Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

General transcription factor 3C polypeptide 2

Gene

GTF3C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

GO - Biological processi

  • 5S class rRNA transcription by RNA polymerase III Source: HGNC
  • transcription, DNA-templated Source: HGNC
  • transcription by RNA polymerase III Source: HGNC
  • tRNA transcription by RNA polymerase III Source: HGNC

Keywordsi

Biological processTranscription

Enzyme and pathway databases

ReactomeiR-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
SignaLinkiQ8WUA4

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 2
Alternative name(s):
TF3C-beta
Transcription factor IIIC 110 kDa subunit
Short name:
TFIIIC 110 kDa subunit
Short name:
TFIIIC110
Transcription factor IIIC subunit beta
Gene namesi
Name:GTF3C2
Synonyms:KIAA0011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115207.13
HGNCiHGNC:4665 GTF3C2
MIMi604883 gene
neXtProtiNX_Q8WUA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115207
PharmGKBiPA29053

Polymorphism and mutation databases

DMDMi48428661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509851 – 911General transcription factor 3C polypeptide 2Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei892PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei895PhosphothreonineCombined sources1
Modified residuei901PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUA4
MaxQBiQ8WUA4
PaxDbiQ8WUA4
PeptideAtlasiQ8WUA4
PRIDEiQ8WUA4
ProteomicsDBi74647
74648 [Q8WUA4-2]

PTM databases

iPTMnetiQ8WUA4
PhosphoSitePlusiQ8WUA4

Expressioni

Gene expression databases

BgeeiENSG00000115207 Expressed in 119 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_GTF3C2
ExpressionAtlasiQ8WUA4 baseline and differential
GenevisibleiQ8WUA4 HS

Organism-specific databases

HPAiHPA035836

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.

Binary interactionsi

Protein-protein interaction databases

BioGridi109231, 74 interactors
CORUMiQ8WUA4
DIPiDIP-38213N
IntActiQ8WUA4, 32 interactors
MINTiQ8WUA4
STRINGi9606.ENSP00000264720

Structurei

3D structure databases

ProteinModelPortaliQ8WUA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati366 – 426WD 1Add BLAST61
Repeati427 – 483WD 2Add BLAST57
Repeati484 – 535WD 3Add BLAST52
Repeati536 – 603WD 4Add BLAST68
Repeati604 – 654WD 5Add BLAST51
Repeati655 – 690WD 6Add BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi151 – 156Poly-Leu6

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IG5U Eukaryota
ENOG410YFGF LUCA
GeneTreeiENSGT00390000018632
HOGENOMiHOG000133051
HOVERGENiHBG056791
InParanoidiQ8WUA4
KOiK15200
OMAiQLWGLGT
OrthoDBiEOG091G07LV
PhylomeDBiQ8WUA4
TreeFamiTF314779

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8WUA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE
60 70 80 90 100
MSLPTPLPGF EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG
110 120 130 140 150
RKRGGRTRKG PKRPQQPNPP SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE
160 170 180 190 200
LLLLKLSKDL DRPESQSPKR PPEDFETPSG ERPRRRAAQV ALLYLQELAE
210 220 230 240 250
ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD GAPRDEDFFL
260 270 280 290 300
QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP
310 320 330 340 350
NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP
360 370 380 390 400
QEEKSPLFSV QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL
410 420 430 440 450
DWCPVPEGAG ASQYVALFSS PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE
460 470 480 490 500
SCPGNRAHFV YGIACDNGCI WDLKFCPSGA WELPGTPRKA PLLPRLGLLA
510 520 530 540 550
LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT LQVGSMQATD
560 570 580 590 600
PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS
610 620 630 640 650
LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI
660 670 680 690 700
NSIKRFLSTE LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF
710 720 730 740 750
TAPRKGTVWS LSGSDWLGTI AAGDISGELI AAILPDMALN PINVKRPVER
760 770 780 790 800
RFPIYKADLI PYQDSPEGPD HSSASSGVPN PPKARTYTET VNHHYLLFQD
810 820 830 840 850
TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV RFSPNLDSYG
860 870 880 890 900
WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF
910
SPTSHRLLPT P
Length:911
Mass (Da):100,680
Last modified:June 7, 2004 - v2
Checksum:iB59D91DE74555192
GO
Isoform 2 (identifier: Q8WUA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-585: MVVFWNL → KKNQNKT
     586-911: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):64,003
Checksum:i0CBDAE93F3E08D6B
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4Q6H0Y4Q6_HUMAN
General transcription factor 3C pol...
GTF3C2
420Annotation score:
H7C3X9H7C3X9_HUMAN
General transcription factor 3C pol...
GTF3C2
181Annotation score:
A0A087WZD8A0A087WZD8_HUMAN
General transcription factor 3C pol...
GTF3C2
584Annotation score:
H7C318H7C318_HUMAN
General transcription factor 3C pol...
GTF3C2
142Annotation score:
C9JQ12C9JQ12_HUMAN
General transcription factor 3C pol...
GTF3C2
74Annotation score:
H7C1A9H7C1A9_HUMAN
General transcription factor 3C pol...
GTF3C2
79Annotation score:
C9JNH7C9JNH7_HUMAN
General transcription factor 3C pol...
GTF3C2
134Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301N → D in AAP88801 (Ref. 3) Curated1
Sequence conflicti301N → D in AAH20981 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010566579 – 585MVVFWNL → KKNQNKT in isoform 2. 1 Publication7
Alternative sequenceiVSP_010567586 – 911Missing in isoform 2. 1 PublicationAdd BLAST326

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13636 mRNA Translation: BAA02800.1
BT009799 mRNA Translation: AAP88801.1
CH471053 Genomic DNA Translation: EAX00595.1
CH471053 Genomic DNA Translation: EAX00596.1
BC000212 mRNA Translation: AAH00212.1
BC020981 mRNA Translation: AAH20981.1
AF054988 mRNA Translation: AAC09349.1
CCDSiCCDS1749.1 [Q8WUA4-1]
PIRiA56465
RefSeqiNP_001030598.1, NM_001035521.2 [Q8WUA4-1]
NP_001305838.1, NM_001318909.1
NP_001512.1, NM_001521.3 [Q8WUA4-1]
UniGeneiHs.745168
Hs.75782

Genome annotation databases

EnsembliENST00000264720; ENSP00000264720; ENSG00000115207 [Q8WUA4-1]
ENST00000359541; ENSP00000352536; ENSG00000115207 [Q8WUA4-1]
GeneIDi2976
KEGGihsa:2976
UCSCiuc002rju.3 human [Q8WUA4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13636 mRNA Translation: BAA02800.1
BT009799 mRNA Translation: AAP88801.1
CH471053 Genomic DNA Translation: EAX00595.1
CH471053 Genomic DNA Translation: EAX00596.1
BC000212 mRNA Translation: AAH00212.1
BC020981 mRNA Translation: AAH20981.1
AF054988 mRNA Translation: AAC09349.1
CCDSiCCDS1749.1 [Q8WUA4-1]
PIRiA56465
RefSeqiNP_001030598.1, NM_001035521.2 [Q8WUA4-1]
NP_001305838.1, NM_001318909.1
NP_001512.1, NM_001521.3 [Q8WUA4-1]
UniGeneiHs.745168
Hs.75782

3D structure databases

ProteinModelPortaliQ8WUA4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109231, 74 interactors
CORUMiQ8WUA4
DIPiDIP-38213N
IntActiQ8WUA4, 32 interactors
MINTiQ8WUA4
STRINGi9606.ENSP00000264720

PTM databases

iPTMnetiQ8WUA4
PhosphoSitePlusiQ8WUA4

Polymorphism and mutation databases

DMDMi48428661

Proteomic databases

EPDiQ8WUA4
MaxQBiQ8WUA4
PaxDbiQ8WUA4
PeptideAtlasiQ8WUA4
PRIDEiQ8WUA4
ProteomicsDBi74647
74648 [Q8WUA4-2]

Protocols and materials databases

DNASUi2976
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264720; ENSP00000264720; ENSG00000115207 [Q8WUA4-1]
ENST00000359541; ENSP00000352536; ENSG00000115207 [Q8WUA4-1]
GeneIDi2976
KEGGihsa:2976
UCSCiuc002rju.3 human [Q8WUA4-1]

Organism-specific databases

CTDi2976
EuPathDBiHostDB:ENSG00000115207.13
GeneCardsiGTF3C2
HGNCiHGNC:4665 GTF3C2
HPAiHPA035836
MIMi604883 gene
neXtProtiNX_Q8WUA4
OpenTargetsiENSG00000115207
PharmGKBiPA29053
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG5U Eukaryota
ENOG410YFGF LUCA
GeneTreeiENSGT00390000018632
HOGENOMiHOG000133051
HOVERGENiHBG056791
InParanoidiQ8WUA4
KOiK15200
OMAiQLWGLGT
OrthoDBiEOG091G07LV
PhylomeDBiQ8WUA4
TreeFamiTF314779

Enzyme and pathway databases

ReactomeiR-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
SignaLinkiQ8WUA4

Miscellaneous databases

ChiTaRSiGTF3C2 human
GeneWikiiGTF3C2
GenomeRNAii2976
PROiPR:Q8WUA4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115207 Expressed in 119 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_GTF3C2
ExpressionAtlasiQ8WUA4 baseline and differential
GenevisibleiQ8WUA4 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUA4
Secondary accession number(s): D6W557, Q16632, Q9BWI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 12, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again