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Entry version 129 (16 Oct 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Sodium-coupled neutral amino acid transporter 5

Gene

SLC38A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Not inhibited by lithium.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.6 mM for histidine (at pH 8.0)1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-352230 Amino acid transport across the plasma membrane

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.18.6.15 the amino acid/auxin permease (aaap) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 5
    Alternative name(s):
    Solute carrier family 38 member 5
    System N transporter 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC38A5
    Synonyms:JM24, SN2, SNAT5
    ORF Names:PP7194
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:18070 SLC38A5

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    300649 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8WUX1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 71HelicalSequence analysisAdd BLAST23
    Topological domaini72 – 87ExtracellularSequence analysisAdd BLAST16
    Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
    Topological domaini109 – 125CytoplasmicSequence analysisAdd BLAST17
    Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
    Topological domaini147 – 166ExtracellularSequence analysisAdd BLAST20
    Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
    Topological domaini188 – 192CytoplasmicSequence analysis5
    Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
    Topological domaini214 – 257ExtracellularSequence analysisAdd BLAST44
    Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
    Topological domaini279 – 295CytoplasmicSequence analysisAdd BLAST17
    Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
    Topological domaini317 – 334ExtracellularSequence analysisAdd BLAST18
    Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
    Topological domaini356 – 376CytoplasmicSequence analysisAdd BLAST21
    Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
    Topological domaini398 – 399ExtracellularSequence analysis2
    Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
    Topological domaini421 – 439CytoplasmicSequence analysisAdd BLAST19
    Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
    Topological domaini461 – 472ExtracellularSequence analysisAdd BLAST12

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    92745

    Open Targets

    More...
    OpenTargetsi
    ENSG00000017483

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA38289

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8WUX1

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC38A5

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74730778

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003121151 – 472Sodium-coupled neutral amino acid transporter 5Add BLAST472

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi221 ↔ 247PROSITE-ProRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8WUX1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8WUX1

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8WUX1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8WUX1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8WUX1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8WUX1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8WUX1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    74716 [Q8WUX1-1]
    74717 [Q8WUX1-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8WUX1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8WUX1

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q8WUX1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in stomach, brain, liver, lung and intestinal tract.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000017483 Expressed in 133 organ(s), highest expression level in body of pancreas

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8WUX1 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8WUX1 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA047411

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    124974, 9 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8WUX1, 8 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000471683

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8WUX1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1305 Eukaryota
    COG0814 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161233

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000013088

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8WUX1

    KEGG Orthology (KO)

    More...
    KOi
    K14992

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FIFMVMS

    Database of Orthologous Groups

    More...
    OrthoDBi
    697331at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8WUX1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF328787

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013057 AA_transpt_TM

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01490 Aa_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8WUX1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MELQDPKMNG ALPSDAVGYR QEREGFLPSR GPAPGSKPVQ FMDFEGKTSF
    60 70 80 90 100
    GMSVFNLSNA IMGSGILGLA YAMAHTGVIF FLALLLCIAL LSSYSIHLLL
    110 120 130 140 150
    TCAGIAGIRA YEQLGQRAFG PAGKVVVATV ICLHNVGAMS SYLFIIKSEL
    160 170 180 190 200
    PLVIGTFLYM DPEGDWFLKG NLLIIIVSVL IILPLALMKH LGYLGYTSGL
    210 220 230 240 250
    SLTCMLFFLV SVIYKKFQLG CAIGHNETAM ESEALVGLPS QGLNSSCEAQ
    260 270 280 290 300
    MFTVDSQMSY TVPIMAFAFV CHPEVLPIYT ELCRPSKRRM QAVANVSIGA
    310 320 330 340 350
    MFCMYGLTAT FGYLTFYSSV KAEMLHMYSQ KDPLILCVRL AVLLAVTLTV
    360 370 380 390 400
    PVVLFPIRRA LQQLLFPGKA FSWPRHVAIA LILLVLVNVL VICVPTIRDI
    410 420 430 440 450
    FGVIGSTSAP SLIFILPSIF YLRIVPSEVE PFLSWPKIQA LCFGVLGVLF
    460 470
    MAVSLGFMFA NWATGQSRMS GH
    Length:472
    Mass (Da):51,457
    Last modified:March 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DDB4C03E5E78734
    GO
    Isoform 2 (identifier: Q8WUX1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:421
    Mass (Da):45,916
    Checksum:i23856C0AB7955E30
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    C9JMY2C9JMY2_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A5
    191Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JNK4C9JNK4_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A5
    279Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JWG4C9JWG4_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A5
    272Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JHH7C9JHH7_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A5
    218Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JJU1C9JJU1_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A5
    163Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087X1I6A0A087X1I6_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A5
    403Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WZF9A0A087WZF9_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A5
    29Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAL55865 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti456G → S in AAK61856 (PubMed:11243884).Curated1
    Sequence conflicti465G → S in AAK61856 (PubMed:11243884).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037396451M → T1 PublicationCorresponds to variant dbSNP:rs17281188EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0297021 – 51Missing in isoform 2. 1 PublicationAdd BLAST51

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF276889 mRNA Translation: AAK61856.1
    AF318358 mRNA Translation: AAL55865.1 Frameshift.
    AK094788 mRNA Translation: BAG52932.1
    CH471224 Genomic DNA Translation: EAW50785.1
    AF196972 Genomic DNA No translation available.
    BC019246 mRNA Translation: AAH19246.1
    BC027721 mRNA Translation: AAH27721.1

    The Consensus CDS (CCDS) project

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    CCDSi
    CCDS14293.1 [Q8WUX1-1]

    Protein sequence database of the Protein Information Resource

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    PIRi
    JC7626

    NCBI Reference Sequences

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    RefSeqi
    NP_277053.2, NM_033518.3 [Q8WUX1-1]
    XP_016885450.1, XM_017029961.1 [Q8WUX1-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000595796; ENSP00000471683; ENSG00000017483 [Q8WUX1-1]
    ENST00000619100; ENSP00000478807; ENSG00000017483 [Q8WUX1-2]
    ENST00000620913; ENSP00000481291; ENSG00000017483 [Q8WUX1-1]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    92745

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:92745

    UCSC genome browser

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    UCSCi
    uc033ecl.2 human [Q8WUX1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF276889 mRNA Translation: AAK61856.1
    AF318358 mRNA Translation: AAL55865.1 Frameshift.
    AK094788 mRNA Translation: BAG52932.1
    CH471224 Genomic DNA Translation: EAW50785.1
    AF196972 Genomic DNA No translation available.
    BC019246 mRNA Translation: AAH19246.1
    BC027721 mRNA Translation: AAH27721.1
    CCDSiCCDS14293.1 [Q8WUX1-1]
    PIRiJC7626
    RefSeqiNP_277053.2, NM_033518.3 [Q8WUX1-1]
    XP_016885450.1, XM_017029961.1 [Q8WUX1-1]

    3D structure databases

    SMRiQ8WUX1
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi124974, 9 interactors
    IntActiQ8WUX1, 8 interactors
    STRINGi9606.ENSP00000471683

    Protein family/group databases

    TCDBi2.A.18.6.15 the amino acid/auxin permease (aaap) family

    PTM databases

    iPTMnetiQ8WUX1
    PhosphoSitePlusiQ8WUX1
    SwissPalmiQ8WUX1

    Polymorphism and mutation databases

    BioMutaiSLC38A5
    DMDMi74730778

    Proteomic databases

    EPDiQ8WUX1
    jPOSTiQ8WUX1
    MassIVEiQ8WUX1
    MaxQBiQ8WUX1
    PaxDbiQ8WUX1
    PeptideAtlasiQ8WUX1
    PRIDEiQ8WUX1
    ProteomicsDBi74716 [Q8WUX1-1]
    74717 [Q8WUX1-2]

    Protocols and materials databases

    The DNASU plasmid repository

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    DNASUi
    92745

    Genome annotation databases

    EnsembliENST00000595796; ENSP00000471683; ENSG00000017483 [Q8WUX1-1]
    ENST00000619100; ENSP00000478807; ENSG00000017483 [Q8WUX1-2]
    ENST00000620913; ENSP00000481291; ENSG00000017483 [Q8WUX1-1]
    GeneIDi92745
    KEGGihsa:92745
    UCSCiuc033ecl.2 human [Q8WUX1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    92745
    DisGeNETi92745

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC38A5
    HGNCiHGNC:18070 SLC38A5
    HPAiHPA047411
    MIMi300649 gene
    neXtProtiNX_Q8WUX1
    OpenTargetsiENSG00000017483
    PharmGKBiPA38289

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1305 Eukaryota
    COG0814 LUCA
    GeneTreeiENSGT00940000161233
    HOGENOMiHOG000013088
    InParanoidiQ8WUX1
    KOiK14992
    OMAiFIFMVMS
    OrthoDBi697331at2759
    PhylomeDBiQ8WUX1
    TreeFamiTF328787

    Enzyme and pathway databases

    ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC38A5 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    92745
    PharosiQ8WUX1

    Protein Ontology

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    PROi
    PR:Q8WUX1

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000017483 Expressed in 133 organ(s), highest expression level in body of pancreas
    ExpressionAtlasiQ8WUX1 baseline and differential
    GenevisibleiQ8WUX1 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR013057 AA_transpt_TM
    PfamiView protein in Pfam
    PF01490 Aa_trans, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS38A5_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUX1
    Secondary accession number(s): B3KT20
    , B5MDE6, B7WPJ9, Q6PIW9, Q8WYU2, Q96PQ4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: March 1, 2002
    Last modified: October 16, 2019
    This is version 129 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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