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Protein

Cotranscriptional regulator FAM172A

Gene

FAM172A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei293NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cotranscriptional regulator FAM172ABy similarity
Alternative name(s):
Protein FAM172A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM172A
Synonyms:C5orf21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000113391.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25365 FAM172A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WUF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83989

Open Targets

More...
OpenTargetsi
ENSG00000113391

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387241

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM172A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730707

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032093119 – 416Cotranscriptional regulator FAM172AAdd BLAST398

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WUF8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WUF8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WUF8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WUF8

PeptideAtlas

More...
PeptideAtlasi
Q8WUF8

PRoteomics IDEntifications database

More...
PRIDEi
Q8WUF8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74667
74668 [Q8WUF8-2]
74669 [Q8WUF8-3]
74670 [Q8WUF8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WUF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WUF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113391 Expressed in 224 organ(s), highest expression level in neocortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_FAM172A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WUF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WUF8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012299
HPA045505

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AGO2. Found in a complex, composed of AGO2, CHD7 and FAM172A.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123840, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WUF8, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379294

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WUF8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi413 – 416Prevents secretion from ERPROSITE-ProRule annotation4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM172 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3967 Eukaryota
ENOG410ZNS0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063907

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046503

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107877

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WUF8

Identification of Orthologs from Complete Genome Data

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OMAi
NTNDNYR

Database of Orthologous Groups

More...
OrthoDBi
1036194at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WUF8

TreeFam database of animal gene trees

More...
TreeFami
TF315960

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR019154 Arb2_domain
IPR039929 FAM172A

The PANTHER Classification System

More...
PANTHERi
PTHR21357:SF3 PTHR21357:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09757 Arb2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00014 ER_TARGET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSISLSSLIL LPIWINMAQI QQGGPDEKEK TTALKDLLSR IDLDELMKKD
60 70 80 90 100
EPPLDFPDTL EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA
110 120 130 140 150
LGEIITKYVY ELLEKDCNLK KVSIPVDATE SEPKSFIFMS EDALTNPQKL
160 170 180 190 200
MVLIHGSGVV RAGQWARRLI INEDLDSGTQ IPFIKRAVAE GYGVIVLNPN
210 220 230 240 250
ENYIEVEKPK IHVQSSSDSS DEPAEKRERK DKVSKETKKR RDFYEKYRNP
260 270 280 290 300
QREKEMMQLY IRENGSPEEH AIYVWDHFIA QAAAENVFFV AHSYGGLAFV
310 320 330 340 350
ELMIQREADV KNKVTAVALT DSVHNVWHQE AGKTIREWMR ENCCNWVSSS
360 370 380 390 400
EPLDTSVESM LPDCPRVSAG TDRHELTSWK SFPSIFKFFT EASEAKTSSL
410
KPAVTRRSHR IKHEEL
Length:416
Mass (Da):47,972
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37D05325D12FE7ED
GO
Isoform 2 (identifier: Q8WUF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-416: ENGSPEEHAI...RSHRIKHEEL → VSEITTFLYYFLYLVYILLYVDCFVFLQEY

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):34,290
Checksum:i4EE1DB236A41AA54
GO
Isoform 3 (identifier: Q8WUF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):42,851
Checksum:i7D958B1DC1AFE20C
GO
Isoform 4 (identifier: Q8WUF8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     126-189: Missing.

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):35,800
Checksum:i085812F213DC7C45
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DMI0B4DMI0_HUMAN
Protein FAM172A
FAM172A
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBM2E9PBM2_HUMAN
Cotranscriptional regulator FAM172A
FAM172A
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti236E → V in CAB66565 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039312131S → N. Corresponds to variant dbSNP:rs17083426Ensembl.1
Natural variantiVAR_080593228E → Q Found in patients with CHARGES; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767629211Ensembl.1
Natural variantiVAR_080594307 – 416Missing Found in a patient with CHARGES; unknown pathological significance. 1 PublicationAdd BLAST110

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0433131 – 46Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_043314126 – 189Missing in isoform 4. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_031749263 – 416ENGSP…KHEEL → VSEITTFLYYFLYLVYILLY VDCFVFLQEY in isoform 2. 1 PublicationAdd BLAST154

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136630 mRNA Translation: CAB66565.1
AK295879 mRNA Translation: BAG58676.1
AK296986 mRNA Translation: BAG59527.1
AK312930 mRNA Translation: BAG35773.1
AC093268 Genomic DNA No translation available.
AC099501 Genomic DNA No translation available.
AC106818 Genomic DNA No translation available.
AC108102 Genomic DNA No translation available.
AC114980 Genomic DNA No translation available.
AC117528 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW96012.1
BC020584 mRNA Translation: AAH20584.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4069.1 [Q8WUF8-1]
CCDS54879.1 [Q8WUF8-4]
CCDS54880.1 [Q8WUF8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001156889.1, NM_001163417.1 [Q8WUF8-3]
NP_001156890.1, NM_001163418.1 [Q8WUF8-4]
NP_114431.2, NM_032042.5 [Q8WUF8-1]
XP_006714780.1, XM_006714717.3 [Q8WUF8-1]
XP_011541974.1, XM_011543672.2 [Q8WUF8-3]
XP_016865444.1, XM_017009955.1 [Q8WUF8-3]
XP_016865445.1, XM_017009956.1 [Q8WUF8-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.600086

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395965; ENSP00000379294; ENSG00000113391 [Q8WUF8-1]
ENST00000505869; ENSP00000426284; ENSG00000113391 [Q8WUF8-4]
ENST00000509163; ENSP00000423841; ENSG00000113391 [Q8WUF8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83989

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83989

UCSC genome browser

More...
UCSCi
uc010jbd.4 human [Q8WUF8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136630 mRNA Translation: CAB66565.1
AK295879 mRNA Translation: BAG58676.1
AK296986 mRNA Translation: BAG59527.1
AK312930 mRNA Translation: BAG35773.1
AC093268 Genomic DNA No translation available.
AC099501 Genomic DNA No translation available.
AC106818 Genomic DNA No translation available.
AC108102 Genomic DNA No translation available.
AC114980 Genomic DNA No translation available.
AC117528 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW96012.1
BC020584 mRNA Translation: AAH20584.1
CCDSiCCDS4069.1 [Q8WUF8-1]
CCDS54879.1 [Q8WUF8-4]
CCDS54880.1 [Q8WUF8-3]
RefSeqiNP_001156889.1, NM_001163417.1 [Q8WUF8-3]
NP_001156890.1, NM_001163418.1 [Q8WUF8-4]
NP_114431.2, NM_032042.5 [Q8WUF8-1]
XP_006714780.1, XM_006714717.3 [Q8WUF8-1]
XP_011541974.1, XM_011543672.2 [Q8WUF8-3]
XP_016865444.1, XM_017009955.1 [Q8WUF8-3]
XP_016865445.1, XM_017009956.1 [Q8WUF8-3]
UniGeneiHs.600086

3D structure databases

ProteinModelPortaliQ8WUF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123840, 12 interactors
IntActiQ8WUF8, 4 interactors
STRINGi9606.ENSP00000379294

PTM databases

iPTMnetiQ8WUF8
PhosphoSitePlusiQ8WUF8

Polymorphism and mutation databases

BioMutaiFAM172A
DMDMi74730707

Proteomic databases

EPDiQ8WUF8
jPOSTiQ8WUF8
MaxQBiQ8WUF8
PaxDbiQ8WUF8
PeptideAtlasiQ8WUF8
PRIDEiQ8WUF8
ProteomicsDBi74667
74668 [Q8WUF8-2]
74669 [Q8WUF8-3]
74670 [Q8WUF8-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83989
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395965; ENSP00000379294; ENSG00000113391 [Q8WUF8-1]
ENST00000505869; ENSP00000426284; ENSG00000113391 [Q8WUF8-4]
ENST00000509163; ENSP00000423841; ENSG00000113391 [Q8WUF8-3]
GeneIDi83989
KEGGihsa:83989
UCSCiuc010jbd.4 human [Q8WUF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83989
DisGeNETi83989
EuPathDBiHostDB:ENSG00000113391.16

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM172A
HGNCiHGNC:25365 FAM172A
HPAiHPA012299
HPA045505
neXtProtiNX_Q8WUF8
OpenTargetsiENSG00000113391
PharmGKBiPA162387241

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3967 Eukaryota
ENOG410ZNS0 LUCA
GeneTreeiENSGT00530000063907
HOGENOMiHOG000046503
HOVERGENiHBG107877
InParanoidiQ8WUF8
OMAiNTNDNYR
OrthoDBi1036194at2759
PhylomeDBiQ8WUF8
TreeFamiTF315960

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM172A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C5orf21

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83989

Protein Ontology

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PROi
PR:Q8WUF8

Gene expression databases

BgeeiENSG00000113391 Expressed in 224 organ(s), highest expression level in neocortex
CleanExiHS_FAM172A
ExpressionAtlasiQ8WUF8 baseline and differential
GenevisibleiQ8WUF8 HS

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR019154 Arb2_domain
IPR039929 FAM172A
PANTHERiPTHR21357:SF3 PTHR21357:SF3, 1 hit
PfamiView protein in Pfam
PF09757 Arb2, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF172A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUF8
Secondary accession number(s): B2R7C6
, B4DJ14, B4DLG5, Q9H0U8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2002
Last modified: January 16, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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