UniProtKB - Q8WU79 (SMAP2_HUMAN)
Stromal membrane-associated protein 2
SMAP2
Functioni
GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 28 – 51 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8WU79 |
SignaLinki | Q8WU79 |
Names & Taxonomyi
Protein namesi | Recommended name: Stromal membrane-associated protein 2Alternative name(s): Stromal membrane-associated protein 1-like |
Gene namesi | Name:SMAP2 Synonyms:SMAP1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25082, SMAP2 |
neXtProti | NX_Q8WU79 |
VEuPathDBi | HostDB:ENSG00000084070 |
Subcellular locationi
Cytoplasm and Cytosol
Note: Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures.By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 64744 |
OpenTargetsi | ENSG00000084070 |
PharmGKBi | PA162403939 |
Miscellaneous databases
Pharosi | Q8WU79, Tbio |
Genetic variation databases
BioMutai | SMAP2 |
DMDMi | 74760545 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000235841 | 1 – 429 | Stromal membrane-associated protein 2Add BLAST | 429 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 219 | PhosphoserineCombined sources | 1 | |
Modified residuei | 223 | PhosphoserineCombined sources | 1 | |
Modified residuei | 225 | PhosphoserineCombined sources | 1 | |
Modified residuei | 231 | PhosphoserineCombined sources | 1 | |
Modified residuei | 240 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8WU79 |
jPOSTi | Q8WU79 |
MassIVEi | Q8WU79 |
MaxQBi | Q8WU79 |
PaxDbi | Q8WU79 |
PeptideAtlasi | Q8WU79 |
PRIDEi | Q8WU79 |
ProteomicsDBi | 74642 [Q8WU79-1] 74643 [Q8WU79-2] 74644 [Q8WU79-3] |
PTM databases
GlyGeni | Q8WU79, 1 site, 2 O-linked glycans (1 site) |
iPTMneti | Q8WU79 |
PhosphoSitePlusi | Q8WU79 |
Expressioni
Gene expression databases
Bgeei | ENSG00000084070, Expressed in blood and 201 other tissues |
ExpressionAtlasi | Q8WU79, baseline and differential |
Genevisiblei | Q8WU79, HS |
Organism-specific databases
HPAi | ENSG00000084070, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with ARF1.
Interacts with PICALM and clathrin heavy chains (By similarity).
By similarityBinary interactionsi
Q8WU79
Protein-protein interaction databases
BioGRIDi | 122260, 160 interactors |
IntActi | Q8WU79, 33 interactors |
MINTi | Q8WU79 |
STRINGi | 9606.ENSP00000361803 |
Miscellaneous databases
RNActi | Q8WU79, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8WU79 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WU79 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 137 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 125 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 138 – 184 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 163 – 232 | Interaction with clathrin heavy chainsBy similarityAdd BLAST | 70 | |
Regioni | 217 – 259 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 340 – 429 | Interaction with PICALMBy similarityAdd BLAST | 90 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 138 – 174 | Basic and acidic residuesSequence analysisAdd BLAST | 37 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 28 – 51 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0703, Eukaryota |
GeneTreei | ENSGT00940000158387 |
HOGENOMi | CLU_023062_5_0_1 |
InParanoidi | Q8WU79 |
OMAi | DKWKRGN |
OrthoDBi | 1097163at2759 |
PhylomeDBi | Q8WU79 |
TreeFami | TF313876 |
Family and domain databases
Gene3Di | 1.10.220.150, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTGKSVKDVD RYQAVLANLL LEEDNKFCAD CQSKGPRWAS WNIGVFICIR
60 70 80 90 100
CAGIHRNLGV HISRVKSVNL DQWTQEQIQC MQEMGNGKAN RLYEAYLPET
110 120 130 140 150
FRRPQIDPAV EGFIRDKYEK KKYMDRSLDI NAFRKEKDDK WKRGSEPVPE
160 170 180 190 200
KKLEPVVFEK VKMPQKKEDP QLPRKSSPKS TAPVMDLLGL DAPVACSIAN
210 220 230 240 250
SKTSNTLEKD LDLLASVPSP SSSGSRKVVG SMPTAGSAGS VPENLNLFPE
260 270 280 290 300
PGSKSEEIGK KQLSKDSILS LYGSQTPQMP TQAMFMAPAQ MAYPTAYPSF
310 320 330 340 350
PGVTPPNSIM GSMMPPPVGM VAQPGASGMV APMAMPAGYM GGMQASMMGV
360 370 380 390 400
PNGMMTTQQA GYMAGMAAMP QTVYGVQPAQ QLQWNLTQMT QQMAGMNFYG
410 420
ANGMMNYGQS MSGGNGQAAN QTLSPQMWK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WV97 | A0A087WV97_HUMAN | Stromal membrane-associated protein... | SMAP2 | 424 | Annotation score: | ||
X6RCC3 | X6RCC3_HUMAN | Stromal membrane-associated protein... | SMAP2 | 174 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048327 | 289 | A → T. Corresponds to variant dbSNP:rs34845213Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043789 | 1 – 80 | Missing in isoform 3. 1 PublicationAdd BLAST | 80 | |
Alternative sequenceiVSP_018504 | 1 – 33 | MTGKS…ADCQS → MIF in isoform 2. 2 PublicationsAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133206 mRNA Translation: CAB61580.1 AL137764 mRNA Translation: CAB70912.1 AK298702 mRNA Translation: BAH12851.1 AK303975 mRNA Translation: BAH14088.1 AK313105 mRNA Translation: BAG35928.1 AK316218 mRNA Translation: BAH14589.1 AL031985 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07220.1 CH471059 Genomic DNA Translation: EAX07222.1 CH471059 Genomic DNA Translation: EAX07221.1 BC014512 mRNA Translation: AAH14512.1 BC021133 mRNA Translation: AAH21133.1 |
CCDSi | CCDS451.1 [Q8WU79-1] CCDS55592.1 [Q8WU79-2] CCDS55593.1 [Q8WU79-3] |
RefSeqi | NP_001185907.1, NM_001198978.1 [Q8WU79-2] NP_001185908.1, NM_001198979.1 NP_001185909.1, NM_001198980.1 [Q8WU79-3] NP_073570.1, NM_022733.2 [Q8WU79-1] |
Genome annotation databases
Ensembli | ENST00000372708; ENSP00000361793; ENSG00000084070 [Q8WU79-2] ENST00000372718; ENSP00000361803; ENSG00000084070 ENST00000539317; ENSP00000442835; ENSG00000084070 [Q8WU79-3] |
GeneIDi | 64744 |
KEGGi | hsa:64744 |
MANE-Selecti | ENST00000372718.8; ENSP00000361803.3; NM_022733.3; NP_073570.1 |
UCSCi | uc001cfj.4, human [Q8WU79-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133206 mRNA Translation: CAB61580.1 AL137764 mRNA Translation: CAB70912.1 AK298702 mRNA Translation: BAH12851.1 AK303975 mRNA Translation: BAH14088.1 AK313105 mRNA Translation: BAG35928.1 AK316218 mRNA Translation: BAH14589.1 AL031985 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07220.1 CH471059 Genomic DNA Translation: EAX07222.1 CH471059 Genomic DNA Translation: EAX07221.1 BC014512 mRNA Translation: AAH14512.1 BC021133 mRNA Translation: AAH21133.1 |
CCDSi | CCDS451.1 [Q8WU79-1] CCDS55592.1 [Q8WU79-2] CCDS55593.1 [Q8WU79-3] |
RefSeqi | NP_001185907.1, NM_001198978.1 [Q8WU79-2] NP_001185908.1, NM_001198979.1 NP_001185909.1, NM_001198980.1 [Q8WU79-3] NP_073570.1, NM_022733.2 [Q8WU79-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2IQJ | X-ray | 1.90 | A/B | 1-132 | [»] | |
SMRi | Q8WU79 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122260, 160 interactors |
IntActi | Q8WU79, 33 interactors |
MINTi | Q8WU79 |
STRINGi | 9606.ENSP00000361803 |
PTM databases
GlyGeni | Q8WU79, 1 site, 2 O-linked glycans (1 site) |
iPTMneti | Q8WU79 |
PhosphoSitePlusi | Q8WU79 |
Genetic variation databases
BioMutai | SMAP2 |
DMDMi | 74760545 |
Proteomic databases
EPDi | Q8WU79 |
jPOSTi | Q8WU79 |
MassIVEi | Q8WU79 |
MaxQBi | Q8WU79 |
PaxDbi | Q8WU79 |
PeptideAtlasi | Q8WU79 |
PRIDEi | Q8WU79 |
ProteomicsDBi | 74642 [Q8WU79-1] 74643 [Q8WU79-2] 74644 [Q8WU79-3] |
Protocols and materials databases
Antibodypediai | 17974, 132 antibodies from 23 providers |
DNASUi | 64744 |
Genome annotation databases
Ensembli | ENST00000372708; ENSP00000361793; ENSG00000084070 [Q8WU79-2] ENST00000372718; ENSP00000361803; ENSG00000084070 ENST00000539317; ENSP00000442835; ENSG00000084070 [Q8WU79-3] |
GeneIDi | 64744 |
KEGGi | hsa:64744 |
MANE-Selecti | ENST00000372718.8; ENSP00000361803.3; NM_022733.3; NP_073570.1 |
UCSCi | uc001cfj.4, human [Q8WU79-1] |
Organism-specific databases
CTDi | 64744 |
DisGeNETi | 64744 |
GeneCardsi | SMAP2 |
HGNCi | HGNC:25082, SMAP2 |
HPAi | ENSG00000084070, Tissue enhanced (lymphoid) |
neXtProti | NX_Q8WU79 |
OpenTargetsi | ENSG00000084070 |
PharmGKBi | PA162403939 |
VEuPathDBi | HostDB:ENSG00000084070 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0703, Eukaryota |
GeneTreei | ENSGT00940000158387 |
HOGENOMi | CLU_023062_5_0_1 |
InParanoidi | Q8WU79 |
OMAi | DKWKRGN |
OrthoDBi | 1097163at2759 |
PhylomeDBi | Q8WU79 |
TreeFami | TF313876 |
Enzyme and pathway databases
PathwayCommonsi | Q8WU79 |
SignaLinki | Q8WU79 |
Miscellaneous databases
BioGRID-ORCSi | 64744, 4 hits in 994 CRISPR screens |
ChiTaRSi | SMAP2, human |
EvolutionaryTracei | Q8WU79 |
GenomeRNAii | 64744 |
Pharosi | Q8WU79, Tbio |
PROi | PR:Q8WU79 |
RNActi | Q8WU79, protein |
Gene expression databases
Bgeei | ENSG00000084070, Expressed in blood and 201 other tissues |
ExpressionAtlasi | Q8WU79, baseline and differential |
Genevisiblei | Q8WU79, HS |
Family and domain databases
Gene3Di | 1.10.220.150, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SMAP2_HUMAN | |
Accessioni | Q8WU79Primary (citable) accession number: Q8WU79 Secondary accession number(s): B2R7T1 Q9UJL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references