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Protein

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Gene

PTPMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986).By similarity1 Publication

Caution

Was originally erroneously termed DUSP23.Curated

Catalytic activityi

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.1 Publication
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (PGS1), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (hCG_1642326), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1)
  2. Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cardiolipin biosynthetic process Source: UniProtKB
  • regulation of intrinsic apoptotic signaling pathway Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS03319-MONOMER
ReactomeiR-HSA-1483148 Synthesis of PG
UniPathwayi
UPA00084;UER00504

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC:3.1.3.271 Publication)
Alternative name(s):
PTEN-like phosphatase
Phosphoinositide lipid phosphatase
Protein-tyrosine phosphatase mitochondrial 1 (EC:3.1.3.16By similarity, EC:3.1.3.48PROSITE-ProRule annotation)
Gene namesi
Name:PTPMT1
Synonyms:MOSP, PLIP
ORF Names:PNAS-129
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110536.13
HGNCiHGNC:26965 PTPMT1
MIMi609538 gene
neXtProtiNX_Q8WUK0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi132C → S: Probable loss of catalytic activity. Does not affect interaction with STYXL1. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000110536
PharmGKBiPA142671115

Chemistry databases

ChEMBLiCHEMBL2052033

Polymorphism and mutation databases

BioMutaiPTPMT1
DMDMi73621420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000002542328 – 201Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1Add BLAST174

Proteomic databases

EPDiQ8WUK0
MaxQBiQ8WUK0
PaxDbiQ8WUK0
PeptideAtlasiQ8WUK0
PRIDEiQ8WUK0
ProteomicsDBi74692
74693 [Q8WUK0-2]

PTM databases

DEPODiQ8WUK0
iPTMnetiQ8WUK0
PhosphoSitePlusiQ8WUK0

Expressioni

Gene expression databases

BgeeiENSG00000110536 Expressed in 188 organ(s), highest expression level in left testis
CleanExiHS_PTPMT1
ExpressionAtlasiQ8WUK0 baseline and differential
GenevisibleiQ8WUK0 HS

Organism-specific databases

HPAiHPA040348
HPA043932

Interactioni

Subunit structurei

Interacts with STYXL1; the interaction inhibits PTPMT1 catalytic activity.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi125402, 90 interactors
IntActiQ8WUK0, 36 interactors
MINTiQ8WUK0
STRINGi9606.ENSP00000325958

Chemistry databases

BindingDBiQ8WUK0

Structurei

3D structure databases

ProteinModelPortaliQ8WUK0
SMRiQ8WUK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 183Tyrosine-protein phosphataseAdd BLAST75

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1719 Eukaryota
ENOG4111IMR LUCA
GeneTreeiENSGT00390000014065
HOGENOMiHOG000220855
HOVERGENiHBG079822
InParanoidiQ8WUK0
KOiK14165
OMAiWRTVNEY
OrthoDBiEOG091G0R21
PhylomeDBiQ8WUK0
TreeFamiTF319745

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUK0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL
60 70 80 90 100
PLRSLTRQLV QDENVRGVIT MNEEYETRFL CNSSQEWKRL GVEQLRLSTV
110 120 130 140 150
DMTGIPTLDN LQKGVQFALK YQSLGQCVYV HCKAGRSRSA TMVAAYLIQV
160 170 180 190 200
HKWSPEEAVR AIAKIRSYIH IRPGQLDVLK EFHKQITARA TKDGTFVISK

T
Length:201
Mass (Da):22,844
Last modified:March 1, 2002 - v1
Checksum:i88A4CC76EEFD0835
GO
Isoform 2 (identifier: Q8WUK0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-148: Missing.

Show »
Length:137
Mass (Da):15,689
Checksum:iE1B3966F55F1065D
GO
Isoform 3 (identifier: Q8WUK0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-151: LVQDENVRGV...MVAAYLIQVH → VSRAGEPGPL...PHQAWPAGCS
     152-201: Missing.

Note: No experimental confirmation available.
Show »
Length:151
Mass (Da):16,459
Checksum:i59DFA3B7642E84F0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQM0E9PQM0_HUMAN
Phosphatidylglycerophosphatase and ...
PTPMT1
168Annotation score:

Sequence cautioni

The sequence AAH14048 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK07545 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04503059 – 151LVQDE…LIQVH → VSRAGEPGPLPRPRRSVPVG PLGSPPSLLSHLFASAAGTG RERARGDHHERGVRDEVPVQ LFTGAQMESRGGCKSHRQDP VIHPHQAWPAGCS in isoform 3. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_01500985 – 148Missing in isoform 2. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_045031152 – 201Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY333987 mRNA Translation: AAP94732.1
AC090559 Genomic DNA No translation available.
AC104942 Genomic DNA No translation available.
BC014048 mRNA Translation: AAH14048.1 Different initiation.
BC020242 mRNA Translation: AAH20242.1
BC073798 mRNA No translation available.
AF277187 mRNA Translation: AAK07545.1 Different initiation.
CCDSiCCDS41643.1 [Q8WUK0-1]
CCDS44593.1 [Q8WUK0-3]
RefSeqiNP_001137456.1, NM_001143984.1 [Q8WUK0-3]
NP_783859.1, NM_175732.2 [Q8WUK0-1]
UniGeneiHs.656205
Hs.742231

Genome annotation databases

EnsembliENST00000326656; ENSP00000325882; ENSG00000110536 [Q8WUK0-2]
ENST00000326674; ENSP00000325958; ENSG00000110536 [Q8WUK0-1]
ENST00000426530; ENSP00000410272; ENSG00000110536 [Q8WUK0-3]
ENST00000643547; ENSP00000494387; ENSG00000285206 [Q8WUK0-2]
ENST00000646905; ENSP00000495288; ENSG00000285206 [Q8WUK0-3]
ENST00000647378; ENSP00000496417; ENSG00000285206 [Q8WUK0-1]
GeneIDi114971
KEGGihsa:114971
UCSCiuc001nfs.5 human [Q8WUK0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY333987 mRNA Translation: AAP94732.1
AC090559 Genomic DNA No translation available.
AC104942 Genomic DNA No translation available.
BC014048 mRNA Translation: AAH14048.1 Different initiation.
BC020242 mRNA Translation: AAH20242.1
BC073798 mRNA No translation available.
AF277187 mRNA Translation: AAK07545.1 Different initiation.
CCDSiCCDS41643.1 [Q8WUK0-1]
CCDS44593.1 [Q8WUK0-3]
RefSeqiNP_001137456.1, NM_001143984.1 [Q8WUK0-3]
NP_783859.1, NM_175732.2 [Q8WUK0-1]
UniGeneiHs.656205
Hs.742231

3D structure databases

ProteinModelPortaliQ8WUK0
SMRiQ8WUK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125402, 90 interactors
IntActiQ8WUK0, 36 interactors
MINTiQ8WUK0
STRINGi9606.ENSP00000325958

Chemistry databases

BindingDBiQ8WUK0
ChEMBLiCHEMBL2052033

PTM databases

DEPODiQ8WUK0
iPTMnetiQ8WUK0
PhosphoSitePlusiQ8WUK0

Polymorphism and mutation databases

BioMutaiPTPMT1
DMDMi73621420

Proteomic databases

EPDiQ8WUK0
MaxQBiQ8WUK0
PaxDbiQ8WUK0
PeptideAtlasiQ8WUK0
PRIDEiQ8WUK0
ProteomicsDBi74692
74693 [Q8WUK0-2]

Protocols and materials databases

DNASUi114971
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326656; ENSP00000325882; ENSG00000110536 [Q8WUK0-2]
ENST00000326674; ENSP00000325958; ENSG00000110536 [Q8WUK0-1]
ENST00000426530; ENSP00000410272; ENSG00000110536 [Q8WUK0-3]
ENST00000643547; ENSP00000494387; ENSG00000285206 [Q8WUK0-2]
ENST00000646905; ENSP00000495288; ENSG00000285206 [Q8WUK0-3]
ENST00000647378; ENSP00000496417; ENSG00000285206 [Q8WUK0-1]
GeneIDi114971
KEGGihsa:114971
UCSCiuc001nfs.5 human [Q8WUK0-1]

Organism-specific databases

CTDi114971
EuPathDBiHostDB:ENSG00000110536.13
GeneCardsiPTPMT1
HGNCiHGNC:26965 PTPMT1
HPAiHPA040348
HPA043932
MIMi609538 gene
neXtProtiNX_Q8WUK0
OpenTargetsiENSG00000110536
PharmGKBiPA142671115
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1719 Eukaryota
ENOG4111IMR LUCA
GeneTreeiENSGT00390000014065
HOGENOMiHOG000220855
HOVERGENiHBG079822
InParanoidiQ8WUK0
KOiK14165
OMAiWRTVNEY
OrthoDBiEOG091G0R21
PhylomeDBiQ8WUK0
TreeFamiTF319745

Enzyme and pathway databases

UniPathwayi
UPA00084;UER00504

BioCyciMetaCyc:HS03319-MONOMER
ReactomeiR-HSA-1483148 Synthesis of PG

Miscellaneous databases

ChiTaRSiPTPMT1 human
GenomeRNAii114971
PROiPR:Q8WUK0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110536 Expressed in 188 organ(s), highest expression level in left testis
CleanExiHS_PTPMT1
ExpressionAtlasiQ8WUK0 baseline and differential
GenevisibleiQ8WUK0 HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTPM1_HUMAN
AccessioniPrimary (citable) accession number: Q8WUK0
Secondary accession number(s): E9PAT8
, Q7Z557, Q96CR2, Q9BXV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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