UniProtKB - Q8WUJ3 (CEMIP_HUMAN)

BLAST

>sp|Q8WUJ3|CEMIP_HUMAN Cell migration-inducing and hyaluronan-binding protein OS=Homo sapiens OX=9606 GN=CEMIP PE=1 SV=2
MGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQ
GKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNF
TIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFF
ERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEG
SRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVF
KLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPID
IQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVN
STILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGE
EIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLE
GTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLI
KDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYI
PKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIP
LGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAI
IRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVG
ESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEG
RHTSALAFRLNNAWQSCPHNNVTGIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHD
VDGSVSEYPGSYLTKNDNWLVRHPDCINVPDWRGAICSGCYAQMYIQAYKTSNLRMKIIK
NDFPSHPLYLEGALTRSTHYQQYQPVVTLQKGYTIHWDQTAPAELAIWLINFNKGDWIRV
GLCYPRGTTFSILSDVHNRLLKQTSKTGVFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFL
KLKAQNEREKFAFCSMKGCERIKIKALIPKNAGVSDCTATAYPKFTERAVVDVPMPKKLF
GSQLKTKDHFLEVKMESSKQHFFHLWNDFAYIEVDGKKYPSSEDGIQVVVIDGNQGRVVS
HTSFRNSILQGIPWQLFNYVATIPDNSIVLMASKGRYVSRGPWTRVLEKLGADRGLKLKE
QMAFVGFKGSFRPIWVTLDTEDHKAKIFQVVPIPVVKKKKL

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History
Entry version 130 (07 Nov 2018)
Sequence version 2 (13 Apr 2004)
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Protein

Cell migration-inducing and hyaluronan-binding protein

Gene

CEMIP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.3 Publications

Catalytic activityⁱ

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.2 Publications

Activity regulationⁱ

Activity is up-regulated by histamine.1 Publication

GO - Molecular functionⁱ

clathrin heavy chain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23509262
ER retention sequence binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23990668
hyaluronic acid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23509262
hyalurononglucosaminidase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23509262

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hyaluronan biosynthetic process Source: Reactome
hyaluronan catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23509262
positive regulation of cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 23990668
positive regulation of peptidyl-threonine phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 23990668
positive regulation of protein kinase C activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23990668
positive regulation of protein targeting to membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 23990668
positive regulation of release of sequestered calcium ion into cytosol
Source: UniProtKB
Inferred from direct assayⁱ
- 23990668
sensory perception of sound
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14577002

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Ligand	Hyaluronic acid

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2142850 Hyaluronan biosynthesis and export

Reactomeⁱ

R-HSA-2142850 Hyaluronan biosynthesis and export

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell migration-inducing and hyaluronan-binding protein (EC:3.2.1.352 Publications)
Gene namesⁱ	Name:CEMIP Synonyms:KIAA1199
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103888.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29213 CEMIP
MIMⁱ	608366 gene
neXtProtⁱ	NX_Q8WUJ3

Keywords - Cellular componentⁱ

Cell membrane, Coated pit, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57214
Open Targets More...OpenTargetsⁱ	ENSG00000103888
PharmGKBⁱ	PA134967531

Polymorphism and mutation databases

BioMutaⁱ	KIAA1199
DMDMⁱ	46396475

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 30	1 PublicationAdd BLAST		30
ChainⁱPRO_0000021538	31 – 1361	Cell migration-inducing and hyaluronan-binding proteinAdd BLAST		1331

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	119	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	165	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	312	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	370	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	420	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	889	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	921	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated; glycosylation is not necessary for HA-binding.2 Publications

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q8WUJ3
PeptideAtlas More...PeptideAtlasⁱ	Q8WUJ3
PRIDEⁱ	Q8WUJ3
ProteomicsDBⁱ	74690 74691 [Q8WUJ3-2]

PTM databases

CarbonylDBⁱ	Q8WUJ3
iPTMnetⁱ	Q8WUJ3
PhosphoSitePlusⁱ	Q8WUJ3

Expressionⁱ

Tissue specificityⁱ

Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.8 Publications

Inductionⁱ

Up-regulated by histamine. Up-regulated by the adapter protein complex 1 (AP-1) and NF-kappaB/RELA. Down-regulated by transforming growth factor TGFB1.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000103888 Expressed in 153 organ(s), highest expression level in trigeminal ganglion
CleanExⁱ	HS_KIAA1199
ExpressionAtlasⁱ	Q8WUJ3 baseline and differential
Genevisibleⁱ	Q8WUJ3 HS

Interactionⁱ

Subunit structureⁱ

Interacts with EPHA2 and ITPR3. Interacts with HSPA5/BIP; the interaction induces calcium leakage from the endoplasmic reticulum and cell migration. Interacts with clathrin heavy chain/CLTC.3 Publications

GO - Molecular functionⁱ

clathrin heavy chain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23509262

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121452, 2 interactors
IntActⁱ	Q8WUJ3, 1 interactor
STRINGⁱ	9606.ENSP00000220244

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WUJ3
SMRⁱ	Q8WUJ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	44 – 166	G8PROSITE-ProRule annotationAdd BLAST	123
Repeatⁱ	572 – 594	PbH1 1Add BLAST	23
Repeatⁱ	595 – 617	PbH1 2Add BLAST	23
Repeatⁱ	719 – 741	PbH1 3Add BLAST	23
Repeatⁱ	798 – 819	PbH1 4Add BLAST	22

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	295 – 591	Necessary for its endoplasmic reticulum (ER) retention and interaction with HSPA51 PublicationAdd BLAST		297

Domainⁱ

The signal sequence is essential in mediating its proper translocation, hyaluronic acid (HA) degradation activity and secretion.

Sequence similaritiesⁱ

Belongs to the CEMIP family.Curated

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IFCM Eukaryota ENOG410XQ01 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121902
HOGENOMⁱ	HOG000290723
HOVERGENⁱ	HBG052198
InParanoidⁱ	Q8WUJ3
KEGG Orthology (KO) More...KOⁱ	K19031
OMAⁱ	HFTAYKN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00JT
PhylomeDBⁱ	Q8WUJ3
TreeFamⁱ	TF316575

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13938 PANDER_like_TMEM2, 1 hit
InterProⁱ	View protein in InterPro IPR019316 G8_domain IPR039477 ILEI/PANDER_dom IPR011050 Pectin_lyase_fold/virulence IPR039473 TMEM2_PANDER-like IPR025155 WxxW_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10162 G8, 1 hit PF15711 ILEI, 2 hits PF13330 Mucin2_WxxW, 1 hit
SMARTⁱ	View protein in SMART SM01225 G8, 1 hit
SUPFAMⁱ	SSF51126 SSF51126, 1 hit
PROSITEⁱ	View protein in PROSITE PS51484 G8, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8WUJ3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAAGRQDFL FKAMLTISWL TLTCFPGATS TVAAGCPDQS PELQPWNPGH 
        60         70         80         90        100
DQDHHVHIGQ GKTLLLTSSA TVYSIHISEG GKLVIKDHDE PIVLRTRHIL 
       110        120        130        140        150
IDNGGELHAG SALCPFQGNF TIILYGRADE GIQPDPYYGL KYIGVGKGGA 
       160        170        180        190        200
LELHGQKKLS WTFLNKTLHP GGMAEGGYFF ERSWGHRGVI VHVIDPKSGT 
       210        220        230        240        250
VIHSDRFDTY RSKKESERLV QYLNAVPDGR ILSVAVNDEG SRNLDDMARK 
       260        270        280        290        300
AMTKLGSKHF LHLGFRHPWS FLTVKGNPSS SVEDHIEYHG HRGSAAARVF 
       310        320        330        340        350
KLFQTEHGEY FNVSLSSEWV QDVEWTEWFD HDKVSQTKGG EKISDLWKAH 
       360        370        380        390        400
PGKICNRPID IQATTMDGVN LSTEVVYKKG QDYRFACYDR GRACRSYRVR 
       410        420        430        440        450
FLCGKPVRPK LTVTIDTNVN STILNLEDNV QSWKPGDTLV IASTDYSMYQ 
       460        470        480        490        500
AEEFQVLPCR SCAPNQVKVA GKPMYLHIGE EIDGVDMRAE VGLLSRNIIV 
       510        520        530        540        550
MGEMEDKCYP YRNHICNFFD FDTFGGHIKF ALGFKAAHLE GTELKHMGQQ 
       560        570        580        590        600
LVGQYPIHFH LAGDVDERGG YDPPTYIRDL SIHHTFSRCV TVHGSNGLLI 
       610        620        630        640        650
KDVVGYNSLG HCFFTEDGPE ERNTFDHCLG LLVKSGTLLP SDRDSKMCKM 
       660        670        680        690        700
ITEDSYPGYI PKPRQDCNAV STFWMANPNN NLINCAAAGS EETGFWFIFH 
       710        720        730        740        750
HVPTGPSVGM YSPGYSEHIP LGKFYNNRAH SNYRAGMIID NGVKTTEASA 
       760        770        780        790        800
KDKRPFLSII SARYSPHQDA DPLKPREPAI IRHFIAYKNQ DHGAWLRGGD 
       810        820        830        840        850
VWLDSCRFAD NGIGLTLASG GTFPYDDGSK QEIKNSLFVG ESGNVGTEMM 
       860        870        880        890        900
DNRIWGPGGL DHSGRTLPIG QNFPIRGIQL YDGPINIQNC TFRKFVALEG 
       910        920        930        940        950
RHTSALAFRL NNAWQSCPHN NVTGIAFEDV PITSRVFFGE PGPWFNQLDM 
       960        970        980        990       1000
DGDKTSVFHD VDGSVSEYPG SYLTKNDNWL VRHPDCINVP DWRGAICSGC 
      1010       1020       1030       1040       1050
YAQMYIQAYK TSNLRMKIIK NDFPSHPLYL EGALTRSTHY QQYQPVVTLQ 
      1060       1070       1080       1090       1100
KGYTIHWDQT APAELAIWLI NFNKGDWIRV GLCYPRGTTF SILSDVHNRL 
      1110       1120       1130       1140       1150
LKQTSKTGVF VRTLQMDKVE QSYPGRSHYY WDEDSGLLFL KLKAQNEREK 
      1160       1170       1180       1190       1200
FAFCSMKGCE RIKIKALIPK NAGVSDCTAT AYPKFTERAV VDVPMPKKLF 
      1210       1220       1230       1240       1250
GSQLKTKDHF LEVKMESSKQ HFFHLWNDFA YIEVDGKKYP SSEDGIQVVV 
      1260       1270       1280       1290       1300
IDGNQGRVVS HTSFRNSILQ GIPWQLFNYV ATIPDNSIVL MASKGRYVSR 
      1310       1320       1330       1340       1350
GPWTRVLEKL GADRGLKLKE QMAFVGFKGS FRPIWVTLDT EDHKAKIFQV 
      1360 
VPIPVVKKKK L

Length:1,361

Mass (Da):152,998

Last modified:April 13, 2004 - v2

Checksum:ⁱ40CDFFB84F99516C

Isoform 2 (identifier: Q8WUJ3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
978-992: NWLVRHPDCINVPDW → KWHSLASKAASGPSG
993-1361: Missing.

« Hide

        10         20         30         40         50
MGAAGRQDFL FKAMLTISWL TLTCFPGATS TVAAGCPDQS PELQPWNPGH 
        60         70         80         90        100
DQDHHVHIGQ GKTLLLTSSA TVYSIHISEG GKLVIKDHDE PIVLRTRHIL 
       110        120        130        140        150
IDNGGELHAG SALCPFQGNF TIILYGRADE GIQPDPYYGL KYIGVGKGGA 
       160        170        180        190        200
LELHGQKKLS WTFLNKTLHP GGMAEGGYFF ERSWGHRGVI VHVIDPKSGT 
       210        220        230        240        250
VIHSDRFDTY RSKKESERLV QYLNAVPDGR ILSVAVNDEG SRNLDDMARK 
       260        270        280        290        300
AMTKLGSKHF LHLGFRHPWS FLTVKGNPSS SVEDHIEYHG HRGSAAARVF 
       310        320        330        340        350
KLFQTEHGEY FNVSLSSEWV QDVEWTEWFD HDKVSQTKGG EKISDLWKAH 
       360        370        380        390        400
PGKICNRPID IQATTMDGVN LSTEVVYKKG QDYRFACYDR GRACRSYRVR 
       410        420        430        440        450
FLCGKPVRPK LTVTIDTNVN STILNLEDNV QSWKPGDTLV IASTDYSMYQ 
       460        470        480        490        500
AEEFQVLPCR SCAPNQVKVA GKPMYLHIGE EIDGVDMRAE VGLLSRNIIV 
       510        520        530        540        550
MGEMEDKCYP YRNHICNFFD FDTFGGHIKF ALGFKAAHLE GTELKHMGQQ 
       560        570        580        590        600
LVGQYPIHFH LAGDVDERGG YDPPTYIRDL SIHHTFSRCV TVHGSNGLLI 
       610        620        630        640        650
KDVVGYNSLG HCFFTEDGPE ERNTFDHCLG LLVKSGTLLP SDRDSKMCKM 
       660        670        680        690        700
ITEDSYPGYI PKPRQDCNAV STFWMANPNN NLINCAAAGS EETGFWFIFH 
       710        720        730        740        750
HVPTGPSVGM YSPGYSEHIP LGKFYNNRAH SNYRAGMIID NGVKTTEASA 
       760        770        780        790        800
KDKRPFLSII SARYSPHQDA DPLKPREPAI IRHFIAYKNQ DHGAWLRGGD 
       810        820        830        840        850
VWLDSCRFAD NGIGLTLASG GTFPYDDGSK QEIKNSLFVG ESGNVGTEMM 
       860        870        880        890        900
DNRIWGPGGL DHSGRTLPIG QNFPIRGIQL YDGPINIQNC TFRKFVALEG 
       910        920        930        940        950
RHTSALAFRL NNAWQSCPHN NVTGIAFEDV PITSRVFFGE PGPWFNQLDM 
       960        970        980        990 
DGDKTSVFHD VDGSVSEYPG SYLTKNDKWH SLASKAASGP SG

Note: No experimental confirmation available.

Show »

Length:992

Mass (Da):110,357

Checksum:ⁱAF371C2A8633012D

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YCE1	H0YCE1_HUMAN	Cell migration-inducing and hyaluro... Cell migration-inducing and hyaluronan-binding protein	CEMIP	76	Annotation score:
H0YL56	H0YL56_HUMAN	Cell migration-inducing and hyaluro... Cell migration-inducing and hyaluronan-binding protein	CEMIP	145	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	558 – 564	HFHLAGD → TRPPTRP in CAB94391 (Ref. 6) Curated		7
Sequence conflictⁱ	862	H → T in AAG41059 (PubMed:11247670).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018165	187	R → C in a family with non-syndromic hearing loss; reduces hyaluronic acid degradation activity. 2 PublicationsCorresponds to variant dbSNP:rs368854657Ensembl.	1
Natural variantⁱVAR_018166	187	R → H in two unrelated families with non-syndromic hearing loss; reduces hyaluronic acid (HA) degradation activity. 2 PublicationsCorresponds to variant dbSNP:rs144446375Ensembl.	1
Natural variantⁱVAR_018167	783	H → R Does not inhibit hyaluronic acid degradation activity. 2 PublicationsCorresponds to variant dbSNP:rs12441101Ensembl.	1
Natural variantⁱVAR_018168	783	H → Y in a sporadic case of non-syndromic hearing loss. 1 PublicationCorresponds to variant dbSNP:rs996035812Ensembl.	1
Natural variantⁱVAR_018169	1109	V → I Does not inhibit hyaluronic acid degradation activity. 2 PublicationsCorresponds to variant dbSNP:rs751807711Ensembl.	1
Natural variantⁱVAR_018170	1169	P → A Common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs16972583Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_009814	978 – 992	NWLVR…NVPDW → KWHSLASKAASGPSG in isoform 2. 1 PublicationAdd BLAST		15
Alternative sequenceⁱVSP_009815	993 – 1361	Missing in isoform 2. 1 PublicationAdd BLAST		369

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB103330 mRNA Translation: BAD02451.1 CH471136 Genomic DNA Translation: EAW99111.1 BC020256 mRNA Translation: AAH20256.1 AB033025 mRNA Translation: BAA86513.1 AL359061 mRNA Translation: CAB94391.1 AY007811 mRNA Translation: AAG41059.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10315.1 [Q8WUJ3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001280227.1, NM_001293298.1 [Q8WUJ3-1] NP_001280233.1, NM_001293304.1 [Q8WUJ3-1] NP_061159.1, NM_018689.2 [Q8WUJ3-1]
UniGeneⁱ	Hs.459088

Genome annotation databases

Ensemblⁱ	ENST00000220244; ENSP00000220244; ENSG00000103888 [Q8WUJ3-1] ENST00000356249; ENSP00000348583; ENSG00000103888 [Q8WUJ3-1] ENST00000394685; ENSP00000378177; ENSG00000103888 [Q8WUJ3-1]
GeneIDⁱ	57214
KEGGⁱ	hsa:57214
UCSC genome browser More...UCSCⁱ	uc002bfw.2 human [Q8WUJ3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WUJ3	Protein KIAA1199 (Fragment)		MACMU		84	UniRef100_Q8WUJ3
UPI000D0C8616		HUMAN		1396

Protein	Similar proteins		Species	Score	Length	Source
Q8WUJ3	Protein KIAA1199 (Fragment)		MACMU		84	UniRef90_Q8WUJ3
Protein KIAA1199		FUKDA		1363
Uncharacterized protein		PROCO		1361
Uncharacterized protein		RABIT		1360
Cell migration inducing hyaluronidase 1		SAIBB		1355
+13

Protein	Similar proteins		Species	Score	Length	Source
Q8WUJ3	Cell migration-inducing and hyaluronan-binding protein		MOUSE		1361	UniRef50_Q8WUJ3
Protein KIAA1199 (Fragment)		MACMU		84
Protein KIAA1199		FUKDA		1363
Uncharacterized protein		PROCO		1361
Uncharacterized protein		RABIT		1360
+448

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB103330 mRNA Translation: BAD02451.1 CH471136 Genomic DNA Translation: EAW99111.1 BC020256 mRNA Translation: AAH20256.1 AB033025 mRNA Translation: BAA86513.1 AL359061 mRNA Translation: CAB94391.1 AY007811 mRNA Translation: AAG41059.1
CCDSⁱ	CCDS10315.1 [Q8WUJ3-1]
RefSeqⁱ	NP_001280227.1, NM_001293298.1 [Q8WUJ3-1] NP_001280233.1, NM_001293304.1 [Q8WUJ3-1] NP_061159.1, NM_018689.2 [Q8WUJ3-1]
UniGeneⁱ	Hs.459088

3D structure databases

ProteinModelPortalⁱ	Q8WUJ3
SMRⁱ	Q8WUJ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121452, 2 interactors
IntActⁱ	Q8WUJ3, 1 interactor
STRINGⁱ	9606.ENSP00000220244

PTM databases

CarbonylDBⁱ	Q8WUJ3
iPTMnetⁱ	Q8WUJ3
PhosphoSitePlusⁱ	Q8WUJ3

Polymorphism and mutation databases

BioMutaⁱ	KIAA1199
DMDMⁱ	46396475

Proteomic databases

PaxDbⁱ	Q8WUJ3
PeptideAtlasⁱ	Q8WUJ3
PRIDEⁱ	Q8WUJ3
ProteomicsDBⁱ	74690 74691 [Q8WUJ3-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000220244; ENSP00000220244; ENSG00000103888 [Q8WUJ3-1] ENST00000356249; ENSP00000348583; ENSG00000103888 [Q8WUJ3-1] ENST00000394685; ENSP00000378177; ENSG00000103888 [Q8WUJ3-1]
GeneIDⁱ	57214
KEGGⁱ	hsa:57214
UCSCⁱ	uc002bfw.2 human [Q8WUJ3-1]

Organism-specific databases

CTDⁱ	57214
DisGeNETⁱ	57214
EuPathDBⁱ	HostDB:ENSG00000103888.15
GeneCardsⁱ	CEMIP
HGNCⁱ	HGNC:29213 CEMIP
MIMⁱ	608366 gene
neXtProtⁱ	NX_Q8WUJ3
OpenTargetsⁱ	ENSG00000103888
PharmGKBⁱ	PA134967531
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFCM Eukaryota ENOG410XQ01 LUCA
GeneTreeⁱ	ENSGT00780000121902
HOGENOMⁱ	HOG000290723
HOVERGENⁱ	HBG052198
InParanoidⁱ	Q8WUJ3
KOⁱ	K19031
OMAⁱ	HFTAYKN
OrthoDBⁱ	EOG091G00JT
PhylomeDBⁱ	Q8WUJ3
TreeFamⁱ	TF316575

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2142850 Hyaluronan biosynthesis and export

Reactomeⁱ

R-HSA-2142850 Hyaluronan biosynthesis and export

Miscellaneous databases

ChiTaRSⁱ	CEMIP human
GeneWikiⁱ	KIAA1199
GenomeRNAiⁱ	57214
Protein Ontology More...PROⁱ	PR:Q8WUJ3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103888 Expressed in 153 organ(s), highest expression level in trigeminal ganglion
CleanExⁱ	HS_KIAA1199
ExpressionAtlasⁱ	Q8WUJ3 baseline and differential
Genevisibleⁱ	Q8WUJ3 HS

Family and domain databases

CDDⁱ	cd13938 PANDER_like_TMEM2, 1 hit
InterProⁱ	View protein in InterPro IPR019316 G8_domain IPR039477 ILEI/PANDER_dom IPR011050 Pectin_lyase_fold/virulence IPR039473 TMEM2_PANDER-like IPR025155 WxxW_domain
Pfamⁱ	View protein in Pfam PF10162 G8, 1 hit PF15711 ILEI, 2 hits PF13330 Mucin2_WxxW, 1 hit
SMARTⁱ	View protein in SMART SM01225 G8, 1 hit
SUPFAMⁱ	SSF51126 SSF51126, 1 hit
PROSITEⁱ	View protein in PROSITE PS51484 G8, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEMIP_HUMAN
Accessionⁱ	Q8WUJ3Primary (citable) accession number: Q8WUJ3 Secondary accession number(s): Q6L9J5 , Q9H1K5, Q9NPN9, Q9ULM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	April 13, 2004
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries

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UniProtKB - Q8WUJ3 (CEMIP_HUMAN)

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Cell migration-inducing and hyaluronan-binding protein

CEMIP

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Endoplasmic reticulum

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Keywords - Cellular componenti

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Organism-specific databases

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Experimental Info

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Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ