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Protein

RelA-associated inhibitor

Gene

PPP1R13L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.4 Publications

Caution

An alternative product iASPP(RAI) has been described (PubMed:15489900, PubMed:10336463). However, it is not detected in vivo and is most probably a cloning artifact (PubMed:15489900).2 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • transcription corepressor activity Source: ProtInc
  • transcription factor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Names & Taxonomyi

Protein namesi
Recommended name:
RelA-associated inhibitor
Alternative name(s):
Inhibitor of ASPP protein
Short name:
Protein iASPP
NFkB-interacting protein 1
PPP1R13B-like protein
Gene namesi
Name:PPP1R13L
Synonyms:IASPP, NKIP1, PPP1R13BL, RAI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104881.14
HGNCiHGNC:18838 PPP1R13L
MIMi607463 gene
neXtProtiNX_Q8WUF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10848
MalaCardsiPPP1R13L
OpenTargetsiENSG00000104881
PharmGKBiPA34195

Polymorphism and mutation databases

BioMutaiPPP1R13L
DMDMi92090607

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669661 – 828RelA-associated inhibitorAdd BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei102PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei123PhosphothreonineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei137Omega-N-methylarginineBy similarity1
Modified residuei142Omega-N-methylarginineBy similarity1
Modified residuei144Omega-N-methylarginineBy similarity1
Modified residuei160Omega-N-methylarginineBy similarity1
Modified residuei167Omega-N-methylarginineCombined sources1
Modified residuei180Omega-N-methylarginineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei205Omega-N-methylarginineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei308PhosphothreonineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei341PhosphothreonineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei597PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8WUF5
MaxQBiQ8WUF5
PaxDbiQ8WUF5
PeptideAtlasiQ8WUF5
PRIDEiQ8WUF5
ProteomicsDBi74665

PTM databases

iPTMnetiQ8WUF5
PhosphoSitePlusiQ8WUF5

Miscellaneous databases

PMAP-CutDBiQ8WUF5

Expressioni

Tissue specificityi

Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.1 Publication

Gene expression databases

BgeeiENSG00000104881
CleanExiHS_PPP1R13L
ExpressionAtlasiQ8WUF5 baseline and differential
GenevisibleiQ8WUF5 HS

Organism-specific databases

HPAiCAB005016
HPA041231
HPA059883

Interactioni

Subunit structurei

Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • transcription factor binding Source: ProtInc

Protein-protein interaction databases

BioGridi116059, 32 interactors
DIPiDIP-29586N
IntActiQ8WUF5, 26 interactors
MINTiQ8WUF5
STRINGi9606.ENSP00000354218

Structurei

Secondary structure

1828
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi627 – 637Combined sources11
Helixi640 – 649Combined sources10
Helixi663 – 669Combined sources7
Helixi673 – 681Combined sources9
Helixi696 – 702Combined sources7
Helixi706 – 713Combined sources8
Turni714 – 716Combined sources3
Helixi731 – 733Combined sources3
Helixi741 – 754Combined sources14
Turni755 – 757Combined sources3
Helixi759 – 761Combined sources3
Beta strandi762 – 767Combined sources6
Beta strandi784 – 791Combined sources8
Beta strandi796 – 803Combined sources8
Beta strandi806 – 811Combined sources6
Helixi812 – 814Combined sources3
Beta strandi815 – 818Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VGEX-ray2.10A607-828[»]
ProteinModelPortaliQ8WUF5
SMRiQ8WUF5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUF5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati659 – 691ANK 1Add BLAST33
Repeati692 – 724ANK 2Add BLAST33
Domaini758 – 820SH3PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 602Pro-richAdd BLAST549
Compositional biasi407 – 444Gln-richAdd BLAST38

Domaini

The N-terminal region is required for cytoplasmic localization.1 Publication

Sequence similaritiesi

Belongs to the ASPP family.Curated

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0515 Eukaryota
ENOG410Y17W LUCA
GeneTreeiENSGT00760000119141
HOVERGENiHBG055210
InParanoidiQ8WUF5
OMAiDWWWASL
OrthoDBiEOG091G0R1R
PhylomeDBiQ8WUF5
TreeFamiTF105545

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR028320 iASPP
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24164 PTHR24164, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WUF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW
60 70 80 90 100
SDSPAPPGPQ AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS
110 120 130 140 150
ESAPTLHPYS PLSPKGRPSS PRTPLYLQPD AYGSLDRATS PRPRAFDGAG
160 170 180 190 200
SSLGRAPSPR PGPGPLRQQG PPTPFDFLGR AGSPRGSPLA EGPQAFFPER
210 220 230 240 250
GPSPRPPATA YDAPASAFGS SLLGSGGSAF APPLRAQDDL TLRRRPPKAW
260 270 280 290 300
NESDLDVAYE KKPSQTASYE RLDVFARPAS PSLQLLPWRE SSLDGLGGTG
310 320 330 340 350
KDNLTSATLP RNYKVSPLAS DRRSDAGSYR RSLGSAGPSG TLPRSWQPVS
360 370 380 390 400
RIPMPPSSPQ PRGAPRQRPI PLSMIFKLQN AFWEHGASRA MLPGSPLFTR
410 420 430 440 450
APPPKLQPQP QPQPQPQSQP QPQLPPQPQT QPQTPTPAPQ HPQQTWPPVN
460 470 480 490 500
EGPPKPPTEL EPEPEIEGLL TPVLEAGDVD EGPVARPLSP TRLQPALPPE
510 520 530 540 550
AQSVPELEEV ARVLAEIPRP LKRRGSMEQA PAVALPPTHK KQYQQIISRL
560 570 580 590 600
FHRHGGPGPG GPEPELSPIT EGSEARAGPP APAPPAPIPP PAPSQSSPPE
610 620 630 640 650
QPQSMEMRSV LRKAGSPRKA RRARLNPLVL LLDAALTGEL EVVQQAVKEM
660 670 680 690 700
NDPSQPNEEG ITALHNAICG ANYSIVDFLI TAGANVNSPD SHGWTPLHCA
710 720 730 740 750
ASCNDTVICM ALVQHGAAIF ATTLSDGATA FEKCDPYREG YADCATYLAD
760 770 780 790 800
VEQSMGLMNS GAVYALWDYS AEFGDELSFR EGESVTVLRR DGPEETDWWW
810 820
AALHGQEGYV PRNYFGLFPR VKPQRSKV
Length:828
Mass (Da):89,091
Last modified:April 4, 2006 - v4
Checksum:i7BEEF239B7CA9C70
GO

Sequence cautioni

The sequence AAD27004 differs from that shown. Reason: Frameshift at positions 439, 483, 562 and 591.Curated
The sequence AAD27005 differs from that shown. Probable cloning artifact.Curated
The sequence AAD27005 differs from that shown. Reason: Frameshift at positions 483, 562 and 591.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198P → S in AAH64913 (PubMed:15489334).Curated1
Sequence conflicti223L → I in AAW51146 (Ref. 2) Curated1
Sequence conflicti317 – 318PL → AA in AAD27004 (PubMed:10336463).Curated2
Sequence conflicti321D → T in AAD27004 (PubMed:10336463).Curated1
Sequence conflicti369P → S in AAW51146 (Ref. 2) Curated1
Sequence conflicti372Missing in AAW51146 (Ref. 2) Curated1
Sequence conflicti426P → Q in AAD27004 (PubMed:10336463).Curated1
Sequence conflicti439 – 440PQ → HP in AAD27004 (PubMed:10336463).Curated2
Sequence conflicti747Y → S in AAW51146 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ888472 mRNA Translation: CAI60219.1
AY869712 mRNA Translation: AAW51146.1
DQ314886 Genomic DNA Translation: ABC40745.1
BC001475 mRNA Translation: AAH01475.1
BC020589 mRNA Translation: AAH20589.1
BC032298 mRNA Translation: AAH32298.1
BC064913 mRNA Translation: AAH64913.1
AF078036 mRNA Translation: AAD27004.1 Frameshift.
AF078037 mRNA Translation: AAD27005.1 Sequence problems.
CCDSiCCDS33050.1
RefSeqiNP_001135974.1, NM_001142502.1
NP_006654.2, NM_006663.3
XP_016881666.1, XM_017026177.1
XP_016881667.1, XM_017026178.1
UniGeneiHs.466937

Genome annotation databases

EnsembliENST00000360957; ENSP00000354218; ENSG00000104881
ENST00000418234; ENSP00000403902; ENSG00000104881
GeneIDi10848
KEGGihsa:10848
UCSCiuc002pbn.4 human

Similar proteinsi

Entry informationi

Entry nameiIASPP_HUMAN
AccessioniPrimary (citable) accession number: Q8WUF5
Secondary accession number(s): Q2PNZ9
, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: April 4, 2006
Last modified: June 20, 2018
This is version 154 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. UniProtKB entry view manual
    User manual for the UniProtKB entry view

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