UniProtKB - Q8WUM4 (PDC6I_HUMAN)

>sp|Q8WUM4|PDC6I_HUMAN Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1
MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDK
HEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEK
SCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDIS
PDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKE
VFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDF
SDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVP
VSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTK
SRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTP
SNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPA
KTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALS
VTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAY
DNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAP
SIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAG
TAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQS
PGQAPYPGPQQPSYPFPQPPQQSYYPQQ

Entry version 192 (12 Aug 2020)
Sequence version 1 (01 Mar 2002)
Previous versions | rss

Help video Add a publication Feedback

Protein

Programmed cell death 6-interacting protein

Gene

PDCD6IP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).By similarity5 Publications

(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).5 Publications

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Cell cycle, Cell division, Host-virus interaction, Protein transport, Transport

Biological process

Apoptosis, Cell cycle, Cell division, Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

PathwayCommonsⁱ	Q8WUM4
Reactomeⁱ	R-HSA-162588, Budding and maturation of HIV virion R-HSA-5210891, Uptake and function of anthrax toxins

Protein family/group databases

MoonDBⁱ	Q8WUM4, Predicted

MoonDBⁱ

Q8WUM4, Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Programmed cell death 6-interacting protein Short name: PDCD6-interacting protein Alternative name(s): ALG-2-interacting protein 1 ALG-2-interacting protein X Hp95
Gene namesⁱ	Name:PDCD6IP Synonyms:AIP1, ALIX, KIAA1375
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170248.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8766, PDCD6IP
MIMⁱ	608074, gene
neXtProtⁱ	NX_Q8WUM4

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoskeleton, Secreted, Tight junction

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	199	F → D: Does not support cytokinesis; loss of normal midbody formation; loss of CHMP4A-, CHMP4B- and CHMP4C-binding in a yeast two-hybrid assay; no effect on localization to the midbody; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications	1
Mutagenesisⁱ	212	I → D: Does not support cytokinesis; loss of normal midbody formation; loss of CHMP4A-, CHMP4B- and CHMP4C-binding in a yeast two-hybrid assay; impairs rescue of PTAP-type L domain-deficient HIV-1 p6; no effect on localization to the midbody. 3 Publications	1
Mutagenesisⁱ	216	L → D: Abolishes interaction with CHMP4B and abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication	1
Mutagenesisⁱ	317	F → A: Diminishes rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication	1
Mutagenesisⁱ	318	I → A: Greatly diminishes rescue of PTAP-type L domain--deficient HIV-1 p6. 1 Publication	1
Mutagenesisⁱ	319	Y → A: Greatly diminishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications	1
Mutagenesisⁱ	319	Y → F: No effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications	1
Mutagenesisⁱ	495	F → D: Impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication	1
Mutagenesisⁱ	498	V → D: Reduces interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications	1
Mutagenesisⁱ	509	V → D: Abolishes interaction with HIV-1 p6; impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications	1
Mutagenesisⁱ	512	C → A: No effect on interaction with HIV-1 p6; impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication	1
Mutagenesisⁱ	676	F → A: Loss of interaction with SDCBP. 1 Publication	1
Mutagenesisⁱ	676	F → D: Abolishes interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6; no effect on cytokinesis, nor on midbody formation. 4 Publications	1
Mutagenesisⁱ	680	L → D: Impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication	1
Mutagenesisⁱ	683	I → A: No effect on interaction with HIV-1 p6. 2 Publications	1
Mutagenesisⁱ	683	I → D: Reduces interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications	1
Mutagenesisⁱ	717 – 720	PSAP → AAAA: No effect on midbody formation, nor on cytokinesis; reduced TSG101-binding; no effect on HIV-1 release. Almost complete loss of TSG101-binding and impaired cytokinesis; when associated with 852-A--A-855. 1 Publication	4
Mutagenesisⁱ	720	P → L: Abolishes interaction with TSG101; no effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication	1
Mutagenesisⁱ	744 – 745	PR → VD: No effect on midbody formation; loss of CD2AP- and SH3KBP1-binding in a yeast two-hybrid assay; no effect on HIV-1 release. 1 Publication	2
Mutagenesisⁱ	757 – 759	RPP → GAA: No effect on midbody formation; loss of SH3GL2-binding in a yeast two-hybrid assay. 1 Publication	3
Mutagenesisⁱ	757 – 758	RP → AA: Abolishes interaction with SH3GL1 and SH3GL2; no effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication	2
Mutagenesisⁱ	794 – 813	Missing : Does not support the formation of normal midbodies; loss of localization to the midbody; loss of CD2AP-, CEP55-, SH3GL2-, SH3KBP1-, TSG101-binding in a yeast two-hybrid assay. 1 PublicationAdd BLAST	20
Mutagenesisⁱ	800 – 802	GPP → AAA: Abolishes interaction with CEP55; inhibits support of cytokinesis. 1 Publication	3
Mutagenesisⁱ	801 – 802	PP → VD: Loss of midbody localization; does not support cytokinesis; loss of CEP55-binding in a yeast two-hybrid assay; no effect on HIV-1 release. 1 Publication	2
Mutagenesisⁱ	801	P → A: Decreased interaction with CEP55. 1 Publication	1
Mutagenesisⁱ	802	P → A: Decreased interaction with CEP55. 1 Publication	1
Mutagenesisⁱ	803 – 804	YP → VD: No effect on CEP55-binding in a yeast two-hybrid assay. 1 Publication	2
Mutagenesisⁱ	805 – 806	TY → VD: Loss of CEP55-binding in a yeast two-hybrid assay. 1 Publication	2
Mutagenesisⁱ	806	Y → A: Abolishes interaction with CEP55. 1 Publication	1
Mutagenesisⁱ	852 – 855	PSYP → ASAA: Loss of homoologimerization and reduced TSG101-binding; decreased HIV-1 release; no effect on cytokinesis. Almost complete loss of TSG101-binding and impaired cytokinesis; when associated with 717-A--A-720. 1 Publication	4
Mutagenesisⁱ	864 – 865	YY → AA: Loss of homooligomerization; reduced TSG101-binding; impaired HIV-1 release. 1 Publication	2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10015
Open Targets More...OpenTargetsⁱ	ENSG00000170248
PharmGKBⁱ	PA33116

Miscellaneous databases

Pharosⁱ	Q8WUM4, Tbio

Pharosⁱ

Q8WUM4, Tbio

Polymorphism and mutation databases

BioMutaⁱ	PDCD6IP
DMDMⁱ	31076831

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000218891	2 – 868	Programmed cell death 6-interacting proteinAdd BLAST		867

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	215	N6-acetyllysineCombined sources	1
Modified residueⁱ	479	PhosphothreonineCombined sources	1
Modified residueⁱ	481	PhosphoserineCombined sources	1
Modified residueⁱ	730	PhosphoserineCombined sources	1
Modified residueⁱ	738	PhosphothreonineCombined sources	1
Modified residueⁱ	741	PhosphothreonineCombined sources	1
Modified residueⁱ	745	Omega-N-methylarginineCombined sources	1

Post-translational modificationⁱ

May be phosphorylated on tyrosine residues by activated PDGFRB.1 Publication

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-419 CPTAC-420
EPDⁱ	Q8WUM4
jPOSTⁱ	Q8WUM4
MassIVEⁱ	Q8WUM4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WUM4
PaxDbⁱ	Q8WUM4
PeptideAtlas More...PeptideAtlasⁱ	Q8WUM4
PRIDEⁱ	Q8WUM4
ProteomicsDBⁱ	20178 74695 [Q8WUM4-1]

2D gel databases

UCD-2DPAGEⁱ	Q8WUM4

UCD-2DPAGEⁱ

Q8WUM4

PTM databases

iPTMnetⁱ	Q8WUM4
MetOSiteⁱ	Q8WUM4
PhosphoSitePlusⁱ	Q8WUM4
SwissPalmⁱ	Q8WUM4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170248, Expressed in corpus callosum and 238 other tissues
ExpressionAtlasⁱ	Q8WUM4, baseline and differential
Genevisibleⁱ	Q8WUM4, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000170248, Low tissue specificity

HPAⁱ

ENSG00000170248, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Self-associates (PubMed:14505570, PubMed:14519844).

Interacts with SH3KBP1/CIN85 (By similarity).

Interacts with PDCD6 in a calcium -dependent manner (PubMed:16957052, PubMed:18256029, PubMed:18940611).

Interacts with TSG101 in a calcium-dependent manner; PDCD6IP homooligomerization may be required for TSG101-binding (PubMed:14505570, PubMed:14519844, PubMed:18641129, PubMed:19520058, PubMed:17350572).

Interacts with SGSM3 (PubMed:15849434). Directly interacts with CHMP4A, CHMP4B and CHMP4C (PubMed:12860994, PubMed:14505569, PubMed:14505570, PubMed:14519844, PubMed:14678797, PubMed:14583093, PubMed:17428861, PubMed:17350572, PubMed:18511562). Directly interacts with CEP55 in a 1:2 stoechiometry (PubMed:17853893, PubMed:17556548, PubMed:18641129, PubMed:18948538). The interaction with CEP55 is required for PDCD6IP targeting to the midbody (PubMed:18641129). May interact with PDGFRB (PubMed:20494825).

Interacts with SH3GL1 and SH3GL2/endophilin-1 (PubMed:17350572).

Forms a complex with SDCBP and SDC2 (PubMed:22660413).

Found in a complex with F-actin, TJP1/ZO-1 and PARD3 (By similarity).

Interacts with CD2AP (PubMed:17853893).

Interacts with ARRDC1 (PubMed:21191027).

By similarity21 Publications

(Microbial infection) Interacts with HIV-1 p6 (PubMed:14505569, PubMed:17350572, PubMed:17277784, PubMed:18066081).

Interacts with HIV-1 p9 (PubMed:18066081).

5 Publications

(Microbial infection) Interacts with EIAV p9.

4 Publications

(Microbial infection) Interacts with Murine leukemia virus Gag polyprotein (via LYPX(n)L motif).

1 Publication

(Microbial infection) Interacts with ebola virus protein VP40 (via YPx(n)L/I motif).

1 Publication

Binary interactionsⁱ

Hide details

Q8WUM4

With	#Exp.	IntAct
CD2AP [Q9Y5K6]	3	EBI-310624,EBI-298152
CEP55 [Q53EZ4]	16	EBI-310624,EBI-747776
CHMP4A [Q9BY43]	3	EBI-310624,EBI-747981
CHMP4B [Q9H444]	6	EBI-310624,EBI-749627
CHMP4C [Q96CF2]	3	EBI-310624,EBI-1221015
FYN [P06241]	6	EBI-310624,EBI-515315
HCK [P08631]	4	EBI-310624,EBI-346340
LGALS3 [P17931]	2	EBI-310624,EBI-1170392
PDCD6 [O75340]	12	EBI-310624,EBI-352915
Chmp4b [Q9D8B3] from Mus musculus.	2	EBI-310624,EBI-8322817
gag [P03347] from Human immunodeficiency virus type 1 group M subtype B (isolate BH10).	2	EBI-310624,EBI-1220741
gag [P69730] from Equine infectious anemia virus (isolate 1369).	2	EBI-310624,EBI-1220941
Hoxa1 [P09022] from Mus musculus.	3	EBI-310624,EBI-3957603
nef [Q90VU7] from Human immunodeficiency virus 1.	4	EBI-310624,EBI-7460704
Serine protease NS3 (PRO_0000308465) from Dengue virus type 2 (strain 16681-PDK53).	3	EBI-310624,EBI-8826747

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	115332, 146 interactors
ComplexPortalⁱ	CPX-3282, Syndecan-1-syntenin-1-ALIX complex
Database of interacting proteins More...DIPⁱ	DIP-29327N
IntActⁱ	Q8WUM4, 72 interactors
Molecular INTeraction database More...MINTⁱ	Q8WUM4
STRINGⁱ	9606.ENSP00000411825

Miscellaneous databases

RNActⁱ	Q8WUM4, protein

RNActⁱ

Q8WUM4, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	18 – 28	Combined sources	11
Beta strandⁱ	32 – 34	Combined sources	3
Helixⁱ	35 – 54	Combined sources	20
Helixⁱ	62 – 76	Combined sources	15
Turnⁱ	77 – 88	Combined sources	12
Beta strandⁱ	93 – 96	Combined sources	4
Beta strandⁱ	98 – 100	Combined sources	3
Turnⁱ	104 – 106	Combined sources	3
Beta strandⁱ	110 – 114	Combined sources	5
Helixⁱ	116 – 136	Combined sources	21
Beta strandⁱ	140 – 142	Combined sources	3
Helixⁱ	143 – 170	Combined sources	28
Beta strandⁱ	171 – 173	Combined sources	3
Helixⁱ	177 – 179	Combined sources	3
Helixⁱ	181 – 205	Combined sources	25
Helixⁱ	210 – 231	Combined sources	22
Helixⁱ	241 – 266	Combined sources	26
Helixⁱ	270 – 290	Combined sources	21
Turnⁱ	292 – 294	Combined sources	3
Helixⁱ	298 – 317	Combined sources	20
Helixⁱ	326 – 328	Combined sources	3
Beta strandⁱ	348 – 350	Combined sources	3
Turnⁱ	354 – 357	Combined sources	4
Helixⁱ	361 – 398	Combined sources	38
Turnⁱ	399 – 402	Combined sources	4
Helixⁱ	403 – 406	Combined sources	4
Beta strandⁱ	408 – 412	Combined sources	5
Helixⁱ	415 – 426	Combined sources	12
Turnⁱ	427 – 429	Combined sources	3
Helixⁱ	430 – 471	Combined sources	42
Turnⁱ	473 – 475	Combined sources	3
Helixⁱ	481 – 514	Combined sources	34
Helixⁱ	517 – 523	Combined sources	7
Helixⁱ	527 – 532	Combined sources	6
Helixⁱ	541 – 543	Combined sources	3
Helixⁱ	547 – 575	Combined sources	29
Helixⁱ	581 – 590	Combined sources	10
Beta strandⁱ	591 – 593	Combined sources	3
Helixⁱ	596 – 639	Combined sources	44
Helixⁱ	644 – 697	Combined sources	54
Beta strandⁱ	802 – 805	Combined sources	4
Turnⁱ	810 – 813	Combined sources	4

Show more details

3D structure databases

SMRⁱ	Q8WUM4
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8WUM4

EvolutionaryTraceⁱ

Q8WUM4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 392	BRO1PROSITE-ProRule annotationAdd BLAST		390

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	176 – 868	Interaction with EIAV p9Add BLAST	693
Regionⁱ	176 – 503	Interaction with CHMP4A, CHMP4B and CHMP4CAdd BLAST	328
Regionⁱ	418 – 868	Interaction with SDCBP1 PublicationAdd BLAST	451
Regionⁱ	503 – 868	Self-associationAdd BLAST	366
Regionⁱ	717 – 720	Interaction with TSG101	4
Regionⁱ	801 – 806	Interaction with CEP551 Publication	6
Regionⁱ	864 – 868	Essential to promote virus budding	5

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	717 – 860	Pro-richAdd BLAST		144

Phylogenomic databases

eggNOGⁱ	KOG2220, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT01000000214627
HOGENOMⁱ	CLU_007181_2_0_1
InParanoidⁱ	Q8WUM4
KEGG Orthology (KO) More...KOⁱ	K12200
OMAⁱ	TKYDQHP
Database of Orthologous Groups More...OrthoDBⁱ	550620at2759
PhylomeDBⁱ	Q8WUM4
TreeFamⁱ	TF323502

Family and domain databases

Gene3Dⁱ	1.25.40.280, 1 hit
InterProⁱ	View protein in InterPro IPR025304, ALIX_V_dom IPR004328, BRO1_dom IPR038499, BRO1_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13949, ALIX_LYPXL_bnd, 1 hit PF03097, BRO1, 1 hit
SMARTⁱ	View protein in SMART SM01041, BRO1, 1 hit
PROSITEⁱ	View protein in PROSITE PS51180, BRO1, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8WUM4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR 
        60         70         80         90        100
RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD 
       110        120        130        140        150
KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA 
       160        170        180        190        200
KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF 
       210        220        230        240        250
LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE VFPVLAAKHC 
       260        270        280        290        300
IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF 
       310        320        330        340        350
SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK 
       360        370        380        390        400
FTDLFEKMVP VSVQQSLAAY NQRKADLVNR SIAQMREATT LANGVLASLN 
       410        420        430        440        450
LPAAIEDVSG DTVPQSILTK SRSVIEQGGI QTVDQLIKEL PELLQRNREI 
       460        470        480        490        500
LDESLRLLDE EEATDNDLRA KFKERWQRTP SNELYKPLRA EGTNFRTVLD 
       510        520        530        540        550
KAVQADGQVK ECYQSHRDTI VLLCKPEPEL NAAIPSANPA KTMQGSEVVN 
       560        570        580        590        600
VLKSLLSNLD EVKKEREGLE NDLKSVNFDM TSKFLTALAQ DGVINEEALS 
       610        620        630        640        650
VTELDRVYGG LTTKVQESLK KQEGLLKNIQ VSHQEFSKMK QSNNEANLRE 
       660        670        680        690        700
EVLKNLATAY DNFVELVANL KEGTKFYNEL TEILVRFQNK CSDIVFARKT 
       710        720        730        740        750
ERDELLKDLQ QSIAREPSAP SIPTPAYQSS PAGGHAPTPP TPAPRTMPPT 
       760        770        780        790        800
KPQPPARPPP PVLPANRAPS ATAPSPVGAG TAAPAPSQTP GSAPPPQAQG 
       810        820        830        840        850
PPYPTYPGYP GYCQMPMPMG YNPYAYGQYN MPYPPVYHQS PGQAPYPGPQ 
       860 
QPSYPFPQPP QQSYYPQQ

Length:868

Mass (Da):96,023

Last modified:March 1, 2002 - v1

Checksum:ⁱ573588D1F612EC93

Isoform 2 (identifier: Q8WUM4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
239-239: K → KYFYFQ

« Hide

        10         20         30         40         50
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR 
        60         70         80         90        100
RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD 
       110        120        130        140        150
KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA 
       160        170        180        190        200
KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF 
       210        220        230        240        250
LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKY FYFQEVFPVL 
       260        270        280        290        300
AAKHCIMQAN AEYHQSILAK QQKKFGEEIA RLQHAAELIK TVASRYDEYV 
       310        320        330        340        350
NVKDFSDKIN RALAAAKKDN DFIYHDRVPD LKDLDPIGKA TLVKSTPVNV 
       360        370        380        390        400
PISQKFTDLF EKMVPVSVQQ SLAAYNQRKA DLVNRSIAQM REATTLANGV 
       410        420        430        440        450
LASLNLPAAI EDVSGDTVPQ SILTKSRSVI EQGGIQTVDQ LIKELPELLQ 
       460        470        480        490        500
RNREILDESL RLLDEEEATD NDLRAKFKER WQRTPSNELY KPLRAEGTNF 
       510        520        530        540        550
RTVLDKAVQA DGQVKECYQS HRDTIVLLCK PEPELNAAIP SANPAKTMQG 
       560        570        580        590        600
SEVVNVLKSL LSNLDEVKKE REGLENDLKS VNFDMTSKFL TALAQDGVIN 
       610        620        630        640        650
EEALSVTELD RVYGGLTTKV QESLKKQEGL LKNIQVSHQE FSKMKQSNNE 
       660        670        680        690        700
ANLREEVLKN LATAYDNFVE LVANLKEGTK FYNELTEILV RFQNKCSDIV 
       710        720        730        740        750
FARKTERDEL LKDLQQSIAR EPSAPSIPTP AYQSSPAGGH APTPPTPAPR 
       760        770        780        790        800
TMPPTKPQPP ARPPPPVLPA NRAPSATAPS PVGAGTAAPA PSQTPGSAPP 
       810        820        830        840        850
PQAQGPPYPT YPGYPGYCQM PMPMGYNPYA YGQYNMPYPP VYHQSPGQAP 
       860        870 
YPGPQQPSYP FPQPPQQSYY PQQ

Show »

Length:873

Mass (Da):96,772

Checksum:ⁱFAC77FBE20C69D70

Isoform 3 (identifier: Q8WUM4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
240-271: EVFPVLAAKHCIMQANAEYHQSILAKQQKKFG → VSYCFYKHLLTLHVKYLDFFVYKKQVETYKEI
272-868: Missing.

« Hide

        10         20         30         40         50
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR 
        60         70         80         90        100
RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD 
       110        120        130        140        150
KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA 
       160        170        180        190        200
KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF 
       210        220        230        240        250
LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKV SYCFYKHLLT 
       260        270 
LHVKYLDFFV YKKQVETYKE I

Show »

Length:271

Mass (Da):30,453

Checksum:ⁱEDE1855B7AFA2275

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9IZF9	C9IZF9_HUMAN	Programmed cell death 6-interacting... Programmed cell death 6-interacting protein	PDCD6IP	153	Annotation score:
F8WDK9	F8WDK9_HUMAN	Programmed cell death 6-interacting... Programmed cell death 6-interacting protein	PDCD6IP	95	Annotation score:
F8WEQ7	F8WEQ7_HUMAN	Programmed cell death 6-interacting... Programmed cell death 6-interacting protein	PDCD6IP	72	Annotation score:
F8WBR8	F8WBR8_HUMAN	Programmed cell death 6-interacting... Programmed cell death 6-interacting protein	PDCD6IP	78	Annotation score:
A0A3B3IT07	A0A3B3IT07_HUMAN	Programmed cell death 6-interacting... Programmed cell death 6-interacting protein	PDCD6IP	300	Annotation score:

Sequence cautionⁱ

The sequence BAA92092 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	580	M → T in BAA92092 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068975	7	V → M1 PublicationCorresponds to variant dbSNP:rs11554560Ensembl.	1
Natural variantⁱVAR_053017	309	A → T1 PublicationCorresponds to variant dbSNP:rs3792594Ensembl.	1
Natural variantⁱVAR_053018	378	V → I2 PublicationsCorresponds to variant dbSNP:rs3203777Ensembl.	1
Natural variantⁱVAR_069765	429	G → S1 PublicationCorresponds to variant dbSNP:rs76608858Ensembl.	1
Natural variantⁱVAR_053019	550	N → S2 PublicationsCorresponds to variant dbSNP:rs9813017Ensembl.	1
Natural variantⁱVAR_053020	638	K → E. Corresponds to variant dbSNP:rs3183982Ensembl.	1
Natural variantⁱVAR_024381	730	S → L1 PublicationCorresponds to variant dbSNP:rs1127732Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_044860	239	K → KYFYFQ in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_057190	240 – 271	EVFPV…QKKFG → VSYCFYKHLLTLHVKYLDFF VYKKQVETYKEI in isoform 3. 1 PublicationAdd BLAST	32
Alternative sequenceⁱVSP_057191	272 – 868	Missing in isoform 3. 1 PublicationAdd BLAST	597

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF349951 mRNA Translation: AAK20398.1 GQ131806 mRNA Translation: ACS12984.1 AF151793 mRNA Translation: AAF08220.1 BT007367 mRNA Translation: AAP36031.1 AC112220 Genomic DNA No translation available. AC123901 Genomic DNA No translation available. BC020066 mRNA Translation: AAH20066.1 BC068454 mRNA Translation: AAH68454.1 AK002122 mRNA Translation: BAA92092.1 Different initiation. AB037796 mRNA Translation: BAA92613.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2660.1 [Q8WUM4-1] CCDS54561.1 [Q8WUM4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001155901.1, NM_001162429.2 [Q8WUM4-2] NP_001243121.1, NM_001256192.1 [Q8WUM4-3] NP_037506.2, NM_013374.5 [Q8WUM4-1]

Genome annotation databases

Ensemblⁱ	ENST00000307296; ENSP00000307387; ENSG00000170248 [Q8WUM4-1] ENST00000457054; ENSP00000411825; ENSG00000170248 [Q8WUM4-2]
GeneIDⁱ	10015
KEGGⁱ	hsa:10015
UCSC genome browser More...UCSCⁱ	uc003cfx.5, human [Q8WUM4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WUM4	BRO1 domain-containing protein		MARMO		954	UniRef90_Q8WUM4
Programmed cell death 6-interacting protein (Fragment)		NEOVI		221
Programmed cell death 6 interacting protein		PONAB		945
Programmed cell death 6 interacting protein		AILME		913
BRO1 domain-containing protein		MYOLU		908
+181
Q8WUM4-3	Programmed cell death 6-interacting protein		CAMDR		246	UniRef90_Q8WUM4-3

Protein	Similar proteins		Species	Score	Length	Source
Q8WUM4	Programmed cell death 6-interacting protein		RAT		873	UniRef50_Q8WUM4
Programmed cell death 6-interacting protein		MOUSE		869
Programmed cell death 6-interacting protein		XENLA		867
BRO1 domain-containing protein		MARMO		954
Programmed cell death 6-interacting protein (Fragment)		NEOVI		221
+911
Q8WUM4-3	Programmed cell death 6-interacting protein		CAMDR		246	UniRef50_Q8WUM4-3
BRO1 domain-containing protein (Fragment)		SCYTO		278
PDC6I (Fragment)		blackstripe livebearer		279
Programmed cell death 6-interacting protein		HUMAN		300
BRO1 domain-containing protein (Fragment)		Micrurus lemniscatus carvalhoi		255
+4

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF349951 mRNA Translation: AAK20398.1 GQ131806 mRNA Translation: ACS12984.1 AF151793 mRNA Translation: AAF08220.1 BT007367 mRNA Translation: AAP36031.1 AC112220 Genomic DNA No translation available. AC123901 Genomic DNA No translation available. BC020066 mRNA Translation: AAH20066.1 BC068454 mRNA Translation: AAH68454.1 AK002122 mRNA Translation: BAA92092.1 Different initiation. AB037796 mRNA Translation: BAA92613.1
CCDSⁱ	CCDS2660.1 [Q8WUM4-1] CCDS54561.1 [Q8WUM4-2]
RefSeqⁱ	NP_001155901.1, NM_001162429.2 [Q8WUM4-2] NP_001243121.1, NM_001256192.1 [Q8WUM4-3] NP_037506.2, NM_013374.5 [Q8WUM4-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2OEV	X-ray	3.30	A	1-698	[»]
	2OEW	X-ray	2.55	A	1-359	[»]
	2OEX	X-ray	2.58	A/B	360-702	[»]
	2OJQ	X-ray	2.87	A	360-702	[»]
	2R02	X-ray	2.60	A	2-698	[»]
	2R03	X-ray	2.59	A	2-698	[»]
	2R05	X-ray	2.55	A	2-698	[»]
	2XS1	X-ray	2.30	A	1-698	[»]
	2XS8	X-ray	2.50	A	1-698	[»]
	2ZNE	X-ray	2.20	C/D	799-812	[»]
	3C3O	X-ray	2.15	A	1-359	[»]
	3C3Q	X-ray	2.10	A	1-359	[»]
	3C3R	X-ray	2.02	A	1-359	[»]
	3E1R	X-ray	2.00	C	797-809	[»]
	3WUV	X-ray	2.79	C/F/I/L/O/R	796-810	[»]
	4JJY	X-ray	6.50	A/B	355-708	[»]
	5V3R	X-ray	1.91	A	1-359	[»]
	5WA1	X-ray	1.87	A	1-358	[»]
SMRⁱ	Q8WUM4
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	115332, 146 interactors
ComplexPortalⁱ	CPX-3282, Syndecan-1-syntenin-1-ALIX complex
DIPⁱ	DIP-29327N
IntActⁱ	Q8WUM4, 72 interactors
MINTⁱ	Q8WUM4
STRINGⁱ	9606.ENSP00000411825

Protein family/group databases

MoonDBⁱ	Q8WUM4, Predicted

MoonDBⁱ

Q8WUM4, Predicted

PTM databases

iPTMnetⁱ	Q8WUM4
MetOSiteⁱ	Q8WUM4
PhosphoSitePlusⁱ	Q8WUM4
SwissPalmⁱ	Q8WUM4

Polymorphism and mutation databases

BioMutaⁱ	PDCD6IP
DMDMⁱ	31076831

2D gel databases

UCD-2DPAGEⁱ	Q8WUM4

UCD-2DPAGEⁱ

Q8WUM4

Proteomic databases

CPTACⁱ	CPTAC-419 CPTAC-420
EPDⁱ	Q8WUM4
jPOSTⁱ	Q8WUM4
MassIVEⁱ	Q8WUM4
MaxQBⁱ	Q8WUM4
PaxDbⁱ	Q8WUM4
PeptideAtlasⁱ	Q8WUM4
PRIDEⁱ	Q8WUM4
ProteomicsDBⁱ	20178 74695 [Q8WUM4-1]

Protocols and materials databases

Antibodypediaⁱ	2777, 362 antibodies
The DNASU plasmid repository More...DNASUⁱ	10015

Genome annotation databases

Ensemblⁱ	ENST00000307296; ENSP00000307387; ENSG00000170248 [Q8WUM4-1] ENST00000457054; ENSP00000411825; ENSG00000170248 [Q8WUM4-2]
GeneIDⁱ	10015
KEGGⁱ	hsa:10015
UCSCⁱ	uc003cfx.5, human [Q8WUM4-1]

Organism-specific databases

CTDⁱ	10015
DisGeNETⁱ	10015
EuPathDBⁱ	HostDB:ENSG00000170248.13
GeneCardsⁱ	PDCD6IP
HGNCⁱ	HGNC:8766, PDCD6IP
HPAⁱ	ENSG00000170248, Low tissue specificity
MIMⁱ	608074, gene
neXtProtⁱ	NX_Q8WUM4
OpenTargetsⁱ	ENSG00000170248
PharmGKBⁱ	PA33116
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2220, Eukaryota
GeneTreeⁱ	ENSGT01000000214627
HOGENOMⁱ	CLU_007181_2_0_1
InParanoidⁱ	Q8WUM4
KOⁱ	K12200
OMAⁱ	TKYDQHP
OrthoDBⁱ	550620at2759
PhylomeDBⁱ	Q8WUM4
TreeFamⁱ	TF323502

Enzyme and pathway databases

PathwayCommonsⁱ	Q8WUM4
Reactomeⁱ	R-HSA-162588, Budding and maturation of HIV virion R-HSA-5210891, Uptake and function of anthrax toxins

Miscellaneous databases

BioGRID-ORCSⁱ	10015, 211 hits in 875 CRISPR screens
ChiTaRSⁱ	PDCD6IP, human
EvolutionaryTraceⁱ	Q8WUM4
GeneWikiⁱ	PDCD6IP
GenomeRNAiⁱ	10015
Pharosⁱ	Q8WUM4, Tbio
Protein Ontology More...PROⁱ	PR:Q8WUM4
RNActⁱ	Q8WUM4, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170248, Expressed in corpus callosum and 238 other tissues
ExpressionAtlasⁱ	Q8WUM4, baseline and differential
Genevisibleⁱ	Q8WUM4, HS

Family and domain databases

Gene3Dⁱ	1.25.40.280, 1 hit
InterProⁱ	View protein in InterPro IPR025304, ALIX_V_dom IPR004328, BRO1_dom IPR038499, BRO1_sf
Pfamⁱ	View protein in Pfam PF13949, ALIX_LYPXL_bnd, 1 hit PF03097, BRO1, 1 hit
SMARTⁱ	View protein in SMART SM01041, BRO1, 1 hit
PROSITEⁱ	View protein in PROSITE PS51180, BRO1, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDC6I_HUMAN
Accessionⁱ	Q8WUM4Primary (citable) accession number: Q8WUM4 Secondary accession number(s): C5MQH7 Q9UKL5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
	Last sequence update:	March 1, 2002
	Last modified:	August 12, 2020
	This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WUM4 (PDC6I_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Programmed cell death 6-interacting protein

PDCD6IP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q8WUM4

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ