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Entry version 125 (08 May 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Cancer/testis antigen 55

Gene

CT55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cancer/testis antigen 55
Alternative name(s):
Tumor antigen BJ-HCC-20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CT55
Synonyms:CXorf48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:26047 CT55

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WUE5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54967

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134977669

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CT55

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68565599

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797391 – 264Cancer/testis antigen 55Add BLAST264

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WUE5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WUE5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WUE5

PeptideAtlas

More...
PeptideAtlasi
Q8WUE5

PRoteomics IDEntifications database

More...
PRIDEi
Q8WUE5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74663
74664 [Q8WUE5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WUE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WUE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169551 Expressed in 39 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WUE5 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120304, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WUE5, 19 interactors

Molecular INTeraction database

More...
MINTi
Q8WUE5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276241

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WUE5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JC2U Eukaryota
ENOG411164K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163821

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112103

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WUE5

Identification of Orthologs from Complete Genome Data

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OMAi
QFCYIWR

Database of Orthologous Groups

More...
OrthoDBi
1242774at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WUE5

TreeFam database of animal gene trees

More...
TreeFami
TF338795

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012340 NA-bd_OB-fold
IPR025223 S1-like_RNA-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14444 S1-like, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249 SSF50249, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WUE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRLLRLALA FYGRTADPAE RQGPQQQGLP QGDTQLTTVQ GVVTSFCGDY
60 70 80 90 100
GMIDESIYFS SDVVTGNVPL KVGQKVNVVV EEDKPHYGLR AIKVDVVPRH
110 120 130 140 150
LYGAGPSDSG TRVLIGCVTS INEDNIYISN SIYFSIAIVS EDFVPYKGDL
160 170 180 190 200
LEVEYSTEPG ISNIKATSVK PIRCIHTEEV CITSVHGRNG VIDYTIFFTL
210 220 230 240 250
DSVKLPDGYV PQVDDIVNVV MVESIQFCFI WRAISITPVH KSSSGFQDDG
260
GLGRPKRERR SQSI
Length:264
Mass (Da):29,052
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EB884C8FD9C823B
GO
Isoform 2 (identifier: Q8WUE5-2) [UniParc]FASTAAdd to basket
Also known as: BJ-HCC-20B

The sequence of this isoform differs from the canonical sequence as follows:
     243-264: Missing.

Show »
Length:242
Mass (Da):26,636
Checksum:i078BE347209E05DB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014465243 – 264Missing in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY352211 mRNA Translation: AAQ90022.1
AF520814 mRNA Translation: AAP47205.1
AK000534 mRNA Translation: BAA91237.1
AL670455 Genomic DNA Translation: CAI41607.1
AL670455 Genomic DNA Translation: CAI41608.1
BC020662 mRNA Translation: AAH20662.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14647.1 [Q8WUE5-2]
CCDS35400.1 [Q8WUE5-1]

NCBI Reference Sequences

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RefSeqi
NP_001026875.1, NM_001031705.2 [Q8WUE5-1]
NP_060333.1, NM_017863.2 [Q8WUE5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276241; ENSP00000276241; ENSG00000169551 [Q8WUE5-1]
ENST00000344129; ENSP00000343893; ENSG00000169551 [Q8WUE5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54967

UCSC genome browser

More...
UCSCi
uc004eyk.2 human [Q8WUE5-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352211 mRNA Translation: AAQ90022.1
AF520814 mRNA Translation: AAP47205.1
AK000534 mRNA Translation: BAA91237.1
AL670455 Genomic DNA Translation: CAI41607.1
AL670455 Genomic DNA Translation: CAI41608.1
BC020662 mRNA Translation: AAH20662.1
CCDSiCCDS14647.1 [Q8WUE5-2]
CCDS35400.1 [Q8WUE5-1]
RefSeqiNP_001026875.1, NM_001031705.2 [Q8WUE5-1]
NP_060333.1, NM_017863.2 [Q8WUE5-2]

3D structure databases

SMRiQ8WUE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120304, 18 interactors
IntActiQ8WUE5, 19 interactors
MINTiQ8WUE5
STRINGi9606.ENSP00000276241

PTM databases

iPTMnetiQ8WUE5
PhosphoSitePlusiQ8WUE5

Polymorphism and mutation databases

BioMutaiCT55
DMDMi68565599

Proteomic databases

EPDiQ8WUE5
jPOSTiQ8WUE5
PaxDbiQ8WUE5
PeptideAtlasiQ8WUE5
PRIDEiQ8WUE5
ProteomicsDBi74663
74664 [Q8WUE5-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54967
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276241; ENSP00000276241; ENSG00000169551 [Q8WUE5-1]
ENST00000344129; ENSP00000343893; ENSG00000169551 [Q8WUE5-2]
GeneIDi54967
KEGGihsa:54967
UCSCiuc004eyk.2 human [Q8WUE5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54967
DisGeNETi54967

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CT55
HGNCiHGNC:26047 CT55
neXtProtiNX_Q8WUE5
PharmGKBiPA134977669

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JC2U Eukaryota
ENOG411164K LUCA
GeneTreeiENSGT00940000163821
HOGENOMiHOG000112103
InParanoidiQ8WUE5
OMAiQFCYIWR
OrthoDBi1242774at2759
PhylomeDBiQ8WUE5
TreeFamiTF338795

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54967

Protein Ontology

More...
PROi
PR:Q8WUE5

Gene expression databases

BgeeiENSG00000169551 Expressed in 39 organ(s), highest expression level in testis
GenevisibleiQ8WUE5 HS

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR025223 S1-like_RNA-bd_dom
PfamiView protein in Pfam
PF14444 S1-like, 2 hits
SUPFAMiSSF50249 SSF50249, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCT55_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUE5
Secondary accession number(s): Q9NWY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2002
Last modified: May 8, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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