Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 131 (07 Oct 2020)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Glutathione-specific gamma-glutamylcyclotransferase 2

Gene

CHAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 15.9 min(-1) for glutathione.1 Publication
  1. KM=3.7 mM for glutathione1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei83Proton acceptorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:ENSG00000143942-MONOMER

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q8WUX2

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-174403, Glutathione synthesis and recycling

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glutathione-specific gamma-glutamylcyclotransferase 21 Publication (EC:4.3.2.71 Publication)
    Short name:
    Gamma-GCG 2Curated
    Alternative name(s):
    Cation transport regulator-like protein 2By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CHAC2Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000143942.4

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:32363, CHAC2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    617446, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8WUX2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    494143

    Open Targets

    More...
    OpenTargetsi
    ENSG00000143942

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA142672120

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8WUX2, Tdark

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CHAC2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74730779

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003149121 – 184Glutathione-specific gamma-glutamylcyclotransferase 2Add BLAST184

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8WUX2

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8WUX2

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8WUX2

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8WUX2

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8WUX2

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8WUX2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8WUX2

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    74718

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8WUX2

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8WUX2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000143942, Expressed in bone marrow and 170 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8WUX2, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000143942, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    138943, 13 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8WUX2, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000295304

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8WUX2, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1184
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8WUX2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3 – 8Substrate bindingBy similarity6

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3182, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000003855

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_070703_2_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8WUX2

    KEGG Orthology (KO)

    More...
    KOi
    K07232

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VVWGIAY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1238273at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8WUX2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313048

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06661, GGCT_like, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006840, ChaC
    IPR013024, GGCT-like
    IPR036568, GGCT-like_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12192, PTHR12192, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04752, ChaC, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF110857, SSF110857, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8WUX2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV
    60 70 80 90 100
    TLVEDPAGCV WGVAYRLPVG KEEEVKAYLD FREKGGYRTT TVIFYPKDPT
    110 120 130 140 150
    TKPFSVLLYI GTCDNPDYLG PAPLEDIAEQ IFNAAGPSGR NTEYLFELAN
    160 170 180
    SIRNLVPEEA DEHLFALEKL VKERLEGKQN LNCI
    Length:184
    Mass (Da):20,875
    Last modified:March 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0F10C446A105E22
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03812382R → G1 PublicationCorresponds to variant dbSNP:rs17851583Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC007883 Genomic DNA Translation: AAY24351.1
    CH471053 Genomic DNA Translation: EAX00172.1
    BC017941 mRNA Translation: AAH17941.1
    BC019239 mRNA Translation: AAH19239.1
    BC025376 mRNA Translation: AAH25376.1
    BC053896 mRNA Translation: AAH53896.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS33196.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001008708.1, NM_001008708.3
    NP_001333056.1, NM_001346127.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000295304; ENSP00000295304; ENSG00000143942

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    494143

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:494143

    UCSC genome browser

    More...
    UCSCi
    uc002rxk.2, human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC007883 Genomic DNA Translation: AAY24351.1
    CH471053 Genomic DNA Translation: EAX00172.1
    BC017941 mRNA Translation: AAH17941.1
    BC019239 mRNA Translation: AAH19239.1
    BC025376 mRNA Translation: AAH25376.1
    BC053896 mRNA Translation: AAH53896.1
    CCDSiCCDS33196.1
    RefSeqiNP_001008708.1, NM_001008708.3
    NP_001333056.1, NM_001346127.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6K95X-ray2.29A/B/C1-184[»]
    SMRiQ8WUX2
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi138943, 13 interactors
    IntActiQ8WUX2, 3 interactors
    STRINGi9606.ENSP00000295304

    PTM databases

    iPTMnetiQ8WUX2
    PhosphoSitePlusiQ8WUX2

    Polymorphism and mutation databases

    BioMutaiCHAC2
    DMDMi74730779

    Proteomic databases

    EPDiQ8WUX2
    jPOSTiQ8WUX2
    MassIVEiQ8WUX2
    MaxQBiQ8WUX2
    PaxDbiQ8WUX2
    PeptideAtlasiQ8WUX2
    PRIDEiQ8WUX2
    ProteomicsDBi74718

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    30211, 107 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    494143

    Genome annotation databases

    EnsembliENST00000295304; ENSP00000295304; ENSG00000143942
    GeneIDi494143
    KEGGihsa:494143
    UCSCiuc002rxk.2, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    494143
    DisGeNETi494143
    EuPathDBiHostDB:ENSG00000143942.4

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CHAC2
    HGNCiHGNC:32363, CHAC2
    HPAiENSG00000143942, Low tissue specificity
    MIMi617446, gene
    neXtProtiNX_Q8WUX2
    OpenTargetsiENSG00000143942
    PharmGKBiPA142672120

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3182, Eukaryota
    GeneTreeiENSGT00390000003855
    HOGENOMiCLU_070703_2_2_1
    InParanoidiQ8WUX2
    KOiK07232
    OMAiVVWGIAY
    OrthoDBi1238273at2759
    PhylomeDBiQ8WUX2
    TreeFamiTF313048

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000143942-MONOMER
    PathwayCommonsiQ8WUX2
    ReactomeiR-HSA-174403, Glutathione synthesis and recycling

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    494143, 14 hits in 871 CRISPR screens

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    494143
    PharosiQ8WUX2, Tdark

    Protein Ontology

    More...
    PROi
    PR:Q8WUX2
    RNActiQ8WUX2, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000143942, Expressed in bone marrow and 170 other tissues
    GenevisibleiQ8WUX2, HS

    Family and domain databases

    CDDicd06661, GGCT_like, 1 hit
    InterProiView protein in InterPro
    IPR006840, ChaC
    IPR013024, GGCT-like
    IPR036568, GGCT-like_sf
    PANTHERiPTHR12192, PTHR12192, 1 hit
    PfamiView protein in Pfam
    PF04752, ChaC, 1 hit
    SUPFAMiSSF110857, SSF110857, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHAC2_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUX2
    Secondary accession number(s): Q8WVI8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2002
    Last modified: October 7, 2020
    This is version 131 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again