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Protein

Ras-related protein Rab-2B

Gene

RAB2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21GTPCombined sources9
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPCombined sources4
Nucleotide bindingi149 – 151GTPCombined sources3

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • positive regulation of exocytosis Source: UniProtKB
  • Rab protein signal transduction Source: GO_Central
  • vesicle-mediated transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2B
Gene namesi
Name:RAB2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000129472.12
HGNCiHGNC:20246 RAB2B
MIMi607466 gene
neXtProtiNX_Q8WUD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129472
PharmGKBiPA134865942

Polymorphism and mutation databases

BioMutaiRAB2B
DMDMi28436385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210711 – 216Ras-related protein Rab-2BAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202PhosphoserineCombined sources1
Lipidationi215S-geranylgeranyl cysteineBy similarity1
Lipidationi216S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ8WUD1
MaxQBiQ8WUD1
PaxDbiQ8WUD1
PeptideAtlasiQ8WUD1
PRIDEiQ8WUD1
ProteomicsDBi74657

PTM databases

iPTMnetiQ8WUD1
PhosphoSitePlusiQ8WUD1
SwissPalmiQ8WUD1

Expressioni

Tissue specificityi

Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.

Gene expression databases

BgeeiENSG00000129472 Expressed in 204 organ(s), highest expression level in bone marrow
CleanExiHS_RAB2B
ExpressionAtlasiQ8WUD1 baseline and differential
GenevisibleiQ8WUD1 HS

Organism-specific databases

HPAiHPA050292

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi124366, 40 interactors
IntActiQ8WUD1, 17 interactors
STRINGi9606.ENSP00000380869

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WUD1
SMRiQ8WUD1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUD1

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ8WUD1
KOiK07878
OMAiYGRPQGP
OrthoDBiEOG091G0QOB
PhylomeDBiQ8WUD1
TreeFamiTF300032

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WUD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW
110 120 130 140 150
LEDARQHSSS NMVIMLIGNK SDLESRRDVK REEGEAFARE HGLIFMETSA
160 170 180 190 200
KTACNVEEAF INTAKEIYRK IQQGLFDVHN EANGIKIGPQ QSISTSVGPS
210
ASQRNSRDIG SNSGCC
Length:216
Mass (Da):24,214
Last modified:March 1, 2002 - v1
Checksum:i80A73F6D259701D8
GO
Isoform 2 (identifier: Q8WUD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MTYAYLFKYI...SFRSITRSYY → MENKSNCKSGI

Show »
Length:151
Mass (Da):16,667
Checksum:i3B7E62B17FFDB278
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PE37E9PE37_HUMAN
Ras-related protein Rab-2B
RAB2B
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168Y → H in AAN86142 (PubMed:12376746).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051709212N → T. Corresponds to variant dbSNP:rs17106411Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558291 – 76MTYAY…TRSYY → MENKSNCKSGI in isoform 2. 2 PublicationsAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468652 mRNA Translation: AAN86142.1
AK296057 mRNA Translation: BAG58820.1
AK315354 mRNA Translation: BAG37750.1
CH471078 Genomic DNA Translation: EAW66382.1
CH471078 Genomic DNA Translation: EAW66383.1
BC020839 mRNA Translation: AAH20839.1
BC066366 mRNA Translation: AAH66366.1
CCDSiCCDS9570.1 [Q8WUD1-1]
RefSeqiNP_001156852.1, NM_001163380.1
NP_116235.2, NM_032846.3 [Q8WUD1-1]
XP_016877200.1, XM_017021711.1
UniGeneiHs.22399

Genome annotation databases

EnsembliENST00000397762; ENSP00000380869; ENSG00000129472 [Q8WUD1-1]
GeneIDi84932
KEGGihsa:84932
UCSCiuc010tlt.2 human [Q8WUD1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468652 mRNA Translation: AAN86142.1
AK296057 mRNA Translation: BAG58820.1
AK315354 mRNA Translation: BAG37750.1
CH471078 Genomic DNA Translation: EAW66382.1
CH471078 Genomic DNA Translation: EAW66383.1
BC020839 mRNA Translation: AAH20839.1
BC066366 mRNA Translation: AAH66366.1
CCDSiCCDS9570.1 [Q8WUD1-1]
RefSeqiNP_001156852.1, NM_001163380.1
NP_116235.2, NM_032846.3 [Q8WUD1-1]
XP_016877200.1, XM_017021711.1
UniGeneiHs.22399

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A5JX-ray1.50A5-176[»]
ProteinModelPortaliQ8WUD1
SMRiQ8WUD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124366, 40 interactors
IntActiQ8WUD1, 17 interactors
STRINGi9606.ENSP00000380869

PTM databases

iPTMnetiQ8WUD1
PhosphoSitePlusiQ8WUD1
SwissPalmiQ8WUD1

Polymorphism and mutation databases

BioMutaiRAB2B
DMDMi28436385

Proteomic databases

EPDiQ8WUD1
MaxQBiQ8WUD1
PaxDbiQ8WUD1
PeptideAtlasiQ8WUD1
PRIDEiQ8WUD1
ProteomicsDBi74657

Protocols and materials databases

DNASUi84932
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397762; ENSP00000380869; ENSG00000129472 [Q8WUD1-1]
GeneIDi84932
KEGGihsa:84932
UCSCiuc010tlt.2 human [Q8WUD1-1]

Organism-specific databases

CTDi84932
EuPathDBiHostDB:ENSG00000129472.12
GeneCardsiRAB2B
H-InvDBiHIX0011509
HGNCiHGNC:20246 RAB2B
HPAiHPA050292
MIMi607466 gene
neXtProtiNX_Q8WUD1
OpenTargetsiENSG00000129472
PharmGKBiPA134865942
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0098 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ8WUD1
KOiK07878
OMAiYGRPQGP
OrthoDBiEOG091G0QOB
PhylomeDBiQ8WUD1
TreeFamiTF300032

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiRAB2B human
EvolutionaryTraceiQ8WUD1
GenomeRNAii84932
PROiPR:Q8WUD1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129472 Expressed in 204 organ(s), highest expression level in bone marrow
CleanExiHS_RAB2B
ExpressionAtlasiQ8WUD1 baseline and differential
GenevisibleiQ8WUD1 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB2B_HUMAN
AccessioniPrimary (citable) accession number: Q8WUD1
Secondary accession number(s): B2RD03, D3DS24, Q6NZ33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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