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Entry version 153 (02 Jun 2021)
Sequence version 3 (17 Oct 2006)
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Protein

Tsukushi

Gene

TSKU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis.

By similarity

Miscellaneous

This factor is named 'Tsukushi' because its expression pattern in chick embryos is similar to the shape of the Japanese horsetail plant, tsukushi.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8WUA8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tsukushi1 Publication
Alternative name(s):
E2-induced gene 4 protein
Leucine-rich repeat-containing protein 54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSKU
Synonyms:E2IG4, LRRC54, TSK
ORF Names:UNQ850/PRO1788
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28850, TSKU

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608015, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WUA8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000182704.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25987

Open Targets

More...
OpenTargetsi
ENSG00000182704

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162407150

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WUA8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSKU

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242832

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024040717 – 353TsukushiAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WUA8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WUA8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WUA8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WUA8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WUA8

PeptideAtlas

More...
PeptideAtlasi
Q8WUA8

PRoteomics IDEntifications database

More...
PRIDEi
Q8WUA8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74652

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8WUA8, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WUA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WUA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By 17-beta-estradiol.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182704, Expressed in endocervix and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WUA8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WUA8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182704, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FZD4 (via FZ domain); competes with WNT2B for binding to FZD4, inhibiting Wnt signaling and repressing peripheral eye development (By similarity).

Interacts with TGFB1; the interaction contributes to regulation of the hair cycle (By similarity).

Interacts with netrin (By similarity).

Interacts with CCN2 (PubMed:30232710).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117468, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WUA8, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8WUA8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000434847

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WUA8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 58LRRNTAdd BLAST42
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati59 – 80LRR 1Add BLAST22
Repeati85 – 106LRR 2Add BLAST22
Repeati109 – 130LRR 3Add BLAST22
Repeati132 – 153LRR 4Add BLAST22
Repeati159 – 179LRR 5Add BLAST21
Repeati185 – 206LRR 6Add BLAST22
Repeati207 – 227LRR 7Add BLAST21
Repeati230 – 249LRR 8Add BLAST20
Repeati255 – 276LRR 9Add BLAST22
Repeati280 – 301LRR 10Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160984

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_785168_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WUA8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFPGCHC

Database of Orthologous Groups

More...
OrthoDBi
1168051at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WUA8

TreeFam database of animal gene trees

More...
TreeFami
TF343079

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8WUA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPWPLLLLLA VSGAQTTRPC FPGCQCEVET FGLFDSFSLT RVDCSGLGPH
60 70 80 90 100
IMPVPIPLDT AHLDLSSNRL EMVNESVLAG PGYTTLAGLD LSHNLLTSIS
110 120 130 140 150
PTAFSRLRYL ESLDLSHNGL TALPAESFTS SPLSDVNLSH NQLREVSVSA
160 170 180 190 200
FTTHSQGRAL HVDLSHNLIH RLVPHPTRAG LPAPTIQSLN LAWNRLHAVP
210 220 230 240 250
NLRDLPLRYL SLDGNPLAVI GPGAFAGLGG LTHLSLASLQ RLPELAPSGF
260 270 280 290 300
RELPGLQVLD LSGNPKLNWA GAEVFSGLSS LQELDLSGTN LVPLPEALLL
310 320 330 340 350
HLPALQSVSV GQDVRCRRLV REGTYPRRPG SSPKVALHCV DTRDSAARGP

TIL
Length:353
Mass (Da):37,807
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80F073221B8A38A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLG7E9PLG7_HUMAN
Tsukushi
TSKU
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN12E9PN12_HUMAN
Tsukushi
TSKU
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti336A → P in AAQ88683 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028725208R → C. Corresponds to variant dbSNP:rs3740772Ensembl.1
Natural variantiVAR_028726248S → N. Corresponds to variant dbSNP:rs11236938Ensembl.1
Natural variantiVAR_028727308V → I. Corresponds to variant dbSNP:rs3740771Ensembl.1
Natural variantiVAR_026726344D → E5 PublicationsCorresponds to variant dbSNP:rs1149621Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF191019 mRNA Translation: AAF09483.1
AY358317 mRNA Translation: AAQ88683.1
BT007440 mRNA Translation: AAP36108.1
AK075476 mRNA Translation: BAG52149.1
BC020975 mRNA Translation: AAH20975.1
AL110276 mRNA Translation: CAB53711.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8246.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T14791

NCBI Reference Sequences

More...
RefSeqi
NP_001245139.1, NM_001258210.1
NP_001305406.1, NM_001318477.1
NP_001305407.1, NM_001318478.1
NP_001305408.1, NM_001318479.1
NP_056331.2, NM_015516.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333090; ENSP00000332668; ENSG00000182704
ENST00000527881; ENSP00000434847; ENSG00000182704
ENST00000612930; ENSP00000482145; ENSG00000182704

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25987

UCSC genome browser

More...
UCSCi
uc001oxt.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191019 mRNA Translation: AAF09483.1
AY358317 mRNA Translation: AAQ88683.1
BT007440 mRNA Translation: AAP36108.1
AK075476 mRNA Translation: BAG52149.1
BC020975 mRNA Translation: AAH20975.1
AL110276 mRNA Translation: CAB53711.1
CCDSiCCDS8246.1
PIRiT14791
RefSeqiNP_001245139.1, NM_001258210.1
NP_001305406.1, NM_001318477.1
NP_001305407.1, NM_001318478.1
NP_001305408.1, NM_001318479.1
NP_056331.2, NM_015516.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117468, 3 interactors
IntActiQ8WUA8, 3 interactors
MINTiQ8WUA8
STRINGi9606.ENSP00000434847

PTM databases

GlyGeniQ8WUA8, 2 sites
iPTMnetiQ8WUA8
PhosphoSitePlusiQ8WUA8

Genetic variation databases

BioMutaiTSKU
DMDMi116242832

Proteomic databases

EPDiQ8WUA8
jPOSTiQ8WUA8
MassIVEiQ8WUA8
MaxQBiQ8WUA8
PaxDbiQ8WUA8
PeptideAtlasiQ8WUA8
PRIDEiQ8WUA8
ProteomicsDBi74652

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2163, 77 antibodies

The DNASU plasmid repository

More...
DNASUi
25987

Genome annotation databases

EnsembliENST00000333090; ENSP00000332668; ENSG00000182704
ENST00000527881; ENSP00000434847; ENSG00000182704
ENST00000612930; ENSP00000482145; ENSG00000182704
GeneIDi25987
KEGGihsa:25987
UCSCiuc001oxt.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25987
DisGeNETi25987

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSKU
HGNCiHGNC:28850, TSKU
HPAiENSG00000182704, Tissue enhanced (liver)
MIMi608015, gene
neXtProtiNX_Q8WUA8
OpenTargetsiENSG00000182704
PharmGKBiPA162407150
VEuPathDBiHostDB:ENSG00000182704.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000160984
HOGENOMiCLU_785168_0_0_1
InParanoidiQ8WUA8
OMAiCFPGCHC
OrthoDBi1168051at2759
PhylomeDBiQ8WUA8
TreeFamiTF343079

Enzyme and pathway databases

PathwayCommonsiQ8WUA8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
25987, 9 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSKU, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25987
PharosiQ8WUA8, Tdark

Protein Ontology

More...
PROi
PR:Q8WUA8
RNActiQ8WUA8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182704, Expressed in endocervix and 214 other tissues
ExpressionAtlasiQ8WUA8, baseline and differential
GenevisibleiQ8WUA8, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 8 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 8 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WUA8
Secondary accession number(s): B3KQT7
, Q6UXK1, Q9UG10, Q9UJX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 17, 2006
Last modified: June 2, 2021
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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