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Protein

Solute carrier family 22 member 17

Gene

SLC22A17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

ReactomeiR-HSA-917937 Iron uptake and transport

Protein family/group databases

TCDBi2.A.1.19.8 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 17
Alternative name(s):
24p3 receptor
Short name:
24p3R
Brain-type organic cation transporter
Lipocalin-2 receptor
Neutrophil gelatinase-associated lipocalin receptor
Short name:
NgalR
Gene namesi
Name:SLC22A17
Synonyms:BOCT, BOIT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000092096.14
HGNCiHGNC:23095 SLC22A17
MIMi611461 gene
neXtProtiNX_Q8WUG5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei303 – 322HelicalSequence analysisAdd BLAST20
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

DisGeNETi51310
OpenTargetsiENSG00000092096
PharmGKBiPA134879149

Polymorphism and mutation databases

DMDMi27805426

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205071 – 538Solute carrier family 22 member 17Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WUG5
PeptideAtlasiQ8WUG5
PRIDEiQ8WUG5
ProteomicsDBi74671
74672 [Q8WUG5-2]
74673 [Q8WUG5-3]

PTM databases

iPTMnetiQ8WUG5
PhosphoSitePlusiQ8WUG5

Expressioni

Tissue specificityi

Expressed in brain.

Inductioni

Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway.2 Publications

Gene expression databases

BgeeiENSG00000092096
CleanExiHS_SLC22A17
ExpressionAtlasiQ8WUG5 baseline and differential
GenevisibleiQ8WUG5 HS

Organism-specific databases

HPAiHPA002728

Interactioni

Protein-protein interaction databases

BioGridi119461, 2 interactors
IntActiQ8WUG5, 1 interactor
MINTiQ8WUG5
STRINGi9606.ENSP00000206544

Structurei

3D structure databases

ProteinModelPortaliQ8WUG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI7 Eukaryota
ENOG411129W LUCA
GeneTreeiENSGT00390000014377
HOVERGENiHBG031124
InParanoidiQ8WUG5
KOiK08213
OrthoDBiEOG091G07Y4
PhylomeDBiQ8WUG5
TreeFamiTF335753

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUG5-1) [UniParc]FASTAAdd to basket
Also known as: NgalR-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDPIFTLA PPLHCHYGAF PPNASGWEQP PNASGVSVAS AALAASAASR
60 70 80 90 100
VATSTDPSCS GFAPPDFNHC LKDWDYNGLP VLTTNAIGQW DLVCDLGWQV
110 120 130 140 150
ILEQILFILG FASGYLFLGY PADRFGRRGI VLLTLGLVGP CGVGGAAAGS
160 170 180 190 200
STGVMALRFL LGFLLAGVDL GVYLMRLELC DPTQRLRVAL AGELVGVGGH
210 220 230 240 250
FLFLGLALVS KDWRFLQRMI TAPCILFLFY GWPGLFLESA RWLIVKRQIE
260 270 280 290 300
EAQSVLRILA ERNRPHGQML GEEAQEALQD LENTCPLPAT SSFSFASLLN
310 320 330 340 350
YRNIWKNLLI LGFTNFIAHA IRHCYQPVGG GGSPSDFYLC SLLASGTAAL
360 370 380 390 400
ACVFLGVTVD RFGRRGILLL SMTLTGIASL VLLGLWDCEH PIFPTVWAQQ
410 420 430 440 450
GNPNRDLNEA AITTFSVLGL FSSQAAAILS TLLAAEVIPT TVRGRGLGLI
460 470 480 490 500
MALGALGGLS GPAQRLHMGH GAFLQHVVLA ACALLCILSI MLLPETKRKL
510 520 530
LPEVLRDGEL CRRPSLLRQP PPTRCDHVPL LATPNPAL
Length:538
Mass (Da):57,686
Last modified:March 1, 2002 - v1
Checksum:iB332F4ED80BF2387
GO
Isoform 2 (identifier: Q8WUG5-2) [UniParc]FASTAAdd to basket
Also known as: NgalR-2

The sequence of this isoform differs from the canonical sequence as follows:
     388-406: CEHPIFPTVWAQQGNPNRD → Y

Show »
Length:520
Mass (Da):55,658
Checksum:i9DA29182875B4D1D
GO
Isoform 3 (identifier: Q8WUG5-3) [UniParc]FASTAAdd to basket
Also known as: NgalR-3

The sequence of this isoform differs from the canonical sequence as follows:
     176-207: RLELCDPTQRLRVALAGELVGVGGHFLFLGLA → PNDHRSLHPLPVLWLAWFVPGVRTVADSEAAD
     208-538: Missing.

Show »
Length:207
Mass (Da):21,712
Checksum:i3A487F92CF729E86
GO

Sequence cautioni

The sequence CAC01119 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC17762 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103E → G in ABG45942 (PubMed:17253959).Curated1
Sequence conflicti124R → G in ABG45942 (PubMed:17253959).Curated1
Sequence conflicti293F → S in CAC01119 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039782176 – 207RLELC…FLGLA → PNDHRSLHPLPVLWLAWFVP GVRTVADSEAAD in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_039783208 – 538Missing in isoform 3. 1 PublicationAdd BLAST331
Alternative sequenceiVSP_003774388 – 406CEHPI…NPNRD → Y in isoform 2. 3 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ658848 mRNA Translation: ABG45942.1
BX161416 mRNA Translation: CAD61891.1
AL049829 Genomic DNA No translation available.
BC020565 mRNA Translation: AAH20565.1
BC090870 mRNA Translation: AAH90870.1
BC111015 mRNA Translation: AAI11016.1
AJ243122 Genomic DNA Translation: CAC17762.1 Different initiation.
AJ243653 mRNA Translation: CAC01119.1 Different initiation.
CCDSiCCDS9593.1 [Q8WUG5-1]
CCDS9594.2 [Q8WUG5-2]
RefSeqiNP_001275979.1, NM_001289050.1
NP_057693.3, NM_016609.4 [Q8WUG5-2]
NP_065105.2, NM_020372.3 [Q8WUG5-1]
XP_005267804.1, XM_005267747.4 [Q8WUG5-1]
XP_016876850.1, XM_017021361.1 [Q8WUG5-1]
XP_016876851.1, XM_017021362.1 [Q8WUG5-2]
UniGeneiHs.373498

Genome annotation databases

EnsembliENST00000397267; ENSP00000380437; ENSG00000092096 [Q8WUG5-1]
ENST00000637426; ENSP00000489868; ENSG00000092096 [Q8WUG5-2]
GeneIDi51310
KEGGihsa:51310
UCSCiuc001wjl.5 human [Q8WUG5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS22AH_HUMAN
AccessioniPrimary (citable) accession number: Q8WUG5
Secondary accession number(s): A4UA13
, A8MUT0, Q2TAB0, Q5BKY8, Q86U04, Q9H1D3, Q9NQD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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