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UniProtKB - Q8WUM4 (PDC6I_HUMAN)

Protein

Programmed cell death 6-interacting protein

Gene

PDCD6IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).By similarity5 Publications
(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).5 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processApoptosis, Cell cycle, Cell division, Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-5210891 Uptake and function of anthrax toxins

Protein family/group databases

MoonDBiQ8WUM4 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death 6-interacting protein
Short name:
PDCD6-interacting protein
Alternative name(s):
ALG-2-interacting protein 1
ALG-2-interacting protein X
Hp95
Gene namesi
Name:PDCD6IP
Synonyms:AIP1, ALIX, KIAA1375
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000170248.13
HGNCiHGNC:8766 PDCD6IP
MIMi608074 gene
neXtProtiNX_Q8WUM4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Secreted, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi199F → D: Does not support cytokinesis; loss of normal midbody formation; loss of CHMP4A-, CHMP4B- and CHMP4C-binding in a yeast two-hybrid assay; no effect on localization to the midbody; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications1
Mutagenesisi212I → D: Does not support cytokinesis; loss of normal midbody formation; loss of CHMP4A-, CHMP4B- and CHMP4C-binding in a yeast two-hybrid assay; impairs rescue of PTAP-type L domain-deficient HIV-1 p6; no effect on localization to the midbody. 3 Publications1
Mutagenesisi216L → D: Abolishes interaction with CHMP4B and abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication1
Mutagenesisi317F → A: Diminishes rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication1
Mutagenesisi318I → A: Greatly diminishes rescue of PTAP-type L domain--deficient HIV-1 p6. 1 Publication1
Mutagenesisi319Y → A: Greatly diminishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications1
Mutagenesisi319Y → F: No effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications1
Mutagenesisi495F → D: Impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication1
Mutagenesisi498V → D: Reduces interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications1
Mutagenesisi509V → D: Abolishes interaction with HIV-1 p6; impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications1
Mutagenesisi512C → A: No effect on interaction with HIV-1 p6; impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication1
Mutagenesisi676F → A: Loss of interaction with SDCBP. 1 Publication1
Mutagenesisi676F → D: Abolishes interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6; no effect on cytokinesis, nor on midbody formation. 4 Publications1
Mutagenesisi680L → D: Impairs rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication1
Mutagenesisi683I → A: No effect on interaction with HIV-1 p6. 2 Publications1
Mutagenesisi683I → D: Reduces interaction with HIV-1 p6 and EIAV p9; abolishes rescue of PTAP-type L domain-deficient HIV-1 p6. 2 Publications1
Mutagenesisi717 – 720PSAP → AAAA: No effect on midbody formation, nor on cytokinesis; reduced TSG101-binding; no effect on HIV-1 release. Almost complete loss of TSG101-binding and impaired cytokinesis; when associated with 852-A--A-855. 1 Publication4
Mutagenesisi720P → L: Abolishes interaction with TSG101; no effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication1
Mutagenesisi744 – 745PR → VD: No effect on midbody formation; loss of CD2AP- and SH3KBP1-binding in a yeast two-hybrid assay; no effect on HIV-1 release. 1 Publication2
Mutagenesisi757 – 759RPP → GAA: No effect on midbody formation; loss of SH3GL2-binding in a yeast two-hybrid assay. 1 Publication3
Mutagenesisi757 – 758RP → AA: Abolishes interaction with SH3GL1 and SH3GL2; no effect on rescue of PTAP-type L domain-deficient HIV-1 p6. 1 Publication2
Mutagenesisi794 – 813Missing : Does not support the formation of normal midbodies; loss of localization to the midbody; loss of CD2AP-, CEP55-, SH3GL2-, SH3KBP1-, TSG101-binding in a yeast two-hybrid assay. 1 PublicationAdd BLAST20
Mutagenesisi800 – 802GPP → AAA: Abolishes interaction with CEP55; inhibits support of cytokinesis. 1 Publication3
Mutagenesisi801 – 802PP → VD: Loss of midbody localization; does not support cytokinesis; loss of CEP55-binding in a yeast two-hybrid assay; no effect on HIV-1 release. 1 Publication2
Mutagenesisi801P → A: Decreased interaction with CEP55. 1 Publication1
Mutagenesisi802P → A: Decreased interaction with CEP55. 1 Publication1
Mutagenesisi803 – 804YP → VD: No effect on CEP55-binding in a yeast two-hybrid assay. 1 Publication2
Mutagenesisi805 – 806TY → VD: Loss of CEP55-binding in a yeast two-hybrid assay. 1 Publication2
Mutagenesisi806Y → A: Abolishes interaction with CEP55. 1 Publication1
Mutagenesisi852 – 855PSYP → ASAA: Loss of homoologimerization and reduced TSG101-binding; decreased HIV-1 release; no effect on cytokinesis. Almost complete loss of TSG101-binding and impaired cytokinesis; when associated with 717-A--A-720. 1 Publication4
Mutagenesisi864 – 865YY → AA: Loss of homooligomerization; reduced TSG101-binding; impaired HIV-1 release. 1 Publication2

Organism-specific databases

DisGeNETi10015
OpenTargetsiENSG00000170248
PharmGKBiPA33116

Polymorphism and mutation databases

BioMutaiPDCD6IP
DMDMi31076831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002188912 – 868Programmed cell death 6-interacting proteinAdd BLAST867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei215N6-acetyllysineCombined sources1
Modified residuei479PhosphothreonineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei738PhosphothreonineCombined sources1
Modified residuei741PhosphothreonineCombined sources1
Modified residuei745Omega-N-methylarginineCombined sources1

Post-translational modificationi

May be phosphorylated on tyrosine residues by activated PDGFRB.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8WUM4
MaxQBiQ8WUM4
PaxDbiQ8WUM4
PeptideAtlasiQ8WUM4
PRIDEiQ8WUM4
ProteomicsDBi74695

2D gel databases

UCD-2DPAGEiQ8WUM4

PTM databases

iPTMnetiQ8WUM4
PhosphoSitePlusiQ8WUM4
SwissPalmiQ8WUM4

Expressioni

Gene expression databases

BgeeiENSG00000170248 Expressed in 227 organ(s), highest expression level in corpus callosum
CleanExiHS_PDCD6IP
ExpressionAtlasiQ8WUM4 baseline and differential
GenevisibleiQ8WUM4 HS

Organism-specific databases

HPAiCAB016212
HPA011905

Interactioni

Subunit structurei

Self-associates (PubMed:14505570, PubMed:14519844). Interacts with SH3KBP1/CIN85 (By similarity). Interacts with PDCD6 in a calcium -dependent manner (PubMed:16957052, PubMed:18256029, PubMed:18940611). Interacts with TSG101 in a calcium-dependent manner; PDCD6IP homooligomerization may be required for TSG101-binding (PubMed:14505570, PubMed:14519844, PubMed:18641129, PubMed:19520058, PubMed:17350572). Interacts with SGSM3 (PubMed:15849434). Directly interacts with CHMP4A, CHMP4B and CHMP4C (PubMed:12860994, PubMed:14505569, PubMed:14505570, PubMed:14519844, PubMed:14678797, PubMed:14583093, PubMed:17428861, PubMed:17350572, PubMed:18511562). Directly interacts with CEP55 in a 1:2 stoechiometry (PubMed:17853893, PubMed:17556548, PubMed:18641129, PubMed:18948538). The interaction with CEP55 is required for PDCD6IP targeting to the midbody (PubMed:18641129). May interact with PDGFRB (PubMed:20494825). Interacts with SH3GL1 and SH3GL2/endophilin-1 (PubMed:17350572). Forms a complex with SDCBP and SDC2 (PubMed:22660413). Found in a complex with F-actin, TJP1/ZO-1 and PARD3 (By similarity). Interacts with CD2AP (PubMed:17853893). Interacts with ARRDC1 (PubMed:21191027).By similarity21 Publications
(Microbial infection) Interacts with HIV-1 p6 (PubMed:14505569, PubMed:17350572, PubMed:17277784, PubMed:18066081). Interacts with HIV-1 p9 (PubMed:18066081).5 Publications
(Microbial infection) Interacts with EIAV p9.4 Publications
(Microbial infection) Interacts with Murine leukemia virus Gag polyprotein (via LYPX(n)L motif).1 Publication
(Microbial infection) Interacts with ebola virus protein VP40 (via YPx(n)L/I motif).1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi115332, 123 interactors
ComplexPortaliCPX-3282 Syndecan-1-syntenin-1-ALIX complex
DIPiDIP-29327N
IntActiQ8WUM4, 68 interactors
MINTiQ8WUM4
STRINGi9606.ENSP00000411825

Structurei

Secondary structure

1868
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WUM4
SMRiQ8WUM4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUM4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 392BRO1PROSITE-ProRule annotationAdd BLAST390

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 868Interaction with EIAV p9Add BLAST693
Regioni176 – 503Interaction with CHMP4A, CHMP4B and CHMP4CAdd BLAST328
Regioni418 – 868Interaction with SDCBP1 PublicationAdd BLAST451
Regioni503 – 868Self-associationAdd BLAST366
Regioni717 – 720Interaction with TSG1014
Regioni801 – 806Interaction with CEP551 Publication6
Regioni864 – 868Essential to promote virus budding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi717 – 860Pro-richAdd BLAST144

Phylogenomic databases

eggNOGiKOG2220 Eukaryota
ENOG410XQX6 LUCA
GeneTreeiENSGT00780000121909
HOGENOMiHOG000006938
HOVERGENiHBG053533
InParanoidiQ8WUM4
KOiK12200
OMAiRNTAIWK
OrthoDBiEOG091G04NC
PhylomeDBiQ8WUM4
TreeFamiTF323502

Family and domain databases

Gene3Di1.25.40.280, 1 hit
InterProiView protein in InterPro
IPR025304 ALIX_V_dom
IPR004328 BRO1_dom
IPR038499 BRO1_sf
PfamiView protein in Pfam
PF13949 ALIX_LYPXL_bnd, 1 hit
PF03097 BRO1, 1 hit
SMARTiView protein in SMART
SM01041 BRO1, 1 hit
PROSITEiView protein in PROSITE
PS51180 BRO1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR 
        60         70         80         90        100
RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD 
       110        120        130        140        150
KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA 
       160        170        180        190        200
KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF 
       210        220        230        240        250
LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE VFPVLAAKHC 
       260        270        280        290        300
IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF 
       310        320        330        340        350
SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK 
       360        370        380        390        400
FTDLFEKMVP VSVQQSLAAY NQRKADLVNR SIAQMREATT LANGVLASLN 
       410        420        430        440        450
LPAAIEDVSG DTVPQSILTK SRSVIEQGGI QTVDQLIKEL PELLQRNREI 
       460        470        480        490        500
LDESLRLLDE EEATDNDLRA KFKERWQRTP SNELYKPLRA EGTNFRTVLD 
       510        520        530        540        550
KAVQADGQVK ECYQSHRDTI VLLCKPEPEL NAAIPSANPA KTMQGSEVVN 
       560        570        580        590        600
VLKSLLSNLD EVKKEREGLE NDLKSVNFDM TSKFLTALAQ DGVINEEALS 
       610        620        630        640        650
VTELDRVYGG LTTKVQESLK KQEGLLKNIQ VSHQEFSKMK QSNNEANLRE 
       660        670        680        690        700
EVLKNLATAY DNFVELVANL KEGTKFYNEL TEILVRFQNK CSDIVFARKT 
       710        720        730        740        750
ERDELLKDLQ QSIAREPSAP SIPTPAYQSS PAGGHAPTPP TPAPRTMPPT 
       760        770        780        790        800
KPQPPARPPP PVLPANRAPS ATAPSPVGAG TAAPAPSQTP GSAPPPQAQG 
       810        820        830        840        850
PPYPTYPGYP GYCQMPMPMG YNPYAYGQYN MPYPPVYHQS PGQAPYPGPQ 
       860 
QPSYPFPQPP QQSYYPQQ
Length:868
Mass (Da):96,023
Last modified:March 1, 2002 - v1
Checksum:i573588D1F612EC93
GO
Isoform 2 (identifier: Q8WUM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-239: K → KYFYFQ

Note: No experimental confirmation available.
Show »
Length:873
Mass (Da):96,772
Checksum:iFAC77FBE20C69D70
GO
Isoform 3 (identifier: Q8WUM4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-271: EVFPVLAAKHCIMQANAEYHQSILAKQQKKFG → VSYCFYKHLLTLHVKYLDFFVYKKQVETYKEI
     272-868: Missing.

Show »
Length:271
Mass (Da):30,453
Checksum:iEDE1855B7AFA2275
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEQ7F8WEQ7_HUMAN
Programmed cell death 6-interacting...
PDCD6IP
72Annotation score:
F8WBR8F8WBR8_HUMAN
Programmed cell death 6-interacting...
PDCD6IP
78Annotation score:
C9IZF9C9IZF9_HUMAN
Programmed cell death 6-interacting...
PDCD6IP
153Annotation score:
F8WDK9F8WDK9_HUMAN
Programmed cell death 6-interacting...
PDCD6IP
95Annotation score:

Sequence cautioni

The sequence BAA92092 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti580M → T in BAA92092 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0689757V → M1 PublicationCorresponds to variant dbSNP:rs11554560Ensembl.1
Natural variantiVAR_053017309A → T1 PublicationCorresponds to variant dbSNP:rs3792594Ensembl.1
Natural variantiVAR_053018378V → I2 PublicationsCorresponds to variant dbSNP:rs3203777Ensembl.1
Natural variantiVAR_069765429G → S1 PublicationCorresponds to variant dbSNP:rs76608858Ensembl.1
Natural variantiVAR_053019550N → S2 PublicationsCorresponds to variant dbSNP:rs9813017Ensembl.1
Natural variantiVAR_053020638K → E. Corresponds to variant dbSNP:rs3183982Ensembl.1
Natural variantiVAR_024381730S → L1 PublicationCorresponds to variant dbSNP:rs1127732Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044860239K → KYFYFQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_057190240 – 271EVFPV…QKKFG → VSYCFYKHLLTLHVKYLDFF VYKKQVETYKEI in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_057191272 – 868Missing in isoform 3. 1 PublicationAdd BLAST597

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349951 mRNA Translation: AAK20398.1
GQ131806 mRNA Translation: ACS12984.1
AF151793 mRNA Translation: AAF08220.1
BT007367 mRNA Translation: AAP36031.1
AC112220 Genomic DNA No translation available.
AC123901 Genomic DNA No translation available.
BC020066 mRNA Translation: AAH20066.1
BC068454 mRNA Translation: AAH68454.1
AK002122 mRNA Translation: BAA92092.1 Different initiation.
AB037796 mRNA Translation: BAA92613.1
CCDSiCCDS2660.1 [Q8WUM4-1]
CCDS54561.1 [Q8WUM4-2]
RefSeqiNP_001155901.1, NM_001162429.2 [Q8WUM4-2]
NP_001243121.1, NM_001256192.1 [Q8WUM4-3]
NP_037506.2, NM_013374.5 [Q8WUM4-1]
UniGeneiHs.475896

Genome annotation databases

EnsembliENST00000307296; ENSP00000307387; ENSG00000170248 [Q8WUM4-1]
ENST00000457054; ENSP00000411825; ENSG00000170248 [Q8WUM4-2]
GeneIDi10015
KEGGihsa:10015
UCSCiuc003cfx.5 human [Q8WUM4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349951 mRNA Translation: AAK20398.1
GQ131806 mRNA Translation: ACS12984.1
AF151793 mRNA Translation: AAF08220.1
BT007367 mRNA Translation: AAP36031.1
AC112220 Genomic DNA No translation available.
AC123901 Genomic DNA No translation available.
BC020066 mRNA Translation: AAH20066.1
BC068454 mRNA Translation: AAH68454.1
AK002122 mRNA Translation: BAA92092.1 Different initiation.
AB037796 mRNA Translation: BAA92613.1
CCDSiCCDS2660.1 [Q8WUM4-1]
CCDS54561.1 [Q8WUM4-2]
RefSeqiNP_001155901.1, NM_001162429.2 [Q8WUM4-2]
NP_001243121.1, NM_001256192.1 [Q8WUM4-3]
NP_037506.2, NM_013374.5 [Q8WUM4-1]
UniGeneiHs.475896

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OEVX-ray3.30A1-698[»]
2OEWX-ray2.55A1-359[»]
2OEXX-ray2.58A/B360-702[»]
2OJQX-ray2.87A360-702[»]
2R02X-ray2.60A2-698[»]
2R03X-ray2.59A2-698[»]
2R05X-ray2.55A2-698[»]
2XS1X-ray2.30A1-698[»]
2XS8X-ray2.50A1-698[»]
2ZNEX-ray2.20C/D799-812[»]
3C3OX-ray2.15A1-359[»]
3C3QX-ray2.10A1-359[»]
3C3RX-ray2.02A1-359[»]
3E1RX-ray2.00C797-809[»]
3WUVX-ray2.79C/F/I/L/O/R796-810[»]
4JJYX-ray6.50A/B355-708[»]
5V3RX-ray1.91A1-359[»]
5WA1X-ray1.87A1-358[»]
ProteinModelPortaliQ8WUM4
SMRiQ8WUM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115332, 123 interactors
ComplexPortaliCPX-3282 Syndecan-1-syntenin-1-ALIX complex
DIPiDIP-29327N
IntActiQ8WUM4, 68 interactors
MINTiQ8WUM4
STRINGi9606.ENSP00000411825

Protein family/group databases

MoonDBiQ8WUM4 Predicted

PTM databases

iPTMnetiQ8WUM4
PhosphoSitePlusiQ8WUM4
SwissPalmiQ8WUM4

Polymorphism and mutation databases

BioMutaiPDCD6IP
DMDMi31076831

2D gel databases

UCD-2DPAGEiQ8WUM4

Proteomic databases

EPDiQ8WUM4
MaxQBiQ8WUM4
PaxDbiQ8WUM4
PeptideAtlasiQ8WUM4
PRIDEiQ8WUM4
ProteomicsDBi74695

Protocols and materials databases

DNASUi10015
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307296; ENSP00000307387; ENSG00000170248 [Q8WUM4-1]
ENST00000457054; ENSP00000411825; ENSG00000170248 [Q8WUM4-2]
GeneIDi10015
KEGGihsa:10015
UCSCiuc003cfx.5 human [Q8WUM4-1]

Organism-specific databases

CTDi10015
DisGeNETi10015
EuPathDBiHostDB:ENSG00000170248.13
GeneCardsiPDCD6IP
H-InvDBiHIX0163463
HGNCiHGNC:8766 PDCD6IP
HPAiCAB016212
HPA011905
MIMi608074 gene
neXtProtiNX_Q8WUM4
OpenTargetsiENSG00000170248
PharmGKBiPA33116
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2220 Eukaryota
ENOG410XQX6 LUCA
GeneTreeiENSGT00780000121909
HOGENOMiHOG000006938
HOVERGENiHBG053533
InParanoidiQ8WUM4
KOiK12200
OMAiRNTAIWK
OrthoDBiEOG091G04NC
PhylomeDBiQ8WUM4
TreeFamiTF323502

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-5210891 Uptake and function of anthrax toxins

Miscellaneous databases

ChiTaRSiPDCD6IP human
EvolutionaryTraceiQ8WUM4
GeneWikiiPDCD6IP
GenomeRNAii10015
PROiPR:Q8WUM4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170248 Expressed in 227 organ(s), highest expression level in corpus callosum
CleanExiHS_PDCD6IP
ExpressionAtlasiQ8WUM4 baseline and differential
GenevisibleiQ8WUM4 HS

Family and domain databases

Gene3Di1.25.40.280, 1 hit
InterProiView protein in InterPro
IPR025304 ALIX_V_dom
IPR004328 BRO1_dom
IPR038499 BRO1_sf
PfamiView protein in Pfam
PF13949 ALIX_LYPXL_bnd, 1 hit
PF03097 BRO1, 1 hit
SMARTiView protein in SMART
SM01041 BRO1, 1 hit
PROSITEiView protein in PROSITE
PS51180 BRO1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDC6I_HUMAN
AccessioniPrimary (citable) accession number: Q8WUM4
Secondary accession number(s): C5MQH7
, E9PFU1, Q6NUS1, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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