLPGQAPPCY APTYFPPGEK PPPYAP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J2D1 | A0A0B4J2D1_HUMAN | Transmembrane protein 255B | TMEM255B | 166 | Annotation score: | ||
A0A0J9YXD2 | A0A0J9YXD2_HUMAN | Transmembrane protein 255B | TMEM255B | 15 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX072579 Genomic DNA No translation available. BX088578 Genomic DNA No translation available. BC018995 mRNA Translation: AAH18995.1 |
CCDSi | CCDS45071.1 |
RefSeqi | NP_872420.1, NM_182614.3 |
Genome annotation databases
Ensembli | ENST00000375353; ENSP00000364502; ENSG00000184497 |
GeneIDi | 348013 |
KEGGi | hsa:348013 |
UCSCi | uc001vuh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX072579 Genomic DNA No translation available. BX088578 Genomic DNA No translation available. BC018995 mRNA Translation: AAH18995.1 |
CCDSi | CCDS45071.1 |
RefSeqi | NP_872420.1, NM_182614.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 131501, 12 interactors |
IntActi | Q8WV15, 8 interactors |
STRINGi | 9606.ENSP00000364502 |
Protein family/group databases
TCDBi | 9.B.200.1.2, the 4 tms tmem255 or pfam fam70 (tmem255) family |
PTM databases
iPTMneti | Q8WV15 |
PhosphoSitePlusi | Q8WV15 |
Genetic variation databases
BioMutai | TMEM255B |
DMDMi | 74751534 |
Proteomic databases
MassIVEi | Q8WV15 |
MaxQBi | Q8WV15 |
PaxDbi | Q8WV15 |
PeptideAtlasi | Q8WV15 |
PRIDEi | Q8WV15 |
ProteomicsDBi | 74733 |
Protocols and materials databases
Antibodypediai | 48950, 35 antibodies |
DNASUi | 348013 |
Genome annotation databases
Ensembli | ENST00000375353; ENSP00000364502; ENSG00000184497 |
GeneIDi | 348013 |
KEGGi | hsa:348013 |
UCSCi | uc001vuh.4, human |
Organism-specific databases
CTDi | 348013 |
DisGeNETi | 348013 |
GeneCardsi | TMEM255B |
HGNCi | HGNC:28297, TMEM255B |
HPAi | ENSG00000184497, Low tissue specificity |
neXtProti | NX_Q8WV15 |
OpenTargetsi | ENSG00000184497 |
PharmGKBi | PA142671886 |
VEuPathDBi | HostDB:ENSG00000184497.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWXU, Eukaryota |
GeneTreei | ENSGT00940000160889 |
HOGENOMi | CLU_068698_1_0_1 |
InParanoidi | Q8WV15 |
OMAi | EVTCHTL |
OrthoDBi | 1106120at2759 |
PhylomeDBi | Q8WV15 |
TreeFami | TF331034 |
Enzyme and pathway databases
PathwayCommonsi | Q8WV15 |
Miscellaneous databases
BioGRID-ORCSi | 348013, 6 hits in 988 CRISPR screens |
ChiTaRSi | TMEM255B, human |
GenomeRNAii | 348013 |
Pharosi | Q8WV15, Tdark |
PROi | PR:Q8WV15 |
RNActi | Q8WV15, protein |
Gene expression databases
Bgeei | ENSG00000184497, Expressed in left lobe of thyroid gland and 162 other tissues |
ExpressionAtlasi | Q8WV15, baseline and differential |
Genevisiblei | Q8WV15, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028014, TMEM255 |
PANTHERi | PTHR33721, PTHR33721, 1 hit |
Pfami | View protein in Pfam PF14967, FAM70, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T255B_HUMAN | |
Accessioni | Q8WV15Primary (citable) accession number: Q8WV15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families