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Entry version 144 (16 Oct 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Zinc finger CCCH domain-containing protein 15

Gene

ZC3H15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri99 – 126C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri174 – 212C3H1-type 2PROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 15
Alternative name(s):
DRG family-regulatory protein 1
Likely ortholog of mouse immediate early response erythropoietin 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H15
Synonyms:DFRP1, LEREPO4
ORF Names:HSPC303, HT010, MSTP012, PP730
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29528 ZC3H15

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WU90

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55854

Open Targets

More...
OpenTargetsi
ENSG00000065548

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409508

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WU90

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3H15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730681

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003246421 – 426Zinc finger CCCH domain-containing protein 15Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WU90

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WU90

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WU90

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WU90

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WU90

PeptideAtlas

More...
PeptideAtlasi
Q8WU90

PRoteomics IDEntifications database

More...
PRIDEi
Q8WU90

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4648
74645 [Q8WU90-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WU90

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WU90

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8WU90

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000065548 Expressed in 238 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WU90 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WU90 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031099
HPA031100
HPA031101

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DRG1; this interaction prevents DRG1 poly-ubiquitination and degradation by proteasome. DRG1-ZC3H15/DFRP1 complex co-sediments with polysomes. Associates with microtubules.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DRG1Q9Y2958EBI-1042636,EBI-719554

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120956, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WU90, 22 interactors

Molecular INTeraction database

More...
MINTi
Q8WU90

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338788

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WU90

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni236 – 260Required for interaction with DRG1By similarityAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili61 – 86Sequence analysisAdd BLAST26
Coiled coili218 – 285Sequence analysisAdd BLAST68

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZC3H15/TMA46 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 126C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri174 – 212C3H1-type 2PROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1763 Eukaryota
COG5252 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015818

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WU90

Identification of Orthologs from Complete Genome Data

More...
OMAi
DIICKFF

Database of Orthologous Groups

More...
OrthoDBi
1358374at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WU90

TreeFam database of animal gene trees

More...
TreeFami
TF300892

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032378 ZC3H15/TMA46_C
IPR041367 Znf-CCCH_4
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16543 DFRP_C, 1 hit
PF18044 zf-CCCH_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356 ZnF_C3H1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WU90-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPKKQAQAG GSKKAEQKKK EKIIEDKTFG LKNKKGAKQQ KFIKAVTHQV
60 70 80 90 100
KFGQQNPRQV AQSEAEKKLK KDDKKKELQE LNELFKPVVA AQKISKGADP
110 120 130 140 150
KSVVCAFFKQ GQCTKGDKCK FSHDLTLERK CEKRSVYIDA RDEELEKDTM
160 170 180 190 200
DNWDEKKLEE VVNKKHGEAE KKKPKTQIVC KHFLEAIENN KYGWFWVCPG
210 220 230 240 250
GGDICMYRHA LPPGFVLKKD KKKEEKEDEI SLEDLIERER SALGPNVTKI
260 270 280 290 300
TLESFLAWKK RKRQEKIDKL EQDMERRKAD FKAGKALVIS GREVFEFRPE
310 320 330 340 350
LVNDDDEEAD DTRYTQGTGG DEVDDSVSVN DIDLSLYIPR DVDETGITVA
360 370 380 390 400
SLERFSTYTS DKDENKLSEA SGGRAENGER SDLEEDNERE GTENGAIDAV
410 420
PVDENLFTGE DLDELEEELN TLDLEE
Length:426
Mass (Da):48,602
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A80B7FDC3376181
GO
Isoform 2 (identifier: Q8WU90-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-205: Missing.
     324-367: DDSVSVNDID...YTSDKDENKL → RGSFVPHLLM...VQILTPTMGN
     368-426: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,947
Checksum:iD6013402EDED333C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WB26F8WB26_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H15
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF67F8WF67_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H15
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C466H7C466_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H15
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28981 differs from that shown. Reason: Frameshift.Curated
The sequence AAF67649 differs from that shown. Reason: Frameshift.Curated
The sequence AAL55770 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ13514 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10G → R in AAL55770 (PubMed:15498874).Curated1
Sequence conflicti16 – 17EQ → DE in AAF67649 (PubMed:10931946).Curated2
Sequence conflicti17Q → T in AAF28981 (Ref. 2) Curated1
Sequence conflicti26D → G in AAL55770 (PubMed:15498874).Curated1
Sequence conflicti37A → T in AAL55770 (PubMed:15498874).Curated1
Sequence conflicti77E → D in AAF28981 (Ref. 2) Curated1
Sequence conflicti77E → D in AAF67649 (PubMed:10931946).Curated1
Sequence conflicti112Q → R in BAA91968 (PubMed:14702039).Curated1
Sequence conflicti342V → A in AAF28981 (Ref. 2) Curated1
Sequence conflicti365N → T in AAF28981 (Ref. 2) Curated1
Sequence conflicti413D → V in AAQ13514 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039867342V → E. Corresponds to variant dbSNP:rs11555006Ensembl.1
Natural variantiVAR_052969408T → P. Corresponds to variant dbSNP:rs1043497Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559921 – 205Missing in isoform 2. 1 PublicationAdd BLAST205
Alternative sequenceiVSP_055993324 – 367DDSVS…DENKL → RGSFVPHLLMLIERNNRKYH NMVKSHQHQSHSAWVQILTP TMGN in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_055994368 – 426Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF109366 mRNA Translation: AAQ13514.1 Frameshift.
AF161421 mRNA Translation: AAF28981.1 Frameshift.
AF220184 mRNA Translation: AAF67649.1 Frameshift.
AK001901 mRNA Translation: BAA91968.1
AK297658 mRNA Translation: BAG60024.1
AF289586 mRNA Translation: AAL55770.1 Frameshift.
AC018867 Genomic DNA Translation: AAX88885.1
CH471058 Genomic DNA Translation: EAX10935.1
CH471058 Genomic DNA Translation: EAX10936.1
BC021102 mRNA Translation: AAH21102.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42791.1 [Q8WU90-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060941.2, NM_018471.2 [Q8WU90-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337859; ENSP00000338788; ENSG00000065548 [Q8WU90-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55854

UCSC genome browser

More...
UCSCi
uc002upo.4 human [Q8WU90-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109366 mRNA Translation: AAQ13514.1 Frameshift.
AF161421 mRNA Translation: AAF28981.1 Frameshift.
AF220184 mRNA Translation: AAF67649.1 Frameshift.
AK001901 mRNA Translation: BAA91968.1
AK297658 mRNA Translation: BAG60024.1
AF289586 mRNA Translation: AAL55770.1 Frameshift.
AC018867 Genomic DNA Translation: AAX88885.1
CH471058 Genomic DNA Translation: EAX10935.1
CH471058 Genomic DNA Translation: EAX10936.1
BC021102 mRNA Translation: AAH21102.1
CCDSiCCDS42791.1 [Q8WU90-1]
RefSeqiNP_060941.2, NM_018471.2 [Q8WU90-1]

3D structure databases

SMRiQ8WU90
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120956, 48 interactors
IntActiQ8WU90, 22 interactors
MINTiQ8WU90
STRINGi9606.ENSP00000338788

PTM databases

iPTMnetiQ8WU90
PhosphoSitePlusiQ8WU90
SwissPalmiQ8WU90

Polymorphism and mutation databases

BioMutaiZC3H15
DMDMi74730681

Proteomic databases

EPDiQ8WU90
jPOSTiQ8WU90
MassIVEiQ8WU90
MaxQBiQ8WU90
PaxDbiQ8WU90
PeptideAtlasiQ8WU90
PRIDEiQ8WU90
ProteomicsDBi4648
74645 [Q8WU90-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55854

Genome annotation databases

EnsembliENST00000337859; ENSP00000338788; ENSG00000065548 [Q8WU90-1]
GeneIDi55854
KEGGihsa:55854
UCSCiuc002upo.4 human [Q8WU90-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55854
DisGeNETi55854

GeneCards: human genes, protein and diseases

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GeneCardsi
ZC3H15
HGNCiHGNC:29528 ZC3H15
HPAiHPA031099
HPA031100
HPA031101
neXtProtiNX_Q8WU90
OpenTargetsiENSG00000065548
PharmGKBiPA162409508

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1763 Eukaryota
COG5252 LUCA
GeneTreeiENSGT00390000015818
InParanoidiQ8WU90
OMAiDIICKFF
OrthoDBi1358374at2759
PhylomeDBiQ8WU90
TreeFamiTF300892

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZC3H15 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55854
PharosiQ8WU90

Protein Ontology

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PROi
PR:Q8WU90

Gene expression databases

BgeeiENSG00000065548 Expressed in 238 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ8WU90 baseline and differential
GenevisibleiQ8WU90 HS

Family and domain databases

InterProiView protein in InterPro
IPR032378 ZC3H15/TMA46_C
IPR041367 Znf-CCCH_4
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF16543 DFRP_C, 1 hit
PF18044 zf-CCCH_4, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 2 hits
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC3HF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WU90
Secondary accession number(s): B4DMW2
, D3DPG7, Q5QTQ4, Q8WZ06, Q9NUZ3, Q9NZ37, Q9P079
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2002
Last modified: October 16, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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