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Entry version 139 (29 Sep 2021)
Sequence version 1 (01 Mar 2002)
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Protein

Sodium-coupled neutral amino acid transporter 5

Gene

SLC38A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Not inhibited by lithium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.6 mM for histidine (at pH 8.0)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8WUX1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-352230, Amino acid transport across the plasma membrane

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.18.6.15, the amino acid/auxin permease (aaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 5
Alternative name(s):
Solute carrier family 38 member 5
System N transporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC38A5
Synonyms:JM24, SN2, SNAT5
ORF Names:PP7194
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18070, SLC38A5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300649, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WUX1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000017483

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 71HelicalSequence analysisAdd BLAST23
Topological domaini72 – 87ExtracellularSequence analysisAdd BLAST16
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 125CytoplasmicSequence analysisAdd BLAST17
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 166ExtracellularSequence analysisAdd BLAST20
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 192CytoplasmicSequence analysis5
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 257ExtracellularSequence analysisAdd BLAST44
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 295CytoplasmicSequence analysisAdd BLAST17
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 334ExtracellularSequence analysisAdd BLAST18
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 376CytoplasmicSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 399ExtracellularSequence analysis2
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 439CytoplasmicSequence analysisAdd BLAST19
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 472ExtracellularSequence analysisAdd BLAST12

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92745

Open Targets

More...
OpenTargetsi
ENSG00000017483

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38289

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WUX1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC38A5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730778

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003121151 – 472Sodium-coupled neutral amino acid transporter 5Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi221 ↔ 247PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WUX1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WUX1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WUX1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WUX1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WUX1

PeptideAtlas

More...
PeptideAtlasi
Q8WUX1

PRoteomics IDEntifications database

More...
PRIDEi
Q8WUX1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74716 [Q8WUX1-1]
74717 [Q8WUX1-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8WUX1, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WUX1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WUX1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8WUX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in stomach, brain, liver, lung and intestinal tract.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000017483, Expressed in body of pancreas and 150 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WUX1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WUX1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000017483, Tissue enriched (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124974, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WUX1, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000471683

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WUX1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WUX1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1305, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161233

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009020_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WUX1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGMELQD

Database of Orthologous Groups

More...
OrthoDBi
697331at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WUX1

TreeFam database of animal gene trees

More...
TreeFami
TF328787

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013057, AA_transpt_TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01490, Aa_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELQDPKMNG ALPSDAVGYR QEREGFLPSR GPAPGSKPVQ FMDFEGKTSF
60 70 80 90 100
GMSVFNLSNA IMGSGILGLA YAMAHTGVIF FLALLLCIAL LSSYSIHLLL
110 120 130 140 150
TCAGIAGIRA YEQLGQRAFG PAGKVVVATV ICLHNVGAMS SYLFIIKSEL
160 170 180 190 200
PLVIGTFLYM DPEGDWFLKG NLLIIIVSVL IILPLALMKH LGYLGYTSGL
210 220 230 240 250
SLTCMLFFLV SVIYKKFQLG CAIGHNETAM ESEALVGLPS QGLNSSCEAQ
260 270 280 290 300
MFTVDSQMSY TVPIMAFAFV CHPEVLPIYT ELCRPSKRRM QAVANVSIGA
310 320 330 340 350
MFCMYGLTAT FGYLTFYSSV KAEMLHMYSQ KDPLILCVRL AVLLAVTLTV
360 370 380 390 400
PVVLFPIRRA LQQLLFPGKA FSWPRHVAIA LILLVLVNVL VICVPTIRDI
410 420 430 440 450
FGVIGSTSAP SLIFILPSIF YLRIVPSEVE PFLSWPKIQA LCFGVLGVLF
460 470
MAVSLGFMFA NWATGQSRMS GH
Length:472
Mass (Da):51,457
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DDB4C03E5E78734
GO
Isoform 2 (identifier: Q8WUX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Show »
Length:421
Mass (Da):45,916
Checksum:i23856C0AB7955E30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JJU1C9JJU1_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A5
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMY2C9JMY2_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A5
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNK4C9JNK4_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A5
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWG4C9JWG4_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A5
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHH7C9JHH7_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A5
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1I6A0A087X1I6_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A5
403Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZF9A0A087WZF9_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A5
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL55865 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti456G → S in AAK61856 (PubMed:11243884).Curated1
Sequence conflicti465G → S in AAK61856 (PubMed:11243884).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037396451M → T1 PublicationCorresponds to variant dbSNP:rs17281188EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0297021 – 51Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF276889 mRNA Translation: AAK61856.1
AF318358 mRNA Translation: AAL55865.1 Frameshift.
AK094788 mRNA Translation: BAG52932.1
CH471224 Genomic DNA Translation: EAW50785.1
AF196972 Genomic DNA No translation available.
BC019246 mRNA Translation: AAH19246.1
BC027721 mRNA Translation: AAH27721.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14293.1 [Q8WUX1-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC7626

NCBI Reference Sequences

More...
RefSeqi
NP_277053.2, NM_033518.3 [Q8WUX1-1]
XP_016885450.1, XM_017029961.1 [Q8WUX1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000595796; ENSP00000471683; ENSG00000017483 [Q8WUX1-1]
ENST00000619100; ENSP00000478807; ENSG00000017483 [Q8WUX1-2]
ENST00000620913; ENSP00000481291; ENSG00000017483 [Q8WUX1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
92745

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:92745

UCSC genome browser

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UCSCi
uc033ecl.2, human [Q8WUX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276889 mRNA Translation: AAK61856.1
AF318358 mRNA Translation: AAL55865.1 Frameshift.
AK094788 mRNA Translation: BAG52932.1
CH471224 Genomic DNA Translation: EAW50785.1
AF196972 Genomic DNA No translation available.
BC019246 mRNA Translation: AAH19246.1
BC027721 mRNA Translation: AAH27721.1
CCDSiCCDS14293.1 [Q8WUX1-1]
PIRiJC7626
RefSeqiNP_277053.2, NM_033518.3 [Q8WUX1-1]
XP_016885450.1, XM_017029961.1 [Q8WUX1-1]

3D structure databases

SMRiQ8WUX1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124974, 9 interactors
IntActiQ8WUX1, 8 interactors
STRINGi9606.ENSP00000471683

Protein family/group databases

TCDBi2.A.18.6.15, the amino acid/auxin permease (aaap) family

PTM databases

GlyGeniQ8WUX1, 1 site
iPTMnetiQ8WUX1
PhosphoSitePlusiQ8WUX1
SwissPalmiQ8WUX1

Genetic variation databases

BioMutaiSLC38A5
DMDMi74730778

Proteomic databases

EPDiQ8WUX1
jPOSTiQ8WUX1
MassIVEiQ8WUX1
MaxQBiQ8WUX1
PaxDbiQ8WUX1
PeptideAtlasiQ8WUX1
PRIDEiQ8WUX1
ProteomicsDBi74716 [Q8WUX1-1]
74717 [Q8WUX1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
43079, 102 antibodies

The DNASU plasmid repository

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DNASUi
92745

Genome annotation databases

EnsembliENST00000595796; ENSP00000471683; ENSG00000017483 [Q8WUX1-1]
ENST00000619100; ENSP00000478807; ENSG00000017483 [Q8WUX1-2]
ENST00000620913; ENSP00000481291; ENSG00000017483 [Q8WUX1-1]
GeneIDi92745
KEGGihsa:92745
UCSCiuc033ecl.2, human [Q8WUX1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
92745
DisGeNETi92745

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC38A5
HGNCiHGNC:18070, SLC38A5
HPAiENSG00000017483, Tissue enriched (pancreas)
MIMi300649, gene
neXtProtiNX_Q8WUX1
OpenTargetsiENSG00000017483
PharmGKBiPA38289
VEuPathDBiHostDB:ENSG00000017483

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1305, Eukaryota
GeneTreeiENSGT00940000161233
HOGENOMiCLU_009020_0_2_1
InParanoidiQ8WUX1
OMAiVGMELQD
OrthoDBi697331at2759
PhylomeDBiQ8WUX1
TreeFamiTF328787

Enzyme and pathway databases

PathwayCommonsiQ8WUX1
ReactomeiR-HSA-352230, Amino acid transport across the plasma membrane

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
92745, 17 hits in 646 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC38A5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
92745
PharosiQ8WUX1, Tbio

Protein Ontology

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PROi
PR:Q8WUX1
RNActiQ8WUX1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000017483, Expressed in body of pancreas and 150 other tissues
ExpressionAtlasiQ8WUX1, baseline and differential
GenevisibleiQ8WUX1, HS

Family and domain databases

InterProiView protein in InterPro
IPR013057, AA_transpt_TM
PfamiView protein in Pfam
PF01490, Aa_trans, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS38A5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUX1
Secondary accession number(s): B3KT20
, B5MDE6, B7WPJ9, Q6PIW9, Q8WYU2, Q96PQ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2002
Last modified: September 29, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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