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Entry version 153 (07 Oct 2020)
Sequence version 3 (08 Feb 2011)
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Protein

Cactin

Gene

CACTIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of innate immune response (PubMed:20829348). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (PubMed:20829348, PubMed:26363554).2 Publications

Miscellaneous

Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

Caution

An ORF (C19orf029 OS) has been described in the opposite strand of the C-terminus of this gene.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processImmunity, Innate immunity, mRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8WUQ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cactin
Alternative name(s):
Renal carcinoma antigen NY-REN-24
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACTIN
Synonyms:C19orf29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000105298.13

Human Gene Nomenclature Database

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HGNCi
HGNC:29938, CACTIN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618536, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WUQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
58509

Open Targets

More...
OpenTargetsi
ENSG00000105298

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134932683

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WUQ7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CACTIN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510133

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002316171 – 758CactinAdd BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei476PhosphoserineCombined sources1
Cross-linki484Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei559PhosphotyrosineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WUQ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WUQ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8WUQ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WUQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WUQ7

PeptideAtlas

More...
PeptideAtlasi
Q8WUQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q8WUQ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74701 [Q8WUQ7-1]
74702 [Q8WUQ7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WUQ7

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q8WUQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WUQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by TNF-alpha/TNFA (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105298, Expressed in amniotic fluid and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WUQ7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WUQ7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105298, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner (PubMed:20829348). Does not interact with RELA NF-kappa-B subunit (PubMed:20829348). Identified in the spliceosome C complex (PubMed:11991638).

Interacts with isoform 2 of TRIM39 (via domain B box-type) (PubMed:26363554).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121836, 53 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8WUQ7

Protein interaction database and analysis system

More...
IntActi
Q8WUQ7, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000415078

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WUQ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WUQ7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili135 – 185Sequence analysisAdd BLAST51
Coiled coili225 – 277Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi101 – 107Poly-Arg7
Compositional biasi129 – 133Poly-Ala5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CACTIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2370, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183102

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011759_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WUQ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLIRFMA

Database of Orthologous Groups

More...
OrthoDBi
1252926at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WUQ7

TreeFam database of animal gene trees

More...
TreeFami
TF300906

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019134, Cactin_C
IPR018816, Cactin_central

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10312, Cactin_mid, 1 hit
PF09732, CactinC_cactus, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRDTRSRSR SAGRRGRRRQ SQSGSRSRSR SHGRRNRRRR EDEGRRRRRR
60 70 80 90 100
RSRERRSDSE EERWQRSGMR SRSPPRPKWH SRDGSSQSDS GEEQSRGQWA
110 120 130 140 150
RRRRRARSWS PSSSASSSAS PGRSQSPRAA AAALSQQQSL QERLRLREER
160 170 180 190 200
KQQEELMKAF ETPEEKRARR LAKKEAKERK KREKMGWGEE YMGYTNTDNP
210 220 230 240 250
FGDNNLLGTF IWNKALEKKG ISHLEEKELK ERNKRIQEDN RLELQKVKQL
260 270 280 290 300
RLEREREKAM REQELEMLQR EKEAEHFKTW EEQEDNFHLQ QAKLRSKIRI
310 320 330 340 350
RDGRAKPIDL LAKYISAEDD DLAVEMHEPY TFLNGLTVAD MEDLLEDIQV
360 370 380 390 400
YMELEQGKNA DFWRDMTTIT EDEISKLRKL EASGKGPGER REGVNASVSS
410 420 430 440 450
DVQSVFKGKT YNQLQVIFQG IEGKIRAGGP NLDMGYWESL LQQLRAHMAR
460 470 480 490 500
ARLRERHQDV LRQKLYKLKQ EQGVESEPLF PILKQEPQSP SRSLEPEDAA
510 520 530 540 550
PTPPGPSSEG GPAEAEVDGA TPTEGDGDGD GEGEGEGEAV LMEEDLIQQS
560 570 580 590 600
LDDYDAGRYS PRLLTAHELP LDAHVLEPDE DLQRLQLSRQ QLQVTGDASE
610 620 630 640 650
SAEDIFFRRA KEGMGQDEAQ FSVEMPLTGK AYLWADKYRP RKPRFFNRVH
660 670 680 690 700
TGFEWNKYNQ THYDFDNPPP KIVQGYKFNI FYPDLIDKRS TPEYFLEACA
710 720 730 740 750
DNKDFAILRF HAGPPYEDIA FKIVNREWEY SHRHGFRCQF ANGIFQLWFH

FKRYRYRR
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:758
Mass (Da):88,702
Last modified:February 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF540F151EB96BEFB
GO
Isoform 2 (identifier: Q8WUQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     758-758: R → RPGPCWRPIR...LAYWQDRMFF

Show »
Length:935
Mass (Da):107,938
Checksum:iE7238F52D6384E50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENY9K7ENY9_HUMAN
Cactin
CACTIN
291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQE3K7EQE3_HUMAN
Cactin
CACTIN
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIU6K7EIU6_HUMAN
Cactin
CACTIN
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMQ0K7EMQ0_HUMAN
Cactin
CACTIN
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC24305 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC32903 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAD42868 differs from that shown. Reason: Frameshift.Curated
The sequence AAH04262 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW69298 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti499A → V in AAH19848 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017856758R → RPGPCWRPIRHCRRDPLWTP TLCRDWPPTHPVLAGGVHFP AAGIPPPGLLTGPWSMRPVT PSFAHIRTVAPSHSPFSGQE GRGPHGCHSPGRSGPAGRLV LQHPTGTSPTEAKRKVPPGP PEGHPTSPVTSPRPPTAPPR HPASSGNSSVCFSKKTCRWE KKSFVLMELAYWQDRMFF in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY917150 mRNA Translation: AAX84551.1
AC005175 Genomic DNA Translation: AAC24305.1 Sequence problems.
AC005542 Genomic DNA Translation: AAC32903.1 Sequence problems.
AF155102 mRNA Translation: AAD42868.1 Frameshift.
CH471139 Genomic DNA Translation: EAW69298.1 Frameshift.
BC004262 mRNA Translation: AAH04262.1 Different initiation.
BC019848 mRNA Translation: AAH19848.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45920.1 [Q8WUQ7-1]

Protein sequence database of the Protein Information Resource

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PIRi
T02672

NCBI Reference Sequences

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RefSeqi
NP_001074012.1, NM_001080543.1 [Q8WUQ7-1]
NP_067054.1, NM_021231.1 [Q8WUQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000221899; ENSP00000221899; ENSG00000105298 [Q8WUQ7-1]
ENST00000248420; ENSP00000248420; ENSG00000105298 [Q8WUQ7-1]
ENST00000429344; ENSP00000415078; ENSG00000105298 [Q8WUQ7-1]
ENST00000585942; ENSP00000465751; ENSG00000105298 [Q8WUQ7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58509

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:58509

UCSC genome browser

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UCSCi
uc002lyh.4, human [Q8WUQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY917150 mRNA Translation: AAX84551.1
AC005175 Genomic DNA Translation: AAC24305.1 Sequence problems.
AC005542 Genomic DNA Translation: AAC32903.1 Sequence problems.
AF155102 mRNA Translation: AAD42868.1 Frameshift.
CH471139 Genomic DNA Translation: EAW69298.1 Frameshift.
BC004262 mRNA Translation: AAH04262.1 Different initiation.
BC019848 mRNA Translation: AAH19848.1
CCDSiCCDS45920.1 [Q8WUQ7-1]
PIRiT02672
RefSeqiNP_001074012.1, NM_001080543.1 [Q8WUQ7-1]
NP_067054.1, NM_021231.1 [Q8WUQ7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6QDVelectron microscopy3.30F637-758[»]
SMRiQ8WUQ7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121836, 53 interactors
CORUMiQ8WUQ7
IntActiQ8WUQ7, 19 interactors
STRINGi9606.ENSP00000415078

PTM databases

iPTMnetiQ8WUQ7
MetOSiteiQ8WUQ7
PhosphoSitePlusiQ8WUQ7

Polymorphism and mutation databases

BioMutaiCACTIN
DMDMi322510133

Proteomic databases

EPDiQ8WUQ7
jPOSTiQ8WUQ7
MassIVEiQ8WUQ7
MaxQBiQ8WUQ7
PaxDbiQ8WUQ7
PeptideAtlasiQ8WUQ7
PRIDEiQ8WUQ7
ProteomicsDBi74701 [Q8WUQ7-1]
74702 [Q8WUQ7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
52584, 80 antibodies

The DNASU plasmid repository

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DNASUi
58509

Genome annotation databases

EnsembliENST00000221899; ENSP00000221899; ENSG00000105298 [Q8WUQ7-1]
ENST00000248420; ENSP00000248420; ENSG00000105298 [Q8WUQ7-1]
ENST00000429344; ENSP00000415078; ENSG00000105298 [Q8WUQ7-1]
ENST00000585942; ENSP00000465751; ENSG00000105298 [Q8WUQ7-1]
GeneIDi58509
KEGGihsa:58509
UCSCiuc002lyh.4, human [Q8WUQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58509
DisGeNETi58509
EuPathDBiHostDB:ENSG00000105298.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CACTIN
HGNCiHGNC:29938, CACTIN
HPAiENSG00000105298, Low tissue specificity
MIMi618536, gene
neXtProtiNX_Q8WUQ7
OpenTargetsiENSG00000105298
PharmGKBiPA134932683

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2370, Eukaryota
GeneTreeiENSGT00950000183102
HOGENOMiCLU_011759_0_0_1
InParanoidiQ8WUQ7
OMAiCLIRFMA
OrthoDBi1252926at2759
PhylomeDBiQ8WUQ7
TreeFamiTF300906

Enzyme and pathway databases

PathwayCommonsiQ8WUQ7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
58509, 693 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CACTIN, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C19orf29

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
58509
PharosiQ8WUQ7, Tbio

Protein Ontology

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PROi
PR:Q8WUQ7
RNActiQ8WUQ7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105298, Expressed in amniotic fluid and 225 other tissues
ExpressionAtlasiQ8WUQ7, baseline and differential
GenevisibleiQ8WUQ7, HS

Family and domain databases

InterProiView protein in InterPro
IPR019134, Cactin_C
IPR018816, Cactin_central
PfamiView protein in Pfam
PF10312, Cactin_mid, 1 hit
PF09732, CactinC_cactus, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATIN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUQ7
Secondary accession number(s): A6NNA9
, A9UL12, O75229, Q7LE08, Q9BTA6, Q9Y5A4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 8, 2011
Last modified: October 7, 2020
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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