UniProtKB - Q8WUW2 (Q8WUW2_HUMAN)
Protein
1-acyl-sn-glycerol-3-phosphate acyltransferase
Gene
AGPAT2
Organism
Homo sapiens (Human)
Status
Functioni
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.ARBA annotation
Catalytic activityi
- (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- (9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- (9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoAARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoAUniRule annotationEC:2.3.1.51UniRule annotation
GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: UniProtKB
GO - Biological processi
- phospholipid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | AcyltransferaseUniRule annotationImported, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotation, Phospholipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: 1-acyl-sn-glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.51UniRule annotation) |
Gene namesi | Name:AGPAT2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 31 – 51 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 124 – 142 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 189 – 208 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5004316632 | 25 – 279 | 1-acyl-sn-glycerol-3-phosphate acyltransferaseSequence analysisAdd BLAST | 255 |
Proteomic databases
MaxQBi | Q8WUW2 |
PeptideAtlasi | Q8WUW2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 93 – 208 | PlsCInterPro annotationAdd BLAST | 116 |
Domaini
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation
Sequence similaritiesi
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.UniRule annotationARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
InterProi | View protein in InterPro IPR004552, AGP_acyltrans IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
TIGRFAMsi | TIGR00530, AGP_acyltrn, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WUW2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELWPCLAAA LLLLLLLLVQ LSRAAEFYAK VALYCALCFT VSAVASLVCL
60 70 80 90 100
LRHGGRTVEN MSIIGWFVRS FKYFYGLRFE VRDPRRLQEA RPCVIVSNHQ
110 120 130 140 150
SILDMMGLME VLPERCVQIA KRELLFLGPV GLIMYLGGVF FINRQRSSTA
160 170 180 190 200
MTVMADLGER MVRENLKVWI YPEGTRNDNG DLLPFKKGAF YLAVQAQVPI
210 220 230 240 250
VPVVYSSFSS FYNTKKKFFT SGTVTVQVLE AIPTSGLTAA DVPALVDTCH
260 270
RAMRTTFLHI SKTPQENGAT AGSGVQPAQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC019292 mRNA Translation: AAH19292.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC019292 mRNA Translation: AAH19292.1 |
3D structure databases
SMRi | Q8WUW2 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q8WUW2 |
PeptideAtlasi | Q8WUW2 |
Family and domain databases
InterProi | View protein in InterPro IPR004552, AGP_acyltrans IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
TIGRFAMsi | TIGR00530, AGP_acyltrn, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8WUW2_HUMAN | |
Accessioni | Q8WUW2Primary (citable) accession number: Q8WUW2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | October 7, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |