RAB2B

Functionⁱ

Required for protein transport from the endoplasmic reticulum to the Golgi complex.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	13 – 21	GTPCombined sources	9
Nucleotide bindingⁱ	61 – 65	GTPBy similarity	5
Nucleotide bindingⁱ	119 – 122	GTPCombined sources	4
Nucleotide bindingⁱ	149 – 151	GTPCombined sources	3

GO - Molecular functionⁱ

GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of exocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19966785
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle-mediated transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-2B
Gene namesⁱ	Name:RAB2B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129472.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20246 RAB2B
MIMⁱ	607466 gene
neXtProtⁱ	NX_Q8WUD1

Keywords - Cellular componentⁱ

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000129472
PharmGKBⁱ	PA134865942

Polymorphism and mutation databases

BioMutaⁱ	RAB2B
DMDMⁱ	28436385

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121071	1 – 216	Ras-related protein Rab-2BAdd BLAST		216

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	202	PhosphoserineCombined sources	1
Lipidationⁱ	215	S-geranylgeranyl cysteineBy similarity	1
Lipidationⁱ	216	S-geranylgeranyl cysteineBy similarity	1

Keywords - PTMⁱ

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	Q8WUD1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WUD1
PaxDbⁱ	Q8WUD1
PeptideAtlas More...PeptideAtlasⁱ	Q8WUD1
PRIDEⁱ	Q8WUD1
ProteomicsDBⁱ	74657

PTM databases

iPTMnetⁱ	Q8WUD1
PhosphoSitePlusⁱ	Q8WUD1
SwissPalmⁱ	Q8WUD1

Expressionⁱ

Tissue specificityⁱ

Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.

Gene expression databases

Bgeeⁱ	ENSG00000129472 Expressed in 204 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_RAB2B
ExpressionAtlasⁱ	Q8WUD1 baseline and differential
Genevisibleⁱ	Q8WUD1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050292

HPAⁱ

HPA050292

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ADAMTSL4	Q6UY14-3	3	EBI-5542466,EBI-10173507
BLZF1	Q9H2G9	5	EBI-5542466,EBI-2548012
FAM114A1	Q8IWE2	5	EBI-5542466,EBI-2686288
FAM71C	Q8NEG0	7	EBI-5542466,EBI-752049
GOLGA2	Q08379	5	EBI-5542466,EBI-618309
ICA1	Q05084	3	EBI-5542466,EBI-1046751

Protein-protein interaction databases

BioGridⁱ	124366, 40 interactors
IntActⁱ	Q8WUD1, 17 interactors
STRINGⁱ	9606.ENSP00000380869

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 14	Combined sources	10
Helixⁱ	19 – 28	Combined sources	10
Beta strandⁱ	41 – 50	Combined sources	10
Beta strandⁱ	53 – 60	Combined sources	8
Helixⁱ	65 – 67	Combined sources	3
Helixⁱ	73 – 76	Combined sources	4
Beta strandⁱ	80 – 87	Combined sources	8
Helixⁱ	91 – 95	Combined sources	5
Helixⁱ	97 – 107	Combined sources	11
Beta strandⁱ	113 – 119	Combined sources	7
Helixⁱ	124 – 126	Combined sources	3
Helixⁱ	131 – 141	Combined sources	11
Beta strandⁱ	144 – 148	Combined sources	5
Turnⁱ	150 – 152	Combined sources	3
Helixⁱ	156 – 172	Combined sources	17

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8WUD1
SMRⁱ	Q8WUD1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8WUD1

EvolutionaryTraceⁱ

Q8WUD1

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	35 – 43	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0098 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118841
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q8WUD1
KEGG Orthology (KO) More...KOⁱ	K07878
OMAⁱ	YGRPQGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QOB
PhylomeDBⁱ	Q8WUD1
TreeFamⁱ	TF300032

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8WUD1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI 
        60         70         80         90        100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW 
       110        120        130        140        150
LEDARQHSSS NMVIMLIGNK SDLESRRDVK REEGEAFARE HGLIFMETSA 
       160        170        180        190        200
KTACNVEEAF INTAKEIYRK IQQGLFDVHN EANGIKIGPQ QSISTSVGPS 
       210 
ASQRNSRDIG SNSGCC

Length:216

Mass (Da):24,214

Last modified:March 1, 2002 - v1

Checksum:ⁱ80A73F6D259701D8

GO

Isoform 2 (identifier: Q8WUD1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-76: MTYAYLFKYI...SFRSITRSYY → MENKSNCKSGI

« Hide

        10         20         30         40         50
MENKSNCKSG IRGAAGALLV YDITRRETFN HLTSWLEDAR QHSSSNMVIM 
        60         70         80         90        100
LIGNKSDLES RRDVKREEGE AFAREHGLIF METSAKTACN VEEAFINTAK 
       110        120        130        140        150
EIYRKIQQGL FDVHNEANGI KIGPQQSIST SVGPSASQRN SRDIGSNSGC 

C

Show »

Length:151

Mass (Da):16,667

Checksum:ⁱ3B7E62B17FFDB278

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PE37	E9PE37_HUMAN		Ras-related protein Rab-2B Ras-related protein Rab-2B	RAB2B	62	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	168	Y → H in AAN86142 (PubMed:12376746).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051709	212	N → T. Corresponds to variant dbSNP:rs17106411Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055829	1 – 76	MTYAY…TRSYY → MENKSNCKSGI in isoform 2. 2 PublicationsAdd BLAST		76

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF468652 mRNA Translation: AAN86142.1 AK296057 mRNA Translation: BAG58820.1 AK315354 mRNA Translation: BAG37750.1 CH471078 Genomic DNA Translation: EAW66382.1 CH471078 Genomic DNA Translation: EAW66383.1 BC020839 mRNA Translation: AAH20839.1 BC066366 mRNA Translation: AAH66366.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9570.1 [Q8WUD1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001156852.1, NM_001163380.1 NP_116235.2, NM_032846.3 [Q8WUD1-1] XP_016877200.1, XM_017021711.1
UniGeneⁱ	Hs.22399

Genome annotation databases

Ensemblⁱ	ENST00000397762; ENSP00000380869; ENSG00000129472 [Q8WUD1-1]
GeneIDⁱ	84932
KEGGⁱ	hsa:84932
UCSC genome browser More...UCSCⁱ	uc010tlt.2 human [Q8WUD1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WUD1	RAB2B, member RAS oncogene family		CALJA		216	UniRef100_Q8WUD1
RAB2B isoform 1		PANTR		216
RAB2B isoform 1		PONAB		216
Uncharacterized protein		AOTNA		216
Uncharacterized protein		PANPA		216
+3

Protein	Similar proteins		Species	Score	Length	Source
Q8WUD1	Ras-related protein Rab-2B		MOUSE		216	UniRef90_Q8WUD1
RAB2B, member RAS oncogene family		CALJA		216
RAB2B isoform 1		PANTR		216
RAB2B isoform 1		PONAB		216
Uncharacterized protein		AOTNA		216
+85
Q8WUD1-2	Uncharacterized protein		OTOGA		147	UniRef90_Q8WUD1-2
UPI00063EE41B		PROCO		151
UPI0003EB05BD		HUMAN		147
UPI000DF6A02C		VULVU		138
UPI000643EF4A		OTOGA		146

Protein	Similar proteins		Species	Score	Length	Source
Q8WUD1	Ras-related protein Rab-2A	)	HUMAN		212	UniRef50_P61019
Ras-related protein Rab-2A		CANLF		212
Ras-related protein Rab-2A		MACFA		212
Ras-related protein Rab-2A		PONAB		212
Ras-related protein Rab-2B		MOUSE		216
+284
Q8WUD1-2	Uncharacterized protein		OTOGA		147	UniRef50_Q8WUD1-2
Putative ras-related protein rab-2 (Fragment)		CONC2		163
Putative gtpase rab2 small g protein (Fragment)		IXORI		159
Uncharacterized protein		TRIRE		151
Uncharacterized protein		COFCA		185
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF468652 mRNA Translation: AAN86142.1 AK296057 mRNA Translation: BAG58820.1 AK315354 mRNA Translation: BAG37750.1 CH471078 Genomic DNA Translation: EAW66382.1 CH471078 Genomic DNA Translation: EAW66383.1 BC020839 mRNA Translation: AAH20839.1 BC066366 mRNA Translation: AAH66366.1
CCDSⁱ	CCDS9570.1 [Q8WUD1-1]
RefSeqⁱ	NP_001156852.1, NM_001163380.1 NP_116235.2, NM_032846.3 [Q8WUD1-1] XP_016877200.1, XM_017021711.1
UniGeneⁱ	Hs.22399

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2A5J	X-ray	1.50	A	5-176	[»]
ProteinModelPortalⁱ	Q8WUD1
SMRⁱ	Q8WUD1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124366, 40 interactors
IntActⁱ	Q8WUD1, 17 interactors
STRINGⁱ	9606.ENSP00000380869

PTM databases

iPTMnetⁱ	Q8WUD1
PhosphoSitePlusⁱ	Q8WUD1
SwissPalmⁱ	Q8WUD1

Polymorphism and mutation databases

BioMutaⁱ	RAB2B
DMDMⁱ	28436385

Proteomic databases

EPDⁱ	Q8WUD1
MaxQBⁱ	Q8WUD1
PaxDbⁱ	Q8WUD1
PeptideAtlasⁱ	Q8WUD1
PRIDEⁱ	Q8WUD1
ProteomicsDBⁱ	74657

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84932
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000397762; ENSP00000380869; ENSG00000129472 [Q8WUD1-1]
GeneIDⁱ	84932
KEGGⁱ	hsa:84932
UCSCⁱ	uc010tlt.2 human [Q8WUD1-1]

Organism-specific databases

CTDⁱ	84932
EuPathDBⁱ	HostDB:ENSG00000129472.12
GeneCardsⁱ	RAB2B
H-InvDBⁱ	HIX0011509
HGNCⁱ	HGNC:20246 RAB2B
HPAⁱ	HPA050292
MIMⁱ	607466 gene
neXtProtⁱ	NX_Q8WUD1
OpenTargetsⁱ	ENSG00000129472
PharmGKBⁱ	PA134865942
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0098 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00760000118841
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q8WUD1
KOⁱ	K07878
OMAⁱ	YGRPQGP
OrthoDBⁱ	EOG091G0QOB
PhylomeDBⁱ	Q8WUD1
TreeFamⁱ	TF300032

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSⁱ	RAB2B human
EvolutionaryTraceⁱ	Q8WUD1
GenomeRNAiⁱ	84932
Protein Ontology More...PROⁱ	PR:Q8WUD1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129472 Expressed in 204 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_RAB2B
ExpressionAtlasⁱ	Q8WUD1 baseline and differential
Genevisibleⁱ	Q8WUD1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB2B_HUMAN
Accessionⁱ	Q8WUD1Primary (citable) accession number: Q8WUD1 Secondary accession number(s): B2RD03, D3DS24, Q6NZ33
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
	Last sequence update:	March 1, 2002
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q8WUD1 (RAB2B_HUMAN)

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Ras-related protein Rab-2B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Endoplasmic reticulum

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ