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Protein

Nuclear pore complex protein Nup133

Gene

NUP133

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in poly(A)+ RNA transport.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural constituent of nuclear pore Source: UniProtKB

GO - Biological processi

  • mRNA export from nucleus Source: UniProtKB
  • neural tube development Source: Ensembl
  • neurogenesis Source: Ensembl
  • nuclear pore distribution Source: GO_Central
  • nuclear pore organization Source: UniProtKB
  • paraxial mesoderm development Source: Ensembl
  • protein import into nucleus Source: GO_Central
  • somite development Source: Ensembl
  • viral process Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68877 Mitotic Prometaphase

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup133
Alternative name(s):
133 kDa nucleoporin
Nucleoporin Nup133
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP133
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000069248.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18016 NUP133

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607613 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WUM0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000069248

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31847

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUP133

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811430

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048381 – 1156Nuclear pore complex protein Nup133Add BLAST1156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei17Omega-N-methylarginineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei28PhosphothreonineCombined sources1
Modified residuei30Omega-N-methylarginineBy similarity1
Modified residuei41PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei489PhosphoserineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei755PhosphoserineCombined sources1
Modified residuei787N6-acetyllysineBy similarity1
Modified residuei1133PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WUM0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8WUM0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WUM0

PeptideAtlas

More...
PeptideAtlasi
Q8WUM0

PRoteomics IDEntifications database

More...
PRIDEi
Q8WUM0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74694

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WUM0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WUM0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8WUM0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000069248 Expressed in 231 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_NUP133

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WUM0 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA059767

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120864, 67 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8WUM0

Protein interaction database and analysis system

More...
IntActi
Q8WUM0, 50 interactors

Molecular INTeraction database

More...
MINTi
Q8WUM0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261396

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8WUM0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WUM0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WUM0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin Nup133 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4121 Eukaryota
ENOG410XNUX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000011529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000293246

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052678

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WUM0

KEGG Orthology (KO)

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KOi
K14300

Identification of Orthologs from Complete Genome Data

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OMAi
VFACSTG

Database of Orthologous Groups

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OrthoDBi
EOG091G01HJ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8WUM0

TreeFam database of animal gene trees

More...
TreeFami
TF106141

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007187 Nucleoporin_Nup133/Nup155_C
IPR037624 Nup133-like
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR13405 PTHR13405, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03177 Nucleoporin_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WUM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPAAPSPRT PGTGSRRGPL AGLGPGSTPR TASRKGLPLG SAVSSPVLFS
60 70 80 90 100
PVGRRSSLSS RGTPTRMFPH HSITESVNYD VKTFGSSLPV KVMEALTLAE
110 120 130 140 150
VDDQLTINID EGGWACLVCK EKLIIWKIAL SPITKLSVCK ELQLPPSDFH
160 170 180 190 200
WSADLVALSY SSPSGEAHST QAVAVMVATR EGSIRYWPSL AGEDTYTEAF
210 220 230 240 250
VDSGGDKTYS FLTAVQGGSF ILSSSGSQLI RLIPESSGKI HQHILPQGQG
260 270 280 290 300
MLSGIGRKVS SLFGILSPSS DLTLSSVLWD RERSSFYSLT SSNISKWELD
310 320 330 340 350
DSSEKHAYSW DINRALKENI TDAIWGSESN YEAIKEGVNI RYLDLKQNCD
360 370 380 390 400
GLVILAAAWH SADNPCLIYY SLITIEDNGC QMSDAVTVEV TQYNPPFQSE
410 420 430 440 450
DLILCQLTVP NFSNQTAYLY NESAVYVCST GTGKFSLPQE KIVFNAQGDS
460 470 480 490 500
VLGAGACGGV PIIFSRNSGL VSITSRENVS ILAEDLEGSL ASSVAGPNSE
510 520 530 540 550
SMIFETTTKN ETIAQEDKIK LLKAAFLQYC RKDLGHAQMV VDELFSSHSD
560 570 580 590 600
LDSDSELDRA VTQISVDLMD DYPASDPRWA ESVPEEAPGF SNTSLIILHQ
610 620 630 640 650
LEDKMKAHSF LMDFIHQVGL FGRLGSFPVR GTPMATRLLL CEHAEKLSAA
660 670 680 690 700
IVLKNHHSRL SDLVNTAILI ALNKREYEIP SNLTPADVFF REVSQVDTIC
710 720 730 740 750
ECLLEHEEQV LRDAPMDSIE WAEVVINVNN ILKDMLQAAS HYRQNRNSLY
760 770 780 790 800
RREESLEKEP EYVPWTATSG PGGIRTVIIR QHEIVLKVAY PQADSNLRNI
810 820 830 840 850
VTEQLVALID CFLDGYVSQL KSVDKSSNRE RYDNLEMEYL QKRSDLLSPL
860 870 880 890 900
LSLGQYLWAA SLAEKYCDFD ILVQMCEQTD NQSRLQRYMT QFADQNFSDF
910 920 930 940 950
LFRWYLEKGK RGKLLSQPIS QHGQLANFLQ AHEHLSWLHE INSQELEKAH
960 970 980 990 1000
ATLLGLANME TRYFAKKKTL LGLSKLAALA SDFSEDMLQE KIEEMAEQER
1010 1020 1030 1040 1050
FLLHQETLPE QLLAEKQLNL SAMPVLTAPQ LIGLYICEEN RRANEYDFKK
1060 1070 1080 1090 1100
ALDLLEYIDE EEDININDLK LEILCKALQR DNWSSSDGKD DPIEVSKDSI
1110 1120 1130 1140 1150
FVKILQKLLK DGIQLSEYLP EVKDLLQADQ LGSLKSNPYF EFVLKANYEY

YVQGQI
Length:1,156
Mass (Da):128,979
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78B733E353824577
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91885 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14106 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61R → G in BAA91829 (PubMed:14702039).Curated1
Sequence conflicti146P → S in BAA91829 (PubMed:14702039).Curated1
Sequence conflicti345L → F in AAH20107 (PubMed:15489334).Curated1
Sequence conflicti626S → N in BAA91829 (PubMed:14702039).Curated1
Sequence conflicti928F → L in BAA91885 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030829106T → P. Corresponds to variant dbSNP:rs428231Ensembl.1
Natural variantiVAR_030830294I → V. Corresponds to variant dbSNP:rs11805194Ensembl.1
Natural variantiVAR_035854326G → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_030831406Q → R. Corresponds to variant dbSNP:rs1065674Ensembl.1
Natural variantiVAR_035855448G → R in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001676 mRNA Translation: BAA91829.1
AK001754 mRNA Translation: BAA91885.1 Different initiation.
AK022572 mRNA Translation: BAB14106.1 Different initiation.
AK314431 mRNA Translation: BAG37045.1
AL121990 Genomic DNA No translation available.
AL139252 Genomic DNA No translation available.
AL160004 Genomic DNA No translation available.
BC020107 mRNA Translation: AAH20107.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1579.1

NCBI Reference Sequences

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RefSeqi
NP_060700.2, NM_018230.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.12457

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261396; ENSP00000261396; ENSG00000069248

Database of genes from NCBI RefSeq genomes

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GeneIDi
55746

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55746

UCSC genome browser

More...
UCSCi
uc001htn.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001676 mRNA Translation: BAA91829.1
AK001754 mRNA Translation: BAA91885.1 Different initiation.
AK022572 mRNA Translation: BAB14106.1 Different initiation.
AK314431 mRNA Translation: BAG37045.1
AL121990 Genomic DNA No translation available.
AL139252 Genomic DNA No translation available.
AL160004 Genomic DNA No translation available.
BC020107 mRNA Translation: AAH20107.1
CCDSiCCDS1579.1
RefSeqiNP_060700.2, NM_018230.2
UniGeneiHs.12457

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKSX-ray2.35A67-514[»]
3CQCX-ray2.53B935-1156[»]
3CQGX-ray3.00B934-1156[»]
3I4RX-ray3.53B517-1156[»]
5A9Qelectron microscopy23.003/C/L/U1-1156[»]
ProteinModelPortaliQ8WUM0
SMRiQ8WUM0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120864, 67 interactors
CORUMiQ8WUM0
IntActiQ8WUM0, 50 interactors
MINTiQ8WUM0
STRINGi9606.ENSP00000261396

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ8WUM0
PhosphoSitePlusiQ8WUM0
SwissPalmiQ8WUM0

Polymorphism and mutation databases

BioMutaiNUP133
DMDMi143811430

Proteomic databases

EPDiQ8WUM0
MaxQBiQ8WUM0
PaxDbiQ8WUM0
PeptideAtlasiQ8WUM0
PRIDEiQ8WUM0
ProteomicsDBi74694

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55746
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261396; ENSP00000261396; ENSG00000069248
GeneIDi55746
KEGGihsa:55746
UCSCiuc001htn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55746
EuPathDBiHostDB:ENSG00000069248.11

GeneCards: human genes, protein and diseases

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GeneCardsi
NUP133

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0001680
HGNCiHGNC:18016 NUP133
HPAiHPA059767
MIMi607613 gene
neXtProtiNX_Q8WUM0
OpenTargetsiENSG00000069248
PharmGKBiPA31847

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4121 Eukaryota
ENOG410XNUX LUCA
GeneTreeiENSGT00390000011529
HOGENOMiHOG000293246
HOVERGENiHBG052678
InParanoidiQ8WUM0
KOiK14300
OMAiVFACSTG
OrthoDBiEOG091G01HJ
PhylomeDBiQ8WUM0
TreeFamiTF106141

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NUP133 human
EvolutionaryTraceiQ8WUM0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NUP133

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55746

Protein Ontology

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PROi
PR:Q8WUM0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000069248 Expressed in 231 organ(s), highest expression level in secondary oocyte
CleanExiHS_NUP133
GenevisibleiQ8WUM0 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR007187 Nucleoporin_Nup133/Nup155_C
IPR037624 Nup133-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR13405 PTHR13405, 1 hit
PfamiView protein in Pfam
PF03177 Nucleoporin_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU133_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUM0
Secondary accession number(s): B2RAZ8
, Q5T8N0, Q9H9W2, Q9NV71, Q9NVC4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: April 3, 2007
Last modified: December 5, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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