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Protein

Protein FAM216A

Gene

FAM216A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-18 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM216A
Gene namesi
Name:FAM216A
Synonyms:C12orf24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000204856.11
HGNCiHGNC:30180 FAM216A
neXtProtiNX_Q8WUB2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204856
PharmGKBiPA128395781

Polymorphism and mutation databases

BioMutaiFAM216A
DMDMi74730685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888611 – 273Protein FAM216AAdd BLAST273

Proteomic databases

MaxQBiQ8WUB2
PaxDbiQ8WUB2
PeptideAtlasiQ8WUB2
PRIDEiQ8WUB2
ProteomicsDBi74653

PTM databases

iPTMnetiQ8WUB2
PhosphoSitePlusiQ8WUB2

Expressioni

Gene expression databases

BgeeiENSG00000204856 Expressed in 196 organ(s), highest expression level in testis
CleanExiHS_C12orf24
ExpressionAtlasiQ8WUB2 baseline and differential
GenevisibleiQ8WUB2 HS

Organism-specific databases

HPAiHPA038286

Interactioni

Protein-protein interaction databases

BioGridi118951, 5 interactors
IntActiQ8WUB2, 2 interactors
MINTiQ8WUB2
STRINGi9606.ENSP00000366901

Structurei

3D structure databases

ProteinModelPortaliQ8WUB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM216 family.Curated

Phylogenomic databases

eggNOGiENOG410IG55 Eukaryota
ENOG4111DX3 LUCA
GeneTreeiENSGT00390000012966
HOGENOMiHOG000111755
HOVERGENiHBG102671
InParanoidiQ8WUB2
OMAiRQYMHVI
OrthoDBiEOG091G19NC
PhylomeDBiQ8WUB2
TreeFamiTF337546

Family and domain databases

InterProiView protein in InterPro
IPR029373 FAM216
PANTHERiPTHR16476 PTHR16476, 1 hit
PfamiView protein in Pfam
PF15107 FAM216B, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8WUB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGQLLPHTA RGLGAAEMPG QGPGSDWTER SSSAEPPAVA GTEGGGGGSA
60 70 80 90 100
GYSCYQNSKG SDRIKDGYKV NSHIAKLQEL WKTPQNQTIH LSKSMMEASF
110 120 130 140 150
FKHPDLTTGQ KRYLCSIAKI YNANYLKMLM KRQYMHVLQH SSQKPGVLTH
160 170 180 190 200
HRSRLSSRYS QKQHYPCTTW RHQLEREDSG SSDIAAASAP EMLIQHSLWR
210 220 230 240 250
PVRNKEGIKT GYASKTRCKS LKIFRRPRKL FMQTVSSDDS ESHMSEEKKE
260 270
EDLLNNFMQS MSIEEQGEHL MLT
Length:273
Mass (Da):30,792
Last modified:March 1, 2002 - v1
Checksum:iB06EF30057AB8586
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VXY8F8VXY8_HUMAN
Protein FAM216A
FAM216A
77Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200R → W in AAB50215 (PubMed:9110174).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032513225R → G. Corresponds to variant dbSNP:rs17188964Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79274 mRNA Translation: AAB50215.1
CR457001 mRNA Translation: CAG33282.1
AC002350 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97917.1
BC020967 mRNA Translation: AAH20967.1
CCDSiCCDS31899.1
RefSeqiNP_037432.2, NM_013300.2
UniGeneiHs.436618

Genome annotation databases

EnsembliENST00000377673; ENSP00000366901; ENSG00000204856
GeneIDi29902
KEGGihsa:29902
UCSCiuc001tqu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79274 mRNA Translation: AAB50215.1
CR457001 mRNA Translation: CAG33282.1
AC002350 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97917.1
BC020967 mRNA Translation: AAH20967.1
CCDSiCCDS31899.1
RefSeqiNP_037432.2, NM_013300.2
UniGeneiHs.436618

3D structure databases

ProteinModelPortaliQ8WUB2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118951, 5 interactors
IntActiQ8WUB2, 2 interactors
MINTiQ8WUB2
STRINGi9606.ENSP00000366901

PTM databases

iPTMnetiQ8WUB2
PhosphoSitePlusiQ8WUB2

Polymorphism and mutation databases

BioMutaiFAM216A
DMDMi74730685

Proteomic databases

MaxQBiQ8WUB2
PaxDbiQ8WUB2
PeptideAtlasiQ8WUB2
PRIDEiQ8WUB2
ProteomicsDBi74653

Protocols and materials databases

DNASUi29902
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377673; ENSP00000366901; ENSG00000204856
GeneIDi29902
KEGGihsa:29902
UCSCiuc001tqu.5 human

Organism-specific databases

CTDi29902
EuPathDBiHostDB:ENSG00000204856.11
GeneCardsiFAM216A
HGNCiHGNC:30180 FAM216A
HPAiHPA038286
neXtProtiNX_Q8WUB2
OpenTargetsiENSG00000204856
PharmGKBiPA128395781
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG55 Eukaryota
ENOG4111DX3 LUCA
GeneTreeiENSGT00390000012966
HOGENOMiHOG000111755
HOVERGENiHBG102671
InParanoidiQ8WUB2
OMAiRQYMHVI
OrthoDBiEOG091G19NC
PhylomeDBiQ8WUB2
TreeFamiTF337546

Miscellaneous databases

GenomeRNAii29902
PROiPR:Q8WUB2

Gene expression databases

BgeeiENSG00000204856 Expressed in 196 organ(s), highest expression level in testis
CleanExiHS_C12orf24
ExpressionAtlasiQ8WUB2 baseline and differential
GenevisibleiQ8WUB2 HS

Family and domain databases

InterProiView protein in InterPro
IPR029373 FAM216
PANTHERiPTHR16476 PTHR16476, 1 hit
PfamiView protein in Pfam
PF15107 FAM216B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF216A_HUMAN
AccessioniPrimary (citable) accession number: Q8WUB2
Secondary accession number(s): A6NH30, Q99776
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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