UniProtKB - Q8WUQ7 (CATIN_HUMAN)
Cactin
CACTIN
Functioni
Miscellaneous
Caution
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- cellular response to interleukin-1 Source: UniProtKB
- cellular response to lipopolysaccharide Source: UniProtKB
- cellular response to tumor necrosis factor Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- mRNA cis splicing, via spliceosome Source: GO_Central
- mRNA splicing, via spliceosome Source: UniProtKB
- multicellular organism development Source: UniProtKB-KW
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- negative regulation of innate immune response Source: GO_Central
- negative regulation of interferon-beta production Source: UniProtKB
- negative regulation of interleukin-8 production Source: UniProtKB
- negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of protein phosphorylation Source: UniProtKB
- negative regulation of toll-like receptor signaling pathway Source: UniProtKB
- negative regulation of tumor necrosis factor production Source: UniProtKB
- negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
- regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Immunity, Innate immunity, mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q8WUQ7 |
Names & Taxonomyi
Protein namesi | Recommended name: CactinAlternative name(s): Renal carcinoma antigen NY-REN-24 |
Gene namesi | Name:CACTIN Synonyms:C19orf29 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105298.13 |
HGNCi | HGNC:29938, CACTIN |
MIMi | 618536, gene |
neXtProti | NX_Q8WUQ7 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- spliceosomal complex Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Nucleus, SpliceosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 58509 |
OpenTargetsi | ENSG00000105298 |
PharmGKBi | PA134932683 |
Miscellaneous databases
Pharosi | Q8WUQ7, Tbio |
Polymorphism and mutation databases
BioMutai | CACTIN |
DMDMi | 322510133 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000231617 | 1 – 758 | CactinAdd BLAST | 758 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 126 | PhosphoserineBy similarity | 1 | |
Cross-linki | 469 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 476 | PhosphoserineCombined sources | 1 | |
Cross-linki | 484 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 559 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8WUQ7 |
jPOSTi | Q8WUQ7 |
MassIVEi | Q8WUQ7 |
MaxQBi | Q8WUQ7 |
PaxDbi | Q8WUQ7 |
PeptideAtlasi | Q8WUQ7 |
PRIDEi | Q8WUQ7 |
ProteomicsDBi | 74701 [Q8WUQ7-1] 74702 [Q8WUQ7-2] |
PTM databases
iPTMneti | Q8WUQ7 |
MetOSitei | Q8WUQ7 |
PhosphoSitePlusi | Q8WUQ7 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000105298, Expressed in amniotic fluid and 225 other tissues |
ExpressionAtlasi | Q8WUQ7, baseline and differential |
Genevisiblei | Q8WUQ7, HS |
Organism-specific databases
HPAi | ENSG00000105298, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner (PubMed:20829348). Does not interact with RELA NF-kappa-B subunit (PubMed:20829348). Identified in the spliceosome C complex (PubMed:11991638).
Interacts with isoform 2 of TRIM39 (via domain B box-type) (PubMed:26363554).
3 PublicationsBinary interactionsi
Q8WUQ7
With | #Exp. | IntAct |
---|---|---|
CLK2 [P49760] | 3 | EBI-348479,EBI-750020 |
Protein-protein interaction databases
BioGRIDi | 121836, 53 interactors |
CORUMi | Q8WUQ7 |
IntActi | Q8WUQ7, 19 interactors |
STRINGi | 9606.ENSP00000415078 |
Miscellaneous databases
RNActi | Q8WUQ7, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 135 – 185 | Sequence analysisAdd BLAST | 51 | |
Coiled coili | 225 – 277 | Sequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 101 – 107 | Poly-Arg | 7 | |
Compositional biasi | 129 – 133 | Poly-Ala | 5 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2370, Eukaryota |
GeneTreei | ENSGT00950000183102 |
HOGENOMi | CLU_011759_0_0_1 |
InParanoidi | Q8WUQ7 |
OMAi | CLIRFMA |
OrthoDBi | 1252926at2759 |
PhylomeDBi | Q8WUQ7 |
TreeFami | TF300906 |
Family and domain databases
InterProi | View protein in InterPro IPR019134, Cactin_C IPR018816, Cactin_central |
Pfami | View protein in Pfam PF10312, Cactin_mid, 1 hit PF09732, CactinC_cactus, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRDTRSRSR SAGRRGRRRQ SQSGSRSRSR SHGRRNRRRR EDEGRRRRRR
60 70 80 90 100
RSRERRSDSE EERWQRSGMR SRSPPRPKWH SRDGSSQSDS GEEQSRGQWA
110 120 130 140 150
RRRRRARSWS PSSSASSSAS PGRSQSPRAA AAALSQQQSL QERLRLREER
160 170 180 190 200
KQQEELMKAF ETPEEKRARR LAKKEAKERK KREKMGWGEE YMGYTNTDNP
210 220 230 240 250
FGDNNLLGTF IWNKALEKKG ISHLEEKELK ERNKRIQEDN RLELQKVKQL
260 270 280 290 300
RLEREREKAM REQELEMLQR EKEAEHFKTW EEQEDNFHLQ QAKLRSKIRI
310 320 330 340 350
RDGRAKPIDL LAKYISAEDD DLAVEMHEPY TFLNGLTVAD MEDLLEDIQV
360 370 380 390 400
YMELEQGKNA DFWRDMTTIT EDEISKLRKL EASGKGPGER REGVNASVSS
410 420 430 440 450
DVQSVFKGKT YNQLQVIFQG IEGKIRAGGP NLDMGYWESL LQQLRAHMAR
460 470 480 490 500
ARLRERHQDV LRQKLYKLKQ EQGVESEPLF PILKQEPQSP SRSLEPEDAA
510 520 530 540 550
PTPPGPSSEG GPAEAEVDGA TPTEGDGDGD GEGEGEGEAV LMEEDLIQQS
560 570 580 590 600
LDDYDAGRYS PRLLTAHELP LDAHVLEPDE DLQRLQLSRQ QLQVTGDASE
610 620 630 640 650
SAEDIFFRRA KEGMGQDEAQ FSVEMPLTGK AYLWADKYRP RKPRFFNRVH
660 670 680 690 700
TGFEWNKYNQ THYDFDNPPP KIVQGYKFNI FYPDLIDKRS TPEYFLEACA
710 720 730 740 750
DNKDFAILRF HAGPPYEDIA FKIVNREWEY SHRHGFRCQF ANGIFQLWFH
FKRYRYRR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ENY9 | K7ENY9_HUMAN | Cactin | CACTIN | 291 | Annotation score: | ||
K7EQE3 | K7EQE3_HUMAN | Cactin | CACTIN | 130 | Annotation score: | ||
K7EIU6 | K7EIU6_HUMAN | Cactin | CACTIN | 117 | Annotation score: | ||
K7EMQ0 | K7EMQ0_HUMAN | Cactin | CACTIN | 141 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 499 | A → V in AAH19848 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017856 | 758 | R → RPGPCWRPIRHCRRDPLWTP TLCRDWPPTHPVLAGGVHFP AAGIPPPGLLTGPWSMRPVT PSFAHIRTVAPSHSPFSGQE GRGPHGCHSPGRSGPAGRLV LQHPTGTSPTEAKRKVPPGP PEGHPTSPVTSPRPPTAPPR HPASSGNSSVCFSKKTCRWE KKSFVLMELAYWQDRMFF in isoform 2. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY917150 mRNA Translation: AAX84551.1 AC005175 Genomic DNA Translation: AAC24305.1 Sequence problems. AC005542 Genomic DNA Translation: AAC32903.1 Sequence problems. AF155102 mRNA Translation: AAD42868.1 Frameshift. CH471139 Genomic DNA Translation: EAW69298.1 Frameshift. BC004262 mRNA Translation: AAH04262.1 Different initiation. BC019848 mRNA Translation: AAH19848.1 |
CCDSi | CCDS45920.1 [Q8WUQ7-1] |
PIRi | T02672 |
RefSeqi | NP_001074012.1, NM_001080543.1 [Q8WUQ7-1] NP_067054.1, NM_021231.1 [Q8WUQ7-1] |
Genome annotation databases
Ensembli | ENST00000221899; ENSP00000221899; ENSG00000105298 [Q8WUQ7-1] ENST00000248420; ENSP00000248420; ENSG00000105298 [Q8WUQ7-1] ENST00000429344; ENSP00000415078; ENSG00000105298 [Q8WUQ7-1] ENST00000585942; ENSP00000465751; ENSG00000105298 [Q8WUQ7-1] |
GeneIDi | 58509 |
KEGGi | hsa:58509 |
UCSCi | uc002lyh.4, human [Q8WUQ7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY917150 mRNA Translation: AAX84551.1 AC005175 Genomic DNA Translation: AAC24305.1 Sequence problems. AC005542 Genomic DNA Translation: AAC32903.1 Sequence problems. AF155102 mRNA Translation: AAD42868.1 Frameshift. CH471139 Genomic DNA Translation: EAW69298.1 Frameshift. BC004262 mRNA Translation: AAH04262.1 Different initiation. BC019848 mRNA Translation: AAH19848.1 |
CCDSi | CCDS45920.1 [Q8WUQ7-1] |
PIRi | T02672 |
RefSeqi | NP_001074012.1, NM_001080543.1 [Q8WUQ7-1] NP_067054.1, NM_021231.1 [Q8WUQ7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6QDV | electron microscopy | 3.30 | F | 637-758 | [»] | |
SMRi | Q8WUQ7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121836, 53 interactors |
CORUMi | Q8WUQ7 |
IntActi | Q8WUQ7, 19 interactors |
STRINGi | 9606.ENSP00000415078 |
PTM databases
iPTMneti | Q8WUQ7 |
MetOSitei | Q8WUQ7 |
PhosphoSitePlusi | Q8WUQ7 |
Polymorphism and mutation databases
BioMutai | CACTIN |
DMDMi | 322510133 |
Proteomic databases
EPDi | Q8WUQ7 |
jPOSTi | Q8WUQ7 |
MassIVEi | Q8WUQ7 |
MaxQBi | Q8WUQ7 |
PaxDbi | Q8WUQ7 |
PeptideAtlasi | Q8WUQ7 |
PRIDEi | Q8WUQ7 |
ProteomicsDBi | 74701 [Q8WUQ7-1] 74702 [Q8WUQ7-2] |
Protocols and materials databases
Antibodypediai | 52584, 80 antibodies |
DNASUi | 58509 |
Genome annotation databases
Ensembli | ENST00000221899; ENSP00000221899; ENSG00000105298 [Q8WUQ7-1] ENST00000248420; ENSP00000248420; ENSG00000105298 [Q8WUQ7-1] ENST00000429344; ENSP00000415078; ENSG00000105298 [Q8WUQ7-1] ENST00000585942; ENSP00000465751; ENSG00000105298 [Q8WUQ7-1] |
GeneIDi | 58509 |
KEGGi | hsa:58509 |
UCSCi | uc002lyh.4, human [Q8WUQ7-1] |
Organism-specific databases
CTDi | 58509 |
DisGeNETi | 58509 |
EuPathDBi | HostDB:ENSG00000105298.13 |
GeneCardsi | CACTIN |
HGNCi | HGNC:29938, CACTIN |
HPAi | ENSG00000105298, Low tissue specificity |
MIMi | 618536, gene |
neXtProti | NX_Q8WUQ7 |
OpenTargetsi | ENSG00000105298 |
PharmGKBi | PA134932683 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2370, Eukaryota |
GeneTreei | ENSGT00950000183102 |
HOGENOMi | CLU_011759_0_0_1 |
InParanoidi | Q8WUQ7 |
OMAi | CLIRFMA |
OrthoDBi | 1252926at2759 |
PhylomeDBi | Q8WUQ7 |
TreeFami | TF300906 |
Enzyme and pathway databases
PathwayCommonsi | Q8WUQ7 |
Miscellaneous databases
BioGRID-ORCSi | 58509, 693 hits in 849 CRISPR screens |
ChiTaRSi | CACTIN, human |
GeneWikii | C19orf29 |
GenomeRNAii | 58509 |
Pharosi | Q8WUQ7, Tbio |
PROi | PR:Q8WUQ7 |
RNActi | Q8WUQ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105298, Expressed in amniotic fluid and 225 other tissues |
ExpressionAtlasi | Q8WUQ7, baseline and differential |
Genevisiblei | Q8WUQ7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019134, Cactin_C IPR018816, Cactin_central |
Pfami | View protein in Pfam PF10312, Cactin_mid, 1 hit PF09732, CactinC_cactus, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CATIN_HUMAN | |
Accessioni | Q8WUQ7Primary (citable) accession number: Q8WUQ7 Secondary accession number(s): A6NNA9 Q9Y5A4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM