UniProtKB - Q8WUM4 (PDC6I_HUMAN)
Programmed cell death 6-interacting protein
PDCD6IP
Functioni
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- proteinase activated receptor binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- actomyosin contractile ring assembly Source: UniProtKB
- apoptotic process Source: UniProtKB-KW
- bicellular tight junction assembly Source: UniProtKB
- maintenance of epithelial cell apical/basal polarity Source: UniProtKB
- midbody abscission Source: UniProtKB
- mitotic cytokinesis Source: UniProtKB
- multivesicular body assembly Source: ParkinsonsUK-UCL
- positive regulation of exosomal secretion Source: UniProtKB
- positive regulation of extracellular exosome assembly Source: UniProtKB
- protein homooligomerization Source: UniProtKB
- protein transport Source: UniProtKB-KW
- regulation of centrosome duplication Source: UniProtKB
- regulation of extracellular exosome assembly Source: UniProtKB
- regulation of membrane permeability Source: UniProtKB
- regulation of necroptotic process Source: Reactome
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB
- viral budding Source: UniProtKB
- viral budding via host ESCRT complex Source: UniProtKB
- viral life cycle Source: Reactome
Keywordsi
Biological process | Apoptosis, Cell cycle, Cell division, Host-virus interaction, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8WUM4 |
Reactomei | R-HSA-162588, Budding and maturation of HIV virion R-HSA-5210891, Uptake and function of anthrax toxins R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5675482, Regulation of necroptotic cell death |
Protein family/group databases
MoonDBi | Q8WUM4, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Programmed cell death 6-interacting proteinShort name: PDCD6-interacting protein Alternative name(s): ALG-2-interacting protein 1 ALG-2-interacting protein X Hp95 |
Gene namesi | Name:PDCD6IP Synonyms:AIP1, ALIX, KIAA1375 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8766, PDCD6IP |
MIMi | 608074, gene |
neXtProti | NX_Q8WUM4 |
VEuPathDBi | HostDB:ENSG00000170248.13 |
Subcellular locationi
Cytoskeleton
- centrosome 2 Publications
Cytoplasm and Cytosol
- cytosol By similarity
Extracellular region or secreted
- extracellular exosome 1 Publication
Other locations
- Melanosome 1 Publication
- tight junction By similarity
- Midbody ring 2 Publications
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 at centrosomes of non-dividing cells. Component of the actomyosin-tight junction complex (By similarity). PDCD6IP targeting to the midbody requires the interaction with CEP55 (PubMed:18641129).By similarity4 Publications
Cytoskeleton
- actomyosin Source: UniProtKB
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum exit site Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular vesicle Source: UniProtKB
Plasma Membrane
- immunological synapse Source: BHF-UCL
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
- Flemming body Source: UniProtKB
- focal adhesion Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoskeleton, Secreted, Tight junctionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 199 | F → D: Does not support cytokinesis; loss of normal midbody formation; loss of CHMP4A-, CHMP4B- and CHMP4C-binding in a yeast two-hybrid assay; no effect on localization to the midbody; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications | 1 | |
Mutagenesisi | 212 | I → D: Does not support cytokinesis; loss of normal midbody formation; loss of CHMP4A-, CHMP4B- and CHMP4C-binding in a yeast two-hybrid assay; impairs rescue of PTAP-type L domain-deficient HIV-1 p6; no effect on localization to the midbody. 3 Publications | 1 | |
Mutagenesisi | 216 | L → D: Abolishes interaction with CHMP4B and abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 317 | F → A: Diminishes rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 318 | I → A: Greatly diminishes rescue of PTAP-type L domain--deficient HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 319 | Y → A: Greatly diminishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications | 1 | |
Mutagenesisi | 319 | Y → F: No effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications | 1 | |
Mutagenesisi | 495 | F → D: Impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 498 | V → D: Reduces interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications | 1 | |
Mutagenesisi | 509 | V → D: Abolishes interaction with HIV-1 p6; impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications | 1 | |
Mutagenesisi | 512 | C → A: No effect on interaction with HIV-1 p6; impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 676 | F → A: Loss of interaction with SDCBP. 1 Publication | 1 | |
Mutagenesisi | 676 | F → D: Abolishes interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6; no effect on cytokinesis, nor on midbody formation. 4 Publications | 1 | |
Mutagenesisi | 680 | L → D: Impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 683 | I → A: No effect on interaction with HIV-1 p6. 2 Publications | 1 | |
Mutagenesisi | 683 | I → D: Reduces interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications | 1 | |
Mutagenesisi | 717 – 720 | PSAP → AAAA: No effect on midbody formation, nor on cytokinesis; reduced TSG101-binding; no effect on HIV-1 release. Almost complete loss of TSG101-binding and impaired cytokinesis; when associated with 852-A--A-855. 1 Publication | 4 | |
Mutagenesisi | 720 | P → L: Abolishes interaction with TSG101; no effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 744 – 745 | PR → VD: No effect on midbody formation; loss of CD2AP- and SH3KBP1-binding in a yeast two-hybrid assay; no effect on HIV-1 release. 1 Publication | 2 | |
Mutagenesisi | 757 – 759 | RPP → GAA: No effect on midbody formation; loss of SH3GL2-binding in a yeast two-hybrid assay. 1 Publication | 3 | |
Mutagenesisi | 757 – 758 | RP → AA: Abolishes interaction with SH3GL1 and SH3GL2; no effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication | 2 | |
Mutagenesisi | 794 – 813 | Missing : Does not support the formation of normal midbodies; loss of localization to the midbody; loss of CD2AP-, CEP55-, SH3GL2-, SH3KBP1-, TSG101-binding in a yeast two-hybrid assay. 1 PublicationAdd BLAST | 20 | |
Mutagenesisi | 800 – 802 | GPP → AAA: Abolishes interaction with CEP55; inhibits support of cytokinesis. 1 Publication | 3 | |
Mutagenesisi | 801 – 802 | PP → VD: Loss of midbody localization; does not support cytokinesis; loss of CEP55-binding in a yeast two-hybrid assay; no effect on HIV-1 release. 1 Publication | 2 | |
Mutagenesisi | 801 | P → A: Decreased interaction with CEP55. 1 Publication | 1 | |
Mutagenesisi | 802 | P → A: Decreased interaction with CEP55. 1 Publication | 1 | |
Mutagenesisi | 803 – 804 | YP → VD: No effect on CEP55-binding in a yeast two-hybrid assay. 1 Publication | 2 | |
Mutagenesisi | 805 – 806 | TY → VD: Loss of CEP55-binding in a yeast two-hybrid assay. 1 Publication | 2 | |
Mutagenesisi | 806 | Y → A: Abolishes interaction with CEP55. 1 Publication | 1 | |
Mutagenesisi | 852 – 855 | PSYP → ASAA: Loss of homoologimerization and reduced TSG101-binding; decreased HIV-1 release; no effect on cytokinesis. Almost complete loss of TSG101-binding and impaired cytokinesis; when associated with 717-A--A-720. 1 Publication | 4 | |
Mutagenesisi | 864 – 865 | YY → AA: Loss of homooligomerization; reduced TSG101-binding; impaired HIV-1 release. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 10015 |
OpenTargetsi | ENSG00000170248 |
PharmGKBi | PA33116 |
Miscellaneous databases
Pharosi | Q8WUM4, Tbio |
Genetic variation databases
BioMutai | PDCD6IP |
DMDMi | 31076831 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000218891 | 2 – 868 | Programmed cell death 6-interacting proteinAdd BLAST | 867 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 215 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 479 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 481 | PhosphoserineCombined sources | 1 | |
Modified residuei | 730 | PhosphoserineCombined sources | 1 | |
Modified residuei | 738 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 741 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 745 | Omega-N-methylarginineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-419 CPTAC-420 |
EPDi | Q8WUM4 |
jPOSTi | Q8WUM4 |
MassIVEi | Q8WUM4 |
MaxQBi | Q8WUM4 |
PaxDbi | Q8WUM4 |
PeptideAtlasi | Q8WUM4 |
PRIDEi | Q8WUM4 |
ProteomicsDBi | 20178 74695 [Q8WUM4-1] |
2D gel databases
UCD-2DPAGEi | Q8WUM4 |
PTM databases
iPTMneti | Q8WUM4 |
MetOSitei | Q8WUM4 |
PhosphoSitePlusi | Q8WUM4 |
SwissPalmi | Q8WUM4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170248, Expressed in corpus callosum and 238 other tissues |
ExpressionAtlasi | Q8WUM4, baseline and differential |
Genevisiblei | Q8WUM4, HS |
Organism-specific databases
HPAi | ENSG00000170248, Low tissue specificity |
Interactioni
Subunit structurei
Self-associates (PubMed:14505570, PubMed:14519844).
Interacts with SH3KBP1/CIN85 (By similarity).
Interacts with PDCD6 in a calcium -dependent manner (PubMed:16957052, PubMed:18256029, PubMed:18940611).
Interacts with TSG101 in a calcium-dependent manner; PDCD6IP homooligomerization may be required for TSG101-binding (PubMed:14505570, PubMed:14519844, PubMed:18641129, PubMed:19520058, PubMed:17350572).
Interacts with SGSM3 (PubMed:15849434). Directly interacts with CHMP4A, CHMP4B and CHMP4C (PubMed:12860994, PubMed:14505569, PubMed:14505570, PubMed:14519844, PubMed:14678797, PubMed:14583093, PubMed:17428861, PubMed:17350572, PubMed:18511562). Directly interacts with CEP55 in a 1:2 stoechiometry (PubMed:17853893, PubMed:17556548, PubMed:18641129, PubMed:18948538). The interaction with CEP55 is required for PDCD6IP targeting to the midbody (PubMed:18641129). May interact with PDGFRB (PubMed:20494825).
Interacts with SH3GL1 and SH3GL2/endophilin-1 (PubMed:17350572).
Forms a complex with SDCBP and SDC2 (PubMed:22660413).
Found in a complex with F-actin, TJP1/ZO-1 and PARD3 (By similarity).
Interacts with CD2AP (PubMed:17853893).
Interacts with ARRDC1 (PubMed:21191027).
By similarity21 Publications(Microbial infection) Interacts with EIAV p9.
4 Publications(Microbial infection) Interacts with Murine leukemia virus Gag polyprotein (via LYPX(n)L motif).
1 Publication(Microbial infection) Interacts with ebola virus protein VP40 (via YPx(n)L/I motif).
1 PublicationBinary interactionsi
Hide detailsQ8WUM4
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- proteinase activated receptor binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115332, 155 interactors |
ComplexPortali | CPX-3282, Syndecan-1-syntenin-1-ALIX complex |
DIPi | DIP-29327N |
IntActi | Q8WUM4, 74 interactors |
MINTi | Q8WUM4 |
STRINGi | 9606.ENSP00000411825 |
Miscellaneous databases
RNActi | Q8WUM4, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8WUM4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WUM4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 392 | BRO1PROSITE-ProRule annotationAdd BLAST | 390 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 176 – 868 | Interaction with EIAV p9Add BLAST | 693 | |
Regioni | 176 – 503 | Interaction with CHMP4A, CHMP4B and CHMP4CAdd BLAST | 328 | |
Regioni | 418 – 868 | Interaction with SDCBP1 PublicationAdd BLAST | 451 | |
Regioni | 503 – 868 | Self-associationAdd BLAST | 366 | |
Regioni | 717 – 720 | Interaction with TSG101 | 4 | |
Regioni | 801 – 806 | Interaction with CEP551 Publication | 6 | |
Regioni | 864 – 868 | Essential to promote virus budding | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 717 – 860 | Pro-richAdd BLAST | 144 |
Phylogenomic databases
eggNOGi | KOG2220, Eukaryota |
GeneTreei | ENSGT01000000214627 |
HOGENOMi | CLU_007181_2_0_1 |
InParanoidi | Q8WUM4 |
OMAi | TKYDQHP |
OrthoDBi | 550620at2759 |
PhylomeDBi | Q8WUM4 |
TreeFami | TF323502 |
Family and domain databases
Gene3Di | 1.25.40.280, 1 hit |
InterProi | View protein in InterPro IPR025304, ALIX_V_dom IPR004328, BRO1_dom IPR038499, BRO1_sf |
Pfami | View protein in Pfam PF13949, ALIX_LYPXL_bnd, 1 hit PF03097, BRO1, 1 hit |
SMARTi | View protein in SMART SM01041, BRO1, 1 hit |
PROSITEi | View protein in PROSITE PS51180, BRO1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR
60 70 80 90 100
RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD
110 120 130 140 150
KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA
160 170 180 190 200
KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF
210 220 230 240 250
LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE VFPVLAAKHC
260 270 280 290 300
IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF
310 320 330 340 350
SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK
360 370 380 390 400
FTDLFEKMVP VSVQQSLAAY NQRKADLVNR SIAQMREATT LANGVLASLN
410 420 430 440 450
LPAAIEDVSG DTVPQSILTK SRSVIEQGGI QTVDQLIKEL PELLQRNREI
460 470 480 490 500
LDESLRLLDE EEATDNDLRA KFKERWQRTP SNELYKPLRA EGTNFRTVLD
510 520 530 540 550
KAVQADGQVK ECYQSHRDTI VLLCKPEPEL NAAIPSANPA KTMQGSEVVN
560 570 580 590 600
VLKSLLSNLD EVKKEREGLE NDLKSVNFDM TSKFLTALAQ DGVINEEALS
610 620 630 640 650
VTELDRVYGG LTTKVQESLK KQEGLLKNIQ VSHQEFSKMK QSNNEANLRE
660 670 680 690 700
EVLKNLATAY DNFVELVANL KEGTKFYNEL TEILVRFQNK CSDIVFARKT
710 720 730 740 750
ERDELLKDLQ QSIAREPSAP SIPTPAYQSS PAGGHAPTPP TPAPRTMPPT
760 770 780 790 800
KPQPPARPPP PVLPANRAPS ATAPSPVGAG TAAPAPSQTP GSAPPPQAQG
810 820 830 840 850
PPYPTYPGYP GYCQMPMPMG YNPYAYGQYN MPYPPVYHQS PGQAPYPGPQ
860
QPSYPFPQPP QQSYYPQQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9IZF9 | C9IZF9_HUMAN | Programmed cell death 6-interacting... | PDCD6IP | 153 | Annotation score: | ||
F8WDK9 | F8WDK9_HUMAN | Programmed cell death 6-interacting... | PDCD6IP | 95 | Annotation score: | ||
F8WEQ7 | F8WEQ7_HUMAN | Programmed cell death 6-interacting... | PDCD6IP | 72 | Annotation score: | ||
F8WBR8 | F8WBR8_HUMAN | Programmed cell death 6-interacting... | PDCD6IP | 78 | Annotation score: | ||
A0A3B3IT07 | A0A3B3IT07_HUMAN | Programmed cell death 6-interacting... | PDCD6IP | 300 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 580 | M → T in BAA92092 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068975 | 7 | V → M1 PublicationCorresponds to variant dbSNP:rs11554560Ensembl. | 1 | |
Natural variantiVAR_053017 | 309 | A → T1 PublicationCorresponds to variant dbSNP:rs3792594Ensembl. | 1 | |
Natural variantiVAR_053018 | 378 | V → I2 PublicationsCorresponds to variant dbSNP:rs3203777Ensembl. | 1 | |
Natural variantiVAR_069765 | 429 | G → S1 PublicationCorresponds to variant dbSNP:rs76608858EnsemblClinVar. | 1 | |
Natural variantiVAR_053019 | 550 | N → S2 PublicationsCorresponds to variant dbSNP:rs9813017Ensembl. | 1 | |
Natural variantiVAR_053020 | 638 | K → E. Corresponds to variant dbSNP:rs3183982Ensembl. | 1 | |
Natural variantiVAR_024381 | 730 | S → L1 PublicationCorresponds to variant dbSNP:rs1127732Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044860 | 239 | K → KYFYFQ in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_057190 | 240 – 271 | EVFPV…QKKFG → VSYCFYKHLLTLHVKYLDFF VYKKQVETYKEI in isoform 3. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_057191 | 272 – 868 | Missing in isoform 3. 1 PublicationAdd BLAST | 597 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF349951 mRNA Translation: AAK20398.1 GQ131806 mRNA Translation: ACS12984.1 AF151793 mRNA Translation: AAF08220.1 BT007367 mRNA Translation: AAP36031.1 AC112220 Genomic DNA No translation available. AC123901 Genomic DNA No translation available. BC020066 mRNA Translation: AAH20066.1 BC068454 mRNA Translation: AAH68454.1 AK002122 mRNA Translation: BAA92092.1 Different initiation. AB037796 mRNA Translation: BAA92613.1 |
CCDSi | CCDS2660.1 [Q8WUM4-1] CCDS54561.1 [Q8WUM4-2] |
RefSeqi | NP_001155901.1, NM_001162429.2 [Q8WUM4-2] NP_001243121.1, NM_001256192.1 [Q8WUM4-3] NP_037506.2, NM_013374.5 [Q8WUM4-1] |
Genome annotation databases
Ensembli | ENST00000307296; ENSP00000307387; ENSG00000170248 [Q8WUM4-1] ENST00000457054; ENSP00000411825; ENSG00000170248 [Q8WUM4-2] |
GeneIDi | 10015 |
KEGGi | hsa:10015 |
UCSCi | uc003cfx.5, human [Q8WUM4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF349951 mRNA Translation: AAK20398.1 GQ131806 mRNA Translation: ACS12984.1 AF151793 mRNA Translation: AAF08220.1 BT007367 mRNA Translation: AAP36031.1 AC112220 Genomic DNA No translation available. AC123901 Genomic DNA No translation available. BC020066 mRNA Translation: AAH20066.1 BC068454 mRNA Translation: AAH68454.1 AK002122 mRNA Translation: BAA92092.1 Different initiation. AB037796 mRNA Translation: BAA92613.1 |
CCDSi | CCDS2660.1 [Q8WUM4-1] CCDS54561.1 [Q8WUM4-2] |
RefSeqi | NP_001155901.1, NM_001162429.2 [Q8WUM4-2] NP_001243121.1, NM_001256192.1 [Q8WUM4-3] NP_037506.2, NM_013374.5 [Q8WUM4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2OEV | X-ray | 3.30 | A | 1-698 | [»] | |
2OEW | X-ray | 2.55 | A | 1-359 | [»] | |
2OEX | X-ray | 2.58 | A/B | 360-702 | [»] | |
2OJQ | X-ray | 2.87 | A | 360-702 | [»] | |
2R02 | X-ray | 2.60 | A | 2-698 | [»] | |
2R03 | X-ray | 2.59 | A | 2-698 | [»] | |
2R05 | X-ray | 2.55 | A | 2-698 | [»] | |
2XS1 | X-ray | 2.30 | A | 1-698 | [»] | |
2XS8 | X-ray | 2.50 | A | 1-698 | [»] | |
2ZNE | X-ray | 2.20 | C/D | 799-812 | [»] | |
3C3O | X-ray | 2.15 | A | 1-359 | [»] | |
3C3Q | X-ray | 2.10 | A | 1-359 | [»] | |
3C3R | X-ray | 2.02 | A | 1-359 | [»] | |
3E1R | X-ray | 2.00 | C | 797-809 | [»] | |
3WUV | X-ray | 2.79 | C/F/I/L/O/R | 796-810 | [»] | |
4JJY | X-ray | 6.50 | A/B | 355-708 | [»] | |
5V3R | X-ray | 1.91 | A | 1-359 | [»] | |
5WA1 | X-ray | 1.87 | A | 1-358 | [»] | |
6KP3 | X-ray | 2.20 | A | 1-359 | [»] | |
SMRi | Q8WUM4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115332, 155 interactors |
ComplexPortali | CPX-3282, Syndecan-1-syntenin-1-ALIX complex |
DIPi | DIP-29327N |
IntActi | Q8WUM4, 74 interactors |
MINTi | Q8WUM4 |
STRINGi | 9606.ENSP00000411825 |
Protein family/group databases
MoonDBi | Q8WUM4, Predicted |
PTM databases
iPTMneti | Q8WUM4 |
MetOSitei | Q8WUM4 |
PhosphoSitePlusi | Q8WUM4 |
SwissPalmi | Q8WUM4 |
Genetic variation databases
BioMutai | PDCD6IP |
DMDMi | 31076831 |
2D gel databases
UCD-2DPAGEi | Q8WUM4 |
Proteomic databases
CPTACi | CPTAC-419 CPTAC-420 |
EPDi | Q8WUM4 |
jPOSTi | Q8WUM4 |
MassIVEi | Q8WUM4 |
MaxQBi | Q8WUM4 |
PaxDbi | Q8WUM4 |
PeptideAtlasi | Q8WUM4 |
PRIDEi | Q8WUM4 |
ProteomicsDBi | 20178 74695 [Q8WUM4-1] |
Protocols and materials databases
Antibodypediai | 2777, 371 antibodies |
DNASUi | 10015 |
Genome annotation databases
Ensembli | ENST00000307296; ENSP00000307387; ENSG00000170248 [Q8WUM4-1] ENST00000457054; ENSP00000411825; ENSG00000170248 [Q8WUM4-2] |
GeneIDi | 10015 |
KEGGi | hsa:10015 |
UCSCi | uc003cfx.5, human [Q8WUM4-1] |
Organism-specific databases
CTDi | 10015 |
DisGeNETi | 10015 |
GeneCardsi | PDCD6IP |
HGNCi | HGNC:8766, PDCD6IP |
HPAi | ENSG00000170248, Low tissue specificity |
MIMi | 608074, gene |
neXtProti | NX_Q8WUM4 |
OpenTargetsi | ENSG00000170248 |
PharmGKBi | PA33116 |
VEuPathDBi | HostDB:ENSG00000170248.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2220, Eukaryota |
GeneTreei | ENSGT01000000214627 |
HOGENOMi | CLU_007181_2_0_1 |
InParanoidi | Q8WUM4 |
OMAi | TKYDQHP |
OrthoDBi | 550620at2759 |
PhylomeDBi | Q8WUM4 |
TreeFami | TF323502 |
Enzyme and pathway databases
PathwayCommonsi | Q8WUM4 |
Reactomei | R-HSA-162588, Budding and maturation of HIV virion R-HSA-5210891, Uptake and function of anthrax toxins R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5675482, Regulation of necroptotic cell death |
Miscellaneous databases
BioGRID-ORCSi | 10015, 219 hits in 1000 CRISPR screens |
ChiTaRSi | PDCD6IP, human |
EvolutionaryTracei | Q8WUM4 |
GeneWikii | PDCD6IP |
GenomeRNAii | 10015 |
Pharosi | Q8WUM4, Tbio |
PROi | PR:Q8WUM4 |
RNActi | Q8WUM4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170248, Expressed in corpus callosum and 238 other tissues |
ExpressionAtlasi | Q8WUM4, baseline and differential |
Genevisiblei | Q8WUM4, HS |
Family and domain databases
Gene3Di | 1.25.40.280, 1 hit |
InterProi | View protein in InterPro IPR025304, ALIX_V_dom IPR004328, BRO1_dom IPR038499, BRO1_sf |
Pfami | View protein in Pfam PF13949, ALIX_LYPXL_bnd, 1 hit PF03097, BRO1, 1 hit |
SMARTi | View protein in SMART SM01041, BRO1, 1 hit |
PROSITEi | View protein in PROSITE PS51180, BRO1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDC6I_HUMAN | |
Accessioni | Q8WUM4Primary (citable) accession number: Q8WUM4 Secondary accession number(s): C5MQH7 Q9UKL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 196 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references