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Entry version 150 (08 May 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Solute carrier family 22 member 17

Gene

SLC22A17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-917937 Iron uptake and transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.19.8 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 17
Alternative name(s):
24p3 receptor
Short name:
24p3R
Brain-type organic cation transporter
Lipocalin-2 receptor
Neutrophil gelatinase-associated lipocalin receptor
Short name:
NgalR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A17
Synonyms:BOCT, BOIT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:23095 SLC22A17

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611461 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8WUG5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei303 – 322HelicalSequence analysisAdd BLAST20
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51310

Open Targets

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OpenTargetsi
ENSG00000092096

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134879149

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLC22A17

Domain mapping of disease mutations (DMDM)

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DMDMi
27805426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205071 – 538Solute carrier family 22 member 17Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8WUG5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WUG5

PeptideAtlas

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PeptideAtlasi
Q8WUG5

PRoteomics IDEntifications database

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PRIDEi
Q8WUG5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74671
74672 [Q8WUG5-2]
74673 [Q8WUG5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WUG5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8WUG5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000092096 Expressed in 160 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WUG5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WUG5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002728

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119461, 2 interactors

Protein interaction database and analysis system

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IntActi
Q8WUG5, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8WUG5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000380437

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IRI7 Eukaryota
ENOG411129W LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160959

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WUG5

KEGG Orthology (KO)

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KOi
K08213

Database of Orthologous Groups

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OrthoDBi
1032137at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8WUG5

TreeFam database of animal gene trees

More...
TreeFami
TF335753

Family and domain databases

Conserved Domains Database

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CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103473 SSF103473, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUG5-1) [UniParc]FASTAAdd to basket
Also known as: NgalR-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASDPIFTLA PPLHCHYGAF PPNASGWEQP PNASGVSVAS AALAASAASR
60 70 80 90 100
VATSTDPSCS GFAPPDFNHC LKDWDYNGLP VLTTNAIGQW DLVCDLGWQV
110 120 130 140 150
ILEQILFILG FASGYLFLGY PADRFGRRGI VLLTLGLVGP CGVGGAAAGS
160 170 180 190 200
STGVMALRFL LGFLLAGVDL GVYLMRLELC DPTQRLRVAL AGELVGVGGH
210 220 230 240 250
FLFLGLALVS KDWRFLQRMI TAPCILFLFY GWPGLFLESA RWLIVKRQIE
260 270 280 290 300
EAQSVLRILA ERNRPHGQML GEEAQEALQD LENTCPLPAT SSFSFASLLN
310 320 330 340 350
YRNIWKNLLI LGFTNFIAHA IRHCYQPVGG GGSPSDFYLC SLLASGTAAL
360 370 380 390 400
ACVFLGVTVD RFGRRGILLL SMTLTGIASL VLLGLWDCEH PIFPTVWAQQ
410 420 430 440 450
GNPNRDLNEA AITTFSVLGL FSSQAAAILS TLLAAEVIPT TVRGRGLGLI
460 470 480 490 500
MALGALGGLS GPAQRLHMGH GAFLQHVVLA ACALLCILSI MLLPETKRKL
510 520 530
LPEVLRDGEL CRRPSLLRQP PPTRCDHVPL LATPNPAL
Length:538
Mass (Da):57,686
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB332F4ED80BF2387
GO
Isoform 2 (identifier: Q8WUG5-2) [UniParc]FASTAAdd to basket
Also known as: NgalR-2

The sequence of this isoform differs from the canonical sequence as follows:
     388-406: CEHPIFPTVWAQQGNPNRD → Y

Show »
Length:520
Mass (Da):55,658
Checksum:i9DA29182875B4D1D
GO
Isoform 3 (identifier: Q8WUG5-3) [UniParc]FASTAAdd to basket
Also known as: NgalR-3

The sequence of this isoform differs from the canonical sequence as follows:
     176-207: RLELCDPTQRLRVALAGELVGVGGHFLFLGLA → PNDHRSLHPLPVLWLAWFVPGVRTVADSEAAD
     208-538: Missing.

Show »
Length:207
Mass (Da):21,712
Checksum:i3A487F92CF729E86
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1C7CYV9A0A1C7CYV9_HUMAN
Solute carrier family 22 member 17
SLC22A17
631Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KVA1H9KVA1_HUMAN
Solute carrier family 22 member 17
SLC22A17
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVR9A0A1B0GVR9_HUMAN
Solute carrier family 22 member 17
SLC22A17
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUC0A0A1B0GUC0_HUMAN
Solute carrier family 22 member 17
SLC22A17
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC01119 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC17762 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103E → G in ABG45942 (PubMed:17253959).Curated1
Sequence conflicti124R → G in ABG45942 (PubMed:17253959).Curated1
Sequence conflicti293F → S in CAC01119 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039782176 – 207RLELC…FLGLA → PNDHRSLHPLPVLWLAWFVP GVRTVADSEAAD in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_039783208 – 538Missing in isoform 3. 1 PublicationAdd BLAST331
Alternative sequenceiVSP_003774388 – 406CEHPI…NPNRD → Y in isoform 2. 3 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ658848 mRNA Translation: ABG45942.1
BX161416 mRNA Translation: CAD61891.1
AL049829 Genomic DNA No translation available.
BC020565 mRNA Translation: AAH20565.1
BC090870 mRNA Translation: AAH90870.1
BC111015 mRNA Translation: AAI11016.1
AJ243122 Genomic DNA Translation: CAC17762.1 Different initiation.
AJ243653 mRNA Translation: CAC01119.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS9593.1 [Q8WUG5-1]
CCDS9594.2 [Q8WUG5-2]

NCBI Reference Sequences

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RefSeqi
NP_001275979.1, NM_001289050.1
NP_057693.3, NM_016609.4 [Q8WUG5-2]
NP_065105.2, NM_020372.3 [Q8WUG5-1]
XP_005267804.1, XM_005267747.4 [Q8WUG5-1]
XP_016876850.1, XM_017021361.1 [Q8WUG5-1]
XP_016876851.1, XM_017021362.1 [Q8WUG5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397267; ENSP00000380437; ENSG00000092096 [Q8WUG5-1]
ENST00000637426; ENSP00000489868; ENSG00000092096 [Q8WUG5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51310

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51310

UCSC genome browser

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UCSCi
uc001wjl.5 human [Q8WUG5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ658848 mRNA Translation: ABG45942.1
BX161416 mRNA Translation: CAD61891.1
AL049829 Genomic DNA No translation available.
BC020565 mRNA Translation: AAH20565.1
BC090870 mRNA Translation: AAH90870.1
BC111015 mRNA Translation: AAI11016.1
AJ243122 Genomic DNA Translation: CAC17762.1 Different initiation.
AJ243653 mRNA Translation: CAC01119.1 Different initiation.
CCDSiCCDS9593.1 [Q8WUG5-1]
CCDS9594.2 [Q8WUG5-2]
RefSeqiNP_001275979.1, NM_001289050.1
NP_057693.3, NM_016609.4 [Q8WUG5-2]
NP_065105.2, NM_020372.3 [Q8WUG5-1]
XP_005267804.1, XM_005267747.4 [Q8WUG5-1]
XP_016876850.1, XM_017021361.1 [Q8WUG5-1]
XP_016876851.1, XM_017021362.1 [Q8WUG5-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119461, 2 interactors
IntActiQ8WUG5, 2 interactors
MINTiQ8WUG5
STRINGi9606.ENSP00000380437

Protein family/group databases

TCDBi2.A.1.19.8 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8WUG5
PhosphoSitePlusiQ8WUG5

Polymorphism and mutation databases

BioMutaiSLC22A17
DMDMi27805426

Proteomic databases

jPOSTiQ8WUG5
PaxDbiQ8WUG5
PeptideAtlasiQ8WUG5
PRIDEiQ8WUG5
ProteomicsDBi74671
74672 [Q8WUG5-2]
74673 [Q8WUG5-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51310
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397267; ENSP00000380437; ENSG00000092096 [Q8WUG5-1]
ENST00000637426; ENSP00000489868; ENSG00000092096 [Q8WUG5-2]
GeneIDi51310
KEGGihsa:51310
UCSCiuc001wjl.5 human [Q8WUG5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51310
DisGeNETi51310

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC22A17
HGNCiHGNC:23095 SLC22A17
HPAiHPA002728
MIMi611461 gene
neXtProtiNX_Q8WUG5
OpenTargetsiENSG00000092096
PharmGKBiPA134879149

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IRI7 Eukaryota
ENOG411129W LUCA
GeneTreeiENSGT00940000160959
InParanoidiQ8WUG5
KOiK08213
OrthoDBi1032137at2759
PhylomeDBiQ8WUG5
TreeFamiTF335753

Enzyme and pathway databases

ReactomeiR-HSA-917937 Iron uptake and transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC22A17 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51310

Protein Ontology

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PROi
PR:Q8WUG5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000092096 Expressed in 160 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ8WUG5 baseline and differential
GenevisibleiQ8WUG5 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22AH_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUG5
Secondary accession number(s): A4UA13
, A8MUT0, Q2TAB0, Q5BKY8, Q86U04, Q9H1D3, Q9NQD5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2002
Last modified: May 8, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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