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UniProtKB - Q8WUN7 (UBTD2_HUMAN)

Entry version 132 (11 Dec 2019)
Sequence version 2 (27 Jun 2006)
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Protein

Ubiquitin domain-containing protein 2

Gene

UBTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin domain-containing protein 2
Alternative name(s):
Dendritic cell-derived ubiquitin-like protein
Short name:
DC-UbP
Ubiquitin-like protein SB72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBTD2
Synonyms:DCUBP
ORF Names:SB72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000168246.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:24463 UBTD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610174 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WUN7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000168246

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162408325

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WUN7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBTD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		109896149

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002443321 – 234Ubiquitin domain-containing protein 2Add BLAST234

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WUN7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WUN7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WUN7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WUN7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WUN7

PeptideAtlas

More...PeptideAtlasi		Q8WUN7

PRoteomics IDEntifications database

More...PRIDEi		Q8WUN7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74697

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WUN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WUN7

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8WUN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168246 Expressed in 210 organ(s), highest expression level in forebrain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WUN7 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA035891
HPA035892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		124917, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q8WUN7, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377381

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WUN7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WUN7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8WUN7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 227Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0013 Eukaryota
ENOG410XRPV LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231205

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WUN7

Identification of Orthologs from Complete Genome Data

More...OMAi		PNSGHEC

Database of Orthologous Groups

More...OrthoDBi		1221075at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WUN7

TreeFam database of animal gene trees

More...TreeFami		TF323925

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.225.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032752 DC-UbP/UBTD2_N
IPR038169 DC-UbP/UBTD2_N_sf
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf
IPR039869 UBTD1/2

The PANTHER Classification System

More...PANTHERi		PTHR13609 PTHR13609, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16455 UBD, 1 hit
PF00240 ubiquitin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WUN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL 
        60         70         80         90        100
RSKRDEFWDT APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL 
       110        120        130        140        150
PHGALTECYD ELGNRYQLPV YCLAPPINMI EEKSDIETLD IPEPPPNSGY 
       160        170        180        190        200
ECQLRLRLST GKDLKLVVRS TDTVFHMKRR LHAAEGVEPG SQRWFFSGRP 
       210        220        230 
LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN
Length:234
Mass (Da):26,190
Last modified:June 27, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FB195CDDE83583E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19910 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL99389 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052694129M → I. Corresponds to variant dbSNP:rs17074452Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC008671 Genomic DNA No translation available.
AC024561 Genomic DNA No translation available.
BC019910 mRNA Translation: AAH19910.1 Different initiation.
AF251700 mRNA Translation: AAL99389.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4379.2

NCBI Reference Sequences

More...RefSeqi		NP_689490.2, NM_152277.2
XP_016865511.1, XM_017010022.1
XP_016865512.1, XM_017010023.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000393792; ENSP00000377381; ENSG00000168246

Database of genes from NCBI RefSeq genomes

More...GeneIDi		92181

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:92181

UCSC genome browser

More...UCSCi		uc003mbp.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008671 Genomic DNA No translation available.
AC024561 Genomic DNA No translation available.
BC019910 mRNA Translation: AAH19910.1 Different initiation.
AF251700 mRNA Translation: AAL99389.1 Different initiation.
CCDSiCCDS4379.2
RefSeqiNP_689490.2, NM_152277.2
XP_016865511.1, XM_017010022.1
XP_016865512.1, XM_017010023.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTNNMR-A129-234[»]
2KSNNMR-A14-141[»]
SMRiQ8WUN7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124917, 13 interactors
IntActiQ8WUN7, 20 interactors
STRINGi9606.ENSP00000377381

PTM databases

iPTMnetiQ8WUN7
PhosphoSitePlusiQ8WUN7
SwissPalmiQ8WUN7

Polymorphism and mutation databases

BioMutaiUBTD2
DMDMi109896149

Proteomic databases

EPDiQ8WUN7
jPOSTiQ8WUN7
MassIVEiQ8WUN7
MaxQBiQ8WUN7
PaxDbiQ8WUN7
PeptideAtlasiQ8WUN7
PRIDEiQ8WUN7
ProteomicsDBi74697

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		92181

Genome annotation databases

EnsembliENST00000393792; ENSP00000377381; ENSG00000168246
GeneIDi92181
KEGGihsa:92181
UCSCiuc003mbp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		92181
EuPathDBiHostDB:ENSG00000168246.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBTD2
HGNCiHGNC:24463 UBTD2
HPAiHPA035891
HPA035892
MIMi610174 gene
neXtProtiNX_Q8WUN7
OpenTargetsiENSG00000168246
PharmGKBiPA162408325

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0013 Eukaryota
ENOG410XRPV LUCA
GeneTreeiENSGT00940000156641
HOGENOMiHOG000231205
InParanoidiQ8WUN7
OMAiPNSGHEC
OrthoDBi1221075at2759
PhylomeDBiQ8WUN7
TreeFamiTF323925

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UBTD2 human
EvolutionaryTraceiQ8WUN7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		92181
PharosiQ8WUN7 Tbio

Protein Ontology

More...PROi		PR:Q8WUN7
RNActiQ8WUN7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168246 Expressed in 210 organ(s), highest expression level in forebrain
GenevisibleiQ8WUN7 HS

Family and domain databases

Gene3Di1.20.225.20, 1 hit
InterProiView protein in InterPro
IPR032752 DC-UbP/UBTD2_N
IPR038169 DC-UbP/UBTD2_N_sf
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf
IPR039869 UBTD1/2
PANTHERiPTHR13609 PTHR13609, 1 hit
PfamiView protein in Pfam
PF16455 UBD, 1 hit
PF00240 ubiquitin, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBTD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUN7
Secondary accession number(s): Q8TDQ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: December 11, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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