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UniProtKB - Q8WUD1 (RAB2B_HUMAN)
Protein
Ras-related protein Rab-2B
Gene
RAB2B
Organism
Homo sapiens (Human)
Status
Functioni
Required for protein transport from the endoplasmic reticulum to the Golgi complex.
CuratedRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 13 – 21 | GTPCombined sources | 9 | |
Nucleotide bindingi | 61 – 65 | GTPBy similarity | 5 | |
Nucleotide bindingi | 119 – 122 | GTPCombined sources | 4 | |
Nucleotide bindingi | 149 – 151 | GTPCombined sources | 3 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of exocytosis Source: UniProtKB
- protein transport Source: UniProtKB-KW
- vesicle-mediated transport Source: UniProtKB-KW
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.5.2, 2681 |
PathwayCommonsi | Q8WUD1 |
Reactomei | R-HSA-8873719, RAB geranylgeranylation |
SignaLinki | Q8WUD1 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-2B |
Gene namesi | Name:RAB2B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20246, RAB2B |
MIMi | 607466, gene |
neXtProti | NX_Q8WUD1 |
VEuPathDBi | HostDB:ENSG00000129472 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Golgi apparatus
- Golgi apparatus membrane Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84932 |
OpenTargetsi | ENSG00000129472 |
PharmGKBi | PA134865942 |
Miscellaneous databases
Pharosi | Q8WUD1, Tdark |
Genetic variation databases
BioMutai | RAB2B |
DMDMi | 28436385 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121071 | 1 – 216 | Ras-related protein Rab-2BAdd BLAST | 216 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 202 | PhosphoserineCombined sources | 1 | |
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 | |
Lipidationi | 216 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Phosphoprotein, PrenylationProteomic databases
EPDi | Q8WUD1 |
jPOSTi | Q8WUD1 |
MassIVEi | Q8WUD1 |
MaxQBi | Q8WUD1 |
PaxDbi | Q8WUD1 |
PeptideAtlasi | Q8WUD1 |
PRIDEi | Q8WUD1 |
ProteomicsDBi | 74657 [Q8WUD1-1] |
PTM databases
iPTMneti | Q8WUD1 |
PhosphoSitePlusi | Q8WUD1 |
SwissPalmi | Q8WUD1 |
Expressioni
Tissue specificityi
Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.
Gene expression databases
Bgeei | ENSG00000129472, Expressed in bone marrow and 217 other tissues |
ExpressionAtlasi | Q8WUD1, baseline and differential |
Genevisiblei | Q8WUD1, HS |
Organism-specific databases
HPAi | ENSG00000129472, Low tissue specificity |
Interactioni
Binary interactionsi
Q8WUD1
Isoform 2 [Q8WUD1-2]
Protein-protein interaction databases
BioGRIDi | 124366, 63 interactors |
IntActi | Q8WUD1, 46 interactors |
STRINGi | 9606.ENSP00000380869 |
Miscellaneous databases
RNActi | Q8WUD1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8WUD1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WUD1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 189 – 216 | DisorderedSequence analysisAdd BLAST | 28 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 35 – 43 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0098, Eukaryota |
GeneTreei | ENSGT00940000153886 |
InParanoidi | Q8WUD1 |
OMAi | VEEAFMI |
OrthoDBi | 1271975at2759 |
PhylomeDBi | Q8WUD1 |
TreeFami | TF300032 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WUD1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW
110 120 130 140 150
LEDARQHSSS NMVIMLIGNK SDLESRRDVK REEGEAFARE HGLIFMETSA
160 170 180 190 200
KTACNVEEAF INTAKEIYRK IQQGLFDVHN EANGIKIGPQ QSISTSVGPS
210
ASQRNSRDIG SNSGCC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITL1 | A0A3B3ITL1_HUMAN | Ras-related protein Rab-2B | RAB2B | 208 | Annotation score: | ||
E9PE37 | E9PE37_HUMAN | Ras-related protein Rab-2B | RAB2B | 62 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 168 | Y → H in AAN86142 (PubMed:12376746).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051709 | 212 | N → T. Corresponds to variant dbSNP:rs17106411Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055829 | 1 – 76 | MTYAY…TRSYY → MENKSNCKSGI in isoform 2. 2 PublicationsAdd BLAST | 76 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF468652 mRNA Translation: AAN86142.1 AK296057 mRNA Translation: BAG58820.1 AK315354 mRNA Translation: BAG37750.1 CH471078 Genomic DNA Translation: EAW66382.1 CH471078 Genomic DNA Translation: EAW66383.1 BC020839 mRNA Translation: AAH20839.1 BC066366 mRNA Translation: AAH66366.1 |
CCDSi | CCDS9570.1 [Q8WUD1-1] |
RefSeqi | NP_001156852.1, NM_001163380.1 NP_116235.2, NM_032846.3 [Q8WUD1-1] XP_016877200.1, XM_017021711.1 |
Genome annotation databases
Ensembli | ENST00000397762; ENSP00000380869; ENSG00000129472 |
GeneIDi | 84932 |
KEGGi | hsa:84932 |
MANE-Selecti | ENST00000397762.6; ENSP00000380869.1; NM_032846.4; NP_116235.2 |
UCSCi | uc010tlt.2, human [Q8WUD1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF468652 mRNA Translation: AAN86142.1 AK296057 mRNA Translation: BAG58820.1 AK315354 mRNA Translation: BAG37750.1 CH471078 Genomic DNA Translation: EAW66382.1 CH471078 Genomic DNA Translation: EAW66383.1 BC020839 mRNA Translation: AAH20839.1 BC066366 mRNA Translation: AAH66366.1 |
CCDSi | CCDS9570.1 [Q8WUD1-1] |
RefSeqi | NP_001156852.1, NM_001163380.1 NP_116235.2, NM_032846.3 [Q8WUD1-1] XP_016877200.1, XM_017021711.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2A5J | X-ray | 1.50 | A | 5-176 | [»] | |
SMRi | Q8WUD1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124366, 63 interactors |
IntActi | Q8WUD1, 46 interactors |
STRINGi | 9606.ENSP00000380869 |
PTM databases
iPTMneti | Q8WUD1 |
PhosphoSitePlusi | Q8WUD1 |
SwissPalmi | Q8WUD1 |
Genetic variation databases
BioMutai | RAB2B |
DMDMi | 28436385 |
Proteomic databases
EPDi | Q8WUD1 |
jPOSTi | Q8WUD1 |
MassIVEi | Q8WUD1 |
MaxQBi | Q8WUD1 |
PaxDbi | Q8WUD1 |
PeptideAtlasi | Q8WUD1 |
PRIDEi | Q8WUD1 |
ProteomicsDBi | 74657 [Q8WUD1-1] |
Protocols and materials databases
Antibodypediai | 22150, 210 antibodies from 31 providers |
DNASUi | 84932 |
Genome annotation databases
Ensembli | ENST00000397762; ENSP00000380869; ENSG00000129472 |
GeneIDi | 84932 |
KEGGi | hsa:84932 |
MANE-Selecti | ENST00000397762.6; ENSP00000380869.1; NM_032846.4; NP_116235.2 |
UCSCi | uc010tlt.2, human [Q8WUD1-1] |
Organism-specific databases
CTDi | 84932 |
DisGeNETi | 84932 |
GeneCardsi | RAB2B |
HGNCi | HGNC:20246, RAB2B |
HPAi | ENSG00000129472, Low tissue specificity |
MIMi | 607466, gene |
neXtProti | NX_Q8WUD1 |
OpenTargetsi | ENSG00000129472 |
PharmGKBi | PA134865942 |
VEuPathDBi | HostDB:ENSG00000129472 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0098, Eukaryota |
GeneTreei | ENSGT00940000153886 |
InParanoidi | Q8WUD1 |
OMAi | VEEAFMI |
OrthoDBi | 1271975at2759 |
PhylomeDBi | Q8WUD1 |
TreeFami | TF300032 |
Enzyme and pathway databases
BRENDAi | 3.6.5.2, 2681 |
PathwayCommonsi | Q8WUD1 |
Reactomei | R-HSA-8873719, RAB geranylgeranylation |
SignaLinki | Q8WUD1 |
Miscellaneous databases
BioGRID-ORCSi | 84932, 11 hits in 1046 CRISPR screens |
ChiTaRSi | RAB2B, human |
EvolutionaryTracei | Q8WUD1 |
GenomeRNAii | 84932 |
Pharosi | Q8WUD1, Tdark |
PROi | PR:Q8WUD1 |
RNActi | Q8WUD1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129472, Expressed in bone marrow and 217 other tissues |
ExpressionAtlasi | Q8WUD1, baseline and differential |
Genevisiblei | Q8WUD1, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB2B_HUMAN | |
Accessioni | Q8WUD1Primary (citable) accession number: Q8WUD1 Secondary accession number(s): B2RD03, D3DS24, Q6NZ33 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families