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Protein

Peptidyl-prolyl cis-trans isomerase-like 4

Gene

PPIL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • regulation of phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central

Keywordsi

Molecular functionIsomerase, RNA-binding, Rotamase

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 4 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin-like protein PPIL4
Rotamase PPIL4
Gene namesi
Name:PPIL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000131013.3
HGNCiHGNC:15702 PPIL4
MIMi607609 gene
neXtProtiNX_Q8WUA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131013
PharmGKBiPA33590

Polymorphism and mutation databases

BioMutaiPPIL4
DMDMi74760546

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330521 – 492Peptidyl-prolyl cis-trans isomerase-like 4Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei393PhosphoserineBy similarity1
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei471PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WUA2
MaxQBiQ8WUA2
PaxDbiQ8WUA2
PeptideAtlasiQ8WUA2
PRIDEiQ8WUA2
ProteomicsDBi74646

PTM databases

iPTMnetiQ8WUA2
PhosphoSitePlusiQ8WUA2

Expressioni

Tissue specificityi

Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000131013 Expressed in 194 organ(s), highest expression level in lung
CleanExiHS_PPIL4
ExpressionAtlasiQ8WUA2 baseline and differential
GenevisibleiQ8WUA2 HS

Organism-specific databases

HPAiHPA031599
HPA031600

Interactioni

Protein-protein interaction databases

BioGridi124467, 25 interactors
ELMiQ8WUA2
IntActiQ8WUA2, 11 interactors
MINTiQ8WUA2
STRINGi9606.ENSP00000253329

Structurei

3D structure databases

ProteinModelPortaliQ8WUA2
SMRiQ8WUA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 161PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161
Domaini240 – 318RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 388Lys-richAdd BLAST68

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0415 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000186284
HOVERGENiHBG057731
InParanoidiQ8WUA2
KOiK12735
OMAiHSVQKNF
OrthoDBiEOG091G0DCF
PhylomeDBiQ8WUA2
TreeFamiTF351865

Family and domain databases

CDDicd01921 cyclophilin_RRM, 1 hit
Gene3Di2.40.100.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR035542 CRIP
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR035538 Cyclophilin_PPIL4
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PTHR11071:SF156 PTHR11071:SF156, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF50891 SSF50891, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8WUA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI
60 70 80 90 100
IQTGDPTGTG RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG
110 120 130 140 150
SDQHGSQFLI TTGENLDYLD GVHTVFGEVT EGMDIIKKIN ETFVDKDFVP
160 170 180 190 200
YQDIRINHTV ILDDPFDDPP DLLIPDRSPE PTREQLDSGR IGADEEIDDF
210 220 230 240 250
KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN VLFVCKLNPV
260 270 280 290 300
TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK
310 320 330 340 350
MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPPNLV
360 370 380 390 400
LKDKVKPKQD TKYDLILDEQ AEDSKSSHSH TSKKHKKKTH HCSEEKEDED
410 420 430 440 450
YMPIKNTNQD IYREMGFGHY EEEESCWEKQ KSEKRDRTQN RSRSRSRERD
460 470 480 490
GHYSNSHKSK YQTDLYERER SKKRDRSRSP KKSKDKEKSK YR
Length:492
Mass (Da):57,225
Last modified:March 1, 2002 - v1
Checksum:i6888B62802E15989
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4S2Q5T4S2_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PPIL4
127Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti389T → A in CAD97776 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357880 mRNA Translation: AAM63961.1
AK315388 mRNA Translation: BAG37781.1
BX537536 mRNA Translation: CAD97776.1
AL078581 Genomic DNA No translation available.
AL357619 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47799.1
BC020986 mRNA Translation: AAH20986.1
CCDSiCCDS34550.1
RefSeqiNP_624311.1, NM_139126.3
UniGeneiHs.744238

Genome annotation databases

EnsembliENST00000253329; ENSP00000253329; ENSG00000131013
GeneIDi85313
KEGGihsa:85313
UCSCiuc003qmo.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357880 mRNA Translation: AAM63961.1
AK315388 mRNA Translation: BAG37781.1
BX537536 mRNA Translation: CAD97776.1
AL078581 Genomic DNA No translation available.
AL357619 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47799.1
BC020986 mRNA Translation: AAH20986.1
CCDSiCCDS34550.1
RefSeqiNP_624311.1, NM_139126.3
UniGeneiHs.744238

3D structure databases

ProteinModelPortaliQ8WUA2
SMRiQ8WUA2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124467, 25 interactors
ELMiQ8WUA2
IntActiQ8WUA2, 11 interactors
MINTiQ8WUA2
STRINGi9606.ENSP00000253329

PTM databases

iPTMnetiQ8WUA2
PhosphoSitePlusiQ8WUA2

Polymorphism and mutation databases

BioMutaiPPIL4
DMDMi74760546

Proteomic databases

EPDiQ8WUA2
MaxQBiQ8WUA2
PaxDbiQ8WUA2
PeptideAtlasiQ8WUA2
PRIDEiQ8WUA2
ProteomicsDBi74646

Protocols and materials databases

DNASUi85313
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253329; ENSP00000253329; ENSG00000131013
GeneIDi85313
KEGGihsa:85313
UCSCiuc003qmo.3 human

Organism-specific databases

CTDi85313
EuPathDBiHostDB:ENSG00000131013.3
GeneCardsiPPIL4
HGNCiHGNC:15702 PPIL4
HPAiHPA031599
HPA031600
MIMi607609 gene
neXtProtiNX_Q8WUA2
OpenTargetsiENSG00000131013
PharmGKBiPA33590
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0415 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000186284
HOVERGENiHBG057731
InParanoidiQ8WUA2
KOiK12735
OMAiHSVQKNF
OrthoDBiEOG091G0DCF
PhylomeDBiQ8WUA2
TreeFamiTF351865

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiPPIL4 human
GeneWikiiPPIL4
GenomeRNAii85313
PROiPR:Q8WUA2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131013 Expressed in 194 organ(s), highest expression level in lung
CleanExiHS_PPIL4
ExpressionAtlasiQ8WUA2 baseline and differential
GenevisibleiQ8WUA2 HS

Family and domain databases

CDDicd01921 cyclophilin_RRM, 1 hit
Gene3Di2.40.100.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR035542 CRIP
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR035538 Cyclophilin_PPIL4
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PTHR11071:SF156 PTHR11071:SF156, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF50891 SSF50891, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPIL4_HUMAN
AccessioniPrimary (citable) accession number: Q8WUA2
Secondary accession number(s): B2RD34, Q7Z3Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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