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Protein

Filamin-binding LIM protein 1

Gene

FBLIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.4 Publications

GO - Molecular functioni

  • filamin binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell-cell adhesion Source: UniProtKB
  • cell junction assembly Source: Reactome
  • regulation of cell shape Source: UniProtKB-KW
  • regulation of integrin activation Source: UniProtKB

Keywordsi

Biological processCell adhesion, Cell shape
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-446353 Cell-extracellular matrix interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Filamin-binding LIM protein 1
Short name:
FBLP-1
Alternative name(s):
Migfilin
Mitogen-inducible 2-interacting protein
Short name:
MIG2-interacting protein
Gene namesi
Name:FBLIM1
Synonyms:FBLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162458.12
HGNCiHGNC:24686 FBLIM1
MIMi607747 gene
neXtProtiNX_Q8WUP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7 – 8KR → TG: Localizes to cell-ECM adhesions; abolishes FLNA and FLNC interactions; failed to decorate actin filaments. 1 Publication2

Organism-specific databases

DisGeNETi54751
OpenTargetsiENSG00000162458
PharmGKBiPA142671776

Polymorphism and mutation databases

BioMutaiFBLIM1
DMDMi125987829

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757321 – 373Filamin-binding LIM protein 1Add BLAST373

Proteomic databases

EPDiQ8WUP2
MaxQBiQ8WUP2
PaxDbiQ8WUP2
PeptideAtlasiQ8WUP2
PRIDEiQ8WUP2
ProteomicsDBi74698
74699 [Q8WUP2-2]
74700 [Q8WUP2-3]

PTM databases

iPTMnetiQ8WUP2
PhosphoSitePlusiQ8WUP2
SwissPalmiQ8WUP2

Expressioni

Tissue specificityi

Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.1 Publication

Gene expression databases

BgeeiENSG00000162458 Expressed in 178 organ(s), highest expression level in thoracic aorta
CleanExiHS_FBLIM1
ExpressionAtlasiQ8WUP2 baseline and differential
GenevisibleiQ8WUP2 HS

Organism-specific databases

HPAiHPA025287
HPA072750

Interactioni

Subunit structurei

Interacts with NKX2-5 (By similarity). Isoform 1 and isoform 3 interact with FERMT2, FLNA, FLNB and FLNC. Isoform 2 interacts with FLNB.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120128, 29 interactors
IntActiQ8WUP2, 11 interactors
STRINGi9606.ENSP00000416387

Structurei

Secondary structure

1373
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WUP2
SMRiQ8WUP2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUP2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 242LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini243 – 300LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini301 – 370LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 85Intrinsically disorderedAdd BLAST85
Regioni1 – 70Filamin-bindingAdd BLAST70
Regioni276 – 373FERMT2-bindingAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 173Pro-richAdd BLAST132

Domaini

The N-terminal region is intrinsically disordered.1 Publication

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000007533
HOVERGENiHBG051561
InParanoidiQ8WUP2
OMAiCYPLNNR
OrthoDBiEOG091G0CJO
PhylomeDBiQ8WUP2
TreeFamiTF320310

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUP2-1) [UniParc]FASTAAdd to basket
Also known as: FBLP-1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKPEKRVA SSVFITLAPP RRDVAVAEEV RQAVCEARRG RPWEAPAPMK
60 70 80 90 100
TPEAGLAGRP SPWTTPGRAA ATVPAAPMQL FNGGCPPPPP VLDGEDVLPD
110 120 130 140 150
LDLLPPPPPP PPVLLPSEEE APAPMGASLI ADLEQLHLSP PPPPPQAPAE
160 170 180 190 200
GPSVQPGPLR PMEEELPPPP AEPVEKGAST DICAFCHKTV SPRELAVEAM
210 220 230 240 250
KRQYHAQCFT CRTCRRQLAG QSFYQKDGRP LCEPCYQDTL ERCGKCGEVV
260 270 280 290 300
RDHIIRALGQ AFHPSCFTCV TCARCIGDES FALGSQNEVY CLDDFYRKFA
310 320 330 340 350
PVCSICENPI IPRDGKDAFK IECMGRNFHE NCYRCEDCRI LLSVEPTDQG
360 370
CYPLNNHLFC KPCHVKRSAA GCC
Length:373
Mass (Da):40,670
Last modified:February 6, 2007 - v2
Checksum:i06B8FB911FCCB194
GO
Isoform 2 (identifier: Q8WUP2-2) [UniParc]FASTAAdd to basket
Also known as: FBLP-1

The sequence of this isoform differs from the canonical sequence as follows:
     298-373: KFAPVCSICE...HVKRSAAGCC → YEKGLCTGWG...TRSGDRDHPG

Note: May be due to competing donor splice site.
Show »
Length:374
Mass (Da):40,306
Checksum:i36BC4CED0B270C4C
GO
Isoform 3 (identifier: Q8WUP2-3) [UniParc]FASTAAdd to basket
Also known as: FBLP-1B

The sequence of this isoform differs from the canonical sequence as follows:
     84-180: Missing.

Note: May be due to exon skipping.
Show »
Length:276
Mass (Da):30,770
Checksum:i77664085430F8163
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWE8E7EWE8_HUMAN
Filamin-binding LIM protein 1
FBLIM1
144Annotation score:
E7EPI5E7EPI5_HUMAN
Filamin-binding LIM protein 1
FBLIM1
104Annotation score:
D6RAI6D6RAI6_HUMAN
Filamin-binding LIM protein 1
FBLIM1
78Annotation score:
E7EN81E7EN81_HUMAN
Filamin-binding LIM protein 1
FBLIM1
144Annotation score:
D6RA19D6RA19_HUMAN
Filamin-binding LIM protein 1
FBLIM1
34Annotation score:
D6R9I4D6R9I4_HUMAN
Filamin-binding LIM protein 1
FBLIM1
31Annotation score:
D6R9V9D6R9V9_HUMAN
Filamin-binding LIM protein 1
FBLIM1
30Annotation score:
D6RAI8D6RAI8_HUMAN
Filamin-binding LIM protein 1
FBLIM1
14Annotation score:
Q5VVD3Q5VVD3_HUMAN
Filamin-binding LIM protein 1
FBLIM1
17Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05014539R → C. Corresponds to variant dbSNP:rs34375304Ensembl.1
Natural variantiVAR_022842191S → F4 PublicationsCorresponds to variant dbSNP:rs10927851Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00878184 – 180Missing in isoform 3. 3 PublicationsAdd BLAST97
Alternative sequenceiVSP_008782298 – 373KFAPV…AAGCC → YEKGLCTGWGAGTGRDPSRV KELSLSPGCWARVSCLLVYY KEYYRAGLGAVAHACNPSTL GGRGGWITRSGDRDHPG in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY180161 mRNA Translation: AAO49012.1
AF459643 mRNA Translation: AAO15549.1
AK027444 mRNA Translation: BAB55115.1
AK055259 mRNA Translation: BAG51492.1
AL450998 Genomic DNA No translation available.
BC019895 mRNA Translation: AAH19895.1
AL133035 mRNA Translation: CAB61365.1
CCDSiCCDS163.1 [Q8WUP2-1]
CCDS30609.1 [Q8WUP2-3]
CCDS44064.1 [Q8WUP2-2]
PIRiT42678
RefSeqiNP_001019386.1, NM_001024215.1 [Q8WUP2-2]
NP_001019387.1, NM_001024216.1 [Q8WUP2-3]
NP_060026.2, NM_017556.2 [Q8WUP2-1]
XP_005245957.1, XM_005245900.1 [Q8WUP2-2]
XP_005245958.1, XM_005245901.1 [Q8WUP2-2]
XP_005245959.1, XM_005245902.1 [Q8WUP2-2]
XP_005245960.1, XM_005245903.1 [Q8WUP2-2]
XP_005245966.1, XM_005245909.3
XP_006710767.1, XM_006710704.3 [Q8WUP2-2]
XP_006710768.1, XM_006710705.1 [Q8WUP2-2]
XP_011539918.1, XM_011541616.2 [Q8WUP2-2]
XP_011539919.1, XM_011541617.2 [Q8WUP2-1]
XP_016857008.1, XM_017001519.1 [Q8WUP2-2]
XP_016857009.1, XM_017001520.1 [Q8WUP2-2]
XP_016857010.1, XM_017001521.1 [Q8WUP2-2]
XP_016857011.1, XM_017001522.1
XP_016857012.1, XM_017001523.1 [Q8WUP2-2]
XP_016857013.1, XM_017001524.1 [Q8WUP2-2]
XP_016857014.1, XM_017001525.1 [Q8WUP2-1]
UniGeneiHs.530101

Genome annotation databases

EnsembliENST00000332305; ENSP00000364920; ENSG00000162458 [Q8WUP2-3]
ENST00000375766; ENSP00000364921; ENSG00000162458 [Q8WUP2-1]
ENST00000375771; ENSP00000364926; ENSG00000162458 [Q8WUP2-1]
ENST00000441801; ENSP00000416387; ENSG00000162458 [Q8WUP2-2]
GeneIDi54751
KEGGihsa:54751
UCSCiuc001axd.2 human [Q8WUP2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY180161 mRNA Translation: AAO49012.1
AF459643 mRNA Translation: AAO15549.1
AK027444 mRNA Translation: BAB55115.1
AK055259 mRNA Translation: BAG51492.1
AL450998 Genomic DNA No translation available.
BC019895 mRNA Translation: AAH19895.1
AL133035 mRNA Translation: CAB61365.1
CCDSiCCDS163.1 [Q8WUP2-1]
CCDS30609.1 [Q8WUP2-3]
CCDS44064.1 [Q8WUP2-2]
PIRiT42678
RefSeqiNP_001019386.1, NM_001024215.1 [Q8WUP2-2]
NP_001019387.1, NM_001024216.1 [Q8WUP2-3]
NP_060026.2, NM_017556.2 [Q8WUP2-1]
XP_005245957.1, XM_005245900.1 [Q8WUP2-2]
XP_005245958.1, XM_005245901.1 [Q8WUP2-2]
XP_005245959.1, XM_005245902.1 [Q8WUP2-2]
XP_005245960.1, XM_005245903.1 [Q8WUP2-2]
XP_005245966.1, XM_005245909.3
XP_006710767.1, XM_006710704.3 [Q8WUP2-2]
XP_006710768.1, XM_006710705.1 [Q8WUP2-2]
XP_011539918.1, XM_011541616.2 [Q8WUP2-2]
XP_011539919.1, XM_011541617.2 [Q8WUP2-1]
XP_016857008.1, XM_017001519.1 [Q8WUP2-2]
XP_016857009.1, XM_017001520.1 [Q8WUP2-2]
XP_016857010.1, XM_017001521.1 [Q8WUP2-2]
XP_016857011.1, XM_017001522.1
XP_016857012.1, XM_017001523.1 [Q8WUP2-2]
XP_016857013.1, XM_017001524.1 [Q8WUP2-2]
XP_016857014.1, XM_017001525.1 [Q8WUP2-1]
UniGeneiHs.530101

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K9UNMR-B1-24[»]
2W0PX-ray1.90C5-19[»]
4P3WX-ray2.00G/H/I/J/K/L5-28[»]
ProteinModelPortaliQ8WUP2
SMRiQ8WUP2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120128, 29 interactors
IntActiQ8WUP2, 11 interactors
STRINGi9606.ENSP00000416387

PTM databases

iPTMnetiQ8WUP2
PhosphoSitePlusiQ8WUP2
SwissPalmiQ8WUP2

Polymorphism and mutation databases

BioMutaiFBLIM1
DMDMi125987829

Proteomic databases

EPDiQ8WUP2
MaxQBiQ8WUP2
PaxDbiQ8WUP2
PeptideAtlasiQ8WUP2
PRIDEiQ8WUP2
ProteomicsDBi74698
74699 [Q8WUP2-2]
74700 [Q8WUP2-3]

Protocols and materials databases

DNASUi54751
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332305; ENSP00000364920; ENSG00000162458 [Q8WUP2-3]
ENST00000375766; ENSP00000364921; ENSG00000162458 [Q8WUP2-1]
ENST00000375771; ENSP00000364926; ENSG00000162458 [Q8WUP2-1]
ENST00000441801; ENSP00000416387; ENSG00000162458 [Q8WUP2-2]
GeneIDi54751
KEGGihsa:54751
UCSCiuc001axd.2 human [Q8WUP2-1]

Organism-specific databases

CTDi54751
DisGeNETi54751
EuPathDBiHostDB:ENSG00000162458.12
GeneCardsiFBLIM1
HGNCiHGNC:24686 FBLIM1
HPAiHPA025287
HPA072750
MIMi607747 gene
neXtProtiNX_Q8WUP2
OpenTargetsiENSG00000162458
PharmGKBiPA142671776
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000007533
HOVERGENiHBG051561
InParanoidiQ8WUP2
OMAiCYPLNNR
OrthoDBiEOG091G0CJO
PhylomeDBiQ8WUP2
TreeFamiTF320310

Enzyme and pathway databases

ReactomeiR-HSA-446353 Cell-extracellular matrix interactions

Miscellaneous databases

ChiTaRSiFBLIM1 human
EvolutionaryTraceiQ8WUP2
GeneWikiiFBLIM1
GenomeRNAii54751
PROiPR:Q8WUP2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162458 Expressed in 178 organ(s), highest expression level in thoracic aorta
CleanExiHS_FBLIM1
ExpressionAtlasiQ8WUP2 baseline and differential
GenevisibleiQ8WUP2 HS

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFBLI1_HUMAN
AccessioniPrimary (citable) accession number: Q8WUP2
Secondary accession number(s): B3KNY0
, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: February 6, 2007
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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