UniProtKB - Q8WUN7 (UBTD2_HUMAN)
Protein
Ubiquitin domain-containing protein 2
Gene
UBTD2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin domain-containing protein 2Alternative name(s): Dendritic cell-derived ubiquitin-like protein Short name: DC-UbP Ubiquitin-like protein SB72 |
Gene namesi | Name:UBTD2 Synonyms:DCUBP ORF Names:SB72 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24463, UBTD2 |
MIMi | 610174, gene |
neXtProti | NX_Q8WUN7 |
VEuPathDBi | HostDB:ENSG00000168246.5 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000168246 |
PharmGKBi | PA162408325 |
Miscellaneous databases
Pharosi | Q8WUN7, Tbio |
Genetic variation databases
BioMutai | UBTD2 |
DMDMi | 109896149 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000244332 | 1 – 234 | Ubiquitin domain-containing protein 2Add BLAST | 234 |
Proteomic databases
EPDi | Q8WUN7 |
jPOSTi | Q8WUN7 |
MassIVEi | Q8WUN7 |
MaxQBi | Q8WUN7 |
PaxDbi | Q8WUN7 |
PeptideAtlasi | Q8WUN7 |
PRIDEi | Q8WUN7 |
ProteomicsDBi | 74697 |
PTM databases
iPTMneti | Q8WUN7 |
PhosphoSitePlusi | Q8WUN7 |
SwissPalmi | Q8WUN7 |
Expressioni
Tissue specificityi
Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000168246, Expressed in forebrain and 224 other tissues |
Genevisiblei | Q8WUN7, HS |
Organism-specific databases
HPAi | ENSG00000168246, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8WUN7
Protein-protein interaction databases
BioGRIDi | 124917, 24 interactors |
IntActi | Q8WUN7, 20 interactors |
STRINGi | 9606.ENSP00000377381 |
Miscellaneous databases
RNActi | Q8WUN7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q8WUN7 |
SMRi | Q8WUN7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WUN7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 152 – 227 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 76 |
Phylogenomic databases
eggNOGi | KOG0013, Eukaryota |
GeneTreei | ENSGT00940000156641 |
HOGENOMi | CLU_070348_0_0_1 |
InParanoidi | Q8WUN7 |
OMAi | GTGGECQ |
OrthoDBi | 1221075at2759 |
PhylomeDBi | Q8WUN7 |
TreeFami | TF323925 |
Family and domain databases
Gene3Di | 1.20.225.20, 1 hit |
InterProi | View protein in InterPro IPR032752, DC-UbP/UBTD2_N IPR038169, DC-UbP/UBTD2_N_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR039869, UBTD1/2 |
PANTHERi | PTHR13609, PTHR13609, 1 hit |
Pfami | View protein in Pfam PF16455, UBD, 1 hit PF00240, ubiquitin, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WUN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL
60 70 80 90 100
RSKRDEFWDT APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL
110 120 130 140 150
PHGALTECYD ELGNRYQLPV YCLAPPINMI EEKSDIETLD IPEPPPNSGY
160 170 180 190 200
ECQLRLRLST GKDLKLVVRS TDTVFHMKRR LHAAEGVEPG SQRWFFSGRP
210 220 230
LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN
Sequence cautioni
The sequence AAH19910 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL99389 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052694 | 129 | M → I. Corresponds to variant dbSNP:rs17074452Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008671 Genomic DNA No translation available. AC024561 Genomic DNA No translation available. BC019910 mRNA Translation: AAH19910.1 Different initiation. AF251700 mRNA Translation: AAL99389.1 Different initiation. |
CCDSi | CCDS4379.2 |
RefSeqi | NP_689490.2, NM_152277.2 XP_016865511.1, XM_017010022.1 XP_016865512.1, XM_017010023.1 |
Genome annotation databases
Ensembli | ENST00000393792; ENSP00000377381; ENSG00000168246 |
GeneIDi | 92181 |
KEGGi | hsa:92181 |
UCSCi | uc003mbp.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008671 Genomic DNA No translation available. AC024561 Genomic DNA No translation available. BC019910 mRNA Translation: AAH19910.1 Different initiation. AF251700 mRNA Translation: AAL99389.1 Different initiation. |
CCDSi | CCDS4379.2 |
RefSeqi | NP_689490.2, NM_152277.2 XP_016865511.1, XM_017010022.1 XP_016865512.1, XM_017010023.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1TTN | NMR | - | A | 129-234 | [»] | |
2KSN | NMR | - | A | 14-141 | [»] | |
BMRBi | Q8WUN7 | |||||
SMRi | Q8WUN7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124917, 24 interactors |
IntActi | Q8WUN7, 20 interactors |
STRINGi | 9606.ENSP00000377381 |
PTM databases
iPTMneti | Q8WUN7 |
PhosphoSitePlusi | Q8WUN7 |
SwissPalmi | Q8WUN7 |
Genetic variation databases
BioMutai | UBTD2 |
DMDMi | 109896149 |
Proteomic databases
EPDi | Q8WUN7 |
jPOSTi | Q8WUN7 |
MassIVEi | Q8WUN7 |
MaxQBi | Q8WUN7 |
PaxDbi | Q8WUN7 |
PeptideAtlasi | Q8WUN7 |
PRIDEi | Q8WUN7 |
ProteomicsDBi | 74697 |
Protocols and materials databases
Antibodypediai | 28892, 176 antibodies |
DNASUi | 92181 |
Genome annotation databases
Ensembli | ENST00000393792; ENSP00000377381; ENSG00000168246 |
GeneIDi | 92181 |
KEGGi | hsa:92181 |
UCSCi | uc003mbp.2, human |
Organism-specific databases
CTDi | 92181 |
GeneCardsi | UBTD2 |
HGNCi | HGNC:24463, UBTD2 |
HPAi | ENSG00000168246, Low tissue specificity |
MIMi | 610174, gene |
neXtProti | NX_Q8WUN7 |
OpenTargetsi | ENSG00000168246 |
PharmGKBi | PA162408325 |
VEuPathDBi | HostDB:ENSG00000168246.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0013, Eukaryota |
GeneTreei | ENSGT00940000156641 |
HOGENOMi | CLU_070348_0_0_1 |
InParanoidi | Q8WUN7 |
OMAi | GTGGECQ |
OrthoDBi | 1221075at2759 |
PhylomeDBi | Q8WUN7 |
TreeFami | TF323925 |
Enzyme and pathway databases
PathwayCommonsi | Q8WUN7 |
Miscellaneous databases
BioGRID-ORCSi | 92181, 2 hits in 989 CRISPR screens |
ChiTaRSi | UBTD2, human |
EvolutionaryTracei | Q8WUN7 |
GenomeRNAii | 92181 |
Pharosi | Q8WUN7, Tbio |
PROi | PR:Q8WUN7 |
RNActi | Q8WUN7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168246, Expressed in forebrain and 224 other tissues |
Genevisiblei | Q8WUN7, HS |
Family and domain databases
Gene3Di | 1.20.225.20, 1 hit |
InterProi | View protein in InterPro IPR032752, DC-UbP/UBTD2_N IPR038169, DC-UbP/UBTD2_N_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR039869, UBTD1/2 |
PANTHERi | PTHR13609, PTHR13609, 1 hit |
Pfami | View protein in Pfam PF16455, UBD, 1 hit PF00240, ubiquitin, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBTD2_HUMAN | |
Accessioni | Q8WUN7Primary (citable) accession number: Q8WUN7 Secondary accession number(s): Q8TDQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references