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Entry version 161 (13 Feb 2019)
Sequence version 4 (04 Apr 2006)
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Protein

RelA-associated inhibitor

Gene

PPP1R13L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.4 Publications

Caution

An alternative product iASPP(RAI) has been described (PubMed:15489900, PubMed:10336463). However, it is not detected in vivo and is most probably a cloning artifact (PubMed:15489900).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • transcription corepressor activity Source: ProtInc
  • transcription factor binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RelA-associated inhibitor
Alternative name(s):
Inhibitor of ASPP protein
Short name:
Protein iASPP
NFkB-interacting protein 1
PPP1R13B-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R13L
Synonyms:IASPP, NKIP1, PPP1R13BL, RAI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104881.14

Human Gene Nomenclature Database

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HGNCi
HGNC:18838 PPP1R13L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607463 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WUF5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10848

MalaCards human disease database

More...
MalaCardsi
PPP1R13L

Open Targets

More...
OpenTargetsi
ENSG00000104881

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34195

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R13L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
92090607

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669661 – 828RelA-associated inhibitorAdd BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei102PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei123PhosphothreonineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei137Omega-N-methylarginineBy similarity1
Modified residuei142Omega-N-methylarginineBy similarity1
Modified residuei144Omega-N-methylarginineBy similarity1
Modified residuei160Omega-N-methylarginineBy similarity1
Modified residuei167Omega-N-methylarginineCombined sources1
Modified residuei180Omega-N-methylarginineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei205Omega-N-methylarginineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei308PhosphothreonineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei341PhosphothreonineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei597PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WUF5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8WUF5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WUF5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WUF5

PeptideAtlas

More...
PeptideAtlasi
Q8WUF5

PRoteomics IDEntifications database

More...
PRIDEi
Q8WUF5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74665

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WUF5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WUF5

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q8WUF5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104881 Expressed in 159 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WUF5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WUF5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005016
HPA041231
HPA059883

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116059, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8WUF5

Database of interacting proteins

More...
DIPi
DIP-29586N

Protein interaction database and analysis system

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IntActi
Q8WUF5, 27 interactors

Molecular INTeraction database

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MINTi
Q8WUF5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1828
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VGEX-ray2.10A607-828[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WUF5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WUF5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WUF5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati659 – 691ANK 1Add BLAST33
Repeati692 – 724ANK 2Add BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini758 – 820SH3PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 602Pro-richAdd BLAST549
Compositional biasi407 – 444Gln-richAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region is required for cytoplasmic localization.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the iASPP family.Curated

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0515 Eukaryota
ENOG410Y17W LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160551

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055210

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WUF5

Identification of Orthologs from Complete Genome Data

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OMAi
SDWWWAS

Database of Orthologous Groups

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OrthoDBi
1041229at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WUF5

TreeFam database of animal gene trees

More...
TreeFami
TF105545

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR028320 iASPP
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR24164 PTHR24164, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF14604 SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8WUF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW
60 70 80 90 100
SDSPAPPGPQ AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS
110 120 130 140 150
ESAPTLHPYS PLSPKGRPSS PRTPLYLQPD AYGSLDRATS PRPRAFDGAG
160 170 180 190 200
SSLGRAPSPR PGPGPLRQQG PPTPFDFLGR AGSPRGSPLA EGPQAFFPER
210 220 230 240 250
GPSPRPPATA YDAPASAFGS SLLGSGGSAF APPLRAQDDL TLRRRPPKAW
260 270 280 290 300
NESDLDVAYE KKPSQTASYE RLDVFARPAS PSLQLLPWRE SSLDGLGGTG
310 320 330 340 350
KDNLTSATLP RNYKVSPLAS DRRSDAGSYR RSLGSAGPSG TLPRSWQPVS
360 370 380 390 400
RIPMPPSSPQ PRGAPRQRPI PLSMIFKLQN AFWEHGASRA MLPGSPLFTR
410 420 430 440 450
APPPKLQPQP QPQPQPQSQP QPQLPPQPQT QPQTPTPAPQ HPQQTWPPVN
460 470 480 490 500
EGPPKPPTEL EPEPEIEGLL TPVLEAGDVD EGPVARPLSP TRLQPALPPE
510 520 530 540 550
AQSVPELEEV ARVLAEIPRP LKRRGSMEQA PAVALPPTHK KQYQQIISRL
560 570 580 590 600
FHRHGGPGPG GPEPELSPIT EGSEARAGPP APAPPAPIPP PAPSQSSPPE
610 620 630 640 650
QPQSMEMRSV LRKAGSPRKA RRARLNPLVL LLDAALTGEL EVVQQAVKEM
660 670 680 690 700
NDPSQPNEEG ITALHNAICG ANYSIVDFLI TAGANVNSPD SHGWTPLHCA
710 720 730 740 750
ASCNDTVICM ALVQHGAAIF ATTLSDGATA FEKCDPYREG YADCATYLAD
760 770 780 790 800
VEQSMGLMNS GAVYALWDYS AEFGDELSFR EGESVTVLRR DGPEETDWWW
810 820
AALHGQEGYV PRNYFGLFPR VKPQRSKV
Length:828
Mass (Da):89,091
Last modified:April 4, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BEEF239B7CA9C70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EN03K7EN03_HUMAN
RelA-associated inhibitor
PPP1R13L
128Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPP1K7EPP1_HUMAN
RelA-associated inhibitor
PPP1R13L
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EML6K7EML6_HUMAN
RelA-associated inhibitor
PPP1R13L
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENG6K7ENG6_HUMAN
RelA-associated inhibitor
PPP1R13L
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD27004 differs from that shown. Reason: Frameshift at positions 439, 483, 562 and 591.Curated
The sequence AAD27005 differs from that shown. Probable cloning artifact.Curated
The sequence AAD27005 differs from that shown. Reason: Frameshift at positions 483, 562 and 591.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198P → S in AAH64913 (PubMed:15489334).Curated1
Sequence conflicti223L → I in AAW51146 (Ref. 2) Curated1
Sequence conflicti317 – 318PL → AA in AAD27004 (PubMed:10336463).Curated2
Sequence conflicti321D → T in AAD27004 (PubMed:10336463).Curated1
Sequence conflicti369P → S in AAW51146 (Ref. 2) Curated1
Sequence conflicti372Missing in AAW51146 (Ref. 2) Curated1
Sequence conflicti426P → Q in AAD27004 (PubMed:10336463).Curated1
Sequence conflicti439 – 440PQ → HP in AAD27004 (PubMed:10336463).Curated2
Sequence conflicti747Y → S in AAW51146 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ888472 mRNA Translation: CAI60219.1
AY869712 mRNA Translation: AAW51146.1
DQ314886 Genomic DNA Translation: ABC40745.1
BC001475 mRNA Translation: AAH01475.1
BC020589 mRNA Translation: AAH20589.1
BC032298 mRNA Translation: AAH32298.1
BC064913 mRNA Translation: AAH64913.1
AF078036 mRNA Translation: AAD27004.1 Frameshift.
AF078037 mRNA Translation: AAD27005.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS33050.1

NCBI Reference Sequences

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RefSeqi
NP_001135974.1, NM_001142502.1
NP_006654.2, NM_006663.3
XP_016881666.1, XM_017026177.1
XP_016881667.1, XM_017026178.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.466937

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000360957; ENSP00000354218; ENSG00000104881
ENST00000418234; ENSP00000403902; ENSG00000104881

Database of genes from NCBI RefSeq genomes

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GeneIDi
10848

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10848

UCSC genome browser

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UCSCi
uc002pbn.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ888472 mRNA Translation: CAI60219.1
AY869712 mRNA Translation: AAW51146.1
DQ314886 Genomic DNA Translation: ABC40745.1
BC001475 mRNA Translation: AAH01475.1
BC020589 mRNA Translation: AAH20589.1
BC032298 mRNA Translation: AAH32298.1
BC064913 mRNA Translation: AAH64913.1
AF078036 mRNA Translation: AAD27004.1 Frameshift.
AF078037 mRNA Translation: AAD27005.1 Sequence problems.
CCDSiCCDS33050.1
RefSeqiNP_001135974.1, NM_001142502.1
NP_006654.2, NM_006663.3
XP_016881666.1, XM_017026177.1
XP_016881667.1, XM_017026178.1
UniGeneiHs.466937

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VGEX-ray2.10A607-828[»]
ProteinModelPortaliQ8WUF5
SMRiQ8WUF5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116059, 33 interactors
CORUMiQ8WUF5
DIPiDIP-29586N
IntActiQ8WUF5, 27 interactors
MINTiQ8WUF5
STRINGi9606.ENSP00000354218

PTM databases

iPTMnetiQ8WUF5
PhosphoSitePlusiQ8WUF5

Polymorphism and mutation databases

BioMutaiPPP1R13L
DMDMi92090607

Proteomic databases

EPDiQ8WUF5
jPOSTiQ8WUF5
MaxQBiQ8WUF5
PaxDbiQ8WUF5
PeptideAtlasiQ8WUF5
PRIDEiQ8WUF5
ProteomicsDBi74665

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360957; ENSP00000354218; ENSG00000104881
ENST00000418234; ENSP00000403902; ENSG00000104881
GeneIDi10848
KEGGihsa:10848
UCSCiuc002pbn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10848
DisGeNETi10848
EuPathDBiHostDB:ENSG00000104881.14

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP1R13L
HGNCiHGNC:18838 PPP1R13L
HPAiCAB005016
HPA041231
HPA059883
MalaCardsiPPP1R13L
MIMi607463 gene
neXtProtiNX_Q8WUF5
OpenTargetsiENSG00000104881
PharmGKBiPA34195

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0515 Eukaryota
ENOG410Y17W LUCA
GeneTreeiENSGT00940000160551
HOVERGENiHBG055210
InParanoidiQ8WUF5
OMAiSDWWWAS
OrthoDBi1041229at2759
PhylomeDBiQ8WUF5
TreeFamiTF105545

Enzyme and pathway databases

ReactomeiR-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP1R13L human
EvolutionaryTraceiQ8WUF5

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PPP1R13L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10848
PMAP-CutDBiQ8WUF5

Protein Ontology

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PROi
PR:Q8WUF5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000104881 Expressed in 159 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ8WUF5 baseline and differential
GenevisibleiQ8WUF5 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR028320 iASPP
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24164 PTHR24164, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIASPP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUF5
Secondary accession number(s): Q2PNZ9
, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: April 4, 2006
Last modified: February 13, 2019
This is version 161 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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