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Protein

DEP domain-containing protein 1B

Gene

DEPDC1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 1B
Alternative name(s):
HBV X-transactivated gene 8 protein
HBV XAg-transactivated protein 8
Gene namesi
Name:DEPDC1B
Synonyms:XTP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000035499.12
HGNCiHGNC:24902 DEPDC1B
MIMi616066 gene
neXtProtiNX_Q8WUY9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55789
OpenTargetsiENSG00000035499
PharmGKBiPA134941087

Polymorphism and mutation databases

BioMutaiDEPDC1B
DMDMi145558895

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847901 – 529DEP domain-containing protein 1BAdd BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUY9
MaxQBiQ8WUY9
PaxDbiQ8WUY9
PeptideAtlasiQ8WUY9
PRIDEiQ8WUY9
ProteomicsDBi74728
74729 [Q8WUY9-2]

PTM databases

iPTMnetiQ8WUY9
PhosphoSitePlusiQ8WUY9

Expressioni

Gene expression databases

BgeeiENSG00000035499 Expressed in 122 organ(s), highest expression level in placenta
CleanExiHS_DEPDC1B
ExpressionAtlasiQ8WUY9 baseline and differential
GenevisibleiQ8WUY9 HS

Organism-specific databases

HPAiHPA038255
HPA072558

Interactioni

Protein-protein interaction databases

BioGridi120903, 38 interactors
IntActiQ8WUY9, 8 interactors
STRINGi9606.ENSP00000265036

Structurei

3D structure databases

ProteinModelPortaliQ8WUY9
SMRiQ8WUY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 108DEPPROSITE-ProRule annotationAdd BLAST85
Domaini201 – 393Rho-GAPPROSITE-ProRule annotationAdd BLAST193

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi468 – 475Poly-Lys8

Phylogenomic databases

eggNOGiENOG410IEI5 Eukaryota
ENOG410YMM7 LUCA
GeneTreeiENSGT00530000063030
HOGENOMiHOG000013064
HOVERGENiHBG059792
InParanoidiQ8WUY9
OMAiQPFQRSW
OrthoDBiEOG091G04WW
PhylomeDBiQ8WUY9
TreeFamiTF328365

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50238 RHOGAP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEHRIVGPGP YRATRLWNET VELFRAKMPL RKHRCRFKSY EHCFTAAEAV
60 70 80 90 100
DWLHELLRCS QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGEEDFEDN
110 120 130 140 150
RHLYRFPPSS PLKPYPKKPP NQKDVIKFPE WNDLPPGTSQ ENIPVRPVVM
160 170 180 190 200
NSEMWYKRHS IAIGEVPACR LVHRRQLTEA NVEEIWKSMT LSYLQKILGL
210 220 230 240 250
DSLEEVLDVK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP HWVLSAMKCL
260 270 280 290 300
ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG
310 320 330 340 350
LLQKEKVAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGF
360 370 380 390 400
GTRTLMVQTF SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ
410 420 430 440 450
TSIEERVAHL RRVQIKYPGA DMDITLSAPS FCRQISPEEF EYQRSYGSQE
460 470 480 490 500
PLAALLEEVI TDAKLSNKEK KKKLKQFQKS YPEVYQERFP TPESAALLFP
510 520
EKPKPKPQLL MWALKKPFQP FQRTRSFRM
Length:529
Mass (Da):61,771
Last modified:April 17, 2007 - v2
Checksum:iE640F8034BD308C6
GO
Isoform 2 (identifier: Q8WUY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-475: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):54,726
Checksum:iC549F29AF83121F8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIB0D6RIB0_HUMAN
DEP domain-containing protein 1B
DEPDC1B
22Annotation score:
D6RDV9D6RDV9_HUMAN
DEP domain-containing protein 1B
DEPDC1B
36Annotation score:

Sequence cautioni

The sequence AAH10904 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91529 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272F → C in AAN31126 (Ref. 1) Curated1
Sequence conflicti272F → C in BAA92089 (PubMed:14702039).Curated1
Sequence conflicti380R → K in AAN31126 (Ref. 1) Curated1
Sequence conflicti402S → P in BAA92089 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031819332R → M2 PublicationsCorresponds to variant dbSNP:rs17856590Ensembl.1
Natural variantiVAR_031820395V → L2 PublicationsCorresponds to variant dbSNP:rs17851707Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042922414 – 475Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303178 mRNA Translation: AAN31126.1
AF488828 mRNA Translation: AAO49477.1
AF490257 mRNA Translation: AAO85465.1
AK001166 mRNA Translation: BAA91529.1 Different initiation.
AK002114 mRNA Translation: BAA92089.1
AK290684 mRNA Translation: BAF83373.1
AK300782 mRNA Translation: BAG62446.1
AC016591 Genomic DNA No translation available.
AC109133 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54998.1
BC010904 mRNA Translation: AAH10904.1 Different initiation.
BC019075 mRNA Translation: AAH19075.1
CCDSiCCDS3977.1 [Q8WUY9-1]
CCDS47214.1 [Q8WUY9-2]
RefSeqiNP_001138680.1, NM_001145208.1 [Q8WUY9-2]
NP_060839.2, NM_018369.2 [Q8WUY9-1]
UniGeneiHs.482233

Genome annotation databases

EnsembliENST00000265036; ENSP00000265036; ENSG00000035499 [Q8WUY9-1]
ENST00000453022; ENSP00000389101; ENSG00000035499 [Q8WUY9-2]
GeneIDi55789
KEGGihsa:55789
UCSCiuc003jsh.4 human [Q8WUY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303178 mRNA Translation: AAN31126.1
AF488828 mRNA Translation: AAO49477.1
AF490257 mRNA Translation: AAO85465.1
AK001166 mRNA Translation: BAA91529.1 Different initiation.
AK002114 mRNA Translation: BAA92089.1
AK290684 mRNA Translation: BAF83373.1
AK300782 mRNA Translation: BAG62446.1
AC016591 Genomic DNA No translation available.
AC109133 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54998.1
BC010904 mRNA Translation: AAH10904.1 Different initiation.
BC019075 mRNA Translation: AAH19075.1
CCDSiCCDS3977.1 [Q8WUY9-1]
CCDS47214.1 [Q8WUY9-2]
RefSeqiNP_001138680.1, NM_001145208.1 [Q8WUY9-2]
NP_060839.2, NM_018369.2 [Q8WUY9-1]
UniGeneiHs.482233

3D structure databases

ProteinModelPortaliQ8WUY9
SMRiQ8WUY9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120903, 38 interactors
IntActiQ8WUY9, 8 interactors
STRINGi9606.ENSP00000265036

PTM databases

iPTMnetiQ8WUY9
PhosphoSitePlusiQ8WUY9

Polymorphism and mutation databases

BioMutaiDEPDC1B
DMDMi145558895

Proteomic databases

EPDiQ8WUY9
MaxQBiQ8WUY9
PaxDbiQ8WUY9
PeptideAtlasiQ8WUY9
PRIDEiQ8WUY9
ProteomicsDBi74728
74729 [Q8WUY9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265036; ENSP00000265036; ENSG00000035499 [Q8WUY9-1]
ENST00000453022; ENSP00000389101; ENSG00000035499 [Q8WUY9-2]
GeneIDi55789
KEGGihsa:55789
UCSCiuc003jsh.4 human [Q8WUY9-1]

Organism-specific databases

CTDi55789
DisGeNETi55789
EuPathDBiHostDB:ENSG00000035499.12
GeneCardsiDEPDC1B
HGNCiHGNC:24902 DEPDC1B
HPAiHPA038255
HPA072558
MIMi616066 gene
neXtProtiNX_Q8WUY9
OpenTargetsiENSG00000035499
PharmGKBiPA134941087
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEI5 Eukaryota
ENOG410YMM7 LUCA
GeneTreeiENSGT00530000063030
HOGENOMiHOG000013064
HOVERGENiHBG059792
InParanoidiQ8WUY9
OMAiQPFQRSW
OrthoDBiEOG091G04WW
PhylomeDBiQ8WUY9
TreeFamiTF328365

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiDEPDC1B human
GenomeRNAii55789
PROiPR:Q8WUY9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000035499 Expressed in 122 organ(s), highest expression level in placenta
CleanExiHS_DEPDC1B
ExpressionAtlasiQ8WUY9 baseline and differential
GenevisibleiQ8WUY9 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50238 RHOGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEP1B_HUMAN
AccessioniPrimary (citable) accession number: Q8WUY9
Secondary accession number(s): A8K3R9
, B4DUT4, Q86WJ3, Q8IZY6, Q9NUN3, Q9NW57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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